Caian L. Vinhaes
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View article: Influence of HIV co-infection on clinical presentation and disease outcome in hospitalized adults with tuberculous meningitis in Brazil: a nationwide observational study
Influence of HIV co-infection on clinical presentation and disease outcome in hospitalized adults with tuberculous meningitis in Brazil: a nationwide observational study Open
Introduction Tuberculous meningitis (TBM) is a severe form of central nervous system infection caused by Mycobacterium tuberculosis (Mtb) that is often associated with significant morbidity and mortality, particularly in people living with…
View article: Challenges and prospects in mentoring medical scientists in Latin America: a narrative review and recommendations.
Challenges and prospects in mentoring medical scientists in Latin America: a narrative review and recommendations. Open
Addressing the systemic barriers to mentoring and training physician-scientists in Latin America is essential for building a robust, research-oriented medical community. The recommended structural reforms, with increasing funding, enhanced…
View article: Intersecting epidemics: deciphering the complexities of tuberculosis-diabetes comorbidity
Intersecting epidemics: deciphering the complexities of tuberculosis-diabetes comorbidity Open
Within the global health landscape, tuberculosis (TB) presents an ongoing challenge, demanding innovative strategies for its control. This review spotlights the intersection of TB with diabetes mellitus (DM), recognized by the World Health…
View article: Machine learning algorithms using national registry data to predict loss to follow-up during tuberculosis treatment
Machine learning algorithms using national registry data to predict loss to follow-up during tuberculosis treatment Open
View article: The role of ESAT-6 in tuberculosis immunopathology
The role of ESAT-6 in tuberculosis immunopathology Open
Despite major global efforts to eliminate tuberculosis, which is caused by Mycobacterium tuberculosis (Mtb), this disease remains as a major plague of humanity. Several factors associated with the host and Mtb interaction favor the infecti…
View article: An integrative multi-omics approach to characterize interactions between tuberculosis and diabetes mellitus
An integrative multi-omics approach to characterize interactions between tuberculosis and diabetes mellitus Open
Tuberculosis-diabetes mellitus (TB-DM) is linked to a distinct inflammatory profile, which can be assessed using multi-omics analyses. Here, a machine learning algorithm was applied to multi-platform data, including cytokines and gene expr…
View article: Machine learning algorithms using national registry data to predict loss to follow- up during tuberculosis treatment
Machine learning algorithms using national registry data to predict loss to follow- up during tuberculosis treatment Open
Background: Identifying patients at increased risk of loss to follow-up (LTFU) is key to developing strategies to optimize the clinical management of tuberculosis (TB). The use of national registry data in prediction models may be a useful…
View article: The sound of silent RNA in tuberculosis and the lncRNA role on infection
The sound of silent RNA in tuberculosis and the lncRNA role on infection Open
Tuberculosis (TB) is one of the leading causes of death worldwide, and Diabetes Mellitus is one of the major comorbidities (TB/DM) associated with the disease. A total of 103 differentially expressed ncRNAs have been identified in the TB a…
View article: UMA ABORDAGEM MULTI-OMICA INTEGRATIVA PARA CARACTERIZAR A INTERAÇÃO ENTRE TUBERCULOSE E DIABETES MELLITUS
UMA ABORDAGEM MULTI-OMICA INTEGRATIVA PARA CARACTERIZAR A INTERAÇÃO ENTRE TUBERCULOSE E DIABETES MELLITUS Open
Introdução: A tuberculose (TB) permanece classificada entre as principais causas de morte no mundo devido a um único agente infeccioso. O diabetes mellitus (DM) pode afetar a ativação imune e tem sido associado a um risco aumentado de TB a…
View article: O SOM DO RNA SILENCIOSO: O PAPEL DOS LNCRNAS NA INTERAÇÃO TUBERCULOSE-DIABETES
O SOM DO RNA SILENCIOSO: O PAPEL DOS LNCRNAS NA INTERAÇÃO TUBERCULOSE-DIABETES Open
Introdução: A tuberculose (TB) é uma das principais causas de morte no mundo, e o Diabetes Mellitus (DM) é uma das principais comorbidades associadas à doença. O DM afeta a resposta inflamatória crônica associada à TB, aumentando o risco d…
