Caiping Chen
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View article: Association and Mechanism of Coexposure to Perfluoroalkyl and Polyfluoroalkyl Substances and Blood Heavy Metals in Metabolic Dysfunction-Associated Steatotic Liver Disease
Association and Mechanism of Coexposure to Perfluoroalkyl and Polyfluoroalkyl Substances and Blood Heavy Metals in Metabolic Dysfunction-Associated Steatotic Liver Disease Open
INTRODUCTION: Heavy metals can increase perfluoroalkyl and polyfluoroalkyl substances (PFAS) adsorption. However, no research has examined the relationship of coexposure to PFAS and heavy metals in metabolic dysfunction-associated steatoti…
View article: Cell-free DNA screening for trisomies 21, 18, and 13: Clinical application and accuracy evaluation
Cell-free DNA screening for trisomies 21, 18, and 13: Clinical application and accuracy evaluation Open
Background Cell-free DNA (cf-DNA) screening for common trisomies has been increasingly assimilated into prenatal care. In this study, we evaluated the Z-score accuracy and the effectiveness of non-invasive prenatal testing (NIPT) for triso…
View article: Dysphagia linked to clinical phenotype and disease progression in spinocerebellar ataxia type 3
Dysphagia linked to clinical phenotype and disease progression in spinocerebellar ataxia type 3 Open
View article: Dysphagia Linked to Clinical Phenotype and Disease Progression in Spinocerebellar Ataxia Type 3
Dysphagia Linked to Clinical Phenotype and Disease Progression in Spinocerebellar Ataxia Type 3 Open
Background Spinocerebellar Ataxia type 3 (SCA3) is a widely recognized autosomal dominant disorder characterized by cerebellar ataxia, particularly prevalent in China. Dysphagia frequently arises in SCA3 and other neurological disorders, r…
View article: GnRHR inhibits the malignant progression of triple-negative breast cancer by upregulating FOS and IFI44L
GnRHR inhibits the malignant progression of triple-negative breast cancer by upregulating FOS and IFI44L Open
Gonadotropin-releasing hormone receptor (GnRHR) has been identified as a factor that hinders the malignant advancement of triple-negative breast cancer (TNBC). Nevertheless, the specific molecular mechanism responsible for this impact rema…
View article: Tetrandrine induces muscle atrophy involving ROS-mediated inhibition of Akt and FoxO3
Tetrandrine induces muscle atrophy involving ROS-mediated inhibition of Akt and FoxO3 Open
View article: Repositioning baloxavir marboxil as VISTA agonist that ameliorates experimental asthma
Repositioning baloxavir marboxil as VISTA agonist that ameliorates experimental asthma Open
V-type immunoglobulin domain–containing suppressor of T-cell activation (VISTA), a novel negative checkpoint regulator, plays an essential role in allergic pulmonary inflammation in mice. Treatment with a VISTA agonistic antibody could sig…
View article: Platelet-Rich Plasma Inhibits Breast Cancer Proliferation
Platelet-Rich Plasma Inhibits Breast Cancer Proliferation Open
Background: Platelet-rich plasma (PRP) helps promote wound healing, but it is unclear whether it stimulates breast cancer cell proliferation, which restricts its application in breast cancer patients. This article explored the effect of PR…
View article: The Characteristics of HER2 Low-Expressing Breast Cancer: a China Single-Center Real-World Data Analysis
The Characteristics of HER2 Low-Expressing Breast Cancer: a China Single-Center Real-World Data Analysis Open
Aim: This study examined the characteristics of HER2-low breast cancer patients in our center. Methods: Data of HER2-negative breast cancer patients were collected, and the patients were divided into HER2-low and HER2-0 groups. The differe…
View article: Identifying the optimal cutoff point of Ki-67 in breast cancer: a single-center experience
Identifying the optimal cutoff point of Ki-67 in breast cancer: a single-center experience Open
Objective Ki-67 is associated with breast cancer subtypes, but the optimal cutoff point of Ki-67 has not been established in our center. We evaluated the cutoff point of Ki-67 in breast cancer and analyzed the associations among Ki-67, cli…
View article: Chrysin Attenuates Oxidative Stress to Alleviate Sevoflurane-Induced Cognitive Impairments in Aged Rats
Chrysin Attenuates Oxidative Stress to Alleviate Sevoflurane-Induced Cognitive Impairments in Aged Rats Open
