Shao‐Qing Cai
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View article: A longitudinal study of developmental quotients in early interventions for children with intellectual disability
A longitudinal study of developmental quotients in early interventions for children with intellectual disability Open
Objective This study aimed to examine the longitudinal relationships among different developmental quotients (DQs) in children with intellectual disability, focusing on the temporal dynamics of adaptive, language, and personal-social devel…
View article: Latent Profile Analysis and Influencing Factors of Learned Helplessness in Maintenance Hemodialysis Patients: A Cross-sectional Study
Latent Profile Analysis and Influencing Factors of Learned Helplessness in Maintenance Hemodialysis Patients: A Cross-sectional Study Open
The findings underscore the complex nature of LH in MHD patients and emphasize the importance of symptom management, hope enhancement, and family support in interventions. Tailored psychological and social support strategies may alleviate …
View article: The role and mechanism of fatty acid oxidation in cancer drug resistance
The role and mechanism of fatty acid oxidation in cancer drug resistance Open
Cancer is a leading cause of death globally. While drug treatment is the most commonly used method for cancer therapy, it is often hampered by drug resistance. Consequently, the mechanisms of drug resistance in cancer therapy have become a…
View article: Effectiveness of brief mindfulness training for athletes' mood: The moderating effect of burnout
Effectiveness of brief mindfulness training for athletes' mood: The moderating effect of burnout Open
The results of this study reveal the effectiveness of brief mindfulness training on athletes' mood and which types of athletes can benefit more from mindfulness training, which provide an empirical basis for intervening on mood.
View article: Association between recurrence risk perception and health behavior in patients with recurrent ischemic stroke in China: The mediation effect of Self-efficacy
Association between recurrence risk perception and health behavior in patients with recurrent ischemic stroke in China: The mediation effect of Self-efficacy Open
Background：This study aims to explore the relationship between recurrence risk perception and health behavior in patients with recurrent ischemic stroke, and the mediating effect of self-efficacy between recurrence risk perception and heal…
View article: Analysis of In Vivo Existence Forms of Nardosinone in Mice by UHPLC-Q-TOF-MS Technique
Analysis of In Vivo Existence Forms of Nardosinone in Mice by UHPLC-Q-TOF-MS Technique Open
Nardosinone, a sesquiterpene peroxide, is one of the main active constituents of the ethnomedicine Nardostachyos Radix et Rhizoma, and it has many bioactivities, such as antiarrhythmia and cardioprotection. To elucidate its in vivo existen…
View article: Paeoniae Radix Rubra can enhance fatty acid β-oxidation and alleviate gut microbiota disorder in α-naphthyl isothiocyanate induced cholestatic model rats
Paeoniae Radix Rubra can enhance fatty acid β-oxidation and alleviate gut microbiota disorder in α-naphthyl isothiocyanate induced cholestatic model rats Open
Cholestasis is the most destructive pathological manifestation of liver disease and available treatments are very limited. Paeoniae Radix Rubra (PRR) is an important traditional Chinese drug used to treat cholestasis. This study combined t…
View article: Metabolism of Paeoniae Radix Rubra and its 14 constituents in mice
Metabolism of Paeoniae Radix Rubra and its 14 constituents in mice Open
Objective: Paeoniae Radix Rubra (PRR) is a commonly used traditional Chinese medicine with the effects of clearing away heat, cooling the blood, and relieving blood stasis. To 1) elucidate the metabolites and metabolic pathways of PRR and …
View article: Elucidation of the Mechanisms and Effective Substances of Paeoniae Radix Rubra Against Toxic Heat and Blood Stasis Syndrome With a Stage-Oriented Strategy
Elucidation of the Mechanisms and Effective Substances of Paeoniae Radix Rubra Against Toxic Heat and Blood Stasis Syndrome With a Stage-Oriented Strategy Open
In the clinical practice of traditional Chinese medicine, toxic heat and blood stasis syndrome (THBSS) is a common syndrome observed in various critical diseases. Paeoniae Radix Rubra (PRR) has known therapeutic effects on THBSS. However, …
View article: A multi-targeting natural product, aiphanol, inhibits tumor growth and metastasis.
