Caecilie M. M. Benckendorff
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View article: Enzymatic synthesis of key RNA therapeutic building blocks using simple phosphate donors
Enzymatic synthesis of key RNA therapeutic building blocks using simple phosphate donors Open
The rapid emergence of RNA therapeutics has highlighted the need for more efficient, scalable and sustainable methods for their manufacture. Biocatalytic approaches hold particular promise, but rely on a secure, sustainable and low-cost su…
View article: Fluorinating the Sugar and the Nucleotide: Exploring Fluorination Within GDP-Mannose Probes Using Chemoenzymatic Synthesis
Fluorinating the Sugar and the Nucleotide: Exploring Fluorination Within GDP-Mannose Probes Using Chemoenzymatic Synthesis Open
Fluorinated glycans offer a prime opportunity to study the intricacies of their associated binding events with proteins, invoke resistance toward enzymatic hydrolysis, and modulate carbohydrate physicochemical properties. Sugar nucleotides…
View article: A biocatalytic platform for nucleotide monophosphate synthesis in continuous flow
A biocatalytic platform for nucleotide monophosphate synthesis in continuous flow Open
Nucleoside monophosphates (NMPs) are the first nucleotides required for the conversion of nucleosides into nucleoside triphosphates. Biocatalysis can offer an environmentally sustainable route to NMPs, but process development is a key cons…
View article: Synthesis of Nucleoside Analogs Containing Sulfur or Selenium Replacements of the Ribose Ring Oxygen or Carbon
Synthesis of Nucleoside Analogs Containing Sulfur or Selenium Replacements of the Ribose Ring Oxygen or Carbon Open
Nucleoside analogs have proven highly successful in many pharmaceutical intervention strategies, and continued exploration of next generation structural motifs is required. Herein we discuss recent advances toward the chemical synthesis of…
View article: Biocatalytic Nucleobase Diversification of 4′‐Thionucleosides and Application of Derived 5‐Ethynyl‐4′‐thiouridine for RNA Synthesis Detection
Biocatalytic Nucleobase Diversification of 4′‐Thionucleosides and Application of Derived 5‐Ethynyl‐4′‐thiouridine for RNA Synthesis Detection Open
Nucleoside and nucleotide analogues have proven to be transformative in the treatment of viral infections and cancer. One branch of structural modification to deliver new nucleoside analogue classes explores replacement of canonical ribose…
View article: Biocatalytic Nucleobase Diversification of 4′‐Thionucleosides and Application of Derived 5‐Ethynyl‐4′‐thiouridine for RNA Synthesis Detection
Biocatalytic Nucleobase Diversification of 4′‐Thionucleosides and Application of Derived 5‐Ethynyl‐4′‐thiouridine for RNA Synthesis Detection Open
Nucleoside and nucleotide analogues have proven to be transformative in the treatment of viral infections and cancer. One branch of structural modification to deliver new nucleoside analogue classes explores replacement of canonical ribose…
View article: 3’-O-β-Glycosylation of nucleoside analogues using a promiscuous bacterial glycosyltransferase
3’-O-β-Glycosylation of nucleoside analogues using a promiscuous bacterial glycosyltransferase Open
Nucleoside analogue therapeutics have a proven capability within drug discovery as antimicrobial, antiviral and antineoplastic agents. However, their efficacy can be limited by poor cellular uptake, high off target toxicity and poor bioava…
View article: Biocatalytic nucleobase diversification of 4’-thionucleosides and de novo RNA synthesis using 5-ethynyl-4’-thiouridine
Biocatalytic nucleobase diversification of 4’-thionucleosides and de novo RNA synthesis using 5-ethynyl-4’-thiouridine Open
Nucleoside and nucleotide analogues have proven transformative in the treatment of viral infections and cancer. One branch of structural modification to deliver new nucleoside analogue classes explores replacement of canonical ribose oxyge…
View article: Purine nucleoside antibiotics: recent synthetic advances harnessing chemistry and biology
Purine nucleoside antibiotics: recent synthetic advances harnessing chemistry and biology Open
This Highlight offers a perspective on recent strategies for synthesising purine nucleoside antibiotics, an untapped source of natural products for developing novel antimicrobial agents.
View article: Preparation of a 4′‐Thiouridine Building‐Block for Solid‐Phase Oligonucleotide Synthesis
Preparation of a 4′‐Thiouridine Building‐Block for Solid‐Phase Oligonucleotide Synthesis Open
Starting from a commercially available thioether, we report a nine‐step synthesis of a 4′‐thiouridine phosphoramidite building‐block. We install the uracil nucleobase using Pummerer‐type glycosylation of a sulfoxide intermediate followed b…
View article: CCDC 2218823: Experimental Crystal Structure Determination
CCDC 2218823: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2193041: Experimental Crystal Structure Determination
CCDC 2193041: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2193043: Experimental Crystal Structure Determination
CCDC 2193043: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2193042: Experimental Crystal Structure Determination
CCDC 2193042: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Synthesis of fluorinated carbocyclic pyrimidine nucleoside analogues
Synthesis of fluorinated carbocyclic pyrimidine nucleoside analogues Open
Synthesis of 6′-fluorinated carbauridine scaffolds enables access to related cytidine, ProTide and 2′-deoxy analogues, alongside preliminary exploration of their biological capabilities in cancer cell viability assays.
View article: Recent Advances in the Chemical Synthesis and Evaluation of Anticancer Nucleoside Analogues
Recent Advances in the Chemical Synthesis and Evaluation of Anticancer Nucleoside Analogues Open
Nucleoside analogues have proven to be highly successful chemotherapeutic agents in the treatment of a wide variety of cancers. Several such compounds, including gemcitabine and cytarabine, are the go-to option in first-line treatments. Ho…