Caijun Sun
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View article: Special Issue: “Innate Immunity to Virus Infection, 2nd Edition”
Special Issue: “Innate Immunity to Virus Infection, 2nd Edition” Open
The frequent emergence of highly pathogenic viruses globally has persistently threatened global health [...]
View article: Single-cell transcriptome profiling reveals immunological fitness of HIV long-term non-progressors
Single-cell transcriptome profiling reveals immunological fitness of HIV long-term non-progressors Open
Long-term non-progressors (LTNPs) represent a valuable model to investigate immunological features associated with non-progression in chronic HIV infection. In this study, single-cell RNA sequencing was performed on peripheral blood mononu…
View article: Niacin, an active form of vitamin B3, exerts antiviral function by recruiting β-arrestin through GPR109A to activate the phosphorylation of ERK and STAT1 axis
Niacin, an active form of vitamin B3, exerts antiviral function by recruiting β-arrestin through GPR109A to activate the phosphorylation of ERK and STAT1 axis Open
The emergence of viral infectious diseases poses a significant threat to public health, and thus the development of effective and safe antiviral drugs is becoming an urgent priority in the pandemic era. Niacin is an active form of vitamin …
View article: Immune Control of AIDS Progression by an Adenovirus‐Based Therapeutic Vaccination in Acute Simian Immunodeficiency Virus‐Infected Macaques
Immune Control of AIDS Progression by an Adenovirus‐Based Therapeutic Vaccination in Acute Simian Immunodeficiency Virus‐Infected Macaques Open
Therapeutic vaccinations that enhance human immunodeficiency virus (HIV)‐specific immunity hold promise for reducing reliance on antiretroviral therapy (ART). We previously developed an adenovirus vector‐infected peripheral blood mononucle…
View article: Relationship between parental vaccine literacy and their willingness to vaccinate children against influenza in china
Relationship between parental vaccine literacy and their willingness to vaccinate children against influenza in china Open
Our study found that parents' vaccine literacy, particularly interactive vaccine literacy, shows a potential association with their willingness to vaccinate their children against influenza. Targeted interventions aimed at improving parent…
View article: Development and comprehensive evaluation of scarless circularization systems for circular RNA therapeutics
Development and comprehensive evaluation of scarless circularization systems for circular RNA therapeutics Open
Circular RNAs (circRNAs) are promising candidates for RNA-based therapeutics due to their enhanced stability and sustained protein production compared to linear mRNAs. Traditional circRNA production methods, such as the Anabaena-based perm…
View article: Biomedical Interventions for HIV Prevention and Control: Beyond Vaccination
Biomedical Interventions for HIV Prevention and Control: Beyond Vaccination Open
The global HIV epidemic remains persistent, mostly because of neither a drug for its cure nor a vaccine for its prevention. An HIV vaccine is thought of as the most cost-effective biomedical intervention to eventually terminate the HIV epi…
View article: Gradient Solvent Replacement‐Mediated Formation of High‐Strength Hydrogel‐Forming Microneedle for Long‐Term Drug Delivery
Gradient Solvent Replacement‐Mediated Formation of High‐Strength Hydrogel‐Forming Microneedle for Long‐Term Drug Delivery Open
The microneedle, a minimally invasive transdermal system, provides a convenient and painless method for drug delivery. Among the various types of microneedles, hydrogel‐forming microneedles (HFMs) demonstrate distinct advantages in terms o…
View article: Purging viral latency by a bifunctional HSV-vectored therapeutic vaccine in chronically SIV-infected macaques
Purging viral latency by a bifunctional HSV-vectored therapeutic vaccine in chronically SIV-infected macaques Open
The persistence of latent viral reservoirs remains the major obstacle to eradicating human immunodeficiency virus (HIV). We herein found that ICP34.5 can act as an antagonistic factor for the reactivation of HIV latency by herpes simplex v…
View article: Exploring the Causal Effects of Micronutrient Supplementation on Susceptibility to Viral Pneumonia: A Mendelian Randomization Study
Exploring the Causal Effects of Micronutrient Supplementation on Susceptibility to Viral Pneumonia: A Mendelian Randomization Study Open
Viral infections have been a severe challenge for global public health, and viral pneumonia is becoming increasingly critical in the post-pandemic era. Observational and basic studies have demonstrated a strong link between host nutrient s…
View article: Purging viral latency by a bifunctional HSV-vectored therapeutic vaccine in chronically SIV-infected macaques
