James C. Slaughter
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View article: Successful Collection of Patient-Reported Outcomes Shows Improvement in Quality of Life, Depression, and Disease Activity among Patients with Inflammatory Bowel Disease: A Real-World Study.
Successful Collection of Patient-Reported Outcomes Shows Improvement in Quality of Life, Depression, and Disease Activity among Patients with Inflammatory Bowel Disease: A Real-World Study. Open
High rate of PRO collection was successful using EMR implementation in a tertiary care clinic setting. Corticosteroid use and psychiatric medication use were associated with worse disease activity, depressive symptoms and quality of life s…
View article: Sleep coach intervention for adolescents with type 1 diabetes: Rationale and trial design
Sleep coach intervention for adolescents with type 1 diabetes: Rationale and trial design Open
If efficacious, Sleep Coach has the potential to improve both cognitive and glycemic outcomes in adolescents with T1D. This individualized, interactive, manualized behavioral intervention can be delivered remotely by trained staff, with th…
View article: Electronic decision aids enhance management of primary care patients with steatotic liver disease: Proof of concept pilot study
Electronic decision aids enhance management of primary care patients with steatotic liver disease: Proof of concept pilot study Open
Background: The approach to appropriate risk stratification for metabolic dysfunction–associated steatotic liver disease (MASLD) is variable, and the adoption of non-invasive liver disease assessments in clinical practice is suboptimal. In…
View article: Near-infrared Spectroscopy and Skin Tone in Children: A Prospective Cohort Study
Near-infrared Spectroscopy and Skin Tone in Children: A Prospective Cohort Study Open
Background: Retrospective studies suggest that pulse oximetry overestimates saturation in children from races that may be associated with darker skin tone. Near-infrared spectroscopy (NIRS) relies on similar optical technology, but less is…
View article: Effects of a parent advocacy intervention on service access for transition‐aged autistic youth: a multisite randomized controlled trial
Effects of a parent advocacy intervention on service access for transition‐aged autistic youth: a multisite randomized controlled trial Open
Background Autistic youth in the United States face many challenges accessing services as they transition to adulthood. Improving parents' ability to advocate for services is a promising way to improve service access. The current study tes…
View article: Evolution of strain diversity and virulence factor repertoire in pediatric Staphylococcus aureus isolates
Evolution of strain diversity and virulence factor repertoire in pediatric Staphylococcus aureus isolates Open
Background Invasive Staphylococcus aureus infections cause high morbidity and mortality in children and adults. With rising antimicrobial resistance, optimal prevention strategies and novel therapeutics are needed. As an effective vaccine …
View article: <scp>THR1VE</scp>!: Randomized controlled trial to reduce diabetes distress in adolescents with type 1 diabetes
<span>THR1VE</span>!: Randomized controlled trial to reduce diabetes distress in adolescents with type 1 diabetes Open
Aims To evaluate the effects of a positive psychology intervention to treat diabetes distress (DD) and improve glycaemic outcomes among adolescents with type 1 diabetes. Methods Adolescents ages 13–17 with elevated DD and their caregivers …
View article: Improving containment and prevention strategies using a patient transfer network representative of patients with multidrug-resistant organisms
Improving containment and prevention strategies using a patient transfer network representative of patients with multidrug-resistant organisms Open
Objectives: Interfacility patient transfers contribute to the regional spread of multidrug-resistant organisms (MDROs). We evaluated whether transfer patterns of inpatients with similar characteristics to carbapenem-resistant Enterobactera…
View article: Impact of transfer from pediatric gastroenterology to adult gastroenterology care in eosinophilic esophagitis
Impact of transfer from pediatric gastroenterology to adult gastroenterology care in eosinophilic esophagitis Open
Summary Given the chronic and progressive course of eosinophilic esophagitis (EoE), patients with pediatric-onset EoE will require uninterrupted gastroenterology (GI) care as they reach adulthood. Yet, the effectiveness of transferring and…
View article: Diastolic dysfunction in patients with Fontan palliation is associated with death and heart transplantation
Diastolic dysfunction in patients with Fontan palliation is associated with death and heart transplantation Open
CMR can identify diastolic dysfunction in the Fontan population. Patients with Fontan circulation who died or had a combined outcome of death or transplant had worse diastolic function by CMR compared to Fontan patients without death or tr…
View article: Physical Activity Correlates With Skeletal Muscle <scp>MRI</scp> Findings in Individuals With Duchenne Muscular Dystrophy
Physical Activity Correlates With Skeletal Muscle <span>MRI</span> Findings in Individuals With Duchenne Muscular Dystrophy Open
Introduction/Aims Skeletal muscle magnetic resonance imaging (MRI) is a validated noninvasive tool to assess Duchenne muscular dystrophy (DMD) progression. There is interest in finding DMD biomarkers that decrease the burden of clinical tr…
View article: Successful collection of patient-reported outcomes shows improvement in quality of life, depression, and disease activity among patients with Inflammatory Bowel Disease: A real-world study
Successful collection of patient-reported outcomes shows improvement in quality of life, depression, and disease activity among patients with Inflammatory Bowel Disease: A real-world study Open
Introduction: Patient reported outcomes (PRO) including patient disease activity scores, quality of life, and depressive symptoms are increasingly being used for clinical care in patients with inflammatory bowel disease (IBD). However, lit…
