Explanipedia

Intubation Trends and Survival in Pediatric In-Hospital Cardiac Arrest Open

Lindsay N. Shepard, Ron Reeder, Jesse Y. Hsu, Garrett Keim, Robert M Sutton , et al. · 2025

Importance The optimal airway management during pediatric in-hospital cardiac arrest (IHCA) is unknown. Objective To evaluate intubation trends during pediatric IHCA between 2000 and 2022, and determine the association of intra-arrest intu…

Review of the ecological aspects of sympatric species Octopus americanus and Octopus insularis (Cephalopoda: Octopodidae) in the Western Atlantic Open

Mariana Osório Côrtes, Bernardo F. Santos, Renato Hajenius Aché de Freitas, Caitlin E. O’Brien, Tatiana Leite · 2025

Due to similarities in morphology and overlapping distribution, Octopus americanus and O. insularis (both formerly designated as O. vulgaris) are now considered to be cryptic species inhabiting the western Atlantic, while O. vulgaris inhab…

Demand for cardiopulmonary resuscitation and bleeding control skills training in an urban region: a feasibility review of a community engagement effort Open

Katherine Hoops, Ashley Bedner, Emily Kemper, Deborah Aksamit, Caitlin E. O’Brien , et al. · 2025

In this community engagement feasibility review, we evaluate the infrastructure warranted to implement bystander CPR and bleeding control skills training to diverse social organizations in an urban region over an 9-month period. Further, w…

Characteristics of Pediatric In-Hospital Cardiac Arrests and Resuscitation Duration Open

Amanda O’Halloran, Ryan W. Morgan, Kevin F. Kennedy, Robert A. Berg, Cody-Aaron Gathers , et al. · 2024

Importance Cardiopulmonary resuscitation (CPR) duration is associated with cardiac arrest survival. Objectives To describe characteristics associated with CPR duration among hospitalized children without return of circulation (ROC) (patien…

Community pharmacists’ attitudes toward and practice of pharmacy-based harm reduction services in Pittsburgh, PA: a descriptive survey Open

Caitlin E. O’Brien, Stephanie Klipp, Raagini Jawa, J. Deanna Wilson · 2024

Ventilator Weaning and Terminal Extubation: Withdrawal of Life-Sustaining Therapy in Children. Secondary Analysis of the Death One Hour After Terminal Extubation Study Open

Charlene Pringle, Stephanie L. Filipp, Wynne Morrison, Nina Fainberg, Melissa Aczon , et al. · 2023

OBJECTIVE: Terminal extubation (TE) and terminal weaning (TW) during withdrawal of life-sustaining therapies (WLSTs) have been described and defined in adults. The recent Death One Hour After Terminal Extubation study aimed to validate a m…

Demand for Cardiopulmonary Resuscitation and Bleeding Control Skills Training in an Urban Region: A Feasibility Review of a Community Engagement Effort Open

Katherine Hoops, Ashley Bedner, Emily Kemper, Deborah Aksamit, Caitlin E. O’Brien , et al. · 2023

In maintained, bi-directional medical-community collaborations, partnering social organizations may request teachings for health skills from their respective health system in an immediate moment-in-time due to certain contextual factors th…

Hypothermic Protection in Neocortex Is Topographic and Laminar, Seizure Unmitigating, and Partially Rescues Neurons Depleted of RNA Splicing Protein Rbfox3/NeuN in Neonatal Hypoxic-Ischemic Male Piglets Open

Christopher T. Primiani, Jennifer K. Lee, Caitlin E. O’Brien, May Chen, Jamie Perin , et al. · 2023

The effects of hypothermia on neonatal encephalopathy may vary topographically and cytopathologically in the neocortex with manifestations potentially influenced by seizures that alter the severity, distribution, and type of neuropathology…

Host obesity alters the ovarian tumor immune microenvironment and impacts response to standard of care chemotherapy Open

Yueying Liu, Jing Yang, Tyvette S. Hilliard, Zhikun Wang, Jeff Johnson , et al. · 2023

Hypothermic Protection in Neocortex is Topographic and Laminar, Seizure Unmitigating, and Partially Rescues Neurons Depleted of RNA Splicing Protein RBFOX3 in Neonatal Hypoxic-Ischemic Piglets Open

