Caesar Z. Li
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View article: Epigenetic aging studies of pair bonding in prairie voles
Epigenetic aging studies of pair bonding in prairie voles Open
View article: Epigenetic predictors of species maximum life span and other life-history traits in mammals
Epigenetic predictors of species maximum life span and other life-history traits in mammals Open
By analyzing 15,000 samples from 348 mammalian species, we derive DNA methylation (DNAm) predictors of maximum life span ( R = 0.89), gestation time ( R = 0.96), and age at sexual maturity ( R = 0.85). Our maximum life-span predictor indic…
View article: Epigenetic predictors of species maximum lifespan and other life history traits in mammals
Epigenetic predictors of species maximum lifespan and other life history traits in mammals Open
Maximum lifespan is an intrinsic characteristic of a biological species and is defined as the longest time an individual of a species has been reported to survive. By analyzing 15K samples derived from 348 mammalian species representing 25…
View article: Reversal of biological age in multiple rat organs by young porcine plasma fraction
Reversal of biological age in multiple rat organs by young porcine plasma fraction Open
View article: Author Correction: Universal DNA methylation age across mammalian tissues
Author Correction: Universal DNA methylation age across mammalian tissues Open
View article: DNA methylation networks underlying mammalian traits
DNA methylation networks underlying mammalian traits Open
Using DNA methylation profiles ( n = 15,456) from 348 mammalian species, we constructed phyloepigenetic trees that bear marked similarities to traditional phylogenetic ones. Using unsupervised clustering across all samples, we identified 5…
View article: Universal DNA methylation age across mammalian tissues
Universal DNA methylation age across mammalian tissues Open
View article: Reversal of Biological Age in Multiple Rat Organs by Young Porcine Plasma Fraction
Reversal of Biological Age in Multiple Rat Organs by Young Porcine Plasma Fraction Open
Young blood plasma is known to confer beneficial effects on various organs in mice and rats. However, it was not known whether plasma from young pigs rejuvenates old rat tissues at the epigenetic level; whether it alters the epigenetic clo…
View article: Author Correction: DNA methylation predicts age and provides insight into exceptional longevity of bats
Author Correction: DNA methylation predicts age and provides insight into exceptional longevity of bats Open
View article: DNA methylation clocks for dogs and humans
DNA methylation clocks for dogs and humans Open
Significance Epigenetic estimators of age (known as clocks) allow one to identify interventions that slow or reverse aging. Previous epigenetic clocks only applied to one species at a time. Here, we describe epigenetic clocks that apply to…
View article: Author response: Genetic loci and metabolic states associated with murine epigenetic aging
Author response: Genetic loci and metabolic states associated with murine epigenetic aging Open
Article Figures and data Abstract Editor's evaluation Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Changes in DNA methyla…
View article: A mammalian methylation array for profiling methylation levels at conserved sequences
A mammalian methylation array for profiling methylation levels at conserved sequences Open
View article: DNA methylation clocks tick in naked mole rats but queens age more slowly than nonbreeders
DNA methylation clocks tick in naked mole rats but queens age more slowly than nonbreeders Open
Naked mole rats (NMRs) live an exceptionally long life, appear not to exhibit age-related decline in physiological capacity and are resistant to age-related diseases. However, it has been unknown whether NMRs also evade aging according to …
View article: Epigenetic models developed for plains zebras predict age in domestic horses and endangered equids
Epigenetic models developed for plains zebras predict age in domestic horses and endangered equids Open
View article: DNA methylation as a tool to explore ageing in wild roe deer populations
DNA methylation as a tool to explore ageing in wild roe deer populations Open
DNA methylation‐based biomarkers of ageing (epigenetic clocks) promise to lead to new insights into evolutionary biology of ageing. Relatively little is known about how the natural environment affects epigenetic ageing effects in wild spec…
View article: Epigenetic clock and methylation studies in vervet monkeys
Epigenetic clock and methylation studies in vervet monkeys Open
DNA methylation-based biomarkers of aging have been developed for many mammals but not yet for the vervet monkey ( Chlorocebus sabaeus ), which is a valuable non-human primate model for biomedical studies. We generated novel DNA methylatio…
View article: Multi-Tissue Methylation Clocks for Age and Sex Estimation in the Common Bottlenose Dolphin
Multi-Tissue Methylation Clocks for Age and Sex Estimation in the Common Bottlenose Dolphin Open