View article: Rate of Change in Cardiac Magnetic Resonance Imaging Measures Is Associated With Death in Duchenne Muscular Dystrophy
Rate of Change in Cardiac Magnetic Resonance Imaging Measures Is Associated With Death in Duchenne Muscular Dystrophy Open
Background Cardiovascular disease is the leading cause of death among patients with Duchenne muscular dystrophy (DMD). Identifying patients at risk of early death could allow for increased monitoring and more intensive therapy. Measures th…
View article: Principal Component Patterns of Pediatric Respiratory Viral Testing Across Health Care Settings
Principal Component Patterns of Pediatric Respiratory Viral Testing Across Health Care Settings Open
BACKGROUND AND OBJECTIVES Factors prompting clinicians to request viral testing in children are unclear. We assessed patterns prompting clinicians to perform viral testing in children discharged from an emergency department (ED) or hospita…
View article: Provider-ordered viral testing and antibiotic administration practices among children with acute respiratory infections across healthcare settings in Nashville, Tennessee
Provider-ordered viral testing and antibiotic administration practices among children with acute respiratory infections across healthcare settings in Nashville, Tennessee Open
Objective: Evaluate the association between provider-ordered viral testing and antibiotic treatment practices among children discharged from an ED or hospitalized with an acute respiratory infection (ARI). Design: Active, prospective ARI s…
View article: The Comorbidity of Patient-Reported Crohn’s Disease Activity and Depression: The Role of Health Behavior Mediators
The Comorbidity of Patient-Reported Crohn’s Disease Activity and Depression: The Role of Health Behavior Mediators Open
Background Longitudinal research reveals a unidirectional relationship between a nonsomatic symptom of depression, a negative view of the self, and later reported Crohn’s disease (CD) activity. We evaluated whether health behaviors mediate…
View article: A high-fat and fructose diet in dogs mirrors insulin resistance and β-cell dysfunction characteristic of impaired glucose tolerance in humans
A high-fat and fructose diet in dogs mirrors insulin resistance and β-cell dysfunction characteristic of impaired glucose tolerance in humans Open
This study examined the impact of a hypercaloric high-fat high-fructose diet (HFFD) in dogs as a potential model for human impaired glucose tolerance (IGT) and type 2 diabetes mellitus (T2DM). The HFFD not only led to weight gain but also …
View article: A High-Fat and Fructose Diet in Dogs Mirrors Insulin Resistance and β-cell Dysfunction Characteristic of Impaired Glucose Tolerance in Humans
A High-Fat and Fructose Diet in Dogs Mirrors Insulin Resistance and β-cell Dysfunction Characteristic of Impaired Glucose Tolerance in Humans Open
This study examined the impact of a hypercaloric high-fat high-fructose diet (HFFD) in dogs as a potential model for human impaired glucose tolerance (IGT) and type 2 diabetes mellitus (T2DM). The HFFD not only led to weight gain but also …
View article: Reliability of Handheld Blood Glucose Monitors in Neonates: Trustworthy Arterial Readings but Capillary Results Warrant Caution for Hypoglycemia
Reliability of Handheld Blood Glucose Monitors in Neonates: Trustworthy Arterial Readings but Capillary Results Warrant Caution for Hypoglycemia Open
Background: Accurate glucose monitoring is vitally important in neonatal intensive care units (NICUs) and clinicians use blood glucose monitors (BGM), such as the Inform II, for bedside glucose monitoring. Studies on BGM use in neonates ha…
View article: Improving parents' ability to advocate for services for youth with autism: A randomized clinical trial
Improving parents' ability to advocate for services for youth with autism: A randomized clinical trial Open
Youth with autism face challenges accessing services as they transition to adulthood. Improving parents' ability to advocate for services on behalf of their youth may be an effective way to improve service access and ultimately transition …
View article: Cardiovascular Measures of All-Cause Mortality in Duchenne Muscular Dystrophy
Cardiovascular Measures of All-Cause Mortality in Duchenne Muscular Dystrophy Open
Background: Cardiopulmonary failure is the leading cause of death in Duchenne muscular dystrophy (DMD). Research into DMD-specific cardiovascular therapies is ongoing, but there are no Food and Drug Administration-approved cardiac end poin…
View article: Prevalence of genetic causes of obesity in clinical practice
Prevalence of genetic causes of obesity in clinical practice Open
Background While obesity is common in the United States, monogenic obesity is rare, accounting for approximately 5% of individuals with obesity. New targeted therapies for genetic forms of obesity are available but there is limited guidanc…
View article: Diagnostic models predicting paediatric viral acute respiratory infections: a systematic review
Diagnostic models predicting paediatric viral acute respiratory infections: a systematic review Open
Objectives To systematically review and evaluate diagnostic models used to predict viral acute respiratory infections (ARIs) in children. Design Systematic review. Data sources PubMed and Embase were searched from 1 January 1975 to 3 Febru…
View article: Data from TR3 Modulates Platinum Resistance in Ovarian Cancer
Data from TR3 Modulates Platinum Resistance in Ovarian Cancer Open
In metastatic ovarian cancer, resistance to platinum chemotherapy is common. Although the orphan nuclear receptor TR3 (nur77/NR4A1) is implicated in mediating chemotherapy-induced apoptosis in cancer cells, its role in ovarian cancer has n…
View article: Supplementary Figures 1-7 from TR3 Modulates Platinum Resistance in Ovarian Cancer
Supplementary Figures 1-7 from TR3 Modulates Platinum Resistance in Ovarian Cancer Open
PDF - 404K, Supplementary Figure 1. TR3 expression in normal and neoplastic ovarian epithelium. Supplementary Figure 2. TR3 expression in ovarian cancer epithelial sub-types. Supplementary Figure 3. Association of TR3 expression with clini…