Explanipedia

Torque teno virus loads and leukocyte populations in stable outpatient solid organ transplant recipients Open

Jip Jonker, Caecilia S E Doorenbos, António W. Gomes‐Neto, Vincent E. de Meijer, Hans Blokzijl , et al. · 2025

These results provide evidence to support the theory that TTV replicates in immature granulocytes. The negative association with total granulocyte count suggests possible antiviral effects or altered granulocyte lifespan. These relationshi…

A novel molecular interaction in bronchiolitis obliterans syndrome in lung transplantation patients: the role of SERPINA3 and osteoprotegerin Open

Yanzhe Liu, Eline A van der Ploeg, Theo Borghuis, Ingrid Menz, Wim Timens , et al. · 2025

Background and objective Chronic lung allograft dysfunction, significantly limits survival after lung transplantation. The obstructive phenotype bronchiolitis obliterans syndrome (BOS) is characterized by the abnormal activation of epithel…

A Comparative Literature Review of "Stroke 120" and "FAST" in Chinas Stroke Emergency Education Open

C. Tji Gan · 2025

Stroke remains one of the major causes of death and disability in China. Pre-hospital delay is a key obstacle hindering timely treatment. Therefore, the effectiveness of stroke education tools is particularly important. Through a systemati…

GLUT and FAPα as molecular markers for interstitial lung disease in systemic sclerosis Open

Bo Broens, Conny J. van der Laken, Teodora Radonic, Esther J. Nossent, Xue D. Manz , et al. · 2025

Symptom Burden and Patient-Reported Outcomes in Kidney Transplant Recipients: Results From the TransplantLines Biobank and Cohort Studies Open

Niels L. Riemersma, Tim J. Knobbe, Daan Kremer, Svea Nolte, Ute Bültmann , et al. · 2025

Design of tennis auxiliary teaching system based on reinforcement learning and multi-feature fusion Open

Shiquan Zhang, C. Tji Gan · 2025

To accurately identify and evaluate tennis movements, a tennis auxiliary teaching system based on reinforcement learning and multi-feature fusion was designed by combining deep learning methods with tennis-related knowledge to recognize an…

Osteoprotegerin Is Elevated in Pulmonary Fibrosis and Associates with Idiopathic Pulmonary Fibrosis Progression: A Pilot Study Open

Habibie Habibie, Kurnia Sari Setio Putri, Carian E. Boorsma, David M. Brass, Peter Heukels , et al. · 2025

Introduction: Osteoprotegerin (OPG), a decoy receptor for receptor activator of NF-κB ligand (RANKL), serves as a biomarker for liver fibrosis severity. Our recent findings show OPG production in fibrotic lung tissue, though its specific c…

Posttransplant Dynamics of Serum T50 and Coronary Artery Calcium Scores Among Kidney Transplant Recipients Open

Amarens van der Vaart, Daan Kremer, Edward R. Smith, Rozemarijn Vliegenthart, Andreas Pasch , et al. · 2025

TransplantLines, a biobank and cohort study of solid organ transplant recipients and donors Open

Anna M Posthumus, Tim J. Knobbe, Daan Kremer, António W. Gomes‐Neto, Isabelle J.C. Dielwart , et al. · 2025

It takes two: Aberrant repair and low-grade inflammation characterize bronchiolitis obliterans syndrome after lung transplantation in serum proteomic analysis Open

Eline A van der Ploeg, Alen Faiz, Greta J. Teitsma, Alejandro Sánchez Brotons, Natalia Govorukhina , et al. · 2025

Differences in the expression of proteins that reflect the complex interplay between aberrant repair and inflammation in BOS were identified. These proteins should be investigated and validated in larger cohorts and may aid in expanding kn…

Timing of lung transplant evaluation: considerations, barriers and alternatives Open

Eline A van der Ploeg, Tjerk H. Hylkema, C. Tji Gan · 2025

Purpose of review Over the past decade, increased knowledge has contributed to improved medical and technical treatments across the spectrum of respiratory diseases. As a result, timing for transplant evaluation might be more challenging. …

<i>Aspergillus</i> After Lung Transplantation: Prophylaxis, Risk Factors, and the Impact on Chronic Lung Allograft Dysfunction Open

Johanna P. van Gemert, Ger Jan Fleurke, Onno W. Akkerman, C. Tji Gan, Willie N. Steenhuis , et al. · 2025

Background Invasive pulmonary aspergillosis (IA) poses significant challenges for lung transplant (LTx) patients, with unclear risk factors and preventive strategies. The effectiveness of nebulized amphotericin B (AmB) or statins for IA pr…

Evaluation of Elexacafor/Tezacaftor/Ivacaftor therapy after lung transplantation in Cystic Fibrosis: The Dutch National KOALA study Open

Johanna P. van Gemert, Bart Luijk, Merel E. Hellemons, K.A. Visser, C. Hansen , et al. · 2025

Muscle Mass, Muscle Strength, and Health-Related Quality of Life in Kidney Transplant Recipients Open

Tim J. Knobbe, Gijs M.M. Lenis, Dirk A.J. van der Vossen, Jory Wentink, Daan Kremer , et al. · 2024

Calciprotein particle counts associate with vascular remodelling in chronic kidney disease Open

Lian Feenstra, Melanie Reijrink, Andreas Pasch, Edward R. Smith, Lotte M Visser , et al. · 2024

Aims Calciprotein particles (CPPs) are circulating calcium and phosphate nanoparticles associated with the development of vascular calcification (VC) in chronic kidney disease (CKD). Although recent studies have been focusing on associatio…

Transcriptomic analyses of lung tissues reveal key genes associated with progression of systemic sclerosis-interstitial lung disease (SSc-ILD) Open

