Explanipedia

Astrocytic glutamate regulation is shaped by adversity and glucocorticoid signalling Open

Dominic Kaul, Amber R. Curry, Nathalie Gerstner, Anna S. Fröhlich, Caine C. Smith , et al. · 2024

Astrocytes are a brain cell type vulnerable to the effects of stress and the development of psychiatric-like phenotypes in animals, yet how this translates to humans is unclear. Here, we probed the diversity of ∼145,000 total human cortica…

Phosphatidylethanol in post-mortem brain: Correlation with blood alcohol concentration and alcohol use disorder Open

Caine C. Smith, Julia Stevens, M Novelli, Dhiraj Maskey, Greg T. Sutherland · 2024

Phosphatidylethanol (PEth) is an alcohol derivative that has been employed as a blood-based biomarker for regular alcohol use. This study investigates the utility of phosphatidylethanol (PEth) as a biomarker for assessing alcohol consumpti…

Phosphatidylethanol in Post-Mortem Brain: Correlation with Blood Alcohol Concentration and Alcohol Use Disorder Open

Caine C. Smith, Julia Stevens, M Novelli, Dhiraj Maskey, Greg Sutherland · 2024

Lipidome changes in alcohol‐related brain damage Open

Caine C. Smith, Donna Sheedy, Holly P. McEwen, Anthony S. Don, Jillian J. Kril , et al. · 2021

Alcohol‐related brain injury is characterized by cognitive deficits and brain atrophy with the prefrontal cortex particularly susceptible. White matter in the human brain is lipid rich and a major target of damage from chronic alcohol abus…

Author response for "Matrix Phase Fractionation: Investigating the Compromise Between Dynamic Range Of Analyte Extraction and Spatial Resolution In Imaging Mass Spectrometry" Open

Matthew B. O’Rourke, Barney Viengkhou, Caine C. Smith, Lorenz Sonderegger, Matthew P. Padula , et al. · 2021

Severe childhood and adulthood stress associates with neocortical layer-specific reductions of mature spines in psychiatric disorders Open

Dominic Kaul, Caine C. Smith, Julia Stevens, Anna S. Fröhlich, Elisabeth B. Binder , et al. · 2020

Severe childhood and adulthood stress associates with neocortical layer-specific reductions of mature spines in psychiatric disorders Open

Dominic Kaul, Caine C. Smith, Julia Stevens, Anna S. Fröhlich, Elisabeth B. Binder , et al. · 2020

Severe stress exposure causes the loss of dendritic spines on cortical pyramidal neurons and induces psychiatric-like symptoms in rodent models. These effects are strongest following early-life stress and are most persistent on apical dend…

Higher Mass Accuracy MALDI‐TOF/TOF Lipid Imaging of Human Brain Tissue in Alzheimer's Disease Open

Matthew B. O’Rourke, Caine C. Smith, Suzanne M. de la Monte, Greg T. Sutherland, Matthew P. Padula · 2019

Matrix‐assisted laser desorption/ionization imaging mass spectrometry (MALDI‐IMS) is a well‐established technique for elucidating the location and relative abundance of a range of biomolecules. More recently, research into this technique h…

‘What did I do Wrong?’ an Empirical Evaluation of Sample Preparation Methodologies in Matrix-Assisted Laser Desorption/Ionization-Mass Spectrometry Imaging Open

Matthew B. O’Rourke, Caine C. Smith, Benita Tse, Greg T. Sutherland, Ben Crossett , et al. · 2019

© 2019 MO Rourke. Aim: This guide aims to broaden the uptake of MALDI-MSI biomedical research by removing the initial 'lag phase' associated with empirical determination in sample preparation and data analysis. Methods: Samples from severa…

The NSW brain tissue resource centre: Banking for alcohol and major neuropsychiatric disorders research Open

Greg T. Sutherland, Donna Sheedy, Julia Stevens, T McCrossin, Caine C. Smith , et al. · 2016

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