Explanipedia

Rapid adaptation of cyanobacteria to environmental perturbations is achieved through structural remodeling of the proteome Open

Snigdha Sarkar, Elise M. Van Fossen, Xiaolu Li, Tong Zhang, Song Feng , et al. · 2025

Dynamic environments require cyanobacteria to rapidly respond to fluctuating light conditions on timescales faster than transcription-translation processes allow, which is possible through immediate regulation of protein function via molec…

Multi-Omics Reveals Temporal Scales of Carbon Metabolism in Synechococcus Elongatus PCC 7942 Under Light Disturbance Open

Connah Johnson, Zachary Johnson, Liam S. Mackey, Xiaolu Li, Natalie Sadler , et al. · 2025

Central carbon metabolism in model cyanobacteria involves multiple pathways to adapt to energy-light limitations across diel cycles. However, the success in mechanistic modeling for phenotypic prediction of the protein regulators in the me…

Cyanobacterial circadian regulation enhances bioproduction under subjective nighttime through rewiring of carbon partitioning dynamics, redox balance orchestration, and cell cycle modulation Open

A. Gilliam, Natalie Sadler, Xiaolu Li, M. G. García-Jiménez, Zachary Johnson , et al. · 2025

Environmental matrix and moisture influence soil microbial phenotypes in a simplified porous media incubation Open

Josué Rodríguez-Ramos, Natalie Sadler, Elias Zegeye, Yuliya Farris, Samuel Purvine , et al. · 2025

Soil moisture and porosity regulate microbial metabolism by influencing factors, such as system chemistry, substrate availability, and soil connectivity. However, accurately representing the soil environment and establishing a tractable mi…

Data for EMSL Project 60578 from December 2023 Open

Scott Baker, Nikola Tolić, William Chrisler, Lye Meng Markillie, Hugh Mitchell , et al. · 2025

Impact of moisture on microbial decomposition phenotypes and enzyme dynamics Open

Nicholas J. Reichart, Sheryl Bell, Vanessa Garayburu‐Caruso, Natalie Sadler, Sharon Zhao , et al. · 2025

Soil organic matter decomposition is a complex process reflecting microbial composition and environmental conditions. Moisture can modulate the connectivity and interactions of microbes. Due to heterogeneity, a deeper understanding of the …

An activity-based probe library for identifying promiscuous amide hydrolases Open

Chathuri J. Kombala, Jared O. Kroll, Lucas Webber, Stephen Callister, Natalie Sadler , et al. · 2025

A fluorogenic library-guided chemoproteomics approach identifies amide hydrolases active on non-natural substrates in soil bacteria with biotechnological relevance.

Transcriptome and Redox Proteome Reveal Temporal Scales of Carbon Metabolism Regulation in Model Cyanobacteria Under Light Disturbance Open

Connah Johnson, Zachary Johnson, Liam S. Mackey, Xiaolu Li, Natalie Sadler , et al. · 2024

We develop a systems approach based on an energy-landscape concept to differentiate interactions involving redox activities and conformational changes of proteins and nucleic acids interactions in multi-layered protein-DNA regulatory netwo…

Accelerating the identification of novel secondary metabolites in bioenergy plant root exudates using MicroED Open

Samantha Powell, Daisy Herrera, Irina El Khoury, C. S. Perdue, Natalie Sadler , et al. · 2024

Small molecule metabolites drive inter- and intraspecies communication and dependencies in diverse biological systems, yet a large proportion of these important chemical compounds remain uncharacterized in plants and microbes. Approximatel…