Explanipedia

Integrating genetic and transcriptomic data to identify genes underlying obesity risk loci Open

Hanfei Xu, Shreyash Gupta, Ian Dinsmore, Abbey Kollu, Anne Marie Cawley , et al. · 2025

Background Genome-wide association studies (GWAS) have identified numerous body mass index (BMI) loci. However, most underlying mechanisms from risk locus to BMI remain unknown. Leveraging omics data through integrative analyses could prov…

Serum Metabolomic Changes Following Bariatric Surgery Adjusted for Measured Glomerular Filtration Rate Suggest Mechanisms of Kidney Protection Open

Benjamin J. Apple, Jingsha Chen, Tooraj Mirshahi, Christopher D. Still, Andrew S. Levey , et al. · 2025

Background Bariatric surgery reduces glomerular hyperfiltration in the short term and is associated with a reduced risk of glomerular filtration rate decline during long-term follow-up. Assessing surgery-induced changes in serum metabolite…

Iron Treatment in Patients with Iron Deficiency Before and After Metabolic and Bariatric Surgery: A Narrative Review Open

Jila Kaberi‐Otarod, Christopher D. Still, G. Craig Wood, Peter N. Benotti · 2024

Iron is an essential nutrient in living organisms with multiple vital functions. Iron deficiency (ID) can cause long term health consequences beyond iron deficiency anemia (IDA). The high prevalence of ID and its long-term effects in patie…

Interpersonal Continuity of Care May Help Delay Progression to Type 2 Diabetes Open

Bobbie Johannes, G. Craig Wood, Arch G. Mainous, Adam Cook, Alanna Kulchak Rahm , et al. · 2024

This study demonstrates an association between increased interpersonal CoC after a person is diagnosed with prediabetes and a reduced risk of progressing to T2D within 3 years.

Association of Malnutrition Risk Screening Variables With Survival to Centenarian Status in the Geisinger Rural Aging Study Cohort Open

Diane C. Mitchell, G. Craig Wood, Ashley C. Flores, Xiang Gao, Christopher D. Still , et al. · 2024

Integrating Genetic and Transcriptomic Data to Identify Genes Underlying Obesity Risk Loci Open

Hanfei Xu, Shreyash Gupta, Ian Dinsmore, Abbey Kollu, Anne Marie Cawley , et al. · 2024

Genome-wide association studies (GWAS) have identified numerous body mass index (BMI) loci. However, most underlying mechanisms from risk locus to BMI remain unknown. Leveraging omics data through integrative analyses could provide more co…

Effects of glucagon-like peptide-1 receptor agonists on upper endoscopy in diabetic and nondiabetic patients Open

Danial Nadeem, Mahdi Taye, Matthew Still, Shannon McShea, Daniel Satterfield , et al. · 2024

GLP-1 RA use can lead to delayed gastric emptying, affecting EGD adequacy regardless of the presence of diabetes, and may warrant dose adjustment to improve the safety and efficacy of these procedures.

Primary care continuity among pre-diabetics and the likelihood of progressing to type 2 diabetes within 3 years Open

Bobbie Johannes, Arch G. Mainous, G. Craig Wood, Adam Cook, Alanna Kulchak Rahm , et al. · 2023

CONTEXT. The transition from pre-diabetes (pre-DM) to type 2 diabetes (T2D) can be prevented or delayed through lifestyle modifications. Primary care and continuity of care may help patients maintain an HbA1c within the pre-diabetic range.…

Qualitative inquiry with persons with obesity about weight management in primary care and referrals Open

Lisa Bailey‐Davis, Angela Marinilli Pinto, David J. Hanna, Michelle I. Cardel, Chad D. Rethorst , et al. · 2023

Introduction Referrals to evidence-based weight management in the community-commercial sector are aligned with clinical recommendations but underutilized. Methods This qualitative study explored patients’ perceptions and expectations about…

