Carlo Saitta
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View article: Conversion Ability of Immunotherapy in Hepatocellular Carcinoma: Insights from the International Converse Study
Conversion Ability of Immunotherapy in Hepatocellular Carcinoma: Insights from the International Converse Study Open
Introduction: The potential for curative conversion with immunotherapy-based systemic treatment used with noncurative intent in patients with hepatocellular carcinoma (HCC) remains debated. This study aimed to provide a reliable epidemiolo…
View article: Outcome of hepatic resection for HCC in ideal and non-ideal candidates
Outcome of hepatic resection for HCC in ideal and non-ideal candidates Open
Background: The Barcelona Clinic Liver Cancer staging system considers, among patients with HCC, “ideal candidates” (ICs) for hepatic resection (HR) those with a single lesion, normal bilirubin, and without clinically significant portal hy…
View article: Risk Factors of Metabolic Dysfunction-associated Steatotic Liver Disease in a Cohort of Patients With Chronic Hepatitis B
Risk Factors of Metabolic Dysfunction-associated Steatotic Liver Disease in a Cohort of Patients With Chronic Hepatitis B Open
In this large European cohort, MASLD and fibrosis were highly prevalent among patients with CHB, whereas MASLD aggravated liver fibrosis. Though screening strategies remain inconsistent, ferritin levels, increased BMI, and type 2 diabetes …
View article: Recurrence rate, features, and outcome after hepatocellular carcinoma curative resection or ablation according to the IMbrave050 criteria: a real-world study
Recurrence rate, features, and outcome after hepatocellular carcinoma curative resection or ablation according to the IMbrave050 criteria: a real-world study Open
View article: Long-term effectiveness, safety, and liver stiffness dynamics of PBC treatment with obeticholic acid in real-world
Long-term effectiveness, safety, and liver stiffness dynamics of PBC treatment with obeticholic acid in real-world Open
View article: Characteristics and Outcomes of Hepatocellular Carcinoma in Patients with Autoimmune Hepatitis
Characteristics and Outcomes of Hepatocellular Carcinoma in Patients with Autoimmune Hepatitis Open
View article: Minimally invasive hepatectomy vs. thermoablation for single small (≤3 cm) hepatocellular carcinoma: A weighted real-life national comparison
Minimally invasive hepatectomy vs. thermoablation for single small (≤3 cm) hepatocellular carcinoma: A weighted real-life national comparison Open
View article: Absence of Viral Replication Is Associated With Improved Outcome in Anti‐<scp>HCV</scp>‐Positive Patients With Hepatocellular Carcinoma
Absence of Viral Replication Is Associated With Improved Outcome in Anti‐<span>HCV</span>‐Positive Patients With Hepatocellular Carcinoma Open
Background and Aims Presence of active hepatitis C virus (HCV) infection may influence the outcome of patients treated for hepatocellular carcinoma (HCC), although this issue has never been adequately assessed in a large series of patients…
View article: Prognostic factors influencing outcomes in hepatocellular carcinoma patients undergoing selective internal radiation therapy
Prognostic factors influencing outcomes in hepatocellular carcinoma patients undergoing selective internal radiation therapy Open
Selective internal radiation therapy (SIRT) has emerged as a viable endovascular treatment strategy for hepatocellular carcinoma (HCC). According to the Barcelona Clinic Liver Cancer (BCLC) classification, SIRT is currently recommended for…
View article: Development and Validation of a Scoring System to Predict Response to Obeticholic Acid in Primary Biliary Cholangitis
Development and Validation of a Scoring System to Predict Response to Obeticholic Acid in Primary Biliary Cholangitis Open
View article: Characteristics and outcome of anti‐hepatitis D virus positive patients with hepatocellular carcinoma
Characteristics and outcome of anti‐hepatitis D virus positive patients with hepatocellular carcinoma Open
