Chenkai Wu
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View article: Exploring social determinants of disability among older filipinos: insights from a polysocial score approach
Exploring social determinants of disability among older filipinos: insights from a polysocial score approach Open
View article: The synergy between life’s essential 8 and muscle strength on cardiovascular disease risk
The synergy between life’s essential 8 and muscle strength on cardiovascular disease risk Open
Background While muscle strength is a known CVD risk factor in aging, its influence across the spectrum of Life’s Essential 8 (LE8) scores - the American Heart Association’s (AHA’s) comprehensive metric of cardiovascular health that includ…
View article: The association between adverse childhood experiences and frailty among middle-aged and older adults in Rural South Africa
The association between adverse childhood experiences and frailty among middle-aged and older adults in Rural South Africa Open
Background: Adverse childhood experiences (ACEs) negatively impact later physical and mental health. However, evidence is lacking in low- and middle-income countries. We examined the association between ACEs and frailty among middle-aged a…
View article: The efficiency and productivity-changing trend of PHCIs since the 2009 health reform in China based on a three-stage DEA and Malmquist Productivity Index
The efficiency and productivity-changing trend of PHCIs since the 2009 health reform in China based on a three-stage DEA and Malmquist Productivity Index Open
The efficiency of PHCIs in Hainan has declined slightly since the health reform. Low level of scale efficiency posed a significant impact on the overall efficiency of the medical services in PHCIs. Among potential inefficient technological…
View article: Implications for developing global health education in China: evidence from an undergraduate teamwork with role-play
Implications for developing global health education in China: evidence from an undergraduate teamwork with role-play Open
Background Since 2012, China has had one degreed undergraduate programme in global health for domestic students. The International Health Project Management course is a core component of this programme’s curriculum, bridging theoretical kn…
View article: Association Between Chewing Capacity and Mortality Risk: The Role of Diet and Ageing
Association Between Chewing Capacity and Mortality Risk: The Role of Diet and Ageing Open
Aim Masticatory dysfunction due to tooth loss is a potentially modifiable risk for mortality, but the pathway behind that remains to be investigated. This prospective study aimed to examine the role of diet and ageing in the associations b…
View article: Barriers and Enablers: Exploring Vaccine Uptake Among Middle-Aged and Older Adults in a Multi-Ethnic Region of China
Barriers and Enablers: Exploring Vaccine Uptake Among Middle-Aged and Older Adults in a Multi-Ethnic Region of China Open
View article: DEVELOPMENT AND VALIDATION OF A MORTALITY PREDICTION MODEL AMONG MIDDLE-AGED AND OLDER FRAIL ADULTS: UK BIOBANK
DEVELOPMENT AND VALIDATION OF A MORTALITY PREDICTION MODEL AMONG MIDDLE-AGED AND OLDER FRAIL ADULTS: UK BIOBANK Open
Research has identified numerous risk factors for frailty and developed prediction models for the onset of frailty. However, little is known about how multimodal risk factors collectively influence the prognosis of frailty. We developed an…
View article: PLASMA PROTEOMIC SIGNATURE OF DEVELOPMENT AND PROGNOSIS OF PHYSICAL FRAILTY
PLASMA PROTEOMIC SIGNATURE OF DEVELOPMENT AND PROGNOSIS OF PHYSICAL FRAILTY Open
The complete understanding of biological mechanisms behind frailty remains elusive. We aimed to investigate the proteomic signature associated with the development and prognosis of frailty. Data from 43,895 participants (aged 39-70 years) …
View article: PLASMA PROTEOMIC SIGNATURE OF DEVELOPMENT AND PROGNOSIS OF SARCOPENIA
PLASMA PROTEOMIC SIGNATURE OF DEVELOPMENT AND PROGNOSIS OF SARCOPENIA Open
Sarcopenia, characterized by muscle loss and functional decline, poses a significant health concern in aging populations. Understanding the proteomic signatures associated with the development and prognosis of sarcopenia is crucial for tar…
View article: Steps to developing a DXA-based risk score for cardiovascular outcomes among older adults: the health, aging, and body composition study
Steps to developing a DXA-based risk score for cardiovascular outcomes among older adults: the health, aging, and body composition study Open
View article: Social Environment, Lifestyle, and Genetic Predisposition With Dementia Risk: A Long-Term Longitudinal Study Among Older Adults
Social Environment, Lifestyle, and Genetic Predisposition With Dementia Risk: A Long-Term Longitudinal Study Among Older Adults Open
Background The role of social environment, that is, the aggregate effect of social determinants of health (SDOHs), in determining dementia is unclear. Methods We developed a novel polysocial risk score for dementia based on 19 SDOH among 5…
View article: Development of a DXA-Based Risk Score for Cardiovascular Outcomes Among Older Adults: The Health, Aging, and Body Composition Study
Development of a DXA-Based Risk Score for Cardiovascular Outcomes Among Older Adults: The Health, Aging, and Body Composition Study Open
Cardiovascular disease (CVD) is the leading cause of death worldwide and its risk factors have long been investigating in epidemiological studies. Although the Framingham Risk Score provided an estimate for cardiovascular risk, it did not …
View article: Exploring the association between regional fat distribution and atrial fibrillation risks: a comprehensive cohort study
Exploring the association between regional fat distribution and atrial fibrillation risks: a comprehensive cohort study Open
Background The contribution of total fat mass and regional fat distribution to the risk of AF has rarely been studied. Methods This prospective cohort study(N=494,063) evaluated the association of total fat mass measured by fat percentage …
View article: Plasma proteomic signature of human longevity
Plasma proteomic signature of human longevity Open
