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View article: Gene–Environment Interaction Affects Risk of Atopic Eczema: Population and In Vitro Studies
Gene–Environment Interaction Affects Risk of Atopic Eczema: Population and In Vitro Studies Open
Background Multiple environmental and genetic factors play a role in the pathogenesis of atopic eczema ( AE ). We aimed to investigate gene–environment interactions (G × E) to improve understanding of the pathophysiology. Methods We analys…
View article: Gene-environment interaction analysis in atopic eczema: evidence from large population datasets and modelling <i>in vitro</i>
Gene-environment interaction analysis in atopic eczema: evidence from large population datasets and modelling <i>in vitro</i> Open
Background Environmental factors play a role in the pathogenesis of complex traits including atopic eczema (AE) and a greater understanding of gene-environment interactions (G*E) is needed to define pathomechanisms for disease prevention. …
View article: Author Correction: Building machine learning prediction models for well-being using predictors from the exposome and genome in a population cohort
Author Correction: Building machine learning prediction models for well-being using predictors from the exposome and genome in a population cohort Open
Correction to: Nature Mental Healthhttps://doi.org/10.1038/s44220-024-00294-2, published online 14 August 2024. This article was originally published under standard Springer Nature license (© The Author(s), under exclusive license to Sprin…
View article: Building machine learning prediction models for wellbeing using predictors from the exposome and genome in a population cohort
Building machine learning prediction models for wellbeing using predictors from the exposome and genome in a population cohort Open
Using longitudinal data of a large population cohort (Netherlands Twin Register; collected 1991-2022), we aim to build machine learning prediction models for adult wellbeing from the exposome and genome, and identify the most predictive fa…
View article: Integrative multi‐omics analysis of genomic, epigenomic, and metabolomics data leads to new insights for <scp>Attention‐Deficit</scp> /Hyperactivity Disorder
Integrative multi‐omics analysis of genomic, epigenomic, and metabolomics data leads to new insights for <span>Attention‐Deficit</span> /Hyperactivity Disorder Open
The evolving field of multi‐omics combines data and provides methods for simultaneous analysis across several omics levels. Here, we integrated genomics (transmitted and non‐transmitted polygenic scores [PGSs]), epigenomics, and metabolomi…
View article: Handedness and 23 Early Life Characteristics in 37,495 Dutch Twins
Handedness and 23 Early Life Characteristics in 37,495 Dutch Twins Open
In studies of singletons, a range of early-life characteristics have been reported to be associated with handedness, but some of these associations have failed to replicate. We examined associations between 23 early life characteristics wi…
View article: Genetic and Environmental Effects on the Early Motor Development as a Function of Parental Educational Attainment
Genetic and Environmental Effects on the Early Motor Development as a Function of Parental Educational Attainment Open
Introduction The contribution of genetic and environmental factors to individual differences in early motor development is still largely uncharted. This large-scale twin study establishes the genetic and environmental influences on the tim…
View article: Integrative Multi-omics Analysis of Childhood Aggressive Behavior
Integrative Multi-omics Analysis of Childhood Aggressive Behavior Open
This study introduces and illustrates the potential of an integrated multi-omics approach in investigating the underlying biology of complex traits such as childhood aggressive behavior. In 645 twins (cases = 42%), we trained single- and i…
View article: Developmental co‐occurrence of psychopathology dimensions in childhood
Developmental co‐occurrence of psychopathology dimensions in childhood Open
Background Comorbidity between psychopathologies may be attributed to genetic and environmental differences between people as well as causal processes within individuals, where one pathology increases risk for another. Disentangling betwee…
View article: A genome-wide association study of total child psychiatric problems scores
A genome-wide association study of total child psychiatric problems scores Open
