Paul M. Thompson
YOU?
Author Swipe
View article: Subtyping schizophrenia via machine learning by using structural neuroimaging
Subtyping schizophrenia via machine learning by using structural neuroimaging Open
View article: The Consortium for Clarity in ADRD Research Through Imaging (CLARiTI): Overview of consortium sites and anticipated enrollment
The Consortium for Clarity in ADRD Research Through Imaging (CLARiTI): Overview of consortium sites and anticipated enrollment Open
INTRODUCTION The Consortium for Clarity in Alzheimer's disease related dementias (ADRD) Research Through Imaging (CLARiTI) is a study that aims to collect standardized imaging and plasma biomarkers on 2000 Clinical Core participants enroll…
View article: Evaluating Sample-Size Efficiency and Sensitivity of Tractometry in Alzheimer’s Disease
Evaluating Sample-Size Efficiency and Sensitivity of Tractometry in Alzheimer’s Disease Open
Tractometry allows quantitative analysis of white matter microstructure along the brain’s fiber tracts, but the impact of study design parameters—such as sample size and along-tract resolution—on sensitivity and specificity is not well und…
View article: ASSESSING THE INFLUENCE OF TRACTOGRAPHY METHODS ON WHITE MATTER MICROSTRUCTURE AND TRACTOMETRY ANALYSIS IN ALZHEIMERS DISEASE
ASSESSING THE INFLUENCE OF TRACTOGRAPHY METHODS ON WHITE MATTER MICROSTRUCTURE AND TRACTOMETRY ANALYSIS IN ALZHEIMERS DISEASE Open
Tractometry enables detailed mapping of white matter microstructure along individual tracts and is widely used to study disease effects such as those seen in Alzheimer’s disease (AD). However, how different tractography algorithms influenc…
View article: Brain morphology mediators of the link between childhood trauma and bipolar disorder: a large-scale international analysis
Brain morphology mediators of the link between childhood trauma and bipolar disorder: a large-scale international analysis Open
Childhood trauma is a risk factor for bipolar disorder, but the biological mechanisms of this association remain incompletely defined. Gray matter differences observed after trauma exposure overlap with those reported in bipolar disorder, …
View article: The Genetic Architecture of the Human Corpus Callosum and its Subregions
The Genetic Architecture of the Human Corpus Callosum and its Subregions Open
View article: Regional brain morphology and current antidepressant use: findings from 32 international cohorts from the ENIGMA major depressive disorder working group
Regional brain morphology and current antidepressant use: findings from 32 international cohorts from the ENIGMA major depressive disorder working group Open
The understanding of how antidepressant (AD) use is associated with brain structure in individuals with major depressive disorder (MDD) remains incomplete. We aimed to examine the association between AD medication use and brain morphology …
View article: The Consortium for Clarity in ADRD Research Through Imaging (CLARiTI): Overview of consortium sites and anticipated enrollment
The Consortium for Clarity in ADRD Research Through Imaging (CLARiTI): Overview of consortium sites and anticipated enrollment Open
INTRODUCTION The Consortium for Clarity in Alzheimer's disease related dementias (ADRD) Research Through Imaging (CLARiTI) is a study that aims to collect standardized imaging and plasma biomarkers on 2000 Clinical Core participants enroll…
View article: Brain-Body Signatures of Trait Anxiety Uniquely Characterized by Functional Dynamics, Allostatic Load and Gene Expression
Brain-Body Signatures of Trait Anxiety Uniquely Characterized by Functional Dynamics, Allostatic Load and Gene Expression Open
Trait anxiety is an individual disposition marked by heightened anticipation of potential threats under uncertainty. It has been associated with allostatic load, the cumulative physiological cost of chronic stress, suggesting that enduring…
View article: Inhibitory control and error processing in Obsessive-Compulsive Disorder: A mega-analysis of task-based fMRI data by the ENIGMA-OCD consortium
Inhibitory control and error processing in Obsessive-Compulsive Disorder: A mega-analysis of task-based fMRI data by the ENIGMA-OCD consortium Open
Objective Obsessive-compulsive disorder (OCD) is a chronic condition in which impaired inhibitory control and excessive error monitoring may contribute to the maintenance of obsessions and compulsions. This mega-analysis investigates neura…