The identification of protein targets that exhibit anti‐aging clinical potential could inform interventions to lengthen the human health span. Most previous proteomics research has been focused on chronological age instead of longevity. We…
View article: Associations between meat consumption and all-cause and cause-specific mortality in middle-aged and older adults with frailty
Associations between meat consumption and all-cause and cause-specific mortality in middle-aged and older adults with frailty Open
View article: Associations between healthy lifestyle and mortality across different social environments: a study among adults with frailty from the UK Biobank
Associations between healthy lifestyle and mortality across different social environments: a study among adults with frailty from the UK Biobank Open
Background Among people living with frailty, adherence to a healthy lifestyle may be a low-cost and effective strategy to decrease frailty-induced health risks across different social environments. Methods We included 15 594 frail particip…
View article: The association between sarcopenia and incident of depressive symptoms: a prospective cohort study
The association between sarcopenia and incident of depressive symptoms: a prospective cohort study Open
View article: Mediating Effect of Diet-Related Aging on the Association between Chewing Capacity and Mortality Risk: A Prospective Population-Based Study
Mediating Effect of Diet-Related Aging on the Association between Chewing Capacity and Mortality Risk: A Prospective Population-Based Study Open
View article: Mechanical Property, Efficacy, and User Experience of an Innovative Wearable Device in Preventing Fall-Induced Injuries
Mechanical Property, Efficacy, and User Experience of an Innovative Wearable Device in Preventing Fall-Induced Injuries Open
Background and Objectives With the global population aging at an unprecedented pace, the imminent surge in falls and fall-induced injuries necessitates urgent attention. Innovative assistive technologies are crucial in addressing this daun…
View article: Modifiable Risk Factors for Dementia by Frailty: Application of Population Intervention Effects
Modifiable Risk Factors for Dementia by Frailty: Application of Population Intervention Effects Open
View article: A Polysocial Approach in Exploring Racial and Ethnic Differences in Dementia and Cognitive Decline Among U.S. Older Adults: Health and Retirement Study
A Polysocial Approach in Exploring Racial and Ethnic Differences in Dementia and Cognitive Decline Among U.S. Older Adults: Health and Retirement Study Open
Background and Objectives The racial or ethnic disparity in the burden of dementia exists among older adults in the United States, whereas gaps remain in understanding the synergic effect of multiple social determinants of health on dimini…
View article: P1119 Increased risk of chronic respiratory disease among individuals with Inflammatory Bowel Disease in a prospective cohort study
P1119 Increased risk of chronic respiratory disease among individuals with Inflammatory Bowel Disease in a prospective cohort study Open
Background Cross-sectional evidence suggests a higher burden of chronic respiratory diseases in people with inflammatory bowel disease (IBD), but there is a lack of prospective evidence to clarify the direction of their associations. This …
View article: Joint Association of Physical Frailty and Self-Rated Health With Mortality Among Community-Dwelling Older Adults
Joint Association of Physical Frailty and Self-Rated Health With Mortality Among Community-Dwelling Older Adults Open
Background The relationship between subjective and objective health is complex and not always matched. Although frailty and self-rated health (SRH) have been separately associated with adverse outcomes, their joint effects remained unclear…
View article: DOES BECOMING FRAIL MEAN THE END? SOCIAL, LIFESTYLE, AND HEALTH SURROGATES OF RESILIENCE IN THE MOST VULNERABLE
DOES BECOMING FRAIL MEAN THE END? SOCIAL, LIFESTYLE, AND HEALTH SURROGATES OF RESILIENCE IN THE MOST VULNERABLE Open
Frailty is a prevalent geriatric syndrome characterized by reduced reserve to stressors and increased vulnerability to adverse outcomes. Despite many efforts, reversing the frail status remains difficult, primarily due to a lack of underst…
View article: Association between multimorbidity and informal long-term care use in China: a nationwide cohort study
Association between multimorbidity and informal long-term care use in China: a nationwide cohort study Open
View article: Developing global health education in Chinese universities: challenges and opportunities
Developing global health education in Chinese universities: challenges and opportunities Open
Global health has increasingly become a critical academic field of study and practice in today's interconnected world.1Merson M.H. University engagement in global health.N Engl J Med. 2014; 370: 1676-1678Crossref PubMed Google Scholar With…
View article: Association of Childhood Adversity With Frailty and the Mediating Role of Unhealthy Lifestyle: A Lifespan Analysis
Association of Childhood Adversity With Frailty and the Mediating Role of Unhealthy Lifestyle: A Lifespan Analysis Open
View article: Changes of ubiquitylated proteins in atrial fibrillation associated with heart valve disease: proteomics in human left atrial appendage tissue
Changes of ubiquitylated proteins in atrial fibrillation associated with heart valve disease: proteomics in human left atrial appendage tissue Open
Background Correlations between posttranslational modifications and atrial fibrillation (AF) have been demonstrated in recent studies. However, it is still unclear whether and how ubiquitylated proteins relate to AF in the left atrial appe…
View article: Prevalence of sufficient physical activity among general adult population and sub-populations with chronic conditions or disability in the USA
Prevalence of sufficient physical activity among general adult population and sub-populations with chronic conditions or disability in the USA Open
Background Recently, the World Health Organization (WHO) released an updated global guideline on physical activity and sedentary behavior, including recommendations for sub-populations living with chronic conditions or disabilities. We aim…