Substantial genetic correlations have been reported across psychiatric disorders and numerous cross-disorder genetic variants have been detected. To identify the genetic variants underlying general psychopathology in childhood, we performe…
View article: Changing genetic architecture of body mass index from infancy to early adulthood: an individual based pooled analysis of 25 twin cohorts
Changing genetic architecture of body mass index from infancy to early adulthood: an individual based pooled analysis of 25 twin cohorts Open
Background Body mass index (BMI) shows strong continuity over childhood and adolescence and high childhood BMI is the strongest predictor of adult obesity. Genetic factors strongly contribute to this continuity, but it is still poorly know…
View article: Integrative multi-omics analysis of genomic, epigenomic, and metabolomics data leads to new insights for Attention-Deficit/Hyperactivity Disorder
Integrative multi-omics analysis of genomic, epigenomic, and metabolomics data leads to new insights for Attention-Deficit/Hyperactivity Disorder Open
The evolving field of multi-omics combines data and provides methods for simultaneous analysis across several omics levels. Here, we integrated genomics (transmitted and non-transmitted polygenic scores (PGS)), epigenomics and metabolomics…
View article: DNA methylation in peripheral tissues and left-handedness
DNA methylation in peripheral tissues and left-handedness Open
Handedness has low heritability and epigenetic mechanisms have been proposed as an etiological mechanism. To examine this hypothesis, we performed an epigenome-wide association study of left-handedness. In a meta-analysis of 3914 adults of…
View article: Persistence of parental‐reported asthma at early ages: A longitudinal twin study
Persistence of parental‐reported asthma at early ages: A longitudinal twin study Open
Background Currently, we cannot predict whether a pre‐school child with asthma‐like symptoms will have asthma at school age. Whether genetic information can help in this prediction depends on the role of genetic factors in persistence of p…
View article: DNA methylation in peripheral tissues and Left-handedness
DNA methylation in peripheral tissues and Left-handedness Open
Handedness has low heritability and epigenetic mechanisms have been proposed as an etiological mechanism. To examine this hypothesis, we performed an epigenome-wide association study (EWAS) of left-handedness. In a meta-analysis of 3,914 a…
View article: Integrative multi-omics analysis of childhood aggressive behavior
Integrative multi-omics analysis of childhood aggressive behavior Open
This study introduces and illustrates the potential of an integrated multi-omics approach in investigating the underlying biology of complex traits such as childhood aggressive behavior. In 645 twins (cases=42%), we trained single- and int…
View article: Educational attainment of same-sex and opposite-sex dizygotic twins: An individual-level pooled study of 19 twin cohorts
Educational attainment of same-sex and opposite-sex dizygotic twins: An individual-level pooled study of 19 twin cohorts Open
Comparing twins from same- and opposite-sex pairs can provide information on potential sex differences in a variety of outcomes, including socioeconomic-related outcomes such as educational attainment. It has been suggested that this desig…
View article: Genetic association study of childhood aggression across raters, instruments, and age.
Genetic association study of childhood aggression across raters, instruments, and age. Open
Childhood aggressive behavior (AGG) has a substantial heritability of around 50%. Here we present a genome-wide association meta-analysis (GWAMA) of childhood AGG, in which all phenotype measures across childhood ages from multiple assesso…
View article: Genetic association study of childhood aggression across raters, instruments, and age
Genetic association study of childhood aggression across raters, instruments, and age Open
Childhood aggressive behavior (AGG) has a substantial heritability of around 50%. Here we present a genome-wide association meta-analysis (GWAMA) of childhood AGG, in which all phenotype measures across childhood ages from multiple assesso…
View article: Predicting Complex Traits and Exposures From Polygenic Scores and Blood and Buccal DNA Methylation Profiles
Predicting Complex Traits and Exposures From Polygenic Scores and Blood and Buccal DNA Methylation Profiles Open
We examined the performance of methylation scores (MS) and polygenic scores (PGS) for birth weight, BMI, prenatal maternal smoking exposure, and smoking status to assess the extent to which MS could predict these traits and exposures over …