Andrew C. Steer
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View article: An oropharyngeal gonorrhoea controlled human infection model: a provisional protocol using a novel Neisseria gonorrhoeae challenge strain
An oropharyngeal gonorrhoea controlled human infection model: a provisional protocol using a novel Neisseria gonorrhoeae challenge strain Open
Introduction Gonorrhoea is a sexually transmissable infection caused by Neisseria gonorrhoeae that causes a significant global burden of disease. Urogenital infection can result in long-term impacts on reproductive, perinatal, and neonata…
View article: Human unconventional T cells shape the early immune response to Group A Streptococcus 3467
Human unconventional T cells shape the early immune response to Group A Streptococcus 3467 Open
Description Streptococcus pyogenes or Group A streptococcus (GAS) is a human-restricted pathogen that continues to represent a major worldwide health burden. The development of protective vaccines has been impeded by several factors includ…
View article: Subclinical exposure to Streptococcus pyogenes drives the development of long-lived immunity
Subclinical exposure to Streptococcus pyogenes drives the development of long-lived immunity Open
Age-related decline in Streptococcus pyogenes infection rates suggests that immunity develops progressively through repeated exposure during early life. However, the intensity or duration of exposure required is unknown, as to why some ind…
View article: Sub-clinical exposure to <i>Streptococcus pyogenes</i> drives the development of immunity
Sub-clinical exposure to <i>Streptococcus pyogenes</i> drives the development of immunity Open
Summary Age-related decline in Streptococcus pyogenes infection rates suggests that immunity develops progressively through repeated exposure during early life. However, the intensity or duration of exposure required is unknown, as to why …
View article: Prevalence of scabies and bacterial skin infection in French Polynesia: A cross-sectional community survey
Prevalence of scabies and bacterial skin infection in French Polynesia: A cross-sectional community survey Open
Introduction The prevalence of scabies and impetigo is high in several Pacific Island countries and has led to the implementation of mass drug administration control strategies. Anecdotal clinical reports have suggested similarly high burd…
View article: Streptococcal Serology Reference Intervals in an Australian Pediatric Cohort
Streptococcal Serology Reference Intervals in an Australian Pediatric Cohort Open
Background Diagnostic criteria for acute rheumatic fever and post-streptococcal glomerulonephritis, the 2 major autoimmune complications of Streptococcus pyogenes infection, include serological evidence of preceding infection. The S. pyoge…
View article: Cardiac monitoring safety assessment framework for early phase group a streptococcal vaccine trials
Cardiac monitoring safety assessment framework for early phase group a streptococcal vaccine trials Open
This paper presents a comprehensive cardiac safety framework for early clinical development of Streptococcus pyogenes (Group A Streptococcus) vaccines, endorsed by the Strep A Vaccine Global Consortium (SAVAC) and the Australian Strep A Va…
View article: Population pharmacokinetics of penicillin G: insights into increased clearance at low concentrations to guide development of improved long-acting formulations for syphilis and prevention of rheumatic fever
Population pharmacokinetics of penicillin G: insights into increased clearance at low concentrations to guide development of improved long-acting formulations for syphilis and prevention of rheumatic fever Open
Although benzylpenicillin (penicillin G) is listed by the World Health Organization as an Essential Medicine, dose optimization is a persistent challenge, especially for long-acting intramuscular formulations. Maintaining sustained antibio…
View article: M1 and done? Global assessment of the invasive potential of group A streptococcal strains
M1 and done? Global assessment of the invasive potential of group A streptococcal strains Open
SCOPUS: no.j
View article: Prevalence-Incidence Bias in Longitudinal Studies of Rheumatic Heart Disease in Fiji
Prevalence-Incidence Bias in Longitudinal Studies of Rheumatic Heart Disease in Fiji Open
Background: Rheumatic heart disease (RHD), a consequence of a dysregulated immune response to Streptococcus pyogenes infection, remains the most commonly acquired cardiovascular condition in under 25-year-olds. Predominantly occurring in l…
View article: Antibody responses against bacterial glycans affinity mature and diversify in germinal centers
Antibody responses against bacterial glycans affinity mature and diversify in germinal centers Open
Summary Anti-carbohydrate antibodies (Abs) play crucial roles in pathogen control, but their generation remains poorly understood. By studying responses to Streptococcus pyogenes in humans, we reveal that the glycan-targeted response shift…
View article: Establishing the lowest penicillin concentration to prevent pharyngitis due to Streptococcus pyogenes using a human challenge model (CHIPS): a randomised, double-blind, placebo-controlled trial
Establishing the lowest penicillin concentration to prevent pharyngitis due to Streptococcus pyogenes using a human challenge model (CHIPS): a randomised, double-blind, placebo-controlled trial Open
The National Health and Medical Research Council of Australia.
