Cailing Lu
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View article: A corpus-based lexical analysis of Chinese medicine research articles.
A corpus-based lexical analysis of Chinese medicine research articles. Open
This study investigates the usefulness of two academic word lists - Coxhead’s (2000) Academic Word List (AWL) and Gardner & Davies’ (2014) Academic Vocabulary List (AVL) - for students of English for Chinese Medical Purposes. The two acade…
View article: Enforced activation of the CREB/KDM2B axis prevents alcohol-induced embryonic developmental delay
Enforced activation of the CREB/KDM2B axis prevents alcohol-induced embryonic developmental delay Open
Unintentional, early pregnancy alcohol consumption affects embryonic development. During the peri-implantation stage, coinciding with the transition from naive to primed pluripotency, the long isoform of KDM2B (KDM2BLF) underlies the de no…
View article: NNMT involving with gastric adenocarcinoma immune infiltration by driving amino acids metabolism
NNMT involving with gastric adenocarcinoma immune infiltration by driving amino acids metabolism Open
Objectives Gastric cancer is a malignant tumor with high incidence rate and high mortality. Gastric adenocarcinoma (STAD) is the main pathological type of gastric cancer. Nicotinamide N-methyltransferase (NNMT) is a methylation enzyme that…
View article: LCMT1 indicates poor prognosis and is essential for cell proliferation in hepatocellular carcinoma
LCMT1 indicates poor prognosis and is essential for cell proliferation in hepatocellular carcinoma Open
BACKGROUND: Hepatocellular carcinoma (HCC) is one of the most malignant type of cancers. Leuci carboxyl methyltransferase 1 (LCMT1) is a protein methyltransferase that plays an improtant regulatory role in both normal and cancer cells. The…
View article: [Retracted] MicroRNA‑126 inhibits the migration and invasion of endometrial cancer cells by targeting insulin receptor substrate 1
[Retracted] MicroRNA‑126 inhibits the migration and invasion of endometrial cancer cells by targeting insulin receptor substrate 1 Open
Following the publication of this paper, it was drawn to the Editors’ attention by a concerned reader that certain of the Transwell cell migration data shown in Fig. 4C were strikingly similar to data appearing in different form in other a…
View article: Dysregulated APP expression and α-secretase processing of APP is involved in manganese-induced cognitive impairment
Dysregulated APP expression and α-secretase processing of APP is involved in manganese-induced cognitive impairment Open
Excessive exposure to manganese (Mn) can cause cognitive impairment, a common feature of Alzheimer's disease (AD), but the mechanisms remain unclear. Amyloid precursor protein (APP) is key to AD pathogenesis, and whether APP and its secret…
View article: Taurine Antagonizes Macrophages M1 Polarization by Mitophagy-Glycolysis Switch Blockage via Dragging SAM-PP2Ac Transmethylation
Taurine Antagonizes Macrophages M1 Polarization by Mitophagy-Glycolysis Switch Blockage via Dragging SAM-PP2Ac Transmethylation Open
The excessive M1 polarization of macrophages drives the occurrence and development of inflammatory diseases. The reprogramming of macrophages from M1 to M2 can be achieved by targeting metabolic events. Taurine promotes for the balance of …
View article: HCF-1 promotes cell cycle progression by regulating the expression of CDC42
HCF-1 promotes cell cycle progression by regulating the expression of CDC42 Open
The eukaryotic cell cycle involves a highly orchestrated series of events in which the cellular genome is replicated during a synthesis (S) phase and each of the two resulting copies are segregated properly during mitosis (M). Host cell fa…
View article: The down-regulation of PP2Ac demethylation attenuates learning and memory impairment in Manganism
The down-regulation of PP2Ac demethylation attenuates learning and memory impairment in Manganism Open
Background: Protein phosphatase 2A (PP2A) is considered a potential therapeutic target for neurodegenerative diseases such as Alzheimer's disease (AD) and Parkinson's disease (PD), and catalytic unit methylation of PP2A that relies on meth…
View article: [Expression, purification and functional assessment of asprosin inclusion body].
