Heinz C. Schröder
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View article: Inorganic polyphosphate, a paradigm changer in 3D printing of <i>β</i>-tricalcium phosphate based materials for bone tissue surgery
Inorganic polyphosphate, a paradigm changer in 3D printing of <i>β</i>-tricalcium phosphate based materials for bone tissue surgery Open
β -Tricalcium phosphate ( β -TCP) is widely used as a material for bone implants due to its excellent biocompatibility, biodegradability, and osteoconductivity, as well as its osteoinductive properties. Here, we demonstrate that the regene…
View article: Eignung rettungsdienstlicher Sichtungskategorien zur Vorhersage des ambulanten oder stationären Weiterversorgungsbedarfs: eine explorative Analyse von Routinedaten
Eignung rettungsdienstlicher Sichtungskategorien zur Vorhersage des ambulanten oder stationären Weiterversorgungsbedarfs: eine explorative Analyse von Routinedaten Open
Zusammenfassung Hintergrund Eine effiziente und patientenzentrierte Notfallversorgung erfordert eine frühzeitige Lenkung des Patientenstroms. Ob dies bereits präklinisch durch den Rettungsdienst möglich ist und zu einer Entlastung der Nota…
View article: Precision Diagnostics - academia, biotech, pharma - collaboration is key
Precision Diagnostics - academia, biotech, pharma - collaboration is key Open
Precision Diagnostics is a pre-requisite for Precision Medicine by enabling a characterization of diseases on a molecular level and stratification of patients leading to mechanism-based treatment. Collaborative approaches in identifying, v…
View article: Polyphosphate Nanoparticles: Balancing Energy Requirements in Tissue Regeneration Processes
Polyphosphate Nanoparticles: Balancing Energy Requirements in Tissue Regeneration Processes Open
Nanoparticles of a particular, evolutionarily old inorganic polymer found across the biological kingdoms have attracted increasing interest in recent years not only because of their crucial role in metabolism but also their potential medic…
View article: The Physiological Inorganic Polymers Biosilica and Polyphosphate as Key Drivers for Biomedical Materials in Regenerative Nanomedicine
The Physiological Inorganic Polymers Biosilica and Polyphosphate as Key Drivers for Biomedical Materials in Regenerative Nanomedicine Open
There is a need for novel nanomaterials with properties not yet exploited in regenerative nanomedicine. Based on lessons learned from the oldest metazoan phylum, sponges, it has been recognized that two previously ignored or insufficiently…
View article: Microfragmented Fat and Biphasic Calcium Phosphates for Alveolar Cleft Repair: Protocol for a Prospective, Nonblinded, First-in-Human Clinical Study
Microfragmented Fat and Biphasic Calcium Phosphates for Alveolar Cleft Repair: Protocol for a Prospective, Nonblinded, First-in-Human Clinical Study Open
Background Biphasic calcium phosphates (BCP) may serve as off-the-shelf alternatives for iliac crest-derived autologous bone in alveolar cleft reconstructions. To add osteoinductivity to the osteoconductive BCPs to achieve similar regenera…
View article: Cell migration, DNA fragmentation and antibacterial properties of novel silver doped calcium polyphosphate nanoparticles
Cell migration, DNA fragmentation and antibacterial properties of novel silver doped calcium polyphosphate nanoparticles Open
View article: Liquid–liquid phase transition as a basis for novel materials for skin repair and regeneration
Liquid–liquid phase transition as a basis for novel materials for skin repair and regeneration Open
Polyphosphate (polyP) is a physiologically significant polymer with regenerative properties, crucial for supplying the metabolic fuel (ATP) essential for various regeneration processes in humans, including wound healing.
View article: Energy level as a theranostic factor for successful therapy of tissue injuries with polyphosphate: the triad metabolic energy - mechanical energy - heat
Energy level as a theranostic factor for successful therapy of tissue injuries with polyphosphate: the triad metabolic energy - mechanical energy - heat Open
Rationale: Tissue regeneration of skin and bone is an energy-intensive, ATP-consuming process that, if impaired, can lead to the development of chronic clinical pictures. ATP levels in the extracellular space including the exudate o…
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View article: Ascorbyl palmitate–PCL fiber mats loaded with strontium polyphosphate nanoparticles for guided bone regeneration
Ascorbyl palmitate–PCL fiber mats loaded with strontium polyphosphate nanoparticles for guided bone regeneration Open
Multifunctional fiber mats are explored as potential bioactive matrices for the development of the next generation of guided bone regeneration membranes with tunable microstructure, strength and therapeutic activity. In the present study, …
View article: Organtransplantierte Patienten in der Notaufnahme
Organtransplantierte Patienten in der Notaufnahme Open
Zusammenfassung Hintergrund Patienten nach solider Organtransplantation stellen in der Notaufnahme ein spezielles Kollektiv dar, wobei atypische Beschwerdebilder sowie komplexe Begleitfaktoren die Behandler vor besondere Herausforderungen …
View article: Künstliche Intelligenz und die Algorithmen des Antisemitismus
Künstliche Intelligenz und die Algorithmen des Antisemitismus Open
Zusammenfassung Künstliche Intelligenz im Zusammenhang mit Antisemitismus ist ein vergleichsweiser junger Forschungsbereich. KI-basierte Ansätze sollen vor allem in der Untersuchung des Antisemitismus im WEB 2.0 zum Einsatz kommen. Der Bei…
View article: Supplementary Dataset S1 from Expansion of a BDCA1<sup>+</sup>CD14<sup>+</sup> Myeloid Cell Population in Melanoma Patients May Attenuate the Efficacy of Dendritic Cell Vaccines
Supplementary Dataset S1 from Expansion of a BDCA1<sup>+</sup>CD14<sup>+</sup> Myeloid Cell Population in Melanoma Patients May Attenuate the Efficacy of Dendritic Cell Vaccines Open
The detailed composition of all gene sets used in GSEA.
