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View article: Right ventricular dysfunctions in type 1 diabetic mice: A longitudinal study
Right ventricular dysfunctions in type 1 diabetic mice: A longitudinal study Open
BACKGROUND Diabetes has become a widespread metabolic disease affecting multiple organs. Among diabetic complications, cardiovascular complications are the main cause of patient morbidity and mortality. Diabetic cardiomyopathy is a diabete…
View article: Advancing Dose-Response Research: Integrating Exposome, Multi-Omics, and Low-Dose Phenomena in Toxicology and Medicine
Advancing Dose-Response Research: Integrating Exposome, Multi-Omics, and Low-Dose Phenomena in Toxicology and Medicine Open
The field of dose-response research has evolved dramatically, propelled by advancements in exposomics concept, multi-omics technologies, and a growing appreciation of low-dose effects across disciplines. This editorial article highlights r…
View article: Application of the CO breath test to explore the reversibility of hyperglycemia’s impact on erythrocyte lifespan
Application of the CO breath test to explore the reversibility of hyperglycemia’s impact on erythrocyte lifespan Open
Hyperglycemia can shorten red blood cell (RBC) lifespan, leading to incorrectly measured glycated hemoglobin (HbA1c) values. Correcting for the impact of the RBC lifespan on HbA1c is a critical issue in clinical practice. Before establishi…
View article: High-Fat Diet Differentially Regulates Fibroblast Growth Factor Expression in Metabolic Tissues of Young and Aged Male Mice
High-Fat Diet Differentially Regulates Fibroblast Growth Factor Expression in Metabolic Tissues of Young and Aged Male Mice Open
Context Fibroblast growth factors (FGFs) play critical roles in metabolism, yet their tissue-specific expression in response to obesity and aging remains unclear. Objective We investigated the mRNA expression profiles of FGFs along with th…
View article: Distinct Features of Proton-Induced X-ray Emission (PIXE) and Inductively Coupled Plasma Mass Spectrometry (ICP-MS) When Used for Elemental Analysis of Nail Samples
Distinct Features of Proton-Induced X-ray Emission (PIXE) and Inductively Coupled Plasma Mass Spectrometry (ICP-MS) When Used for Elemental Analysis of Nail Samples Open
Biomarkers, such as toenails, are commonly used to investigate the health status of individuals. Nails samples are a useful marker of exposure, as they are easy to collect, store, and represent exposure from 6 to 12 months. There are multi…
View article: Oxidative stress and pediatric diabetic cardiovascular complications: emerging research and clinical applications
Oxidative stress and pediatric diabetic cardiovascular complications: emerging research and clinical applications Open
The prevalence and incidence of diabetes in pediatrics have dramatically increased over the last three decades. Comparatively, pediatric diabetes has faster pancreatic β-cells decline and early progression to complications compared with ad…
View article: Non-native aquatic species in the Dongting Lake basin, China
Non-native aquatic species in the Dongting Lake basin, China Open
Dongting Lake is the second largest freshwater lake in China, supports high biodiversity and many endemic or endangered species, such as finless porpoise (Neophocaena phocaenoides), Baer's pochard (Aythya baeri), and east Asian minnow (Och…
View article: Coevolutionary dynamics in the grass-livestock social-ecological system of China’s alpine pastoral areas: A case study of the Qilian Mountains region in China
Coevolutionary dynamics in the grass-livestock social-ecological system of China’s alpine pastoral areas: A case study of the Qilian Mountains region in China Open
Evaluating the dynamic co-evolution and feedback mechanisms within socio-ecological systems is crucial for determining the resilience and sustainability of environmental governance strategies. The grass-livestock system, as a complex entit…
View article: Exacerbation by knocking-out metallothionein gene of obesity-induced cardiac remodeling is associated with the activation of CARD9 signaling
Exacerbation by knocking-out metallothionein gene of obesity-induced cardiac remodeling is associated with the activation of CARD9 signaling Open
Obesity increases the risk of metabolic syndrome including insulin resistance, dyslipidemia, and cardiovascular disease. We demonstrated insulin resistance, cardiac hypertrophy, and cardiac inflammation in an obese mouse model induced by a…
View article: Fracture Behavior Considerations for the TRISO Particle Matrix
Fracture Behavior Considerations for the TRISO Particle Matrix Open
To assess whether matrix fracture would result in an unacceptable loss of containment or confinement in TRISO fuel particles, it is crucial to evaluate the micro-tensile strength, fracture toughness, and irradiation effects on matrix mater…
View article: Curcumin derivative WZ35 efficiently suppresses colon cancer progression through inducing ROS production and ER stress-dependent apoptosis: Am J Cancer Res. 2017; 7(2): 275-288
Curcumin derivative WZ35 efficiently suppresses colon cancer progression through inducing ROS production and ER stress-dependent apoptosis: Am J Cancer Res. 2017; 7(2): 275-288 Open
[This corrects the article on p. 275 in vol. 7, PMID: 28337376.].
