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View article: Ligand-specific regulation of a binary enhancer code dictating cellular senescence
Ligand-specific regulation of a binary enhancer code dictating cellular senescence Open
Cellular senescence, a major contributor to aging and age-related pathologies, is characterized by irreversible proliferative arrest and a disease-linked, proinflammatory profile known as the Senescence Associated Secretory Phenotype (SASP…
View article: In vitro heterochronic parabiosis identifies pigment epithelium-derived factor as a systemic mediator of rejuvenation by young blood
In vitro heterochronic parabiosis identifies pigment epithelium-derived factor as a systemic mediator of rejuvenation by young blood Open
Several decades of heterochronic parabiosis (HCPB) studies have demonstrated the restorative impact of young blood, and deleterious influence of aged blood, on physiological function and homeostasis across tissues, although few of the fact…
View article: Procrustes is a machine-learning approach that removes cross-platform batch effects from clinical RNA sequencing data
Procrustes is a machine-learning approach that removes cross-platform batch effects from clinical RNA sequencing data Open
View article: 222-K Integrated immunoprofiling and RNA sequencing (RNA-seq) for anti-PD-1 response prediction in head and neck squamous cell carcinomas (HNSCC)
222-K Integrated immunoprofiling and RNA sequencing (RNA-seq) for anti-PD-1 response prediction in head and neck squamous cell carcinomas (HNSCC) Open
Background While PD-1 inhibitors are promising therapies for HNSCC, better methods are needed to predict response. We used integrated immunoprofiling of peripheral blood mononuclear cells (PBMCs) and RNA-seq of tumor tissue to identify nov…
View article: 1215P Comparative analysis of cfDNA liquid biopsy and tumor-based next-generation sequencing (NGS) approaches
1215P Comparative analysis of cfDNA liquid biopsy and tumor-based next-generation sequencing (NGS) approaches Open
View article: Genome-wide assays to characterize rAAV integration into human genomic DNA in vivo
Genome-wide assays to characterize rAAV integration into human genomic DNA in vivo Open
Adeno-associated viral (AAV) vectors are used to treat genetic diseases, expressing therapeutic genes from both extrachromosomal episomes and payloads that integrate into the host genome. Assays were developed to evaluate HR-mediated on-ta…
View article: Identification and functional validation of an enhancer variant in the 9p21.3 locus associated with glaucoma risk and elevated expression of <i> p16 <sup>INK4a</sup> </i>
Identification and functional validation of an enhancer variant in the 9p21.3 locus associated with glaucoma risk and elevated expression of <i> p16 <sup>INK4a</sup> </i> Open
Glaucoma is a leading cause of irreversible blindness, with advanced age being the single most significant risk factor. However, the mechanisms underlying the relationship between aging and glaucoma remain unclear. Genome‐wide association …
View article: Identification and functional validation of an enhancer variant in the 9p21.3 locus associated with glaucoma risk and elevated expression of<i>p16<sup>INK4a</sup></i>
Identification and functional validation of an enhancer variant in the 9p21.3 locus associated with glaucoma risk and elevated expression of<i>p16<sup>INK4a</sup></i> Open
Glaucoma is a leading cause of irreversible blindness, with advanced age being the single most significant risk factor. However, the mechanisms underlying the relationship between aging and glaucoma remain unclear. Genome-wide association …
View article: The regulation of Insulin/IGF-1 signaling by miR-142-3p associated with human longevity
The regulation of Insulin/IGF-1 signaling by miR-142-3p associated with human longevity Open
MicroRNAs (miRNAs) have been demonstrated to modulate life span in the invertebrates C. elegans and Drosophila by targeting conserved pathways of aging, such as insulin/IGF-1 signaling (IIS). However, a role for miRNAs in modulating human …
View article: Molecular characterization of precise in vivo targeted gene integration in human cells using AAVHSC15
Molecular characterization of precise in vivo targeted gene integration in human cells using AAVHSC15 Open
Targeted gene integration via precise homologous recombination (HR)-based gene editing has the potential to correct genetic diseases. AAV (adeno-associated virus) can mediate nuclease-free gene integration at a disease-causing locus. Thera…
View article: Age- and Tissue-Specific Expression of Senescence Biomarkers in Mice
Age- and Tissue-Specific Expression of Senescence Biomarkers in Mice Open
Cellular senescence is a state of irreversible cellular growth arrest accompanied by distinct changes in gene expression and the acquisition of a complex proinflammatory secretory profile termed the senescence-associated secretory phenotyp…
View article: Challenges and progress in interpretation of non-coding genetic variants associated with human disease
Challenges and progress in interpretation of non-coding genetic variants associated with human disease Open
Genome-wide association studies have shown that the far majority of disease-associated variants reside in the non-coding regions of the genome, suggesting that gene regulatory changes contribute to disease risk. To identify truly causal no…
View article: LSD1n is an H4K20 demethylase regulating memory formation via transcriptional elongation control
LSD1n is an H4K20 demethylase regulating memory formation via transcriptional elongation control Open