Purging viral latency by a bifunctional HSV-vectored therapeutic vaccine in chronically SIV-infected macaques Open
The persistence of latent viral reservoirs remains the major obstacle to eradicating human immunodeficiency virus (HIV). We herein found that ICP34.5 can act as an antagonistic factor for the reactivation of HIV latency by herpes simplex v…
View article: Purging viral latency by a bifunctional HSV-vectored therapeutic vaccine in chronically SIV-infected macaques
Purging viral latency by a bifunctional HSV-vectored therapeutic vaccine in chronically SIV-infected macaques Open
The persistence of latent viral reservoirs remains the major obstacle to eradicating human immunodeficiency virus (HIV). We herein reported that recombinant herpes simplex virus type I (HSV-1) with ICP34.5 deletion could more effectively r…
View article: A Recombinant Mosaic HAs Influenza Vaccine Elicits Broad-Spectrum Immune Response and Protection of Influenza a Viruses
A Recombinant Mosaic HAs Influenza Vaccine Elicits Broad-Spectrum Immune Response and Protection of Influenza a Viruses Open
The annual co-circulation of two influenza A subtypes, H1N1 and H3N2, viruses in humans poses significant public health threats worldwide. However, the continuous antigenic drift and shift of influenza viruses limited the effectiveness of …
View article: Treatment as the Best Prevention: Twice-Yearly Lenacapavir, a Game Changer in Ending the AIDS Epidemic
Treatment as the Best Prevention: Twice-Yearly Lenacapavir, a Game Changer in Ending the AIDS Epidemic Open
Despite over four decades of unremitting efforts since the discovery of acquired immunodeficiency syndrome (AIDS)/human immunodeficiency virus (HIV), there remains no cure for HIV nor a vaccine for its prevention [...]
View article: ZIKV induces P62-mediated autophagic degradation of TRAF6 through TRAF6-NS1 interaction
ZIKV induces P62-mediated autophagic degradation of TRAF6 through TRAF6-NS1 interaction Open
Tumor necrosis factor receptor-associated factor 6 (TRAF6) is crucial in flavivirus infections, modulating the host immune response through interactions with viral proteins. Despite its importance, the relationship between TRAF6 and Zika v…
View article: A broad-spectrum multiepitope vaccine against seasonal influenza A and B viruses in mice
A broad-spectrum multiepitope vaccine against seasonal influenza A and B viruses in mice Open
Funding bodies are described in the Acknowledgments section.
View article: c-FLIP facilitates ZIKV infection by mediating caspase-8/3-dependent apoptosis
c-FLIP facilitates ZIKV infection by mediating caspase-8/3-dependent apoptosis Open
c-FLIP functions as a dual regulator of apoptosis and inflammation, yet its implications in Zika virus (ZIKV) infection remain partially understood, especially in the context of ZIKV-induced congenital Zika syndrome (CZS) where both apopto…
View article: Reviewer #2 (Public Review): Purging viral latency by a bifunctional HSV-vectored therapeutic vaccine in chronically SIV-infected macaques
Reviewer #2 (Public Review): Purging viral latency by a bifunctional HSV-vectored therapeutic vaccine in chronically SIV-infected macaques Open
The persistence of latent viral reservoirs remains the major obstacle to eradicating human immunodeficiency virus (HIV). We herein reported that recombinant herpes simplex virus type I (HSV-1) with ICP34.5 deletion could more effectively r…
View article: Purging viral latency by a bifunctional HSV-vectored therapeutic vaccine in chronically SIV-infected macaques
Purging viral latency by a bifunctional HSV-vectored therapeutic vaccine in chronically SIV-infected macaques Open
The persistence of latent viral reservoirs remains the major obstacle to eradicating human immunodeficiency virus (HIV). We herein found that ICP34.5 can act as an antagonistic factor for the reactivation of HIV latency by herpes simplex v…
View article: Author response: Purging viral latency by a bifunctional HSV-vectored therapeutic vaccine in chronically SIV-infected macaques
Author response: Purging viral latency by a bifunctional HSV-vectored therapeutic vaccine in chronically SIV-infected macaques Open
The persistence of latent viral reservoirs remains the major obstacle to eradicating human immunodeficiency virus (HIV). We herein reported that recombinant herpes simplex virus type I (HSV-1) with ICP34.5 deletion could more effectively r…
View article: Reviewer #1 (Public Review): Purging viral latency by a bifunctional HSV-vectored therapeutic vaccine in chronically SIV-infected macaques
Reviewer #1 (Public Review): Purging viral latency by a bifunctional HSV-vectored therapeutic vaccine in chronically SIV-infected macaques Open
The persistence of latent viral reservoirs remains the major obstacle to eradicating human immunodeficiency virus (HIV). We herein reported that recombinant herpes simplex virus type I (HSV-1) with ICP34.5 deletion could more effectively r…