Background & Aims Chronic hepatitis D virus (HDV) often leads to end‐stage liver disease and hepatocellular carcinoma (HCC). Comprehensive data pertaining to large populations with HDV and HCC are missing, therefore we sought to assess the…
View article: Mitochondrial DNA is a target of HBV integration
Mitochondrial DNA is a target of HBV integration Open
View article: Maternal and Neonatal Outcomes in Intrahepatic Cholestasis of Pregnancy
Maternal and Neonatal Outcomes in Intrahepatic Cholestasis of Pregnancy Open
The aims of our study were to evaluate the maternal and fetal outcomes of intrahepatic cholestasis of pregnancy (ICP). In this observational, retrospective case–control study, we included all pregnant women who gave birth with a diagnosis …
View article: Landscape of alcohol-related hepatocellular carcinoma in the last 15 years highlights the need to expand surveillance programs
Landscape of alcohol-related hepatocellular carcinoma in the last 15 years highlights the need to expand surveillance programs Open
View article: Hypergammaglobulinemia before Starting DAA Therapy Is A Strong Predictor of Disease Progression in Cirrhotic Patients Even after HCV Clearance
Hypergammaglobulinemia before Starting DAA Therapy Is A Strong Predictor of Disease Progression in Cirrhotic Patients Even after HCV Clearance Open
The predictive factors of long-term clinical benefits in patients with hepatitis C virus (HCV)—related liver cirrhosis after Direct Antiviral Agents (DAA) treatment are still undefined. The aim of this study was to identify any predictors …
View article: Predictors of serious adverse events and non‐response in cirrhotic patients with primary biliary cholangitis treated with obeticholic acid
Predictors of serious adverse events and non‐response in cirrhotic patients with primary biliary cholangitis treated with obeticholic acid Open
Background & Aims Obeticholic acid (OCA) has recently been restricted in patients with primary biliary cholangitis (PBC) with “advanced cirrhosis” because of its narrow therapeutic index. We aimed to better define the predicting factors of…
View article: Mitochondrial DNA is a frequent target of HBV integration
Mitochondrial DNA is a frequent target of HBV integration Open
Hepatitis B virus (HBV) may integrate into the genome of an infected cell and contribute to hepatocarcinogenesis. In this study, we applied a new high-throughput HBV integration sequencing approach that allows sensitive identification of H…
View article: Fatty Liver as Potential Biomarker of Atherosclerotic Damage in Familial Combined Hyperlipidemia
Fatty Liver as Potential Biomarker of Atherosclerotic Damage in Familial Combined Hyperlipidemia Open
Familial combined hyperlipidemia (FCH) is a very common inherited lipid disorder, characterized by a high risk of developing cardiovascular (CV) disease and metabolic complications, including insulin resistance (IR) and type 2 diabetes mel…
View article: Occult Hepatitis B Virus Infection: An Update
Occult Hepatitis B Virus Infection: An Update Open
Occult hepatitis B virus (HBV) infection (OBI) refers to a condition in which replication-competent viral DNA is present in the liver (with detectable or undetectable HBV DNA in the serum) of individuals testing negative for the HBV surfac…
View article: Characteristics and survival of patients with primary biliary cholangitis and hepatocellular carcinoma
Characteristics and survival of patients with primary biliary cholangitis and hepatocellular carcinoma Open
View article: Ficolin-2 Plasma Level Assesses Liver Fibrosis in Non-Alcoholic Fatty Liver Disease
Ficolin-2 Plasma Level Assesses Liver Fibrosis in Non-Alcoholic Fatty Liver Disease Open
Fibrosis is the strongest predictor for disease-specific mortality in non-alcoholic fatty liver diseases (NAFLD), but the need for liver biopsy limits its diagnosis. We assessed the performance of plasma ficolin-2 (FCN-2) as a biomarker of…
