Explanipedia

Supplementary Figure S1 from KRAS Inhibition Activates an Actionable CD24 “Do Not Eat Me” Signal in Pancreatic Cancer Open

Minghui Liu, Jun Yao, Zhenzhen Xun, Phuoc T. Nguyen, Xiaofei Wang , et al. · 2025

Figure S1 shows characterization of premalignant lesions in KRAS G12C and G12D mice.

Supplementary Figure S4 from KRAS Inhibition Activates an Actionable CD24 “Do Not Eat Me” Signal in Pancreatic Cancer Open

Minghui Liu, Er-Yen Yen, Jun Yao, Zhenzhen Xun, Xiaofei Wang , et al. · 2025

Figure S4 shows targeting CD24 sensitizes pancreatic cancer to KRAS inhibitors.

Supplementary Table S3 from KRAS Inhibition Activates an Actionable CD24 “Do Not Eat Me” Signal in Pancreatic Cancer Open

Minghui Liu, Er-Yen Yen, Zecheng Yang, Abdelrahman Yousef, Yiming Cai , et al. · 2025

Supplementary Table S3 shows the percentage of immune cells in mouse KRAS G12C and G12D tumors tissues.

Supplementary Figure S3 from KRAS Inhibition Activates an Actionable CD24 “Do Not Eat Me” Signal in Pancreatic Cancer Open

Jun Yao, Zhenzhen Xun, Xiaofei Wang, Zecheng Yang, Abdelrahman Yousef , et al. · 2025

Figure S3 shows KRAS G12C inhibitor reprograms PDAC tumor microenvironment.

ATRX Loss Predicts Poor Outcomes and Reveals a Therapeutic Vulnerability to TEAD Inhibition in Soft Tissue Sarcomas Open

Ryan A. Denu, Anand K. Singh, Yingda Jiang, Zheng Zhao, Khalida Wani , et al. · 2025

ATRX is one of the most frequently altered genes in sarcoma and encodes an ATP-dependent chromatin remodeler implicated in maintaining heterochromatin. However, ATRX alterations have not been leveraged for sarcoma treatment. We observed lo…

Neutrophil count is an independent prognostic indicator in early T-cell precursor lymphoblastic leukemia Open

Jieping Lin, Xiaoyuan Gong, Chengming He, Yiming Cai, Xuan Zhou , et al. · 2025

Purpose Early T-cell precursor lymphoblastic leukemia (ETP-ALL) is an immunophenotypically defined subgroup of T-ALL associated with poor prognosis. However, emerging studies indicate that the prognosis of ETP-ALL is not inferior to that o…

Therapeutic targeting of syndecan-1 axis overcomes acquired resistance to KRAS-targeted therapy in gastrointestinal cancers Open

Madelaine Skolastika Theardy, Mitsunobu Takeda, Alexey V. Sorokin, Shuaitong Chen, Zecheng Yang , et al. · 2025

The therapeutic benefit of recently developed mutant KRAS (KRAS∗) inhibitors remains limited by the rapid onset of resistance. Here, we aim to delineate mechanisms underlying acquired resistance and identify actionable targets for overcomi…

Comparing the efficacy and safety of venetoclax combined with hypomethylating agents versus intensive chemotherapy as induction therapy in newly diagnosed core binding factor acute myeloid leukemia patients Open

Jingyi Shen, Meng Shan, Mengqian Chu, Yiming Cai, Jingwen Rui , et al. · 2025

Microbial lysates as low-cost serum replacements in cellular agriculture media formulation Open

James Dolgin, Damayanti Chakravarty, Sean F. Sullivan, Yiming Cai, Taehwan Lim , et al. · 2024

Cultivated meat, the process of generating meat in vitro without sacrificing animals, is a promising alternative to the traditional practice of livestock agriculture. However, the success of this field depends on finding sustainable and ec…

Therapeutic targeting of Syndecan-1 axis overcomes acquired resistance to KRAS-targeted therapy in gastrointestinal cancers Open

Mitsunobu Takeda, Madelaine Skolastika Theardy, Alexey V. Sorokin, Oluwadara Coker, Preeti Kanikarla Marie , et al. · 2024

The therapeutic benefit of recently developed mutant KRAS (mKRAS) inhibitors has been limited by the rapid onset of resistance. Here, we aimed to delineate the mechanisms underlying acquired resistance to mKRAS inhibition and identify acti…

Effects of PCSK9 Inhibitors on Early Neurologic Deterioration in Patients with Acute Non-Cardioembolism without Hemorrhagic Transformation After Intravenous Thrombolysis Open

Junjie Lei, Qian Fan, Xiaofeng Chen, Wenbin Li, Yanfang Peng , et al. · 2024

Background: END (Early Neurologic Deterioration) significantly elevates the risk of morbidity and mortality. While numerous studies have investigated END following hemorrhagic transformation post-thrombolysis in acute cerebral infarction r…

Cupriavidus B-7 immobilized biochar: an effective solution for Cd accumulation alleviation and growth promotion in pakchoi (Brassica Chinensis L.) Open

Yefang Sun, Da Ouyang, Yiming Cai, Ting Guo, Mei Li , et al. · 2024

Cd contamination, especially in farmland soil, can pose serious threats to human health as well as ecological security. Stabilization is an important strategy for agricultural soil Cd remediation. In this study, a Cd-resistant strain ( Cup…

Clopidogrel with indobufen or aspirin in minor ischemic stroke or high-risk transient ischemic attack: a randomized controlled clinical study Open