View article: A multi-center, prospective cohort study of whole blood gene expression in the tuberculosis-diabetes interaction
A multi-center, prospective cohort study of whole blood gene expression in the tuberculosis-diabetes interaction Open
Diabetes mellitus (DM) increases tuberculosis (TB) severity. We compared blood gene expression in adults with pulmonary TB, with or without diabetes mellitus (DM) from sites in Brazil and India. RNA sequencing (RNAseq) performed at baselin…
View article: Interplay between systemic inflammation, anemia, and mycobacterial dissemination and its impact on mortality in TB-associated HIV: a prospective cohort study
Interplay between systemic inflammation, anemia, and mycobacterial dissemination and its impact on mortality in TB-associated HIV: a prospective cohort study Open
Introduction Anemia frequently affects people living with HIV (PLHIV). Nevertheless, the impact of anemia on treatment outcomes of patients with HIV-associated tuberculosis (TB) and the underlying molecular profiles are not fully character…
View article: An Integrative Multi-Omics Approach to Characterize Interactions between Tuberculosis and Diabetes Mellitus
An Integrative Multi-Omics Approach to Characterize Interactions between Tuberculosis and Diabetes Mellitus Open
View article: Association between severe anaemia and inflammation, risk of IRIS and death in persons with HIV: A multinational cohort study
Association between severe anaemia and inflammation, risk of IRIS and death in persons with HIV: A multinational cohort study Open
Intramural Research Program of National Institute of Allergy and Infectious Diseases/National Institutes of Health (NIAID/NIH). Coordena...·o de Aperfei..oamento de Pessoal de N.ível Superior (Finance code: 001) and the Conselho Nacional d…
View article: Grand challenges in major tropical diseases
Grand challenges in major tropical diseases Open
Programa de Pesquisa Intramural da Fundação Oswaldo Cruz.
\nCoordenação de Aperfeiçoamento de Pessoal de Nível Superior CAPES).
\nFundação de Amparo à Pesquisa do Estado da Bahia (FAPESB).
\nConselho Nacional de Desenvolvimento Científico…
View article: Host-directed therapies in pulmonary tuberculosis: Updates on anti-inflammatory drugs
Host-directed therapies in pulmonary tuberculosis: Updates on anti-inflammatory drugs Open
Tuberculosis (TB) is a lethal disease and remains one of the top ten causes of mortality by an infectious disease worldwide. It can also result in significant morbidity related to persistent inflammation and tissue damage. Pulmonary TB tre…
View article: Relationship Between Anemia and Systemic Inflammation in People Living With HIV and Tuberculosis: A Sub-Analysis of the CADIRIS Clinical Trial
Relationship Between Anemia and Systemic Inflammation in People Living With HIV and Tuberculosis: A Sub-Analysis of the CADIRIS Clinical Trial Open
People with HIV (PWH) are at increased risk of developing active tuberculosis (TB), and anemia is a common complication in both conditions. Anemia in TB patients has been linked to immune activation, levels of inflammatory biomarkers in bl…
View article: CD4 T cells are rapidly depleted from tuberculosis granulomas following acute SIV co-infection
CD4 T cells are rapidly depleted from tuberculosis granulomas following acute SIV co-infection Open
HIV/Mycobacterium tuberculosis (Mtb) co-infected individuals have an increased risk of tuberculosis prior to loss of peripheral CD4 T cells, raising the possibility that HIV co-infection leads to CD4 T cell depletion in lung tissue before …
View article: Severe Anaemia as an Indicator of Tuberculosis Dissemination, Systemic Inflammation and a Predictor of Mortality in Persons with Advanced HIV: A Prospective Cohort Study
Severe Anaemia as an Indicator of Tuberculosis Dissemination, Systemic Inflammation and a Predictor of Mortality in Persons with Advanced HIV: A Prospective Cohort Study Open
View article: CD4 T cells are rapidly depleted from tuberculosis granulomas following acute SIV co-infection
CD4 T cells are rapidly depleted from tuberculosis granulomas following acute SIV co-infection Open
The HIV-mediated decline in circulating CD4 T cells correlates with increased risk of active tuberculosis (TB) 1–4 . However, HIV/ Mycobacterium tuberculosis (Mtb) co-infected individuals also have an increased incidence of TB prior to los…
View article: Dissecting disease tolerance in Plasmodium vivax malaria using the systemic degree of inflammatory perturbation