Christopher T. Primiani, Jennifer K. Lee, Caitlin E. O’Brien, May Chen, Jamie Perin , et al. · 2023

The effects of hypothermia on neonatal encephalopathy may vary regionally, spatially, and cytopathologically in the gyrencephalic neocortex with manifestations potentially influenced by seizures that alter the severity and distribution of …

Outcomes of the "BRCA Quality Improvement Dissemination Program": An initiative to improve patient receipt of cancer genetics services at five health systems Open

Erica M. Bednar, Minxing Chen, Michael T. Walsh, Amanda L. Eppolito, Molly H. Klein , et al. · 2023

Cuttlefish conservation: a global review of methods to ameliorate unwanted fishing mortality and other anthropogenic threats to sustainability Open

C.J. Barrett, Jilali Bensbai, Matt K. Broadhurst, Paco Bustamante, Rulon W. Clark , et al. · 2022

Cuttlefish are an important global fisheries resource, and their demand is placing increasing pressure on populations in many areas, necessitating conservation measures. We reviewed evidence from case studies spanning Europe, Africa, Asia,…

Development and use of an infant resuscitation performance tool (Infa-RePT) to improve team performance Open

Kristen T. Leeman, Ravikiran M. Raju, Caitlin E. O’Brien, Denise M. Casey, Anne Hansen · 2022

Use of an end-tidal carbon dioxide-guided algorithm during cardiopulmonary resuscitation improves short-term survival in paediatric swine Open

Caitlin E. O’Brien, Polan T. Santos, Ewa Kulikowicz, Shawn Adams, Jennifer K. Lee , et al. · 2021

Oleuropein Activates Neonatal Neocortical Proteasomes, but Proteasome Gene Targeting by AAV9 Is Variable in a Clinically Relevant Piglet Model of Brain Hypoxia-Ischemia and Hypothermia Open

Nagat El Demerdash, May Chen, Caitlin E. O’Brien, Shawn Adams, Ewa Kulikowicz , et al. · 2021

Cerebral hypoxia-ischemia (HI) compromises the proteasome in a clinically relevant neonatal piglet model. Protecting and activating proteasomes could be an adjunct therapy to hypothermia. We investigated whether chymotrypsin-like proteasom…

Extracorporeal cardiopulmonary resuscitation for the treatment of amlodipine overdose in a pediatric patient Open

Katherine Giuliano, Y Julia Chen, Kristen Coletti, Caitlin E. O’Brien, Eric B. Jelin , et al. · 2021

We present the case of a 16-year-old female with systemic lupus erythematosus who presented with shock of unclear etiology, refractory to fluid resuscitation and triple vasopressors. She suffered pulseless electrical activity and underwent…

Combining Hypothermia and Oleuropein Subacutely Protects Subcortical White Matter in a Swine Model of Neonatal Hypoxic-Ischemic Encephalopathy Open

Jennifer K. Lee, Polan T. Santos, May Chen, Caitlin E. O’Brien, Ewa Kulikowicz , et al. · 2020

Neonatal hypoxia-ischemia (HI) causes white matter injury that is not fully prevented by therapeutic hypothermia. Adjuvant treatments are needed. We compared myelination in different piglet white matter regions. We then tested whether oleu…

Neurologic effects of short-term treatment with a soluble epoxide hydrolase inhibitor after cardiac arrest in pediatric swine Open

Caitlin E. O’Brien, Polan T. Santos, Ewa Kulikowicz, Jennifer K. Lee, Raymond C. Koehler , et al. · 2020

Background Cardiac arrest (CA) is the most common cause of acute neurologic insult in children. Many survivors have significant neurocognitive deficits at 1 year of recovery. Epoxyeicosatrienoic acids (EETs) are multifunctional endogenous …

The use of pressure‐controlled mechanical ventilation in a swine model of intraoperative pediatric cardiac arrest Open

Francis Lapid, Caitlin E. O’Brien, Sapna R. Kudchadkar, Jennifer K. Lee, Elizabeth A. Hunt , et al. · 2020

Background Current pediatric resuscitation guidelines suggest that resuscitators using an advanced airway deliver 8‐10 breaths per minute while carefully avoiding excessive ventilation. In the intraoperative setting, having a dedicated ven…