View article: Supplementary Table and Figure Legends from Expansion of a BDCA1<sup>+</sup>CD14<sup>+</sup> Myeloid Cell Population in Melanoma Patients May Attenuate the Efficacy of Dendritic Cell Vaccines
Supplementary Table and Figure Legends from Expansion of a BDCA1<sup>+</sup>CD14<sup>+</sup> Myeloid Cell Population in Melanoma Patients May Attenuate the Efficacy of Dendritic Cell Vaccines Open
Legends for Supplementary Tables S1-S2 and Supplementary Figures S1-S12.
View article: Supplementary Table S1 from Expansion of a BDCA1<sup>+</sup>CD14<sup>+</sup> Myeloid Cell Population in Melanoma Patients May Attenuate the Efficacy of Dendritic Cell Vaccines
Supplementary Table S1 from Expansion of a BDCA1<sup>+</sup>CD14<sup>+</sup> Myeloid Cell Population in Melanoma Patients May Attenuate the Efficacy of Dendritic Cell Vaccines Open
A list of all molecules detected by antibody microarray (Multiplex analysis) with their UniPort entry name.
View article: Supplementary Table S2 from Expansion of a BDCA1<sup>+</sup>CD14<sup>+</sup> Myeloid Cell Population in Melanoma Patients May Attenuate the Efficacy of Dendritic Cell Vaccines
Supplementary Table S2 from Expansion of a BDCA1<sup>+</sup>CD14<sup>+</sup> Myeloid Cell Population in Melanoma Patients May Attenuate the Efficacy of Dendritic Cell Vaccines Open
GSEA raw data generated by Bubble GUM software.
View article: Supplementary Table S1 from Expansion of a BDCA1<sup>+</sup>CD14<sup>+</sup> Myeloid Cell Population in Melanoma Patients May Attenuate the Efficacy of Dendritic Cell Vaccines
Supplementary Table S1 from Expansion of a BDCA1<sup>+</sup>CD14<sup>+</sup> Myeloid Cell Population in Melanoma Patients May Attenuate the Efficacy of Dendritic Cell Vaccines Open
A list of all molecules detected by antibody microarray (Multiplex analysis) with their UniPort entry name.
View article: Supplementary Table S2 from Expansion of a BDCA1<sup>+</sup>CD14<sup>+</sup> Myeloid Cell Population in Melanoma Patients May Attenuate the Efficacy of Dendritic Cell Vaccines
Supplementary Table S2 from Expansion of a BDCA1<sup>+</sup>CD14<sup>+</sup> Myeloid Cell Population in Melanoma Patients May Attenuate the Efficacy of Dendritic Cell Vaccines Open
GSEA raw data generated by Bubble GUM software.
View article: Supplementary Figures S1-S12 from Expansion of a BDCA1<sup>+</sup>CD14<sup>+</sup> Myeloid Cell Population in Melanoma Patients May Attenuate the Efficacy of Dendritic Cell Vaccines
Supplementary Figures S1-S12 from Expansion of a BDCA1<sup>+</sup>CD14<sup>+</sup> Myeloid Cell Population in Melanoma Patients May Attenuate the Efficacy of Dendritic Cell Vaccines Open
The gating strategy applied to isolate and determine the frequency of BDCA1+ DCs, BDCA1+ CD14+ cells, monocytes and MDSCs from PBMCS of melanoma patients or healthy donors by FACS (S1); The distribution of potentially "missed genes" over t…
View article: Supplementary Dataset S1 from Expansion of a BDCA1<sup>+</sup>CD14<sup>+</sup> Myeloid Cell Population in Melanoma Patients May Attenuate the Efficacy of Dendritic Cell Vaccines
Supplementary Dataset S1 from Expansion of a BDCA1<sup>+</sup>CD14<sup>+</sup> Myeloid Cell Population in Melanoma Patients May Attenuate the Efficacy of Dendritic Cell Vaccines Open
The detailed composition of all gene sets used in GSEA.
