Xiaoping Chen
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View article: A Modified Chen’s U-Suture Technique with or Without a Stent in Pancreaticojejunostomy for Patients with Soft Pancreas and Small Pancreatic Duct: A Multicenter Cohort Study
A Modified Chen’s U-Suture Technique with or Without a Stent in Pancreaticojejunostomy for Patients with Soft Pancreas and Small Pancreatic Duct: A Multicenter Cohort Study Open
This technique is reliable for patients with soft pancreas and small pancreatic duct, including those who have ducts too small to undergo stent placement.
View article: Table S5 from Exon Skipping of <i>Ste20-</i><i>Like</i><i> Kinase</i> Enhances Glycolysis and Tumor Progression by Activating Enolase 1–Mediated Phosphoenolpyruvate Production
Table S5 from Exon Skipping of <i>Ste20-</i><i>Like</i><i> Kinase</i> Enhances Glycolysis and Tumor Progression by Activating Enolase 1–Mediated Phosphoenolpyruvate Production Open
Differentially Expressed Peptides in LiP-SMap
View article: Figure S6 from Exon Skipping of <i>Ste20-</i><i>Like</i><i> Kinase</i> Enhances Glycolysis and Tumor Progression by Activating Enolase 1–Mediated Phosphoenolpyruvate Production
Figure S6 from Exon Skipping of <i>Ste20-</i><i>Like</i><i> Kinase</i> Enhances Glycolysis and Tumor Progression by Activating Enolase 1–Mediated Phosphoenolpyruvate Production Open
PEP enhances glycolysis via glycolytic enzyme stabilization and activation
View article: Figure S7 from Exon Skipping of <i>Ste20-</i><i>Like</i><i> Kinase</i> Enhances Glycolysis and Tumor Progression by Activating Enolase 1–Mediated Phosphoenolpyruvate Production
Figure S7 from Exon Skipping of <i>Ste20-</i><i>Like</i><i> Kinase</i> Enhances Glycolysis and Tumor Progression by Activating Enolase 1–Mediated Phosphoenolpyruvate Production Open
The TGFβ/SMAD3/KHDRBS1 axis promotes SLK exon skipping
View article: Table S2 from Exon Skipping of <i>Ste20-</i><i>Like</i><i> Kinase</i> Enhances Glycolysis and Tumor Progression by Activating Enolase 1–Mediated Phosphoenolpyruvate Production
Table S2 from Exon Skipping of <i>Ste20-</i><i>Like</i><i> Kinase</i> Enhances Glycolysis and Tumor Progression by Activating Enolase 1–Mediated Phosphoenolpyruvate Production Open
Expression matrix of Alternative splicing pathway in ICGC sample
View article: Table S4 from Exon Skipping of <i>Ste20-</i><i>Like</i><i> Kinase</i> Enhances Glycolysis and Tumor Progression by Activating Enolase 1–Mediated Phosphoenolpyruvate Production
Table S4 from Exon Skipping of <i>Ste20-</i><i>Like</i><i> Kinase</i> Enhances Glycolysis and Tumor Progression by Activating Enolase 1–Mediated Phosphoenolpyruvate Production Open
U-13C-glucose–Metabolic Flux analysis in MHCC-97H-SLKv and MHCC-97H-Vector cell lines.
View article: Figure S2 from Exon Skipping of <i>Ste20-</i><i>Like</i><i> Kinase</i> Enhances Glycolysis and Tumor Progression by Activating Enolase 1–Mediated Phosphoenolpyruvate Production
Figure S2 from Exon Skipping of <i>Ste20-</i><i>Like</i><i> Kinase</i> Enhances Glycolysis and Tumor Progression by Activating Enolase 1–Mediated Phosphoenolpyruvate Production Open
Identification of SLKv promote glycolysis in H3B-8800 responded splicing events
View article: Table S3 from Exon Skipping of <i>Ste20-</i><i>Like</i><i> Kinase</i> Enhances Glycolysis and Tumor Progression by Activating Enolase 1–Mediated Phosphoenolpyruvate Production
Table S3 from Exon Skipping of <i>Ste20-</i><i>Like</i><i> Kinase</i> Enhances Glycolysis and Tumor Progression by Activating Enolase 1–Mediated Phosphoenolpyruvate Production Open
Metabolite expression matrix in MHCC-97H cells treated with either DMSO or H3B-8800
View article: Figure S3 from Exon Skipping of <i>Ste20-</i><i>Like</i><i> Kinase</i> Enhances Glycolysis and Tumor Progression by Activating Enolase 1–Mediated Phosphoenolpyruvate Production
Figure S3 from Exon Skipping of <i>Ste20-</i><i>Like</i><i> Kinase</i> Enhances Glycolysis and Tumor Progression by Activating Enolase 1–Mediated Phosphoenolpyruvate Production Open
