Chih‐Wei Hsu
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View article: The concentration-dependent protective effects by new generation hypoglycemic agents on delirium, depression, dementia and coma: evidence from a network meta-analysis
The concentration-dependent protective effects by new generation hypoglycemic agents on delirium, depression, dementia and coma: evidence from a network meta-analysis Open
Objectives: Emerging evidence suggests that glucagon-like peptide-1 (GLP-1) receptor agonists and sodium-glucose co-transporter 2 (SGLT2) inhibitors may exert neuroprotective effects. However, the comparative efficacy of individual agents …
View article: Risk of Parkinson’s disease after human papillomavirus infection: a nationwide cohort study
Risk of Parkinson’s disease after human papillomavirus infection: a nationwide cohort study Open
View article: Uncovering predictors of bipolar II conversion to bipolar I: A machine learning analysis of national health records in Taiwan
Uncovering predictors of bipolar II conversion to bipolar I: A machine learning analysis of national health records in Taiwan Open
Our findings highlight the utility of machine learning in stratifying BD-II patients at elevated risk for BD-I conversion, offering a data-driven framework to support early clinical intervention and personalized care.
View article: Mortality among transgender persons: a Taiwan matched-population and sibling-comparison cohort study
Mortality among transgender persons: a Taiwan matched-population and sibling-comparison cohort study Open
View article: Audiovestibular Dysfunction in Hyper-IgE Syndrome: A Systematic Review of Characteristics, Pathophysiology, Diagnosis, and Management
Audiovestibular Dysfunction in Hyper-IgE Syndrome: A Systematic Review of Characteristics, Pathophysiology, Diagnosis, and Management Open
Hyper-IgE syndrome (HIES) is a rare genetic immunodeficiency characterized by elevated serum IgE levels and associated immune dysregulation, manifesting in recurrent infections, eczema, and skeletal abnormalities. Emerging evidence suggest…
View article: Suicide risk on Christmas Eve, Christmas Day, New Year's Day, and Valentine's Day: a systematic review and meta-analysis
Suicide risk on Christmas Eve, Christmas Day, New Year's Day, and Valentine's Day: a systematic review and meta-analysis Open
Objective Holidays are times of celebration of family and loved ones which can be difficult for some people. This study assessed the risk of suicide on Christmas Eve, Christmas Day, New Year's Day, and Valentine's Day. Methods We searched …
View article: Association between vitamin D deficiency and risk of venous thromboembolism: a matched cohort study of 139,690 patients
Association between vitamin D deficiency and risk of venous thromboembolism: a matched cohort study of 139,690 patients Open
Background Vitamin D deficiency (VDD) may contribute to venous thromboembolism (VTE) through effects on coagulation and endothelial function, but existing studies show inconsistent results. We investigated the association between VDD and V…
View article: Dose-response efficacy and safety of lumateperone in bipolar depression: A preliminary meta-analysis of randomized controlled trials
Dose-response efficacy and safety of lumateperone in bipolar depression: A preliminary meta-analysis of randomized controlled trials Open
Background: The optimal lumateperone dose for bipolar depression remains uncertain. Aims: To examine its dose–response relationship for efficacy and safety. Methods: We systematically searched major databases to 1 July 2025. Efficacy outco…
View article: The Preventive Effects of GLP-1 Receptor Agonists and SGLT2 Inhibitors on Cancer Metastasis: A Network Meta-Analysis of 67 Randomized Controlled Trials
The Preventive Effects of GLP-1 Receptor Agonists and SGLT2 Inhibitors on Cancer Metastasis: A Network Meta-Analysis of 67 Randomized Controlled Trials Open
Metastatic cancer, characterized by poor survival outcomes and grim prognosis, represents the final stage of malignancy. The current evidence regarding the prophylactic effects of glucagon-like peptide-1 (GLP-1) receptor agonists and sodiu…
View article: Trajectory of efficacy and safety across ulotaront dose levels in schizophrenia: a systematic review and dose–response meta-analysis
Trajectory of efficacy and safety across ulotaront dose levels in schizophrenia: a systematic review and dose–response meta-analysis Open
Background Ulotaront is an experimental antipsychotic for schizophrenia, but its optimal dose is unclear. This study aimed to evaluate dose–response relationships for efficacy and safety in people with schizophrenia. Methods A systematic r…