View article: Image-based meta- and mega-analysis (IBMMA): A unified framework for large-scale, multi-site, neuroimaging data analysis
Image-based meta- and mega-analysis (IBMMA): A unified framework for large-scale, multi-site, neuroimaging data analysis Open
The increasing scale and complexity of neuroimaging datasets aggregated from multiple study sites present substantial analytic challenges, as existing statistical analysis tools struggle to handle missing voxel-data, suffer from limited co…
View article: ConspEmoLLM-v2: A Robust and Stable Model to Detect Sentiment-Transformed Conspiracy Theories
ConspEmoLLM-v2: A Robust and Stable Model to Detect Sentiment-Transformed Conspiracy Theories Open
Despite the many benefits of large language models (LLMs), they can also cause harm, e.g., through automatic generation of misinformation, including conspiracy theories. Moreover, LLMs can also “disguise” conspiracy theories by altering ch…
View article: Natural Language Processing for Cardiology: A Narrative Review
Natural Language Processing for Cardiology: A Narrative Review Open
Cardiovascular diseases are becoming increasingly prevalent in modern society, with a profound impact on global health and well-being. These Cardiovascular disorders are complex and multifactorial, influenced by genetic predispositions, li…
View article: Classification of major depressive disorder using vertex-wise brain sulcal depth, curvature, and thickness with a deep and a shallow learning model
Classification of major depressive disorder using vertex-wise brain sulcal depth, curvature, and thickness with a deep and a shallow learning model Open
Major depressive disorder (MDD) is a complex psychiatric disorder that affects the lives of hundreds of millions of individuals around the globe. Even today, researchers debate if morphological alterations in the brain are linked to MDD, l…
View article: Volumetric Differences of Thalamic Nuclei are Associated with Post-Trauma Psychopathology
Volumetric Differences of Thalamic Nuclei are Associated with Post-Trauma Psychopathology Open
Whole thalamus volume and volumes of the sensorimotor and limbic thalamus may play an important role in the development of PTSD and MDD in the aftermath of trauma exposure. The interaction between PTSD and MDD symptoms and contrasting effe…
View article: Reduced Adult Survival Estimated in Areas of Decline of Harbour Seal Populations in Scotland
Reduced Adult Survival Estimated in Areas of Decline of Harbour Seal Populations in Scotland Open
Understanding the demographic drivers behind observed changes in wild populations is key to inferring intrinsic and extrinsic causes behind such changes. In Scotland, harbour seal populations have undergone regional declines since the earl…
View article: Surface-based morphometry reveals divergent aging trajectories in veterans with and without traumatic brain injury
Surface-based morphometry reveals divergent aging trajectories in veterans with and without traumatic brain injury Open
This study investigates how traumatic brain injury (TBI) alters cortical aging by comparing cortical thickness (CT) and surface area (SA) in 34 brain regions between TBI survivors and age-matched controls. Using a cross-sectional retrospec…
View article: The history of the semantic hacking project and the lessons it teaches for modern cognitive security
The history of the semantic hacking project and the lessons it teaches for modern cognitive security Open
The Semantic Hacking Project ran from 2001 to 2003. It focused on how information systems (and the human decisions shaped by them) could be exploited through attacks not on code or infrastructure, but on meaning. This work is relevant to c…
View article: Neuroanatomical Correlates of Negative Symptoms in Schizophrenia
Neuroanatomical Correlates of Negative Symptoms in Schizophrenia Open
Background Schizophrenia is characterized by widespread structural brain abnormalities, but associations between structural abnormalities and negative symptom severity are not well understood. Negative symptoms have been conceptualized in …
View article: Adopting open-science infrastructure in the ENIGMA-Parkinson’s Disease consortium: A case study
Adopting open-science infrastructure in the ENIGMA-Parkinson’s Disease consortium: A case study Open
The adoption of open science principles for data has been instrumental in enabling the creation and reuse of large datasets and efficient collaboration, but requires a dedicated open data sharing infrastructure. Although clinical neuroscie…
