C Michael White
YOU?
Author Swipe
View article: Alkaline loading of extracellular vesicles produced from human neural stem cell-derived neurospheres enables CNS drug delivery
Alkaline loading of extracellular vesicles produced from human neural stem cell-derived neurospheres enables CNS drug delivery Open
The blood brain barrier and blood tumor barrier (BBB and BTB, respectively) represent significant obstacles for the delivery of drugs to treat diseases of the central nervous system, such as brain cancers and neurodegenerative diseases. Ex…
View article: Machine Aesthetics: Material Indices of Post‐Digital Architecture
Machine Aesthetics: Material Indices of Post‐Digital Architecture Open
Virtual technologies, such as AI and parametric protocols, can mash‐up infinite architectural forms in infinite configurations. Perhaps it is beneficial for students to concentrate on the real world for a while. Architectural educator Cale…
View article: Andexanet alfa versus PCC products for factor Xa inhibitor bleeding: A systematic review with meta‐analysis
Andexanet alfa versus PCC products for factor Xa inhibitor bleeding: A systematic review with meta‐analysis Open
Previous meta‐analyses assessed andexanet alfa (AA) or prothrombin complex concentrate (PCC) products for the treatment of Factor Xa inhibitor (FXaI)‐associated major bleeding. However, they did not include recent studies or assess the imp…
View article: Eye Drop Quality Issues: Can the FDA See This One Through?
Eye Drop Quality Issues: Can the FDA See This One Through? Open
The Food and Drug Administration (FDA) has long suffered from a lack of resources limiting their inspection capacity. They have fallen behind on proactive surveillance inspections of foreign manufacturing sites, relying instead on for-caus…
View article: An update on the clinical pharmacology of kratom: uses, abuse potential, and future considerations
An update on the clinical pharmacology of kratom: uses, abuse potential, and future considerations Open
With the increasing use of kratom in clinical practice, clinicians should be aware of the potential benefits and adverse effects associated with kratom. While many patients may benefit from kratom use with few or no reported adverse effect…
View article: 2031 Lying and standing blood pressure and ECG for the falling patient
2031 Lying and standing blood pressure and ECG for the falling patient Open
Introduction Many elderly patients admitted to hospital have presented following a fall. Causes for falls are often complex and multifactorial, but causes such as postural hypotension and cardiac arrhythmias are easily diagnosed with lying…
View article: Does Early Vasopressin in Septic Shock Improve Outcomes? An Important Piece to This Emerging Puzzle Has Arrived
Does Early Vasopressin in Septic Shock Improve Outcomes? An Important Piece to This Emerging Puzzle Has Arrived Open
In this month’s Annals of Pharmacotherapy, the largest observational study assessing the early versus later use of vasopressin has been published. When this new study is combined with the other available observational studies, there are 2 …
View article: Are the ground states of randomly interacting bosons random?
Are the ground states of randomly interacting bosons random? Open
Bosonic degrees of freedom and their emergence as a part of complex quantum many-body dynamics, symmetries, collective behavior, clustering and phase transitions play an important role in modern studies of quantum systems. In this work we …
View article: How the pandemic set back drug safety
How the pandemic set back drug safety Open
The best form of inspection is an unannounced one, but the pandemic changed the game for regulators. They’ll need to work together to protect consumers. Manipulating data, destroying documents, altering staff training records, retesting sa…
View article: Response to Letter to the Editor by Dr Robinson
Response to Letter to the Editor by Dr Robinson Open
We thank Dr Robinson for expressing his concerns. Our commentary does not say the US Food and Drug Administration (FDA) should oversee all international clinical trials.1 It says the rules pertaining to clinical trials in developing countr…
View article: Efficacy of early treatment with hydroxychloroquine in people with mild to moderate COVID-19: A systematic review and meta-analysis
Efficacy of early treatment with hydroxychloroquine in people with mild to moderate COVID-19: A systematic review and meta-analysis Open
Introduction No early treatment intervention for COVID-19 has proven effective to date. We systematically reviewed the efficacy of hydroxychloroquine as early treatment for COVID-19. Material and methods Randomized controlled trials (RCTs)…