Objective Anesthesia-induced cognitive impairments are common for elder patients after surgery. Oxidative stress is the predominant factor contributing to the impairments. This study was to assess the therapeutic potential of an anti-oxida…
View article: Supplementary Figure Legends 1-2 from Angiopoietin-1 Overexpression Modulates Vascular Endothelium to Facilitate Tumor Cell Dissemination and Metastasis Establishment
Supplementary Figure Legends 1-2 from Angiopoietin-1 Overexpression Modulates Vascular Endothelium to Facilitate Tumor Cell Dissemination and Metastasis Establishment Open
Supplementary Figure Legends 1-2 from Angiopoietin-1 Overexpression Modulates Vascular Endothelium to Facilitate Tumor Cell Dissemination and Metastasis Establishment
View article: Supplementary Figure 2 from Angiopoietin-1 Overexpression Modulates Vascular Endothelium to Facilitate Tumor Cell Dissemination and Metastasis Establishment
Supplementary Figure 2 from Angiopoietin-1 Overexpression Modulates Vascular Endothelium to Facilitate Tumor Cell Dissemination and Metastasis Establishment Open
Supplementary Figure 2 from Angiopoietin-1 Overexpression Modulates Vascular Endothelium to Facilitate Tumor Cell Dissemination and Metastasis Establishment
View article: Supplementary Figure 2 from Angiopoietin-1 Overexpression Modulates Vascular Endothelium to Facilitate Tumor Cell Dissemination and Metastasis Establishment
Supplementary Figure 2 from Angiopoietin-1 Overexpression Modulates Vascular Endothelium to Facilitate Tumor Cell Dissemination and Metastasis Establishment Open
Supplementary Figure 2 from Angiopoietin-1 Overexpression Modulates Vascular Endothelium to Facilitate Tumor Cell Dissemination and Metastasis Establishment
View article: Supplementary Figure 1 from Angiopoietin-1 Overexpression Modulates Vascular Endothelium to Facilitate Tumor Cell Dissemination and Metastasis Establishment
Supplementary Figure 1 from Angiopoietin-1 Overexpression Modulates Vascular Endothelium to Facilitate Tumor Cell Dissemination and Metastasis Establishment Open
Supplementary Figure 1 from Angiopoietin-1 Overexpression Modulates Vascular Endothelium to Facilitate Tumor Cell Dissemination and Metastasis Establishment
View article: Supplementary Figure Legends 1-2 from Angiopoietin-1 Overexpression Modulates Vascular Endothelium to Facilitate Tumor Cell Dissemination and Metastasis Establishment
Supplementary Figure Legends 1-2 from Angiopoietin-1 Overexpression Modulates Vascular Endothelium to Facilitate Tumor Cell Dissemination and Metastasis Establishment Open
Supplementary Figure Legends 1-2 from Angiopoietin-1 Overexpression Modulates Vascular Endothelium to Facilitate Tumor Cell Dissemination and Metastasis Establishment
View article: Supplementary Figure 1 from Angiopoietin-1 Overexpression Modulates Vascular Endothelium to Facilitate Tumor Cell Dissemination and Metastasis Establishment
Supplementary Figure 1 from Angiopoietin-1 Overexpression Modulates Vascular Endothelium to Facilitate Tumor Cell Dissemination and Metastasis Establishment Open
Supplementary Figure 1 from Angiopoietin-1 Overexpression Modulates Vascular Endothelium to Facilitate Tumor Cell Dissemination and Metastasis Establishment
View article: Data from Angiopoietin-1 Overexpression Modulates Vascular Endothelium to Facilitate Tumor Cell Dissemination and Metastasis Establishment
Data from Angiopoietin-1 Overexpression Modulates Vascular Endothelium to Facilitate Tumor Cell Dissemination and Metastasis Establishment Open
The angiopoietin-1 (Ang1)/Tie2 signaling pathway is known to play an important role in the regulation of vascular maturation and maintenance of vessel integrity. In this study, we have investigated the effect of systemic Tie2 activation or…
View article: Data from Angiopoietin-1 Overexpression Modulates Vascular Endothelium to Facilitate Tumor Cell Dissemination and Metastasis Establishment
Data from Angiopoietin-1 Overexpression Modulates Vascular Endothelium to Facilitate Tumor Cell Dissemination and Metastasis Establishment Open
The angiopoietin-1 (Ang1)/Tie2 signaling pathway is known to play an important role in the regulation of vascular maturation and maintenance of vessel integrity. In this study, we have investigated the effect of systemic Tie2 activation or…
View article: Circular RNA ATP2C1 (has_circ_0005797) sponges miR-432/miR-335 to promote breast cancer progression through regulating CCND1 expression.