View article: Supplementary Figures S1-S12 from Expansion of a BDCA1<sup>+</sup>CD14<sup>+</sup> Myeloid Cell Population in Melanoma Patients May Attenuate the Efficacy of Dendritic Cell Vaccines
Supplementary Figures S1-S12 from Expansion of a BDCA1<sup>+</sup>CD14<sup>+</sup> Myeloid Cell Population in Melanoma Patients May Attenuate the Efficacy of Dendritic Cell Vaccines Open
The gating strategy applied to isolate and determine the frequency of BDCA1+ DCs, BDCA1+ CD14+ cells, monocytes and MDSCs from PBMCS of melanoma patients or healthy donors by FACS (S1); The distribution of potentially "missed genes" over t…
View article: Supplementary Table and Figure Legends from Expansion of a BDCA1<sup>+</sup>CD14<sup>+</sup> Myeloid Cell Population in Melanoma Patients May Attenuate the Efficacy of Dendritic Cell Vaccines
Supplementary Table and Figure Legends from Expansion of a BDCA1<sup>+</sup>CD14<sup>+</sup> Myeloid Cell Population in Melanoma Patients May Attenuate the Efficacy of Dendritic Cell Vaccines Open
Legends for Supplementary Tables S1-S2 and Supplementary Figures S1-S12.
View article: Data from Expansion of a BDCA1<sup>+</sup>CD14<sup>+</sup> Myeloid Cell Population in Melanoma Patients May Attenuate the Efficacy of Dendritic Cell Vaccines
Data from Expansion of a BDCA1<sup>+</sup>CD14<sup>+</sup> Myeloid Cell Population in Melanoma Patients May Attenuate the Efficacy of Dendritic Cell Vaccines Open
The tumor microenvironment is characterized by regulatory T cells, type II macrophages, myeloid-derived suppressor cells, and other immunosuppressive cells that promote malignant progression. Here we report the identification of a novel BD…
View article: Data from Expansion of a BDCA1<sup>+</sup>CD14<sup>+</sup> Myeloid Cell Population in Melanoma Patients May Attenuate the Efficacy of Dendritic Cell Vaccines
Data from Expansion of a BDCA1<sup>+</sup>CD14<sup>+</sup> Myeloid Cell Population in Melanoma Patients May Attenuate the Efficacy of Dendritic Cell Vaccines Open
The tumor microenvironment is characterized by regulatory T cells, type II macrophages, myeloid-derived suppressor cells, and other immunosuppressive cells that promote malignant progression. Here we report the identification of a novel BD…
View article: CANNA-TICS: Efficacy and safety of oral treatment with nabiximols in adults with chronic tic disorders – Results of a prospective, multicenter, randomized, double-blind, placebo controlled, phase IIIb superiority study
CANNA-TICS: Efficacy and safety of oral treatment with nabiximols in adults with chronic tic disorders – Results of a prospective, multicenter, randomized, double-blind, placebo controlled, phase IIIb superiority study Open
Preliminary data suggest that cannabis-based medicines might be a promising new treatment for patients with Tourette syndrome (TS)/chronic tic disorders (CTD) resulting in an improvement of tics, comorbidities, and quality of life. This ra…
View article: Acceleration of Wound Healing through Amorphous Calcium Carbonate, Stabilized with High-Energy Polyphosphate
Acceleration of Wound Healing through Amorphous Calcium Carbonate, Stabilized with High-Energy Polyphosphate Open
Amorphous calcium carbonate (ACC), precipitated in the presence of inorganic polyphosphate (polyP), has shown promise as a material for bone regeneration due to its morphogenetic and metabolic energy (ATP)-delivering properties. The latter…
View article: Precision Diagnostics – From Discovery to Commercialization
Precision Diagnostics – From Discovery to Commercialization Open
Precise diagnostics are a pre-requisite for Precision Medicine by enabling a characterization of diseases on a molecular level leading to mechanism-based treatment. Giving the right drug to the right patient at the right dose and at the ri…
View article: Inorganic Polyphosphate: Coacervate Formation and Functional Significance in Nanomedical Applications
Inorganic Polyphosphate: Coacervate Formation and Functional Significance in Nanomedical Applications Open
Inorganic polyphosphates (polyP) are long-chain polymers of orthophosphate residues, which, depending on the external conditions, can be present both physiologically and synthetically in either soluble, nanoparticulate or coacervate form. …
View article: Artikulation, Anerkennung und Adressierung in digitalen Kontexten
Artikulation, Anerkennung und Adressierung in digitalen Kontexten Open