Exon skipping of SLK promotes PEP accumulation and predicts poor prognosis
View article: Figure S1 from Exon Skipping of <i>Ste20-</i><i>Like</i><i> Kinase</i> Enhances Glycolysis and Tumor Progression by Activating Enolase 1–Mediated Phosphoenolpyruvate Production
Figure S1 from Exon Skipping of <i>Ste20-</i><i>Like</i><i> Kinase</i> Enhances Glycolysis and Tumor Progression by Activating Enolase 1–Mediated Phosphoenolpyruvate Production Open
The splicing inhibitor H3B-8800 modulates tumor glycolysis and TCA cycle
View article: Figure S8 from Exon Skipping of <i>Ste20-</i><i>Like</i><i> Kinase</i> Enhances Glycolysis and Tumor Progression by Activating Enolase 1–Mediated Phosphoenolpyruvate Production
Figure S8 from Exon Skipping of <i>Ste20-</i><i>Like</i><i> Kinase</i> Enhances Glycolysis and Tumor Progression by Activating Enolase 1–Mediated Phosphoenolpyruvate Production Open
SLK-targeting ASO inhibits tumor growth and glycolysis
View article: Figure S5 from Exon Skipping of <i>Ste20-</i><i>Like</i><i> Kinase</i> Enhances Glycolysis and Tumor Progression by Activating Enolase 1–Mediated Phosphoenolpyruvate Production
Figure S5 from Exon Skipping of <i>Ste20-</i><i>Like</i><i> Kinase</i> Enhances Glycolysis and Tumor Progression by Activating Enolase 1–Mediated Phosphoenolpyruvate Production Open
S2-ENO1ph promotes glycolysis and PEP synthesis via dimerization
View article: Figure S4 from Exon Skipping of <i>Ste20-</i><i>Like</i><i> Kinase</i> Enhances Glycolysis and Tumor Progression by Activating Enolase 1–Mediated Phosphoenolpyruvate Production
Figure S4 from Exon Skipping of <i>Ste20-</i><i>Like</i><i> Kinase</i> Enhances Glycolysis and Tumor Progression by Activating Enolase 1–Mediated Phosphoenolpyruvate Production Open
SLKv activates tumor glycolysis in an ENO1-dependent manner
View article: Data from Exon Skipping of <i>Ste20-</i><i>Like</i><i> Kinase</i> Enhances Glycolysis and Tumor Progression by Activating Enolase 1–Mediated Phosphoenolpyruvate Production
Data from Exon Skipping of <i>Ste20-</i><i>Like</i><i> Kinase</i> Enhances Glycolysis and Tumor Progression by Activating Enolase 1–Mediated Phosphoenolpyruvate Production Open
RNA splicing is frequently dysregulated in tumors. Aberrant RNA splicing can alter tumor metabolism, highlighting the need to elucidate the alternative splicing events that shape the metabolic landscape. In this study, we identified exon s…
View article: Table S1 from Exon Skipping of <i>Ste20-</i><i>Like</i><i> Kinase</i> Enhances Glycolysis and Tumor Progression by Activating Enolase 1–Mediated Phosphoenolpyruvate Production
Table S1 from Exon Skipping of <i>Ste20-</i><i>Like</i><i> Kinase</i> Enhances Glycolysis and Tumor Progression by Activating Enolase 1–Mediated Phosphoenolpyruvate Production Open
Primer and ASO sequences
View article: Synchronous hepatectomy and splenectomy for patients with BCLC stage 0/A hepatocellular carcinoma and clinically significant portal hypertension: A multicenter retrospective cohort study
Synchronous hepatectomy and splenectomy for patients with BCLC stage 0/A hepatocellular carcinoma and clinically significant portal hypertension: A multicenter retrospective cohort study Open
View article: PA2G4 in health and disease: An underestimated multifunctional regulator
PA2G4 in health and disease: An underestimated multifunctional regulator Open
View article: Neuroscience of cancer: unraveling the complex interplay between the nervous system, the tumor and the tumor immune microenvironment
Neuroscience of cancer: unraveling the complex interplay between the nervous system, the tumor and the tumor immune microenvironment Open
The study of the multifaceted interactions between neuroscience and cancer is an emerging field with significant implications for understanding tumor biology and the innovation in therapeutic approaches. Increasing evidence suggests that n…
View article: Transcriptome based weighted gene coexpression network analysis reveals synergistic effects of darkness and mechanical stimulation on pod development in peanut (Arachis hypogea L.)