View article: Sedative‐Hypnotic Agents That Impact Gamma‐Aminobutyric Acid Receptors: Focus on Flunitrazepam, Gamma‐Hydroxybutyric Acid, Phenibut, and Selank
Sedative‐Hypnotic Agents That Impact Gamma‐Aminobutyric Acid Receptors: Focus on Flunitrazepam, Gamma‐Hydroxybutyric Acid, Phenibut, and Selank Open
There are many nonopioid central nervous system depressant substances that share a gamma‐aminobutyric acid (GABA) receptor–related mechanism of action. These sedatives‐hypnotics can be indicated to treat anxiety, seizures, depression, and …
View article: Drugs of Abuse: How Clinical Pharmacology Brings Clarity to the Shadows
Drugs of Abuse: How Clinical Pharmacology Brings Clarity to the Shadows Open
We believe that clinical pharmacology has something unique and valuable to add to our understanding of the issues underlying the worldwide epidemic of drug misuse and addiction. Appreciating the pharmacological similarities and differences…
View article: Impact of Prophylactic Hydroxychloroquine on People at High Risk of COVID-19: A Systematic Review and Meta-Analysis
Impact of Prophylactic Hydroxychloroquine on People at High Risk of COVID-19: A Systematic Review and Meta-Analysis Open
There are no proven prophylactic interventions for COVID-19. We systematically reviewed the efficacy of prophylactic hydroxychloroquine for COVID-19. Studies evaluating hydroxychloroquine for prophylaxis of COVID-19 were searched in severa…
View article: Efficacy and Safety of Hydroxychloroquine for Hospitalized COVID-19 Patients: A Systematic Review and Meta-Analysis
Efficacy and Safety of Hydroxychloroquine for Hospitalized COVID-19 Patients: A Systematic Review and Meta-Analysis Open
We systematically reviewed the efficacy and safety of hydroxychloroquine as treatment for hospitalized COVID-19. Randomized controlled trials (RCTs) evaluating hydroxychloroquine as treatment for hospitalized COVID-19 patients were searche…
View article: Ranitidine’s <i>N</i>-nitrosodimethylamine Problem May be Tip of the Iceberg
Ranitidine’s <i>N</i>-nitrosodimethylamine Problem May be Tip of the Iceberg Open
Lior Z. Braunstein, MD; Elizabeth D. Kantor, PhD; Kelli O’Connell, MSPHc; Amber Jessop Hudspeth, MSc; Qian Wu, PhD; Nicola Zenzola, MSc; David Y. Light, BSc
View article: Efficacy and harms of remdesivir for the treatment of COVID-19: A systematic review and meta-analysis
Efficacy and harms of remdesivir for the treatment of COVID-19: A systematic review and meta-analysis Open
Background Efficacy and safety of treatments for hospitalized COVID-19 are uncertain. We systematically reviewed efficacy and safety of remdesivir for the treatment of COVID-19. Methods Studies evaluating remdesivir in adults with hospital…
View article: Genome-wide analysis of BMI in adolescents and young adults reveals additional insight into the effects of genetic loci over the life course
Genome-wide analysis of BMI in adolescents and young adults reveals additional insight into the effects of genetic loci over the life course Open
Genetic loci for body mass index (BMI) in adolescence and young adulthood, a period of high risk for weight gain, are understudied, yet may yield important insight into the etiology of obesity and early intervention. To identify novel gene…
View article: Quality evaluation of case series describing four-factor prothrombin complex concentrate in oral factor Xa inhibitor-associated bleeding: a systematic review
Quality evaluation of case series describing four-factor prothrombin complex concentrate in oral factor Xa inhibitor-associated bleeding: a systematic review Open
Introduction As oral factor Xa (oFXa) inhibitor use has increased, so has publication of case series describing related bleeding managed with four-factor prothrombin complex concentrate (4F-PCC). Objective This review aimed to identify cas…
View article: Update Alert 3: Hydroxychloroquine or Chloroquine for the Treatment or Prophylaxis of COVID-19
Update Alert 3: Hydroxychloroquine or Chloroquine for the Treatment or Prophylaxis of COVID-19 Open
Letters21 October 2020Update Alert 3: Hydroxychloroquine or Chloroquine for the Treatment or Prophylaxis of COVID-19FREEAdrian V. Hernandez, MD, PhD, Yuani M. Roman, MD, MPH, Vinay Pasupuleti, MD, MS, PhD, Joshuan J. Barboza, MSc, and C. M…
View article: Developing Consistent and Useful Quality Improvement Study Data Extraction for Health Systems
Developing Consistent and Useful Quality Improvement Study Data Extraction for Health Systems Open
Purpose of reviewTo determine if the consistency of data extraction improves after creating explicit instructions for quality improvement study assessment criteria. Key messages• Findings: Creating explicit instructions to accompany qualit…