Carla Valsecchi
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View article: Evaluation of Artificial Intelligence-Generated Synthetic Data for Clinical Research in Secondary Cardiovascular Prevention of Patients with Dyslipidemia
Evaluation of Artificial Intelligence-Generated Synthetic Data for Clinical Research in Secondary Cardiovascular Prevention of Patients with Dyslipidemia Open
IntroductionData is crucial in modern healthcare, bearing the potential to improve patient care by powering clinical research and enhancing public health. However, the promise of real-world data to enable personalized medicine, guide polic…
View article: Predictive parameters for spontaneous joint bleeding during emicizumab prophylaxis
Predictive parameters for spontaneous joint bleeding during emicizumab prophylaxis Open
Emicizumab is approved for prophylaxis of patients with hemophilia A (HA). Despite its efficacy in reducing bleeding, some patients on emicizumab still experience hemarthrosis, but no tool is yet available to identify those at a higher ris…
View article: Markedly Reduced FVIII Recovery Associated with Anti-FVIII Peg Antibodies after BNT162b2 Sars-Cov-2 Vaccination
Markedly Reduced FVIII Recovery Associated with Anti-FVIII Peg Antibodies after BNT162b2 Sars-Cov-2 Vaccination Open
Background The covalent link of polyethylene glycol (PEG) chains to recombinant factor VIII (FVIII) molecule is one of the most established approaches to produce novel therapeutic FVIII products with extended half-life (EHL). To date, thre…
View article: Reduced FVIII recovery associated with anti-FVIII PEG antibodies after BNT162b2 SARS-CoV-2 vaccination
Reduced FVIII recovery associated with anti-FVIII PEG antibodies after BNT162b2 SARS-CoV-2 vaccination Open
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View article: An observational study to verify the influence of different nutritional corn silage-based strategies on efficient use of dietary nutrients, faecal fermentation profile, and profitability in a cohort of intensive dairy farms
An observational study to verify the influence of different nutritional corn silage-based strategies on efficient use of dietary nutrients, faecal fermentation profile, and profitability in a cohort of intensive dairy farms Open
Sixty-six dairy farms (as average, 167.0 ± 106.5 milking cows and milk yield of 31.4 ± 5.1) were visited to identify different nutritional approaches adopted in dairy cows diet formulation. Forage, TMR, faecal, and milk samples from lactat…
View article: Assessment of feed and economic efficiency of dairy farms based on multivariate aggregation of partial indicators measured on field
Assessment of feed and economic efficiency of dairy farms based on multivariate aggregation of partial indicators measured on field Open
Many of the metrics used to evaluate farm performance are only partial indicators of farm operations, which are assumed to be best predictors of the whole farm efficiency. The main objective of this work was to identify aggregated multiple…
View article: Performance of a clinical risk prediction model for inhibitor formation in severe haemophilia A
Performance of a clinical risk prediction model for inhibitor formation in severe haemophilia A Open
Background There is a need to identify patients with haemophilia who have a very low or high risk of developing inhibitors. These patients could be candidates for personalized treatment strategies. Aims The aim of this study was to externa…
View article: IgG subclasses as biomarkers for persistence of factor VIII inhibitors in previously untreated patients with severe haemophilia A
IgG subclasses as biomarkers for persistence of factor VIII inhibitors in previously untreated patients with severe haemophilia A Open
Summary We investigated longitudinally the behaviour of anti‐factor VIII (anti‐FVIII) IgG subclasses for 6 months from inhibitor development in 43 patients from the Survey of Inhibitors in Plasma‐Products Exposed Toddlers (SIPPET) trial wh…
View article: Evaluation of a New, Rapid, Fully Automated Assay for the Measurement of ADAMTS13 Activity
Evaluation of a New, Rapid, Fully Automated Assay for the Measurement of ADAMTS13 Activity Open
Thrombotic thrombocytopenic purpura (TTP) is a rare thrombotic microangiopathy (TMA) characterized by the severe deficiency of a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13 (ADAMTS13) activity (< 10%). R…
View article: Molecular Aggregation of Marketed Recombinant FVIII Products: Biochemical Evidence and Functional Effects
Molecular Aggregation of Marketed Recombinant FVIII Products: Biochemical Evidence and Functional Effects Open
Background Recombinant (rec-) coagulation factor VIII concentrates available for hemophilia A (HA) treatment differ in cell line production and structure, which could affect their pharmacodynamics and immunogenicity. Clinical trials showed…
View article: Nonneutralizing antibodies against factor VIII and risk of inhibitor development in severe hemophilia A
Nonneutralizing antibodies against factor VIII and risk of inhibitor development in severe hemophilia A Open
Key Points Nonneutralizing antibodies against FVIII are detected in untreated or minimally treated patients with hemophilia A. The presence of nonneutralizing antibodies is associated with a substantially increased risk of inhibitor develo…
View article: Next-Generation Sequencing and In Vitro Expression Study of ADAMTS13 Single Nucleotide Variants in Deep Vein Thrombosis
Next-Generation Sequencing and In Vitro Expression Study of ADAMTS13 Single Nucleotide Variants in Deep Vein Thrombosis Open
Three SNVs (p.Val154Ile, p.Asp187His and p.Arg421Cys) showed reduced ex vivo and in vitro ADAMTS13 levels. However, the low frequency of these variants makes it difficult to confirm their association with DVT.