Circular RNA ATP2C1 (has_circ_0005797) sponges miR-432/miR-335 to promote breast cancer progression through regulating CCND1 expression. Open
Breast cancer (BC) is the most frequently diagnosed malignancy in the world. Accumulating evidence has indicated that circular RNAs (circRNAs) play essential roles in BC. Here we investigated the biological functions of circATP2C as a comp…
View article: Discovery of Orally Bioavailable <i>N</i>-Benzylpiperidinol Derivatives as Potent and Selective USP7 Inhibitors with In Vivo Antitumor Immunity Activity against Colon Cancer
Discovery of Orally Bioavailable <i>N</i>-Benzylpiperidinol Derivatives as Potent and Selective USP7 Inhibitors with In Vivo Antitumor Immunity Activity against Colon Cancer Open
USP7 emerges as a potential therapeutic target for cancers, as it plays an important role in the development of tumorigenesis by stabilizing multiple cancer-relevant proteins. Nevertheless, the discovery of drug-like USP7 inhibitors remain…
View article: Case report: Blepharospasm in peak-dose dyskinesia may benefit from amantadine in Parkinson's disease
Case report: Blepharospasm in peak-dose dyskinesia may benefit from amantadine in Parkinson's disease Open
Introduction Blepharospasm is uncommon in Parkinson's disease, especially in the peak-dose dyskinesia period. Case presentation We herein present the case of a patient with PD who developed blepharospasm in the peak-dose dyskinesia period.…
View article: MYPT1 reduction is a pathogenic factor of erectile dysfunction
MYPT1 reduction is a pathogenic factor of erectile dysfunction Open
View article: Tas2R activation relaxes airway smooth muscle by release of Gα <sub>t</sub> targeting on AChR signaling
Tas2R activation relaxes airway smooth muscle by release of Gα <sub>t</sub> targeting on AChR signaling Open
Both chronic obstructive pulmonary disease (COPD) and asthma are severe respiratory diseases. Bitter receptor–mediated bronchodilation is a potential therapy for asthma, but the mechanism underlying the agonistic relaxation of airway smoot…
View article: Axillary Lymph Node Dissection Can Be Omitted in Breast Cancer Patients With Mastectomy and False-Negative Frozen Section in Sentinel Lymph Node Biopsy
Axillary Lymph Node Dissection Can Be Omitted in Breast Cancer Patients With Mastectomy and False-Negative Frozen Section in Sentinel Lymph Node Biopsy Open
Background The IBCSG 23-01 and AMAROS trials both reported that axillary lymph node dissection (ALND) did not change survival rates in breast cancer patients with positive nodes detected by sentinel lymph node biopsy (SLNB). The aim of thi…
View article: Gonadotropin-releasing hormone receptor inhibits triple-negative breast cancer proliferation and metastasis
Gonadotropin-releasing hormone receptor inhibits triple-negative breast cancer proliferation and metastasis Open
Background Gonadotropin-releasing hormone receptor (GnRHR) is expressed in several malignant tumors and inhibits the proliferation and metastasis of cancer cells, but its role in triple-negative breast cancers (TNBCs) is unclear. This stud…
View article: Screening of Breast Cancer Methylation Biomarkers Based on the TCGA Database
Screening of Breast Cancer Methylation Biomarkers Based on the TCGA Database Open
The 10 breast cancer methylation sites screened in the present study can effectively distinguish breast cancer from 31 other solid tumors, and they are expected to be used as biomarkers for early screening of breast cancer.
View article: The STING antagonist H‐151 ameliorates psoriasis via suppression of STING/NF‐κB‐mediated inflammation
The STING antagonist H‐151 ameliorates psoriasis via suppression of STING/NF‐κB‐mediated inflammation Open
Background and Purpose Psoriasis is a chronic inflammatory skin disease associated with both innate and adaptive immune responses. The stimulator of interferon genes (STING) protein engages in sensing of cytosolic DNA to initiate dsDNA‐dri…
View article: A Transposon-Associated CRISPR/Cas9 System Specifically Eliminates both Chromosomal and Plasmid-Borne <i>mcr-1</i> in Escherichia coli
A Transposon-Associated CRISPR/Cas9 System Specifically Eliminates both Chromosomal and Plasmid-Borne <i>mcr-1</i> in Escherichia coli Open
The global spread of antimicrobial-resistant bacteria has been one of the most severe threats to public health. The emergence of the mcr-1 gene has posed a considerable threat to antimicrobial medication since it deactivates one last-resor…
View article: Identification of high-risk genes in triple-negative breast cancer by bioinformatics
Identification of high-risk genes in triple-negative breast cancer by bioinformatics Open
Background Current research has failed to find a target gene for triple-negative breast cancer (TNBC), which has resulted in the treatment for TNBC being less effective than that for other types of breast cancer. Finding high-risk genes fo…