Transcriptome based weighted gene coexpression network analysis reveals synergistic effects of darkness and mechanical stimulation on pod development in peanut (Arachis hypogea L.) Open
Background: Peanut is an important oil crop with atypical fruitification pattern which require darkness and mechanical stimulation to facilitate normal pod development. Despite some progress in understanding peanut pod development and its …
View article: B cells and tertiary lymphoid structures in tumors: immunity cycle, clinical impact, and therapeutic applications
B cells and tertiary lymphoid structures in tumors: immunity cycle, clinical impact, and therapeutic applications Open
Tumorigenesis involves a multifaceted and heterogeneous interplay characterized by perturbations in individual immune surveillance. Tumor-infiltrating lymphocytes, as orchestrators of adaptive immune responses, constitute the principal com…
View article: Identification of candidate genes associated with resistance to aflatoxin production in peanut through genetic mapping and transcriptome analysis
Identification of candidate genes associated with resistance to aflatoxin production in peanut through genetic mapping and transcriptome analysis Open
Peanut (Arachis hypogaea L.) is a globally significant oil and economic crop, serving as a primary source of edible oil and protein. Aflatoxin contamination is a main risk factor for peanut food safety and industry development worldwide. T…
View article: Immune dynamics shaping pre-metastatic and metastatic niches in liver metastases: from molecular mechanisms to therapeutic strategies
Immune dynamics shaping pre-metastatic and metastatic niches in liver metastases: from molecular mechanisms to therapeutic strategies Open
Liver metastases are commonly detected in the advanced stages of various malignant tumors, representing a significant clinical challenge. Throughout the process of liver metastases formation, immune cells play a pivotal role, particularly …
View article: Genome‐wide association study reveals the genetic basis of amino acids contents variations in Peanut (<i>Arachis hypogaea</i> L.)
Genome‐wide association study reveals the genetic basis of amino acids contents variations in Peanut (<i>Arachis hypogaea</i> L.) Open
Peanut is a significant source of protein for human consumption. One of the primary objectives in peanut breeding is the development of new cultivars with enhanced nutritional values. To further this goal, a genome‐wide association study (…
View article: Inhibition of PTPRE suppresses tumor progression and improves sorafenib response in hepatocellular carcinoma
Inhibition of PTPRE suppresses tumor progression and improves sorafenib response in hepatocellular carcinoma Open
Hepatocellular carcinoma (HCC) has a poor prognosis, and the efficacy of current therapeutic strategies is extremely limited in advanced diseases. Our previous study reported that protein tyrosine phosphatase receptor epsilon (PTPRE) is a …
View article: Multi-molecular hyperspectral PRM-SRS microscopy
Multi-molecular hyperspectral PRM-SRS microscopy Open
Lipids play crucial roles in many biological processes. Mapping spatial distributions and examining the metabolic dynamics of different lipid subtypes in cells and tissues are critical to better understanding their roles in aging and disea…
View article: DEAD‐Box Helicase 17 exacerbates non‐alcoholic steatohepatitis via transcriptional repression of cyp2c29, inducing hepatic lipid metabolism disorder and eliciting the activation of M1 macrophages
DEAD‐Box Helicase 17 exacerbates non‐alcoholic steatohepatitis via transcriptional repression of cyp2c29, inducing hepatic lipid metabolism disorder and eliciting the activation of M1 macrophages Open
Objective Our study was to elucidate the role of RNA helicase DEAD‐Box Helicase 17 ( DDX17 ) in NAFLD and to explore its underlying mechanisms. Methods We created hepatocyte‐specific Ddx17 ‐deficient mice aim to investigate the impact of D…
View article: YTHDF2 Is a Therapeutic Target for HCC by Suppressing Immune Evasion and Angiogenesis Through ETV5/PD‐L1/VEGFA Axis
YTHDF2 Is a Therapeutic Target for HCC by Suppressing Immune Evasion and Angiogenesis Through ETV5/PD‐L1/VEGFA Axis Open
N6‐methyladenosine (m 6 A) modification orchestrates cancer formation and progression by affecting the tumor microenvironment (TME). For hepatocellular carcinoma (HCC), immune evasion and angiogenesis are characteristic features of its TME…
View article: Targeting VPS72 inhibits ACTL6A/MYC axis activity in HCC progression
Targeting VPS72 inhibits ACTL6A/MYC axis activity in HCC progression Open
Background and Aims: HCC is a highly heterogeneous disease that is caused largely by genomic copy number variations. Herein, the mechanistic and therapeutically targeted role of vacuolar protein sorting 72 homologue (VPS72), a novel copy n…
View article: ALKBH5 prevents hepatocellular carcinoma progression by post-transcriptional inhibition of PAQR4 in an m6A dependent manner
ALKBH5 prevents hepatocellular carcinoma progression by post-transcriptional inhibition of PAQR4 in an m6A dependent manner Open
View article: Additional file 3 of ALKBH5 prevents hepatocellular carcinoma progression by post-transcriptional inhibition of PAQR4 in an m6A dependent manner
Additional file 3 of ALKBH5 prevents hepatocellular carcinoma progression by post-transcriptional inhibition of PAQR4 in an m6A dependent manner Open
Additional file 3. Overexpression of ALKBH5 decreased the proliferation capacity in 2 HCC cell lines, while co-overexpressed of PAQR4 reverted this phenomenon (A and B). Overexpression of ALKBH5 decreased the invasion and migration ability…