[Expression, purification and functional assessment of asprosin inclusion body]. Open
We successfully obtained recombinant asprosin using a prokaryotic expression system. The recombinant asprosin can decrease glycogen content in MIHA cells and increase blood glucose level in mice.
View article: Pentachloronitrobenzene alters progesterone production and primordial follicle recruitment in cultured granulosa cells and rat ovary†
Pentachloronitrobenzene alters progesterone production and primordial follicle recruitment in cultured granulosa cells and rat ovary† Open
Pentachloronitrobenzene (PCNB) is an organochlorine fungicide widely used for crop production and has become an environmental concern. Little is known about the effect of PCNB on ovarian steroidogenesis and follicular development. We found…
View article: Mutation screening of crystallin genes in Chinese families with congenital cataracts.
Mutation screening of crystallin genes in Chinese families with congenital cataracts. Open
In this study, we identified four novel mutations in crystallin genes in Chinese families with congenital cataracts. The results expand the mutational spectrum of crystallin genes, which may be helpful for the molecular diagnosis of congen…
View article: Proteomics and phosphoproteomics study of LCMT1 overexpression and oxidative stress: overexpression of LCMT1 arrests H<sub>2</sub>O<sub>2</sub>-induced lose of cells viability
Proteomics and phosphoproteomics study of LCMT1 overexpression and oxidative stress: overexpression of LCMT1 arrests H<sub>2</sub>O<sub>2</sub>-induced lose of cells viability Open
These data provide proteomics and phosphoproteomics insights into the association of LCMT1-dependent PP2Ac methylation and oxidative stress and indirectly indicate that the methylation of PP2A plays an important role against oxidative stre…
View article: Proteomics and phosphoproteomics study of LCMT1 overexpression and oxidative stress: overexpression of LCMT1 arrests H<sub>2</sub>O<sub>2</sub>-induced lose of cells viability
Proteomics and phosphoproteomics study of LCMT1 overexpression and oxidative stress: overexpression of LCMT1 arrests H<sub>2</sub>O<sub>2</sub>-induced lose of cells viability Open
Objectives: Protein phosphatase 2A (PP2A), a major serine/threonine phosphatase, is also known to be a target of ROS. The methylation of PP2A can be catalyzed by leucine carboxyl methyltransferase-1 (LCMT1), which regulates PP2A activity a…
View article: Investigating knowledge and use of technical vocabulary in Traditional Chinese Medicine
Investigating knowledge and use of technical vocabulary in Traditional Chinese Medicine Open
This research investigates the nature of vocabulary, especially technical vocabulary, in the specialized discipline of Traditional Chinese medicine (TCM), which is an important area of higher education. It consists of three linked studies …
View article: Exome sequencing reveals novel IRXI mutation in congenital heart disease
Exome sequencing reveals novel IRXI mutation in congenital heart disease Open
Genetic variation in specific transcription factors during heart formation may lead to congenital heart disease (CHD) or even miscarriage. The aim of the present study was to identify CHD‑associated genes using next generation sequencing (…
View article: <i>TCF21</i> rs12190287 Polymorphisms Are Associated with Ventricular Septal Defects in a Chinese Population
<i>TCF21</i> rs12190287 Polymorphisms Are Associated with Ventricular Septal Defects in a Chinese Population Open
Our results demonstrate that rs12190287 polymorphisms confer predisposition to VSDs in the Chinese population studied here.
View article: MicroRNA-126 inhibits the migration and invasion of endometrial cancer cells by targeting insulin receptor substrate 1
MicroRNA-126 inhibits the migration and invasion of endometrial cancer cells by targeting insulin receptor substrate 1 Open
MicroRNAs (miRs) have been demonstrated to serve important roles in the development and progression of human cancer, primarily through the direct targeting of oncogenes or tumor suppressors. It has been previously suggested that miR-126 ma…