View article: Alzheimer’s Disease-Like Brain Pattern Biomarker: Capturing Risks and Predicting Disease Onset
Alzheimer’s Disease-Like Brain Pattern Biomarker: Capturing Risks and Predicting Disease Onset Open
View article: Using Diffusion Transformers to Generate Synthetic Diffusion Scalar Maps for Data Augmentation
Using Diffusion Transformers to Generate Synthetic Diffusion Scalar Maps for Data Augmentation Open
Generation of high-quality synthetic brain MRI data could be beneficial for advancing neuroimaging research, particularly when access to large-scale, labeled datasets is limited. In this work, we leverage a pretrained Diffusion Transformer…
View article: Generating diffusion MRI scalar maps from T1-weighted images using Reversible GANs
Generating diffusion MRI scalar maps from T1-weighted images using Reversible GANs Open
Diffusion tensor imaging (DTI) provides valuable insights into brain tissue microstructure, but acquiring high-quality DTI data is time-intensive and not always feasible. To mitigate data scarcity and enhance accessibility, we investigate …
View article: Evaluation of Deep Learning Algorithms to Predict Multiple Dementia-Related Neuropathologies from Brain MRI, Clinical and Genetic Data
Evaluation of Deep Learning Algorithms to Predict Multiple Dementia-Related Neuropathologies from Brain MRI, Clinical and Genetic Data Open
Alzheimer’s disease and related dementias (ADRD) involve overlapping neurodegenerative and vascular pathologies—such as amyloid-β (Aβ), tau, cerebral amyloid angiopathy (CAA), TDP-43, and alpha-synuclein—that complicate diagnosis and treat…
View article: DTI versus NODDI White Matter Microstructural Biomarkers of Alzheimer’s Disease
DTI versus NODDI White Matter Microstructural Biomarkers of Alzheimer’s Disease Open
Diffusion MRI (dMRI) is a powerful tool to assess white matter (WM) microstructural abnormalities in Alzheimer’s disease (AD). The fourth phase of the Alzheimer’s Disease Neuroimaging Initiative (ADNI) now includes multiple multishell dMRI…
View article: Predicting Regional Cerebral Blood Flow Using Voxel-Wise Resting-State Functional MRI
Predicting Regional Cerebral Blood Flow Using Voxel-Wise Resting-State Functional MRI Open
Background: Regional cerebral blood flow (rCBF) is a putative biomarker for neuropsychiatric disorders, including major depressive disorder (MDD). Methods: Here, we show that rCBF can be predicted from resting-state functional MRI (rsfMRI)…
View article: Streamline Density Normalization: A Robust Approach to Mitigate Bundle Variability in Multi-Site Diffusion MRI
Streamline Density Normalization: A Robust Approach to Mitigate Bundle Variability in Multi-Site Diffusion MRI Open
Tractometry enables quantitative analysis of tissue microstructure is sensitive to variability introduced during tractography and bundle segmentation. Differences in processing parameters and bundle geometry can lead to inconsistent stream…
View article: White Matter Tract Vulnerability to Amyloid Pathology on the Alzheimer’s Disease Continuum
White Matter Tract Vulnerability to Amyloid Pathology on the Alzheimer’s Disease Continuum Open
Alzheimer’s disease (AD) is marked by progressive cognitive decline and memory loss, due to the abnormal accumulation of amyloid-beta ( Aβ ) plaques, which facilitate the spread of tau pathology, and a gradually spreading pattern of neuron…
View article: White matter microstructure changes across the lifespan: a meta-analysis of longitudinal diffusion MRI studies
White matter microstructure changes across the lifespan: a meta-analysis of longitudinal diffusion MRI studies Open
Background White matter in the human brain is known to play a critical role in facilitating communication between different brain regions. White matter microstructure is often quantified using fractional anisotropy (FA) derived from diffus…
View article: Association between polygenic risk for Major Depression and brain structure in a mega-analysis of 50,975 participants across 11 studies
Association between polygenic risk for Major Depression and brain structure in a mega-analysis of 50,975 participants across 11 studies Open
Major Depression (MD) is a prevalent, disabling and life-limiting condition. The neurobiological associations of genetic risk for MD remain under-explored in large samples, with no comprehensive mega-analysis conducted to date. Our study a…