Caifeng Yang
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View article: Factor IX-Padua AAV gene therapy in hemophilia B: phases 1/2 and 3 trials
Factor IX-Padua AAV gene therapy in hemophilia B: phases 1/2 and 3 trials Open
Gene therapy for hemophilia B with adeno-associated virus (AAV) vector has achieved great advances over the last decade. We previously conducted a pilot study demonstrating the safety and efficacy of AAV-factor IX (FIX) Padua gene therapy …
View article: Gender differences in the mediation of BMI and hepatic steatosis by sex hormones: Insights from NHANES 2017 to 2023
Gender differences in the mediation of BMI and hepatic steatosis by sex hormones: Insights from NHANES 2017 to 2023 Open
Obesity, often assessed by body mass index (BMI), is closely associated with hepatic steatosis, but the role of sex hormones in mediating this relationship, particularly between genders, is not fully understood. Using National Health and N…
View article: The tumor-associated fibroblasts regulate urothelial carcinoma progression
The tumor-associated fibroblasts regulate urothelial carcinoma progression Open
Tumor-associated fibroblasts (CAFs) regulate tumorigenesis, tumor cell proliferation, and metastasis via secreting related regulatory factors; however, the evidence for CAFs in regulating development of upper tract urothelial carcinoma (UT…
View article: Study on the association between neovascularization of culprit lesions and plaque rupture in patients with acute myocardial infarction
Study on the association between neovascularization of culprit lesions and plaque rupture in patients with acute myocardial infarction Open
Background Neovascularization (NV) within plaques is widely recognized as an important indicator of plaque vulnerability; however, the relationship between NV and plaque rupture in patients with acute myocardial infarction (AMI) has not be…
View article: Clinical characteristics and prognosis of myocardial infarction with nonobstructive coronary arteries evaluated by optical coherence tomography
Clinical characteristics and prognosis of myocardial infarction with nonobstructive coronary arteries evaluated by optical coherence tomography Open
Myocardial infarction with nonobstructive coronary artery (MINOCA) is a heterogeneous disease with different pathophysiological mechanisms and prognosis. In recent years, it has been found that the incidence of major cardiovascular adverse…
View article: Efficacy and safety of Factor IX Padua gene transfer via BBM-H901 among Chinese patients with haemophilia B: A multicentre, single-arm, phase 1/2 and 3 study and long-term follow-up of a phase 1 pilot study
Efficacy and safety of Factor IX Padua gene transfer via BBM-H901 among Chinese patients with haemophilia B: A multicentre, single-arm, phase 1/2 and 3 study and long-term follow-up of a phase 1 pilot study Open
Building on promising phase 1 pilot results demonstrating safety and efficacy of BBM-H901 (AAV-mediated FIX Padua gene therapy) in restoring factor IX activity (FIX:C) among 10 patients with haemophilia B, we conducted current studies to v…
View article: Hen Egg White Lysozyme (HEWL) Confers Resistance to Verticillium Wilt in Cotton by Inhibiting the Spread of Fungus and Generating ROS Burst
Hen Egg White Lysozyme (HEWL) Confers Resistance to Verticillium Wilt in Cotton by Inhibiting the Spread of Fungus and Generating ROS Burst Open
Verticillium wilt is a soil-borne vascular disease caused by the fungal pathogen Verticillium dahliae. It causes great harm to upland cotton (Gossypium hirsutum) yield and quality. A previous study has shown that Hen egg white lysozyme (HE…
View article: Metabolic Engineering of Model Microorganisms for the Production of Xanthophyll
Metabolic Engineering of Model Microorganisms for the Production of Xanthophyll Open
Xanthophyll is an oxidated version of carotenoid. It presents significant value to the pharmaceutical, food, and cosmetic industries due to its specific antioxidant activity and variety of colors. Chemical processing and conventional extra…
View article: Comparison of Activity and Safety of DSPAα1 and Its N-Glycosylation Mutants
Comparison of Activity and Safety of DSPAα1 and Its N-Glycosylation Mutants Open
DSPAα1 is a potent rude thrombolytic protein with high medicative value. DSPAα1 has two natural N-glycan sites (N153Q-S154-S155, N398Q-K399-T400) that may lead to immune responses when administered in vivo. We aimed to study the effect of …
View article: Influence of the COVID-19 Pandemic on the Prevalence Pattern of Allergens
Influence of the COVID-19 Pandemic on the Prevalence Pattern of Allergens Open