Rare coding variants in CHRNB2 reduce the likelihood of smoking Open

Veera M. Rajagopal, Kyoko Watanabe, Joelle Mbatchou, Ariane Ayer, Peter Quon , et al. · 2023

Prior metabolic surgery reduced COVID-19 severity: Systematic analysis from year one of the COVID-19 pandemic Open

G. Craig Wood, Peter N. Benotti, Rodrigo M. Fano, James Dove, David D.K. Rolston , et al. · 2023

Obesity medicine as a subspecialty and United States certification – A review Open

Angela Fitch, Deborah B. Horn, Christopher D. Still, Lydia C. Alexander, Sandra Christensen , et al. · 2023

Prospective Study of Diet Quality and the Risk of Dementia in the Oldest Old Open

Ashley C. Flores, Gordon L. Jensen, Diane C. Mitchell, Muzi Na, G. Craig Wood , et al. · 2023

This study examined the associations between overall diet quality and the risk of dementia in a rural cohort among the oldest old. Included in this prospective cohort study were 2232 participants aged ≥ 80 years and dementia-free at the ba…

Prospective Study of Diet Quality and the Risk of Dementia in the Oldest Old Open

Ashley C. Flores, Gordon L. Jensen, Diane C. Mitchell, Muzi Na, G. Craig Wood , et al. · 2023

Quantifying the phenome‐wide disease burden of obesity using electronic health records and genomics Open

Jamie R. Robinson, Robert J. Carroll, Lisa Bastarache, Qingxia Chen, James P. Pirruccello , et al. · 2022

Objective High BMI is associated with many comorbidities and mortality. This study aimed to elucidate the overall clinical risk of obesity using a genome‐ and phenome‐wide approach. Methods This study performed a phenome‐wide association s…

OR10-1 Body Mass Index and Weight Reductions in Patients With Obesity Due to Heterozygous Variants in POMC, PCSK1, and LEPR After 1 Year of Setmelanotide Open

I. Sadaf Farooqi, Jennifer Miller, Olga Ohayan, Cecilia Scimia, Christopher D. Still , et al. · 2022

Background The melanocortin-4 receptor (MC4R) pathway is a key regulator of energy balance. Heterozygous variants of the genes for proopiomelanocortin (POMC), leptin receptor (LEPR), and proprotein convertase subtilisin/kexin type 1 (PCSK1…

Overweight and Obesity Management for Primary Care Clinicians: Executive Summary Open

John E. Anderson, Robert F. Kushner, Eden Miller, Joseph Nadglowski, Christopher D. Still · 2022

Obesity imposes a substantial health burden and has increased in prevalence in recent years.Despite its health impacts, obesity remains undertreated in primary care settings because of a variety of barriers.Recommended approaches to the cl…

Comparative Safety and Effectiveness of Roux-en-Y Gastric Bypass and Sleeve Gastrectomy for Weight Loss and Type 2 Diabetes Across Race and Ethnicity in the PCORnet Bariatric Study Cohort Open

Karen J. Coleman, Robert Wellman, Stephanie L. Fitzpatrick, Molly B. Conroy, Callie Hlavin , et al. · 2022

Importance Bariatric surgery is the most effective treatment for severe obesity; yet it is unclear whether the long-term safety and comparative effectiveness of these operations differ across racial and ethnic groups. Objective To compare …

Multiancestry exome sequencing reveals INHBE mutations associated with favorable fat distribution and protection from diabetes Open

Parsa Akbari, Olukayode Sosina, Jonas Bovijn, Karl Landheer, Jonas B. Nielsen , et al. · 2022

Germline Mutations in <i>CIDEB</i> and Protection against Liver Disease Open

Niek Verweij, Mary E. Haas, Jonas B. Nielsen, Olukayode Sosina, Minhee Kim , et al. · 2022

Rare germline mutations in CIDEB conferred substantial protection from liver disease. (Funded by Regeneron Pharmaceuticals.).