Dissecting disease tolerance in Plasmodium vivax malaria using the systemic degree of inflammatory perturbation Open
Homeostatic perturbation caused by infection fosters two major defense strategies, resistance and tolerance, which promote the host’s survival. Resistance relates to the ability of the host to restrict the pathogen load. Tolerance minimize…
View article: Dissecting disease tolerance in Plasmodium vivax malaria using the systemic degree of inflammatory perturbation
Dissecting disease tolerance in Plasmodium vivax malaria using the systemic degree of inflammatory perturbation Open
Homeostatic perturbation caused by infection fosters two major defense strategies, resistance and tolerance, which promote the host’s survival. Resistance relates to the ability of the host to restrict the pathogen load. Tolerance minimize…
View article: Divergence in Accuracy of Diabetes Screening Methods in Tuberculosis Patients: A Cross- Sectional Study from Brazil and Peru
Divergence in Accuracy of Diabetes Screening Methods in Tuberculosis Patients: A Cross- Sectional Study from Brazil and Peru Open
Background: To evaluate the accuracy of distinct diabetes mellitus (DM) screening methods in persons with active Tuberculosis PWTB. Methods: Levels of fasting plasma glucose (FPG) and glycated hemoglobin (HbA1c) at the time of tuberculosis…
View article: Divergence in Accuracy of Diabetes Screening Methods in Tuberculosis Patients: A Cross-Sectional Study from Brazil and Peru
Divergence in Accuracy of Diabetes Screening Methods in Tuberculosis Patients: A Cross-Sectional Study from Brazil and Peru Open
To evaluate the accuracy of distinct diabetes mellitus (DM) screening methods in persons with active Tuberculosis PWTB.Levels of fasting plasma glucose (FPG) and glycated hemoglobin (HbA1c) at the time of tuberculosis diagnosis at the stud…
View article: Zika-exposed microcephalic neonates exhibit higher degree of inflammatory imbalance in cerebrospinal fluid
Zika-exposed microcephalic neonates exhibit higher degree of inflammatory imbalance in cerebrospinal fluid Open
View article: Dissecting Disease Tolerance in <i>Plasmodium vivax</i> Malaria Using the Systemic Degree of Inflammatory Perturbation
Dissecting Disease Tolerance in <i>Plasmodium vivax</i> Malaria Using the Systemic Degree of Inflammatory Perturbation Open
Homeostatic perturbation caused by infection fosters two major defense stratagems, resistance and tolerance, which promote the host’s survival. Resistance relates to the ability of the host to restrict the pathogen load. Tolerance minimize…
View article: Systemic Inflammation Associated with Immune Reconstitution Inflammatory Syndrome in Persons Living with HIV
Systemic Inflammation Associated with Immune Reconstitution Inflammatory Syndrome in Persons Living with HIV Open
Antiretroviral therapy (ART) has represented a major advancement in the care of people living with HIV (PLWHH), resulting in significant reductions in morbidity and mortality through immune reconstitution and attenuation of homeostatic dis…
View article: PD-1 blockade exacerbates <i>Mycobacterium tuberculosis</i> infection in rhesus macaques
PD-1 blockade exacerbates <i>Mycobacterium tuberculosis</i> infection in rhesus macaques Open
Blockade of the PD-1 coinhibitory pathway compromises immune control of Mycobacterium tuberculosis infection in rhesus macaques.
View article: Hydroxyurea treatment is associated with reduced degree of oxidative perturbation in children and adolescents with sickle cell anemia
Hydroxyurea treatment is associated with reduced degree of oxidative perturbation in children and adolescents with sickle cell anemia Open
Sickle cell anemia (SCA) is the most common inherited hemolytic anemia worldwide. Here, we performed an exploratory study to investigate the systemic oxidative stress in children and adolescents with SCA. Additionally, we evaluated the pot…
View article: Clinical and Immunologic Predictors of <i>Mycobacterium avium</i> Complex Immune Reconstitution Inflammatory Syndrome in a Contemporary Cohort of Patients With Human Immunodeficiency Virus
Clinical and Immunologic Predictors of <i>Mycobacterium avium</i> Complex Immune Reconstitution Inflammatory Syndrome in a Contemporary Cohort of Patients With Human Immunodeficiency Virus Open
Background People with human immunodeficiency virus (HIV) can present with new or worsening symptoms associated with Mycobacterium avium complex (MAC) infection shortly after antiretroviral therapy (ART) initiation as MAC immune reconstitu…