Accurate identification of individual ages within wild bottlenose dolphins ( Tursiops truncatus ) is critical for determining population health and the development of population management strategies. As such, we analyzed DNA methylation (…
View article: Epigenetic clock and DNA methylation analysis of porcine models of aging and obesity
Epigenetic clock and DNA methylation analysis of porcine models of aging and obesity Open
DNA-methylation profiles have been used successfully to develop highly accurate biomarkers of age, epigenetic clocks, for many species. Using a custom methylation array, we generated DNA methylation data from n = 238 porcine tissues includ…
View article: Epigenetic clock and methylation studies in cats
Epigenetic clock and methylation studies in cats Open
Human DNA methylation profiles have been used successfully to develop highly accurate biomarkers of aging (“epigenetic clocks”). Although these human epigenetic clocks are not immediately applicable to all species of the animal kingdom, th…
View article: A New<i>ℓ</i><sub>0</sub>-Regularized Log-Linear Poisson Graphical Model with Applications to RNA Sequencing Data
A New<i>ℓ</i><sub>0</sub>-Regularized Log-Linear Poisson Graphical Model with Applications to RNA Sequencing Data Open
In this article, we develop a new ℓ 0 -based sparse Poisson graphical model with applications to gene network inference from RNA-seq gene expression count data. Assuming a pair-wise Markov property, we …
View article: Genetic Loci and Metabolic States Associated With Murine Epigenetic Aging
Genetic Loci and Metabolic States Associated With Murine Epigenetic Aging Open
Changes in DNA methylation (DNAm) are linked to aging. Here, we profile highly conserved CpGs in 339 predominantly female mice belonging to the BXD family for which we have deep longevity and genomic data. We use a ‘pan-mammalian’ microarr…
View article: Multi-species and multi-tissue methylation clocks for age estimation in toothed whales and dolphins
Multi-species and multi-tissue methylation clocks for age estimation in toothed whales and dolphins Open
View article: Author Correction: DNA methylation predicts age and provides insight into exceptional longevity of bats
Author Correction: DNA methylation predicts age and provides insight into exceptional longevity of bats Open
View article: Multi-tissue methylation clocks for age estimation in the common bottlenose dolphin
Multi-tissue methylation clocks for age estimation in the common bottlenose dolphin Open
Accurate identification of individual ages within wild bottlenose dolphins ( Tursiops truncatus ) is critical for determining population health and the development of population management strategies. As such, we analyzed DNA methylation p…
View article: Epigenetic clock and methylation study of oocytes from a bovine model of reproductive aging
Epigenetic clock and methylation study of oocytes from a bovine model of reproductive aging Open
Cattle are an attractive animal model of fertility in women due to their high degree of similarity relative to follicle selection, embryo cleavage, blastocyst formation, and gestation length. To facilitate future studies of the epigenetic …
View article: Epigenetic models predict age and aging in plains zebras and other equids
Epigenetic models predict age and aging in plains zebras and other equids Open
Five of the seven extant wild species of the genus Equus are species of significant conservation concern. Effective conservation and management of such threatened wildlife populations depends on the ability to estimate demographic trends a…
View article: DNA methylation clocks show slower progression of aging in naked mole-rat queens
DNA methylation clocks show slower progression of aging in naked mole-rat queens Open
Naked mole-rats (NMRs) live an exceptionally long life, appear not to exhibit age-related decline in physiological capacity, and are seemingly resistant to age-related diseases. However, it has been unknown whether NMRs also evade aging ac…
View article: DNA methylation predicts age and provides insight into exceptional longevity of bats
DNA methylation predicts age and provides insight into exceptional longevity of bats Open
View article: A mammalian methylation array for profiling methylation levels at conserved sequences
A mammalian methylation array for profiling methylation levels at conserved sequences Open
Infinium methylation arrays are not available for the vast majority of non-human mammals. Moreover, even if species-specific arrays were available, probe differences between them would confound cross-species comparisons. To address these c…
View article: Epigenetic clock and DNA methylation analysis of porcine models of aging and obesity
Epigenetic clock and DNA methylation analysis of porcine models of aging and obesity Open
DNA-methylation profiles have been used successfully to develop highly accurate biomarkers of age, epigenetic clocks, for many species. Using a custom methylation array, we generated DNA methylation data from n=238 porcine tissues includin…