View article: Streptococcus pyogenes pharyngitis elicits diverse antibody responses to key vaccine antigens influenced by the imprint of past infections
Streptococcus pyogenes pharyngitis elicits diverse antibody responses to key vaccine antigens influenced by the imprint of past infections Open
Knowledge gaps regarding human immunity to Streptococcus pyogenes have impeded vaccine development. To address these gaps and evaluate vaccine candidates, we established a human challenge model of S. pyogenes pharyngitis. Here, we analyse …
View article: Community perceptions and acceptability of mass drug administration for the control of neglected tropical diseases in Asia-Pacific countries: A systematic scoping review of qualitative research
Community perceptions and acceptability of mass drug administration for the control of neglected tropical diseases in Asia-Pacific countries: A systematic scoping review of qualitative research Open
BackgroundPreventative chemotherapy and mass drug administration have been identified as effective strategies for the prevention, treatment, control and elimination of several NTDs in the Asia-Pacific region. Qualitative research can provi…
View article: Systematic review of the evidence for treatment and management of common skin conditions in resource‐limited settings: An update
Systematic review of the evidence for treatment and management of common skin conditions in resource‐limited settings: An update Open
Introduction The skin is the largest and most visible organ of the human body. As such, skin infections can have a significant impact on overall health, social wellbeing and self‐image. In 2019, we published a systematic review of the trea…
View article: Costs of primary healthcare presentations and hospital admissions for scabies and related skin infections in Fiji, 2018–2019
Costs of primary healthcare presentations and hospital admissions for scabies and related skin infections in Fiji, 2018–2019 Open
Scabies and related bacterial skin and soft tissue infections (SSTIs) are highly prevalent in many tropical, low- and middle-income settings. These skin conditions contribute to higher healthcare costs and burdens on healthcare systems. Th…
View article: Multi-methods process evaluation of the SToP (See, Treat, Prevent) trial: a cluster randomised, stepped wedge trial to support healthy skin
Multi-methods process evaluation of the SToP (See, Treat, Prevent) trial: a cluster randomised, stepped wedge trial to support healthy skin Open
This trial was funded by the WA Department of Health, Australian National Health and Medical Research Council (NHMRC), and Healthway.
View article: NEARER SCAN (LENO BESIK) evaluation of a task-sharing echocardiographic active case finding programme for rheumatic heart disease in Australia and Timor-Leste: protocol for a hybrid type II effectiveness-implementation study
NEARER SCAN (LENO BESIK) evaluation of a task-sharing echocardiographic active case finding programme for rheumatic heart disease in Australia and Timor-Leste: protocol for a hybrid type II effectiveness-implementation study Open
Introduction Rheumatic heart disease (RHD) is underdiagnosed globally resulting in missed treatment opportunities and adverse clinical outcomes. We describe the protocol for a study which aims to co-design, implement and conduct an evaluat…
View article: Ivermectin-Based Mass Drug Administration for Scabies in Northern India: A Single-Arm Community Intervention Trial
Ivermectin-Based Mass Drug Administration for Scabies in Northern India: A Single-Arm Community Intervention Trial Open
Background Scabies and impetigo cause direct health effects and contribute to severe infectious and immune-mediated complications. Ivermectin-based mass drug administration can reduce scabies and impetigo prevalence in island settings with…
View article: Transmission potential of <i>Streptococcus pyogenes</i> during a controlled human infection trial of pharyngitis
Transmission potential of <i>Streptococcus pyogenes</i> during a controlled human infection trial of pharyngitis Open
Controlled human infection (CHI) models can provide insights into transmission of pathogens such as Streptococcus pyogenes (Strep A). As part of the Controlled Human Infection with Penicillin for Streptococcus pyogenes (CHIPS) trial, we ex…
View article: Living with rheumatic fever and rheumatic heart disease in Victoria, Australia: A qualitative study
Living with rheumatic fever and rheumatic heart disease in Victoria, Australia: A qualitative study Open
Background In Victoria, Australia, children with Pacific Islander (‘Pacific’) ethnicities are overrepresented in acute rheumatic fever (ARF) and rheumatic heart disease (RHD). In June 2023, ARF and RHD became notifiable in Victoria. To inf…
View article: Evaluation of a multiplex-qPCR for paediatric pleural empyema—An observational study in hospitalised children
Evaluation of a multiplex-qPCR for paediatric pleural empyema—An observational study in hospitalised children Open
Pleural empyema is a serious complication of pneumonia in children. Negative bacterial cultures commonly impede optimal antibiotic therapy. To improve bacterial identification, we developed a molecular assay and evaluated its performance c…
View article: Intramuscular versus enteral penicillin prophylaxis to prevent progression of rheumatic heart disease: Study protocol for a noninferiority randomized trial (the GOALIE trial)
Intramuscular versus enteral penicillin prophylaxis to prevent progression of rheumatic heart disease: Study protocol for a noninferiority randomized trial (the GOALIE trial) Open
ClinicalTrials.gov: NCT05693545.