Caiqing Zheng
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View article: An orthology-based methodology as a complementary approach to retrieve evolutionarily conserved A-to-I RNA editing sites
An orthology-based methodology as a complementary approach to retrieve evolutionarily conserved A-to-I RNA editing sites Open
Adar-mediated adenosine-to-inosine (A-to-I) mRNA editing is a conserved mechanism that exerts diverse regulatory functions during the development, evolution, and adaptation of metazoans. The accurate detection of RNA editing sites helps us…
View article: Conserved A-to-I RNA editing with non-conserved recoding expands the candidates of functional editing sites
Conserved A-to-I RNA editing with non-conserved recoding expands the candidates of functional editing sites Open
Adenosine-to-inosine (A-to-I) RNA editing recodes the genome and confers flexibility for the organisms to adapt to the environment. It is believed that RNA recoding sites are well suited for facilitating adaptive evolution by increasing th…
View article: Comparative genomic analyses reveal evidence for adaptive A-to-I RNA editing in insect <i>Adar</i> gene
Comparative genomic analyses reveal evidence for adaptive A-to-I RNA editing in insect <i>Adar</i> gene Open
Although A-to-I RNA editing leads to similar effects to A-to-G DNA mutation, nonsynonymous RNA editing (recoding) is believed to confer its adaptiveness by 'epigenetically' regulating proteomic diversity in a temporospatial manner, avoidin…
View article: The Many Roles of A-to-I RNA Editing in Animals: Functional or Adaptive?
The Many Roles of A-to-I RNA Editing in Animals: Functional or Adaptive? Open
Metazoan adenosine-to-inosine (A-to-I) RNA editing is a highly conserved mechanism that diversifies the transcriptome by post-transcriptionally converting adenosine to inosine. Millions of editing sites have been identified in different sp…
View article: A full repertoire of Hemiptera genomes reveals a multi-step evolutionary trajectory of auto-RNA editing site in insect <i>Adar</i> gene
A full repertoire of Hemiptera genomes reveals a multi-step evolutionary trajectory of auto-RNA editing site in insect <i>Adar</i> gene Open
Adenosine-to-inosine (A-to-I) RNA editing, mediated by metazoan ADAR enzymes, is a prevalent post-transcriptional modification that diversifies the proteome and promotes adaptive evolution of organisms. The Drosophila Adar gene has an auto…
View article: Duclauxin Derivatives From Fungi and Their Biological Activities
Duclauxin Derivatives From Fungi and Their Biological Activities Open
Duclauxin is a heptacyclic oligophenalenone dimer consisting of an isocoumarin and a dihydroisocoumarin unit. These two tricyclic moieties are joined by a cyclopentane ring to form a unique hinge or castanets-like structure. Duclauxin is e…