View article: Efficacy of horticultural therapy on symptoms and functional outcomes in individuals with depressive disorders: A systematic review and meta-analysis of randomized controlled trials
Efficacy of horticultural therapy on symptoms and functional outcomes in individuals with depressive disorders: A systematic review and meta-analysis of randomized controlled trials Open
This review provides preliminary support for the efficacy of HT in depressive disorders. Given methodological limitations and potential biases, further well-designed trials with registration, blinded assessors, and long-term follow-up are …
View article: Potential placebo bias in current trials of delirium prevention: a network meta‐analysis of 86 randomized controlled trials
Potential placebo bias in current trials of delirium prevention: a network meta‐analysis of 86 randomized controlled trials Open
Aim Numerous network meta‐analyses (NMAs) have reported inconsistent findings on the efficacy of various pharmacologic treatments for delirium prevention in high‐risk patients. A potential confounder was the study design—using a placebo co…
View article: Enhanced Photonic Transistor Memory Performance Through Morphology‐Dependent Scattering Effects and Amplified Spontaneous Emission
Enhanced Photonic Transistor Memory Performance Through Morphology‐Dependent Scattering Effects and Amplified Spontaneous Emission Open
Recent studies of nanofibers on organic field‐effect transistor (OFET) photonic memory devices have gained significant attention due to their versatility and adaptability for achieving high performance. This research explores the integrati…
View article: Risk of Hearing Loss in Patients Treated with Exendin-4 Derivatives: A Network Meta-Analysis of Glucagon-like Peptide-1 Receptor Agonists and Sodium–Glucose Cotransporter 2 Inhibitors
Risk of Hearing Loss in Patients Treated with Exendin-4 Derivatives: A Network Meta-Analysis of Glucagon-like Peptide-1 Receptor Agonists and Sodium–Glucose Cotransporter 2 Inhibitors Open
Background/Objectives: Emerging evidence suggests an association between glucagon-like peptide-1 (GLP-1) receptor agonists and sodium–glucose co-transporter 2 (SGLT2) inhibitors with altered risk of damage in the inner ear system. However,…
View article: Audiovestibular Dysfunction in Patients with Hashimoto’s Disease: A Systematic Review
Audiovestibular Dysfunction in Patients with Hashimoto’s Disease: A Systematic Review Open
Although the inner ear is considered an immune-privileged organ because of the blood–labyrinth barrier, accumulating evidence has revealed an unexpected relation between Hashimoto’s disease and inner ear damage manifesting as audiovestibul…
View article: The efficacy and safety of anti-amyloid monoclonal antibody versus acetylcholinesterase inhibitor with an in-depth analysis across genotypes and disease stages: a systematic review and meta-analysis
The efficacy and safety of anti-amyloid monoclonal antibody versus acetylcholinesterase inhibitor with an in-depth analysis across genotypes and disease stages: a systematic review and meta-analysis Open
View article: Learning and language in the unconscious human hippocampus
Learning and language in the unconscious human hippocampus Open
Consciousness is a fundamental component of cognition, 1 but the degree to which higher-order perception relies on it remains disputed. 2,3 Here we demonstrate the persistence of learning, semantic processing, and online prediction in indi…
View article: The Efficacy and Acceptability of Non‐Invasive Brain Stimulation Interventions for Obsessive‐Compulsive Disorder Management: A Network Meta‐Analysis Based on 24 Stimulation Methods
The Efficacy and Acceptability of Non‐Invasive Brain Stimulation Interventions for Obsessive‐Compulsive Disorder Management: A Network Meta‐Analysis Based on 24 Stimulation Methods Open
Introduction Despite the high lifetime prevalence and elevated disability rates, treatments for obsessive‐compulsive disorder (OCD) have limited efficacy. Considering the abnormal connectivity in the cortical‐striatal‐thalamic‐cortical loo…
View article: Organic Room‐Temperature Phosphorescent Materials for High‐Performance Floating Gate Photomemory and Synaptic Phototransistor Applications
Organic Room‐Temperature Phosphorescent Materials for High‐Performance Floating Gate Photomemory and Synaptic Phototransistor Applications Open
Room‐temperature phosphorescent (RTP) materials, owing to their long‐lived triplet exciton characteristics, exhibit significant potential for applications in photomemory and artificial photosynapses. However, fluorescent materials are ofte…
View article: Haloperidol in treating delirium, reducing mortality, and preventing delirium occurrence: Bayesian and frequentist meta-analyses
Haloperidol in treating delirium, reducing mortality, and preventing delirium occurrence: Bayesian and frequentist meta-analyses Open