Xudong Liu, Xuxian Lv, Yanfang Peng, Jianing Wang, Junjie Lei , et al. · 2024

Background Ischemic stroke and transient ischemic attack (TIA) are the most prevalent cerebrovascular diseases. The conventional antiplatelet drugs are associated with an inherent bleeding risk, while indobufen is a new antiplatelet drug a…

Comparative and phylogenetic analysis of the complete chloroplast genomes of Osmanthus (Oleaceae) species Open

Jiangpeng Dai, Qiaozhen Liu, Zhi-Jie Tan, Yiming Cai, Xiaoxia Gao , et al. · 2024

As one genus of Oleaceae, Osmanthus is well-known for its high ornamental value. Due to the deficiency of clearly discriminatory traits, the species classification of genus Osmanthus is controversial. Here, we obtained two chloroplast geno…

Power trading Raft consensus mechanism considering green certificate and carbon emission weights Open

Xiaoping Xiong, Yufei Liu, Huijie Qu, Yiming Cai · 2023

The consensus mechanism is a critical technology in the power trading blockchain distributed power trading platforms, which are gradually being applied and promoted to achieve the “dual carbon” goal. Green-certificate trading and carbon em…

KRAS Inhibition Activates an Actionable CD24 “Don’t Eat Me” Signal in Pancreatic Cancer Open

Yongkun Wei, Minghui Liu, Er-Yen Yen, Jun Yao, Phuoc T Nguyen , et al. · 2023

KRAS G12C inhibitors (G12Ci) have produced encouraging, albeit modest and transient, clinical benefit in pancreatic ductal adenocarcinoma (PDAC). Identifying and targeting resistance mechanisms to G12Ci treatment is therefore crucial. To b…

Randomized Controlled Clinical Study of Clopidogrel with Indobufen or Aspirin in Minor Ischemic Stroke or High-risk Transient Ischemic Attack Open

Xudong Liu, Xuxian Lv, Yanfang Peng, Jianing Wang, Junjie Lei , et al. · 2023

Background Ischemic stroke and transient ischemic attack (TIA) are the most prevalent cerebrovascular diseases. The conventional antiplatelet drugs are associated with an inherent bleeding risk, along with the issues of aspirin and clopido…

Social rank-dependent effects of testosterone on huddling strategies in mice Open

Ye Zhao, Xueyong Yin, Yang Yu, Shihao Huang, Hao Feng , et al. · 2023

Histone demethylase KDM2A is a selective vulnerability of cancers relying on alternative telomere maintenance Open

Fei Li, Yizhe Wang, Inah Hwang, Ja-Young Jang, Libo Xu , et al. · 2023

mRNA-lipid Nanoparticle Vaccines: Structure and Delivery Open

Yiming Cai, Junru Liao, Haocheng Tan · 2023

As the latest generation of vaccine production technology, mRNA vaccine has achieved vaccine production and clinical application, such as COVID-19 mRNA vaccine. However, a substantial inherent limitation in the development of mRNA vaccines…

Histone demethylase KDM2A is a selective vulnerability of cancers relying on alternative telomere maintenance Open

Fei Li, Yizhe Wang, Inah Hwang, Ja-Young Jang, Libo Xu , et al. · 2023

Telomere length maintenance is essential for cellular immortalization and tumorigenesis. 5% - 10% of human cancers rely on a recombination-based mechanism termed alternative lengthening of telomeres (ALT) to sustain their replicative immor…

Association between fear of COVID-19 and hoarding behavior during the outbreak of the COVID-19 pandemic: The mediating role of mental health status Open

Ye Zhao, Yang Yu, Ruofan Zhao, Yiming Cai, Shuai Gao , et al. · 2022

Hoarding behavior can effectively improve people's ability to resist risks, so as to reduce the negative effects of risks. However, excessive hoarding behavior will seriously reduce people's quality of life. The COVID-19 pandemic can cause…

Anti-GD2 antibody dinutuximab inhibits triple-negative breast tumor growth by targeting GD2<sup>+</sup> breast cancer stem-like cells Open

Stanley Ly, Vivek Anand, Fouad El-Dana, Khoa Nguyen, Yiming Cai , et al. · 2021

Background Triple-negative breast cancer (TNBC) is the most aggressive breast cancer subtype with no effective standard therapy. Breast cancer stem-like cells (BCSCs) in primary TNBCs are reported to be responsible for metastatic spread of…

Tuberculosis drug discovery: an in-house toxin blocks pathogenic bacterial growth Open

Yiming Cai, B. F. Usher · 2021

Tuberculosis causes more deaths worldwide every year than any other infectious disease, except COVID-19. Today, its treatment is getting increasingly challenging due to the rise of antibiotic-resistant variants of disease-causing bacteria.…

Engineering of an enhanced synthetic Notch receptor by reducing ligand-independent activation Open

Zijie Yang, Ziyan Yu, Yiming Cai, Rongrong Du, Liang Cai · 2020

Notch signaling is highly conserved in most animals and plays critical roles during neurogenesis as well as embryonic development. Synthetic Notch-based systems, modeled from Notch receptors, have been developed to sense and respond to a s…

Power Makes You Selfish? When and How Power Affect Pro-Social Behavior Open

Yiming Cai, Yaozhong Liu · 2019

Power is the basic component of our society. In social psychology, the study of power usually focuses on the sense of power. Early research always focused on the negative effects of power, but it is difficult to explain the complex effects…

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