Introduction: The effect of the COVID-19 pandemic on allergic diseases is not certain, as people’s living habits and the environment have been affected by the pandemic. The present study described the influence of the COVID-19 pandemic on …
View article: Different N-Glycosylation Sites Reduce the Activity of Recombinant DSPAα2
Different N-Glycosylation Sites Reduce the Activity of Recombinant DSPAα2 Open
Bat plasminogen activators α2 (DSPAα2) has extremely high medicinal value as a powerful natural thrombolytic protein. However, wild-type DSPAα2 has two N-glycosylation sites (N185 and N398) and its non-human classes of high-mannose-type N-…
View article: The introduction of an N-glycosylation site into prochymosin greatly enhances its production and secretion by Pichia pastoris
The introduction of an N-glycosylation site into prochymosin greatly enhances its production and secretion by Pichia pastoris Open
Background N-glycosylation is one of the most important post-translational modifications. Many studies have shown that N-glycosylation has a significant effect on the secretion level of heterologous glycoproteins in yeast cells. However, t…
View article: Dysregulated behaviour of hair follicle stem cells triggers alopecia and provides potential therapeutic targets
Dysregulated behaviour of hair follicle stem cells triggers alopecia and provides potential therapeutic targets Open
Due to a steady increase in the number of individuals suffering from alopecia, this condition has recently received increasing attention. Alopecia can be caused by various pathological, environmental or psychological factors, eventually re…
View article: Additional file 3 of The introduction of an N-glycosylation site into prochymosin greatly enhances its production and secretion by Pichia pastoris
Additional file 3 of The introduction of an N-glycosylation site into prochymosin greatly enhances its production and secretion by Pichia pastoris Open
Additional file 3. Classification of DIPs according to GO, KEGG and COG enrichment methods.
View article: Additional file 2 of The introduction of an N-glycosylation site into prochymosin greatly enhances its production and secretion by Pichia pastoris
Additional file 2 of The introduction of an N-glycosylation site into prochymosin greatly enhances its production and secretion by Pichia pastoris Open
Additional file 2: Table S1. Protein identification and abundance of differential interacting proteins with chy and chy34
View article: Non-invasive neuromodulation effects on painful diabetic peripheral neuropathy: a systematic review and meta-analysis
Non-invasive neuromodulation effects on painful diabetic peripheral neuropathy: a systematic review and meta-analysis Open
Diabetic Peripheral Neuropathy (DPN) typically is accompanied by painful symptoms. Several therapeutic agents have been tried for symptomatic relief, but with varying results. The use of non-invasive neuromodulation (NINM) is a potential t…
View article: Influence of different biomass ash additive on anthracite pyrolysis process and char gasification reactivity
Influence of different biomass ash additive on anthracite pyrolysis process and char gasification reactivity Open
Catalytic coal gasification technology shows prominent advantages in enhancing coal gasification reactivity and is restrained by the cost of catalyst. Two typical biomass ash additions, corn stalk ash (CSA, high K–Na and low Si) and poplar…
View article: Non-invasive prediction model for high-risk esophageal varices in the Chinese population
Non-invasive prediction model for high-risk esophageal varices in the Chinese population Open
The non-invasive prediction model for predicting HEVs in patients with viral cirrhosis was successfully established. The new model is reliable for predicting HEVs and has clinical applicability.
View article: Ozone therapy promotes the differentiation of basal keratinocytes via increasing Tp63‐mediated transcription of KRT10 to improve psoriasis
Ozone therapy promotes the differentiation of basal keratinocytes via increasing Tp63‐mediated transcription of KRT10 to improve psoriasis Open
Psoriasis is a chronic immune‐mediated inflammatory dermatosis. Recently, ozone therapy has been applicated to psoriasis treatment; however, the mechanism by which ozone therapy improves psoriasis remains unclear. The excessive proliferati…
View article: New formula for predicting standard liver and spleen volumes in Chinese adults
New formula for predicting standard liver and spleen volumes in Chinese adults Open
BACKGROUNDThe liver volume and spleen volum are useful index for cirrhosis patients with esphageal varices. But the calculation of the volume is time-consuming and boring. To solve the problem, we successfully established the liver and spl…