View article: Cannabis Use Disorder Emergency Department Visits and Hospitalizations and 5-Year Mortality
Cannabis Use Disorder Emergency Department Visits and Hospitalizations and 5-Year Mortality Open
Importance Cannabis use disorders (CUD) are associated with adverse health effects, including mental disorders and motor vehicle collision-related injuries. However, little is known about whether CUDs are associated with increased mortalit…
View article: Audiological Features in Patients with Rheumatoid Arthritis: A Systematic Review
Audiological Features in Patients with Rheumatoid Arthritis: A Systematic Review Open
Hearing impairment in patients with rheumatoid arthritis has been underestimated for decades. Rheumatoid arthritis can affect both the middle ear (specifically, the incudomalleolar and incudostapedial joints) and inner ear (including the c…
View article: Audiovestibular Dysfunction Related to Anti-Phospholipid Syndrome: A Systematic Review
Audiovestibular Dysfunction Related to Anti-Phospholipid Syndrome: A Systematic Review Open
Background: Anti-phospholipid syndrome (APS) has emerged as a significant issue in autoimmune diseases over recent decades. Its hallmark feature is thromboembolic events, potentially affecting any vascularized area including the microcircu…
View article: Efficacy and acceptability of lurasidone for bipolar depression: a systematic review and dose–response meta-analysis
Efficacy and acceptability of lurasidone for bipolar depression: a systematic review and dose–response meta-analysis Open
Question The optimal dose of lurasidone for bipolar depression is unclear. This study examined its dose–response relationship for efficacy, acceptability, and metabolic/endocrine profiles. Study selection and analysis Five databases and gr…
View article: The association between health literacy and colorectal cancer screening uptake in Taiwan
The association between health literacy and colorectal cancer screening uptake in Taiwan Open
Background Population-based cancer screening programs have been confirmed as a cost-effective strategy for early detection of colorectal cancer, leading to reduced mortality and morbidity. In Taiwan, the government has provided an immunoch…
View article: Efficacy of Horticultural Therapy on Positive, Negative, and Affective Symptoms in Individuals with Schizophrenia: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Efficacy of Horticultural Therapy on Positive, Negative, and Affective Symptoms in Individuals with Schizophrenia: A Systematic Review and Meta-Analysis of Randomized Controlled Trials Open
Background/Objectives: Positive symptoms, negative symptoms, and emotional disturbances are core features of schizophrenia. Although horticultural therapy (HT) has shown promise as an adjunctive treatment, evidence supporting its effective…
View article: Comparing subjective quality of recovery between remimazolam- and propofol-based total intravenous anesthesia for surgical procedures: a meta-analysis
Comparing subjective quality of recovery between remimazolam- and propofol-based total intravenous anesthesia for surgical procedures: a meta-analysis Open
View article: The association between diverse psychological protocols and the efficacy of psilocybin-assisted therapy for clinical depressive symptoms: a Bayesian meta-analysis
The association between diverse psychological protocols and the efficacy of psilocybin-assisted therapy for clinical depressive symptoms: a Bayesian meta-analysis Open
Objective Psilocybin-assisted therapy has shown promising efficacy on clinical depressive symptoms. However, diverse psychological support or psychotherapy was performed with psilocybin treatment. This study aimed to explore the associatio…
View article: Audiovestibular Dysfunction in Systemic Lupus Erythematosus Patients: A Systematic Review
Audiovestibular Dysfunction in Systemic Lupus Erythematosus Patients: A Systematic Review Open
Audiovestibular dysfunction in patients with systemic lupus erythematosus has been underestimated for decades. Systemic lupus erythematosus can affect both the auditory and vestibular systems simultaneously. Several potential pathophysiolo…
View article: The effects of mindful exercise on cognition in patients with schizophrenia: A systematic review and meta-analysis of randomized controlled trials
The effects of mindful exercise on cognition in patients with schizophrenia: A systematic review and meta-analysis of randomized controlled trials Open
Cognitive impairment is a core symptom of schizophrenia. This study investigated the effects of mindful exercise on the cognitive performance of individuals with schizophrenia. A systematic review and meta-analysis were performed from ince…