Yehya Al-Adwi, Johanna Westra, Harry van Goor, Léon C.L.T. van Kempen, Mohammed Osman , et al. · 2024

Plasma symmetric dimethylarginine and kidney graft function in kidney transplant recipients Open

Daan Kremer, Sovia Salamah, Dion Groothof, Adrian Post, Tim J. Knobbe , et al. · 2024

Journal Article Accepted manuscript Plasma Symmetric Dimethylarginine and Kidney Graft Function in Kidney Transplant Recipients Get access Daan Kremer, Daan Kremer University of Groningen, University Medical Center Groningen, Department of…

The gut microbiome in end-stage lung disease and lung transplantation Open

S. Zhang, J. Casper Swarte, Ranko Gaćeša, Tim J. Knobbe, Daan Kremer , et al. · 2024

Gut dysbiosis has been associated with impaired outcomes in liver and kidney transplant recipients, but the gut microbiome of lung transplant recipients has not been extensively explored. We assessed the gut microbiome in 64 fecal samples …

Iron deficiency, anemia, and patient-reported outcomes in kidney transplant recipients Open

Daan Kremer, Tim J. Knobbe, Joanna Sophia J. Vinke, Dion Groothof, Adrian Post , et al. · 2024

Lung transplant airway complications treated with biodegradable airway stents: The Dutch multi‐center experience Open

Roel Pel, C. Tji Gan, Johannes M. A. Daniels, Dieuwertje Ruigrok, Merel E. Hellemons , et al. · 2024

Introduction Treatment of post lung‐transplant airway complications is challenging, and treatment with conventional airway stents is associated with adverse events. More recently, biodegradable airway stents (BDS) have been introduced and …

Health-related quality of life is linked to the gut microbiome in kidney transplant recipients Open

J. Casper Swarte, Tim J. Knobbe, Johannes R. Björk, Ranko Gaćeša, Lianne M. Nieuwenhuis , et al. · 2023

High serum C-X-C motif chemokine ligand 10 (CXCL10) levels may be associated with new onset interstitial lung disease in patients with systemic sclerosis: evidence from observational, clinical, transcriptomic and in vitro studies Open

Yehya Al-Adwi, Isabella M. Atzeni, Berber Doornbos‐van der Meer, Marcel J. van der Leij, Rita Delphine Maiko Varkevisser , et al. · 2023

Transatlantic veno-venous ECMO bridge for lung transplantation Open

Johanna P. van Gemert, Joep M. Droogh, I. Finkenzeller, J.D. Botero Bahamón, C. Tji Gan , et al. · 2023

The Gut Microbiome in End-stage Lung Disease and Lung Transplantation Open

Shuyan Zhang, J. Casper Swarte, Ranko Gaćeša, Tim J. Knobbe, Daan Kremer , et al. · 2023

Background Gut dysbiosis has been associated with impaired outcomes in liver and kidney transplant recipients but the gut microbiome of lung transplant recipients has not been previously studied. Methods We assessed the gut microbiome in 6…

Multiple indicators of gut dysbiosis predict all-cause and cause-specific mortality in solid organ transplant recipients Open

J. Casper Swarte, Shuyan Zhang, Lianne M. Nieuwenhuis, Ranko Gaćeša, Tim J. Knobbe , et al. · 2023

Objective Gut microbiome composition is associated with multiple diseases, but relatively little is known about its relationship with long-term outcome measures. While gut dysbiosis has been linked to mortality risk in the general populati…

Modelling Acid-Induced Lung Damage in Precision-Cut Lung Slices: An Ex Vivo Animal Model Open

C.A.F. Möes, C. Tji Gan, Leonie H. Venema, Roland F. Hoffmann, Barbro N. Melgert , et al. · 2023

Background: Donor lungs are often discarded, with gastric aspiration accounting for ~9% of lungs unsuitable for transplantation. To increase the donor pool, it is important to understand the pathophysiology of aspiration-induced lung damag…

Three Decades Single Center Experience of Airway Complications After Lung Transplantation Open

R. van Pel, C. Tji Gan, W. van der Bij, Erik A.M. Verschuuren, J. P. A. van Gemert , et al. · 2023

Post lung transplantation airway complications like necrosis, stenosis, malacia and dehiscence cause significant morbidity, and are most likely caused by post-operative hypo perfusion of the anastomosis. Treatment can be challenging, and a…

Non-tuberculous mycobacteria disease pre-lung transplantation: A systematic review of the treatment regimens and duration pre- and post-transplant. Open

Johanna P. van Gemert, Sofanne J. Ravensbergen, Erik A.M. Verschuuren, Huib A.M. Kerstjens, Brigitte W.M. Willemse , et al. · 2023

The median treatment duration pre-LTx was 10 months (IQR 6-17) and 2 months (IQR 2-8) directly post-LTx. Patients with longer treatment duration for NTM-PD pre-LTx and with sputum non-conversion are at risk for NTM disease post-LTx and for…

Can ultrasound of the major salivary glands differentiate Sjögren's disease from its major mimics? Open

Konstantina Delli, Jolien F. van Nimwegen, Suzanne Arends, Alja J. Stel, C. Tji Gan , et al. · 2023

This study indicates that SGUS has a potentially high diagnostic accuracy to discriminate SjD from systemic diseases which can also cause salivary gland involvement.

Sleep quality, fatigue, societal participation and health-related quality of life in kidney transplant recipients: a cross-sectional and longitudinal cohort study Open

Tim J. Knobbe, Daan Kremer, Michele F. Eisenga, Marco van Londen, Coby Annema , et al. · 2023

Background Fatigue and impaired health-related quality of life (HRQoL) are common among kidney transplant recipients (KTR). We hypothesized that both may partially be attributable to poor sleep. Methods Cross-sectional and longitudinal dat…

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