View article: Chromium Selectively Accumulates in the Rat Hippocampus after 90 Days of Exposure to Cr(VI) in Drinking Water and Induces Age- and Sex-Dependent Metal Dyshomeostasis
Chromium Selectively Accumulates in the Rat Hippocampus after 90 Days of Exposure to Cr(VI) in Drinking Water and Induces Age- and Sex-Dependent Metal Dyshomeostasis Open
Hexavalent chromium (Cr[VI]) is a widespread environmental pollutant in air and water that is primarily attributed to industrial pollution. The current maximum contaminant levels (MCLs) for drinking water from the World Health Organization…
View article: Design of linked-domain protein inhibitors of UBE2D as tools to study cellular ubiquitination
Design of linked-domain protein inhibitors of UBE2D as tools to study cellular ubiquitination Open
Ubiquitin (Ub) is a post-translational modification that largely controls proteostasis through mechanisms spanning transcription, translation, and notably, protein degradation. Ub conjugation occurs through a hierarchical cascade of three …
View article: Blockchain Consensus Algorithm for Supply Chain Information Security Sharing Based on Convolutional Neural Networks
Blockchain Consensus Algorithm for Supply Chain Information Security Sharing Based on Convolutional Neural Networks Open
To solve the problems of data silos and information asymmetry in traditional supply chain information security sharing, this article combines Convolutional Neural Networks (CNN) and blockchain consensus algorithms, analyzes data and uses b…
View article: Diabetic cardiomyopathy: Importance of direct evidence to support the roles of NOD-like receptor protein 3 inflammasome and pyroptosis
Diabetic cardiomyopathy: Importance of direct evidence to support the roles of NOD-like receptor protein 3 inflammasome and pyroptosis Open
Recently, the roles of pyroptosis, a form of cell death induced by activated NOD-like receptor protein 3 (NLRP3) inflammasome, in the pathogenesis of diabetic cardiomyopathy (DCM) have been extensively investigated. However, most studies h…
View article: Editorial: Cardiovascular diseases related to diabetes and obesity - volume IV
Editorial: Cardiovascular diseases related to diabetes and obesity - volume IV Open
Keywords: diabetic complications, cardiovascular diseases, obesity, hypertension, risk factor, diabetic cardiomyopathy
View article: Female Rat Behavior Effects from Low Levels of Hexavalent Chromium (Cr[VI]) in Drinking Water Evaluated with a Toxic Aging Coin Approach
Female Rat Behavior Effects from Low Levels of Hexavalent Chromium (Cr[VI]) in Drinking Water Evaluated with a Toxic Aging Coin Approach Open
We are facing a critical aging crisis, with geriatric populations (65+) growing to unprecedented proportions and ~4 million people (a 6.5-fold increase) expected to become centenarians by 2050. This is compounded by environmental pollution…
View article: Withaferin A as a Potential Therapeutic Target for the Treatment of Angiotensin II-Induced Cardiac Cachexia
Withaferin A as a Potential Therapeutic Target for the Treatment of Angiotensin II-Induced Cardiac Cachexia Open
In our previous studies, we showed that the generation of ovarian tumors in NSG mice (immune-compromised) resulted in the induction of muscle and cardiac cachexia, and treatment with withaferin A (WFA; a steroidal lactone) attenuated both …
View article: Excessive fat expenditure in MCT-induced heart failure rats is associated with BMAL1/REV-ERBα circadian rhythmic loop disruption
Excessive fat expenditure in MCT-induced heart failure rats is associated with BMAL1/REV-ERBα circadian rhythmic loop disruption Open
Fat loss predicts adverse outcomes in advanced heart failure (HF). Disrupted circadian clocks are a primary cause of lipid metabolic issues, but it's unclear if this disruption affects fat expenditure in HF. To address this issue, we inves…
View article: Perspective of <i>Dose-Response</i>: New Chapter With New “Exposome” and “-omics”
Perspective of <i>Dose-Response</i>: New Chapter With New “Exposome” and “-omics” Open
This is an editorial from the new editor-in-chief, EIC, who starts his role in March 2024. Due to the remarkable advance of various research fields in terms of its concepts and technology, the emerging concepts of “Exposome” and associated…
View article: Multiomics Analysis of PCB126’s Effect on a Mouse Chronic-Binge Alcohol Feeding Model
Multiomics Analysis of PCB126’s Effect on a Mouse Chronic-Binge Alcohol Feeding Model Open
Previous work has demonstrated that PCB126 is a modifying factor in metabolic dysfunction-associated steatotic liver disease (MASLD), and our current work suggests that pollutants also modify ALD. PCB126 may, in part, be contributing to th…
View article: Glucagon-like-peptide-1 receptor agonists and the management of type 2 diabetes-backwards and forwards
Glucagon-like-peptide-1 receptor agonists and the management of type 2 diabetes-backwards and forwards Open
This editorial is stimulated by the article by Alqifari et al published in the World Journal of Diabetes (2024). Alqifari et al focus on practical advice for the clinical use of glucagon-like-peptide-1 (GLP-1) receptor agonists (GLP-1RAs) …