Communicating risk of diabetes to patients results in lower incidence at 1- and 3-year follow-up and improved preventive intervention Open

Lisa Bailey‐Davis, G. Craig Wood, Carolyn F. McCabe, Adam Cook, David D.K. Rolston , et al. · 2022

Objective One-third of American adults are estimated to have prediabetes but the vast majority are unaware. Accordingly, persons with prediabetes are equally unaware of their personal susceptibility of developing type 2 diabetes and the im…

Population-scale analysis of common and rare genetic variation associated with hearing loss in adults Open

Kavita Praveen, Lee Dobbyn, Lauren Gurski, Ariane Ayer, Jeffrey Staples , et al. · 2022

Prospective Study of Diet Quality and the Risk of Dementia in the Oldest Old Open

Ashley C. Flores, Gordon L. Jensen, Diane C. Mitchell, Muzi Na, G. Craig Wood , et al. · 2022

Fat Free Weight Prediction in Morbidly Obese Females [Corrigendum] Open

Ion D. Bucaloiu, G. Craig Wood, Evan Norfolk, Christopher D. Still, James E. Hartle , et al. · 2022

[This corrects the article DOI: 10.2147/IJNRD.S24173.].

Qualitative inquiry with primary care providers and specialists about adult weight management care and referrals Open

Lisa Bailey‐Davis, Angela Marinilli Pinto, David J. Hanna, Chad D. Rethorst, Christopher D. Still , et al. · 2022

Obesity is a highly prevalent disease and providers are expected to offer or refer patients for weight management yet increasingly fewer clinical visits address obesity. Challenges to offering care are known but less is known about referra…

Effects of sustained weight loss on outcomes associated with obesity comorbidities and healthcare resource utilization Open

G. Craig Wood, Lisa Bailey‐Davis, Peter N. Benotti, Adam Cook, James Dove , et al. · 2021

Objective Determine the impact of long-term non-surgical weight loss maintenance on clinical relevance for osteoarthritis, cancer, opioid use, and depression/anxiety and healthcare resource utilization. Methods A cohort of adults receiving…

Aqueous Metabolite Trends for the Progression of Nonalcoholic Fatty Liver Disease in Female Bariatric Surgery Patients by Targeted 1H-NMR Metabolomics Open

Emma Robinson, Matthew C. Taddeo, Xin Chu, Wei‐Xing Shi, Craig K. Wood , et al. · 2021

Determining biomarkers and better characterizing the biochemical progression of nonalcoholic fatty liver disease (NAFLD) remains a clinical challenge. A targeted 1H-NMR study of serum, combined with clinical variables, detected and localiz…

Impact of Sustained Weight Loss on Cardiometabolic Outcomes Open

Lisa Bailey‐Davis, G. Craig Wood, Peter N. Benotti, Adam Cook, James Dove , et al. · 2021

Obesity increases the risk of developing type 2 diabetes, hypertension, and hyperlipidemia. We sought to determine the impact of obesity maintenance, weight regain, weight loss maintenance, and magnitudes of weight loss on future risk and …

Differential DNA methylation and changing cell-type proportions as fibrotic stage progresses in NAFLD Open

Nicholas D. Johnson, Xiumei Wu, Christopher D. Still, Xin Chu, Anthony Petrick , et al. · 2021

Background Non-alcoholic fatty liver disease (NAFLD) is characterized by changes in cell composition that occur throughout disease pathogenesis, which includes the development of fibrosis in a subset of patients. DNA methylation (DNAm) is …

Sequencing of 640,000 exomes identifies <i>GPR75</i> variants associated with protection from obesity Open

Parsa Akbari, Ankit Gilani, Olukayode Sosina, Jack A. Kosmicki, Lori Khrimian , et al. · 2021

How genes affect human obesity Obesity is linked to many human diseases, including diabetes, cancer, and heart disease. There is thus great interest in understanding how genes predispose individuals to, or protect individuals from, obesity…

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