A multi-targeting natural product, aiphanol, inhibits tumor growth and metastasis. Open
Cancer is one of the main causes of death in humans worldwide, the development of more effective anticancer drugs that can inhibit the malignant progression of cancer cells is of great significance. Aiphanol is a natural product identified…
View article: 177 Saponins, Including 11 New Compounds in Wild Ginseng Tentatively Identified via HPLC-IT-TOF-MSn, and Differences among Wild Ginseng, Ginseng under Forest, and Cultivated Ginseng
177 Saponins, Including 11 New Compounds in Wild Ginseng Tentatively Identified via HPLC-IT-TOF-MSn, and Differences among Wild Ginseng, Ginseng under Forest, and Cultivated Ginseng Open
Wild ginseng (W-GS), ginseng under forest (F-GS, planted in mountain forest and growing in natural environment), and cultivated ginseng (C-GS) were compared via HPLC-DAD and HPLC-IT-TOF-MSn. A total of 199 saponins, including 16 potential …
View article: Eleven Absorbed Constituents and 91 Metabolites of Chuanxiong Rhizoma Decoction in Rats
Eleven Absorbed Constituents and 91 Metabolites of Chuanxiong Rhizoma Decoction in Rats Open
Objective: Chuanxiong Rhizoma (CR, the dried rhizomes of Ligusticum chuanxiong ) is a well-known traditional Chinese medicine that promotes qi to activate blood, dispels wind, and relieves pain. To date, more than 118 constituents of CR ha…
View article: Exploring the In Vivo Existence Forms (23 Original Constituents and 147 Metabolites) of Astragali Radix Total Flavonoids and Their Distributions in Rats Using HPLC-DAD-ESI-IT-TOF-MSn
Exploring the In Vivo Existence Forms (23 Original Constituents and 147 Metabolites) of Astragali Radix Total Flavonoids and Their Distributions in Rats Using HPLC-DAD-ESI-IT-TOF-MSn Open
Astragali Radix total flavonoids (ARTF) is one of the main bioactive components of Astragali Radix (AR), and has many pharmacological effects. However, its metabolism and effective forms remains unclear. The HPLC-DAD-ESI-IT-TOF-MSn techniq…
View article: The Relative Content and Distribution of Absorbed Volatile Organic Compounds in Rats Administered Asari Radix et Rhizoma Are Different between Powder- and Decoction-Treated Groups
The Relative Content and Distribution of Absorbed Volatile Organic Compounds in Rats Administered Asari Radix et Rhizoma Are Different between Powder- and Decoction-Treated Groups Open
Asari Radix et Rhizoma (ARR) is an important traditional Chinese medicine. Volatile organic compounds (VOCs) are the main active constituents of ARR. Research on the metabolite profile of VOCs and the difference of absorbed constituents in…
View article: Metabolites of Medicarpin and Their Distributions in Rats
Metabolites of Medicarpin and Their Distributions in Rats Open
Medicarpin is a bioactive pterocarpan that has been attracting increasing attention in recent years. However, its metabolic fate in vivo is still unknown. To clarify its metabolism and the distribution of its metabolites in rats after oral…
View article: Investigation of the In Vivo Metabolism of Sibirioside A and Angoroside C in Rats by HPLC-ESI-IT-TOF-MSn
Investigation of the In Vivo Metabolism of Sibirioside A and Angoroside C in Rats by HPLC-ESI-IT-TOF-MSn Open
Sibirioside A and angoroside C are two important phenylpropanoid glycosides of the traditional Chinese medicine Scrophulariae Radix. High performance liquid chromatography, coupled with an ion trap time-of-flight multistage mass spectromet…
View article: Chemical Constituents from the Roots and Rhizomes of Asarum heterotropoides var. mandshuricum and the In Vitro Anti-Inflammatory Activity
Chemical Constituents from the Roots and Rhizomes of Asarum heterotropoides var. mandshuricum and the In Vitro Anti-Inflammatory Activity Open
Anti-inflammatory compounds were investigated from the ethanol extract of the roots and rhizomes of Asarum heterotropoides var. mandshuricum, a traditional Chinese medicine called Xixin and used for pain and inflammatory. Nine new compound…