Reply to: In a paediatric animal model of cardiac arrest: Is diastolic blood pressure associated with survival during resuscitation? Open

Caitlin E. O’Brien, Donald H. Shaffner · 2019

Association of diastolic blood pressure with survival during paediatric cardiopulmonary resuscitation Open

Caitlin E. O’Brien, Polan T. Santos, Michael Reyes, Shawn Adams, C. Danielle Hopkins , et al. · 2019

The Effect of Asphyxia Arrest Duration on a Pediatric End-Tidal co 2-Guided Chest Compression Delivery Model* Open

Jennifer L. Hamrick, Justin Hamrick, Caitlin E. O’Brien, Michael Reyes, Polan T. Santos , et al. · 2019

Objectives: To determine the effect of the duration of asphyxial arrest on the survival benefit previously seen with end-tidal co 2 -guided chest compression delivery. Design: Preclinical randomized controlled study. Setting: University an…

Supplementary Material for: Hypoxia-Ischemia and Hypothermia Independently and Interactively Affect Neuronal Pathology in Neonatal Piglets with Short-Term Recovery Open

Caitlin E. O’Brien, Polan T. Santos, Ewa Kulikowicz, M. Reyes, Raymond C. Koehler , et al. · 2019

Therapeutic hypothermia is the standard of clinical care for moderate neonatal hypoxic-ischemic encephalopathy. We investigated the independent and interactive effects of hypoxia-ischemia (HI) and temperature on neuronal survival and injur…

Improved Cardiopulmonary Resuscitation Performance With CODE ACES 2 : A Resuscitation Quality Bundle Open

Elizabeth A. Hunt, Justin Jeffers, LeAnn M. McNamara, Heather Newton, K. Ford , et al. · 2018

Background Over 6000 children have an in‐hospital cardiac arrest in the United States annually. Most will not survive to discharge, with significant variability in survival across hospitals suggesting improvement in resuscitation performan…

Proteasome Biology Is Compromised in White Matter After Asphyxic Cardiac Arrest in Neonatal Piglets Open

Polan T. Santos, Caitlin E. O’Brien, May Chen, C. Danielle Hopkins, Shawn Adams , et al. · 2018

Background Neurological deficits in hypoxic‐ischemic encephalopathy, even with therapeutic hypothermia, are partially attributed to white matter injury. We theorized that proteasome insufficiency contributes to white matter injury. Methods…

Pilot Study to Compare the Use of End‐Tidal Carbon Dioxide–Guided and Diastolic Blood Pressure–Guided Chest Compression Delivery in a Swine Model of Neonatal Asphyxial Cardiac Arrest Open

Caitlin E. O’Brien, Michael Reyes, Polan T. Santos, Sophia E. Heitmiller, Ewa Kulikowicz , et al. · 2018

Background The American Heart Association recommends use of physiologic feedback when available to optimize chest compression delivery. We compared hemodynamic parameters during cardiopulmonary resuscitation in which either end‐tidal carbo…

Non-rheumatic streptococcal myocarditis mimicking acute myocardial infarction in an adolescent male Open

Caitlin E. O’Brien, John D. Coulson, Priya Sekar, Jon R. Resar, Kristen Nelson McMillan · 2018

An adolescent male with a recent history of streptococcal pharyngitis presented with severe substernal chest pain, troponin leak, and ST-segment elevation, which are suggestive of acute inferolateral myocardial infarction. The coronary ang…

Effect of Intravenous Administration of Cobalt Chloride to Horses on Clinical and Hemodynamic Variables Open

Teresa A. Burns, Katarzyna A. Dembek, Ahmed Kamr, Steven Dooley, L.K. Dunbar , et al. · 2017

Background Cobalt chloride (CoCl 2 ) is administered to racehorses to enhance performance. The purpose of this study was to evaluate the clinical, cardiovascular, and endocrine effects of parenterally administered CoCl 2 . Objectives To de…

Major Observations from a Specialized REU Program for Engineering Students with ADHD Open

Arash E. Zaghi, Mark Tehranipoor, Caitlin E. O’Brien · 2016

Students with Attention Deficit Hyperactivity Disorder (ADHD) tend to experience the traditional education system differently than their peers. The engineering education system has yet to realize unique potential of these students and iden…

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