Explanipedia

Harnessing the potential of AI in lifelong learning for medical undergraduates Open

Nathasha Luke, Shing Chuan Hooi, Celestial T. Yap · 2025

Interplay Between the Cytoskeleton and DNA Damage Response in Cancer Progression Open

Clarissa Esmeralda Halim, Shuo Deng, Karen Crasta, Celestial T. Yap · 2025

DNA damage has emerged as a critical factor in fuelling the development and progression of cancer. DNA damage response (DDR) pathways lie at the crux of cell fate decisions following DNA damage induction, which can either trigger the repai…

Large language models (ChatGPT) in medical education: Embrace or abjure? Open

Nathasha Luke, Reshma Taneja, Kenneth H K Ban, Dujeepa D. Samarasekera, Celestial T. Yap · 2023

PI3K/AKT Signaling Tips the Balance of Cytoskeletal Forces for Cancer Progression Open

Shuo Deng, Hin Chong Leong, Arpita Datta, Vennila Gopal, Alan Prem Kumar , et al. · 2022

The PI3K/AKT signaling pathway plays essential roles in multiple cellular processes, which include cell growth, survival, metabolism, and motility. In response to internal and external stimuli, the PI3K/AKT signaling pathway co-opts other …

Cytoskeletal Dynamics in Epithelial-Mesenchymal Transition: Insights into Therapeutic Targets for Cancer Metastasis Open

Arpita Datta, Shuo Deng, Vennila Gopal, Kenneth Chun-Hong Yap, Clarissa Esmeralda Halim , et al. · 2021

In cancer cells, a vital cellular process during metastasis is the transformation of epithelial cells towards motile mesenchymal cells called the epithelial to mesenchymal transition (EMT). The cytoskeleton is an active network of three in…

Putting the BRK on breast cancer: From molecular target to therapeutics Open

Hui Li Ang, Yi Yuan, Xianning Lai, Tuan Zea Tan, Lingzhi Wang , et al. · 2020

BReast tumor Kinase (BRK, also known as PTK6) is a non-receptor tyrosine kinase that is highly expressed in breast carcinomas while having low expression in the normal mammary gland, which hints at the oncogenic nature of this kinase in br…

Development and validation of a serum microRNA biomarker panel for detecting gastric cancer in a high-risk population Open

Jimmy Bok Yan So, Ritika Kapoor, Feng Zhu, Calvin Jianyi Koh, Lihan Zhou , et al. · 2020

Objective An unmet need exists for a non-invasive biomarker assay to aid gastric cancer diagnosis. We aimed to develop a serum microRNA (miRNA) panel for identifying patients with all stages of gastric cancer from a high-risk population. D…

Involvement of STAT5 in Oncogenesis Open

Clarissa Esmeralda Halim, Shuo Deng, Mei Shan Ong, Celestial T. Yap · 2020

Signal transducer and activator of transcription (STAT) proteins, and in particular STAT3, have been established as heavily implicated in cancer. Recently, the involvement of STAT5 signalling in the pathology of cancer has been shown to be…

Cytoskeletal Proteins in Cancer and Intracellular Stress: A Therapeutic Perspective Open

Mei Shan Ong, Shuo Deng, Clarissa Esmeralda Halim, Wanpei Cai, Tuan Zea Tan , et al. · 2020

Cytoskeletal proteins, which consist of different sub-families of proteins including microtubules, actin and intermediate filaments, are essential for survival and cellular processes in both normal as well as cancer cells. However, in canc…

Understanding factors that motivate research performance and career longevity of science, technology, engineering and mathematics postgraduates Open

Margaret Tan, Jonathan S. Herberg, Celestial T. Yap, Dujeepa D. Samarasekera, Zhi Xiong Chen · 2019

Given the high investments in training and mentoring graduates who have chosen the research career path, and considering a high attrition of these graduates moving on to non-research type of careers, it is important to understand the facto…

Autophagy Modulators: Mechanistic Aspects and Drug Delivery Systems Open

Shima Tavakol, Milad Ashrafizadeh, Shuo Deng, Maryam Azarian, Asghar Abdoli , et al. · 2019

Autophagy modulation is considered to be a promising programmed cell death mechanism to prevent and cure a great number of disorders and diseases. The crucial step in designing an effective therapeutic approach is to understand the correct…

Author Correction: PTEN-L is a novel protein phosphatase for ubiquitin dephosphorylation to inhibit PINK1–Parkin-mediated mitophagy Open

Liming Wang, Yik-Lam Cho, Yancheng Tang, Jigang Wang, Jung‐Eun Park , et al. · 2018

