Caiping Yan
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View article: 3D printed scaffolds regulated by neural-bone metabolic coupling promote bone unit regeneration
3D printed scaffolds regulated by neural-bone metabolic coupling promote bone unit regeneration Open
The bone unit (BU) is a multicellular functional unit composed of neuromodulatory networks, bone tissue, and functional blood vessels. As a functional extension of bone regeneration, the BU coordinates neural signal, regeneration of the ci…
View article: Aging‐Regulating Microspheres for Enhancing Mitochondrial Biogenesis in Early Senescence and Clearing Late Senescent Cells
Aging‐Regulating Microspheres for Enhancing Mitochondrial Biogenesis in Early Senescence and Clearing Late Senescent Cells Open
Targeting senescent cells represents a promising strategy for treating degenerative diseases. Within the senescent microenvironment of degenerating tissues, two distinct types of senescent cells coexist: early senescent cells, characterize…
View article: Manganese-Based Polyoxometalate Nanozyme-Metformin Co-functionalized Hydrogel Promotes Diabetic Wound Regeneration by Enhancing Phagocyte Efferocytosis
Manganese-Based Polyoxometalate Nanozyme-Metformin Co-functionalized Hydrogel Promotes Diabetic Wound Regeneration by Enhancing Phagocyte Efferocytosis Open
Efferocytosis, mediated by macrophages and dendritic cells (DCs), clears apoptotic cells to maintain tissue homeostasis, suppress inflammation, and promote repair. In diabetic wounds, hyperglycemia disrupts their efferocytic function, impe…
View article: Three-dimensional-printed scaffolds functionalized with stem cell recruitment and cell respiration regulation for diabetic bone defects
Three-dimensional-printed scaffolds functionalized with stem cell recruitment and cell respiration regulation for diabetic bone defects Open
High-glucose microenvironment in diabetic patients is a source of damage to the cellular mitochondrial respiratory chain (MRC), which results in the generation of reactive oxygen species (ROS) and leads to mitochondrial dysfunction, cellul…
View article: Dual-Stream Intermediate Fusion Network for Image Forgery Localization
Dual-Stream Intermediate Fusion Network for Image Forgery Localization Open
Nowadays, powerful image editing applications not only simplify image processing significantly but also enhance the realism of processed digital images. However, this convenience has presented unprecedented challenges in verifying the auth…
View article: Titanium implants with antiaging effect to repair senile osteoporosis fracture
Titanium implants with antiaging effect to repair senile osteoporosis fracture Open
Accelerated population ageing has brought a great burden to the development of society. Repairing senile osteoporosis fractures is a great challenge, but a desirable way to address this issue is by developing multifunctional titanium(Ti) i…
View article: HDA-GAN： hybrid dual attention generative adversarial network for image inpainting
HDA-GAN： hybrid dual attention generative adversarial network for image inpainting Open
目的 图像修复是指用合理的内容来填补图像缺失或损坏的部分。尽管生成对抗网络（generative adversarial network，GAN）取得了巨大的进步，但当缺失区域很大时，现有的大多数方法仍然会产生扭曲的结构和模糊的纹理。其中一个主要原因是卷积操作的局域性，它不考虑全局或远距离结构信息，只是扩大了局部感受野。方法 为了克服上述问题，提出了一种新的图像修复网络，即混合注意力生成对抗网络（hybrid dual attention generativeadversa…
View article: TransU<sup>2</sup>-Net: A Hybrid Transformer Architecture for Image Splicing Forgery Detection
TransU<sup>2</sup>-Net: A Hybrid Transformer Architecture for Image Splicing Forgery Detection Open
In recent years, various convolutional neural network (CNN) based frameworks have been presented to detect forged regions in images. However, most of the existing models can not obtain satisfactory performance due to tampered areas with va…
View article: [Effectiveness of bone transport with a locking plate versus conventional bone transport for tibial defects].
[Effectiveness of bone transport with a locking plate versus conventional bone transport for tibial defects]. Open
BTLP is safe and effective in the treatment of tibial defects. BTLP has apparent advantages over the conventional bone transport technique in osteotomy time, external fixation index, and lower limb functional recovery.
View article: β-Ecdysterone Enhanced Bone Regeneration Through the BMP-2/SMAD/RUNX2/Osterix Signaling Pathway
β-Ecdysterone Enhanced Bone Regeneration Through the BMP-2/SMAD/RUNX2/Osterix Signaling Pathway Open
Graphical Abstract Schematic illustrations of the fabrication of the bone defect model and action of β-Ecd in promoting bone regeneration and repair of bone defects. We established a rat model of a femoral bone defect in vivo to evaluate t…
View article: Marein Prevented LPS-Induced Osteoclastogenesis by Regulating the NF-κB Pathway In Vitro
Marein Prevented LPS-Induced Osteoclastogenesis by Regulating the NF-κB Pathway In Vitro Open
Many bone diseases such as osteolysis, osteomyelitis, and septic arthritis are caused by gram-negative bacterial infection, and lipopolysaccharide (LPS), a bacterial product, plays an essential role in this process. Drugs that inhibit LPS-…
View article: Marein prevented LPS-induced osteoclastogenesis by regulating the NF-κB pathway in vitro
Marein prevented LPS-induced osteoclastogenesis by regulating the NF-κB pathway in vitro Open
Gram-negative bacterial infection causes many bone diseases such as osteolysis, osteomyelitis and septic arthritis. Lipopolysaccharide (LPS), a bacteria product, played an important role in this process. Drugs that inhibited LPS-induced os…
View article: [Comparison of effectiveness of femoral neck system and cannulate compression screw in treatment of femoral neck fracture in young and middle-aged patients].
[Comparison of effectiveness of femoral neck system and cannulate compression screw in treatment of femoral neck fracture in young and middle-aged patients]. Open
FNS can accelerate the healing of femoral neck fractures in young and middle-aged patients, so that patients can start functional exercise as soon as possible, thereby reducing the incidence of related complications.
View article: Applications of Functionalized Hydrogels in the Regeneration of the Intervertebral Disc
Applications of Functionalized Hydrogels in the Regeneration of the Intervertebral Disc Open
Intervertebral disc degeneration (IDD) is caused by genetics, aging, and environmental factors and is one of the leading causes of low back pain. The treatment of IDD presents many challenges. Hydrogels are biomaterials that possess proper…
View article: β-Ecdysterone Prevents LPS-Induced Osteoclastogenesis by Regulating NF-κB Pathway in Vitro
β-Ecdysterone Prevents LPS-Induced Osteoclastogenesis by Regulating NF-κB Pathway in Vitro Open
BackgroundLipopolysaccharide (LPS), a bacteria product, plays an important role in orthopedic diseases. Drugs that inhibit LPS-induced osteoclastogenesis are urgently needed for the prevention of bone destruction.MethodsIn this study, we e…