View article: Ficolin-2 Plasma Levels Assesses Liver Fibrosis in Non-Alcoholic Fatty Liver Disease
Ficolin-2 Plasma Levels Assesses Liver Fibrosis in Non-Alcoholic Fatty Liver Disease Open
Background & Aims: In the next 20 years, non-alcoholic fatty liver disease (NAFLD) is expected to become the leading cause of liver transplantation. Fibrosis is the most important prognostic factor for liver-related outcomes and mortality,…
View article: Xpert bladder monitor may avoid cystoscopies in patients under “active surveillance” for recurrent bladder cancer (BIAS project): longitudinal cohort study
Xpert bladder monitor may avoid cystoscopies in patients under “active surveillance” for recurrent bladder cancer (BIAS project): longitudinal cohort study Open
View article: Over time evaluation of glycaemic control in direct‐acting antiviral‐treated hepatitis C virus/diabetic individuals with chronic hepatitis or with cirrhosis
Over time evaluation of glycaemic control in direct‐acting antiviral‐treated hepatitis C virus/diabetic individuals with chronic hepatitis or with cirrhosis Open
Background Data concerning the impact of hepatitis C virus (HCV) cure on type 2 diabetes mellitus (T2DM) are controversial. The aim of the study was to evaluate the effects of anti‐HCV direct‐acting antiviral (DAA) treatments on long‐term …
View article: POS-426 IgAN in a patient with Wilson's Disease: a very rare association
POS-426 IgAN in a patient with Wilson's Disease: a very rare association Open
Wilson's disease (WD) is a genetic autosomal recessive disease, due to a mutation of the ATP7B gene, characterized by copper accumulation in the liver, eyes, and nerves. Renal involvement has been reported very rarely, affecting only 5 % o…
View article: Occult hepatitis B virus infection predicts non‐alcoholic steatohepatitis in severely obese individuals from Italy
Occult hepatitis B virus infection predicts non‐alcoholic steatohepatitis in severely obese individuals from Italy Open
Background & Aims Obesity is associated with non‐alcoholic fatty liver (NAFL), which may progress towards non‐alcoholic steatohepatitis (NASH), cirrhosis and hepatocellular carcinoma (HCC). Occult hepatitis B virus infection (OBI) may cont…
View article: Frequency of somatic mutations in TERT promoter, TP53 and CTNNB1 genes in patients with hepatocellular carcinoma from Southern Italy
Frequency of somatic mutations in TERT promoter, TP53 and CTNNB1 genes in patients with hepatocellular carcinoma from Southern Italy Open
Somatic mutations in the TERT promoter and in the TP53 and CTNNB1 genes are considered drivers for hepatocellular carcinoma (HCC) development. They show variable frequencies in different geographic areas, possibly depending on liver diseas…
View article: Obesity and liver cancer
Obesity and liver cancer Open
L'objectif de notre article est de clarifier les rapports existant entre plusieurs phénomènes qui possèdent chacun certaines caractéristiques de ce qui est appelé la « déférence ». Nous proposerons une distinction entre la déférence lingui…
View article: Free episomal and integrated HBV DNA in HBsAg-negative patients with intrahepatic cholangiocarcinoma
Free episomal and integrated HBV DNA in HBsAg-negative patients with intrahepatic cholangiocarcinoma Open
There is evidence that chronic hepatitis B virus (HBV) infection is associated with an increased risk of intrahepatic cholangiocarcinoma (ICC) development, and it has been hypothesized an etiological role of HBV in the development of this …
View article: NS3 Variability in Hepatitis C Virus Genotype 1A Isolates from Liver Tissue and Serum Samples of Treatment-Naïve Patients with Chronic Hepatitis C
NS3 Variability in Hepatitis C Virus Genotype 1A Isolates from Liver Tissue and Serum Samples of Treatment-Naïve Patients with Chronic Hepatitis C Open
Background: Hepatitis C virus (HCV) NS3 resistance-associated substitutions (RASs) reduce HCV susceptibility to protease inhibitors. Little is known about NS3 RASs in viral isolates from the liver of chronic hepatitis C (CHC)…