PTEN-L is a novel protein phosphatase for ubiquitin dephosphorylation to inhibit PINK1–Parkin-mediated mitophagy Open

Liming Wang, Yik-Lam Cho, Yancheng Tang, Jigang Wang, Jung‐Eun Park , et al. · 2018

Long Non-coding RNA Landscape in Colorectal Cancer Open

Mei Shan Ong, Wanpei Cai, Tuan Zea Tan, Ruby Yun‐Ju Huang, Shing Chuan Hooi , et al. · 2018

Increasing number of reports have shown the involvement of LncRNAs in the tumour progression in multiple cancers including colorectal and female reproductive cancers such as ovarian and breast. In particular, the profiling of lncRNAs in co…

‘Lnc’‐ing Wnt in female reproductive cancers: therapeutic potential of long non‐coding RNAs in Wnt signalling Open

Mei Shan Ong, Wanpei Cai, Yi Yuan, Hin Chong Leong, Tuan Zea Tan , et al. · 2017

Recent discoveries in the non‐coding genome have challenged the original central dogma of molecular biology, as non‐coding RNAs and related processes have been found to be important in regulating gene expression. MicroRNAs and long non‐cod…

Breast Cancer: Exploring the Facts and Holistic Needs during and beyond Treatment Open

Nick Zhi Peng Ng, Mei Xuan Ong, Tamilarasi Jegadeesan, Shuo Deng, Celestial T. Yap · 2017

Breast cancer patients face challenges throughout the journey of diagnosis, treatment, post-treatment, and recovery. The breast cancer patient is exposed to a multidisciplinary team including doctors, nurses, therapists, counselors, and ps…

Wanted DEAD/H or Alive: Helicases Winding Up in Cancers Open

Wanpei Cai, Zhi Xiong Chen, Grishma Rane, Shikha Satendra Singh, Zhang’E Choo , et al. · 2016

Cancer is one of the most studied areas of human biology over the past century. Despite having attracted much attention, hype, and investments, the search to find a cure for cancer remains an uphill battle. Recent discoveries that challeng…

Manganese Superoxide Dismutase Expression Regulates the Switch Between an Epithelial and a Mesenchymal-Like Phenotype in Breast Carcinoma Open

Ser Yue Loo, Jayshree L. Hirpara, Vijay Pandey, Tuan Zea Tan, Celestial T. Yap , et al. · 2016

These data underscore the involvement of MnSOD in regulating the switch between the EMT and MET-associated phenotype by influencing cellular redox environment via its effect on the intracellular ratio between O2(-•) and H2O2. Strategies to…

Gelsolin-Cu/ZnSOD interaction alters intracellular reactive oxygen species levels to promote cancer cell invasion Open

Lalchhandami Tochhawng, Shuo Deng, Ganesan Pugalenthi, Alan Prem Kumar, Kiat Hon Lim , et al. · 2016

The actin-binding protein, gelsolin, is a well known regulator of cancer cell invasion. However, the mechanisms by which gelsolin promotes invasion are not well established. As reactive oxygen species (ROS) have been shown to promote cance…

Gelsolin-mediated activation of PI3K/Akt pathway is crucial for hepatocyte growth factor-induced cell scattering in gastric carcinoma Open

Baohua Huang, Shuo Deng, Ser Yue Loo, Arpita Datta, Yan Lin Yap , et al. · 2016

In gastric cancer (GC), the main subtypes (diffuse and intestinal types) differ in pathological characteristics, with diffuse GC exhibiting early disseminative and invasive behaviour. A distinctive feature of diffuse GC is loss of intercel…

DEAD-box RNA Helicases: the microRNA managers of breast cancer Open

Wanpei Cai, Chao Wang, Jen Nee Goh, Ser Yue Loo, Celestial T. Yap , et al. · 2015

The roles of non-coding RNAs in cancers, microRNA (miRNA) especially, have sparked interest in the field of RNA research in recent years. The once widely accepted ‘central dogma of genetics’ describing the flow of cellular protein expressi…

HDAC1 and HDAC2 independently predict mortality in hepatocellular carcinoma by a competing risk regression model in a Southeast Asian population Open

SER YENG LER, Carol Ho Wing Leung, Lay Wai Khin, Guo‐Dong Lu, Manuel Salto‐Tellez , et al. · 2015

Histone deacetylases (HDACs) are enzymes involved in transcriptional repression. We aimed to examine the significance of HDAC1 and HDAC2 gene expression in the prediction of recurrence and survival in 156 patients with hepatocellular carci…

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