Caitlin S. Latimer
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View article: Genome‐wide association studies of TDP‐43 proteinopathy and hippocampal sclerosis reveal shared genetic associations with APOE and TMEM106B
Genome‐wide association studies of TDP‐43 proteinopathy and hippocampal sclerosis reveal shared genetic associations with APOE and TMEM106B Open
INTRODUCTION Transactive response DNA binding protein 43 kDa (TDP‐43) proteinopathy has been linked to cognitive decline and often co‐occurs with hippocampal sclerosis (HS). To identify genetic markers of TDP‐43 proteinopathy and HS, we pe…
View article: Plasma and cerebrospinal fluid biomarkers in aged dogs with cognitive decline
Plasma and cerebrospinal fluid biomarkers in aged dogs with cognitive decline Open
Background Canine cognitive dysfunction syndrome (CCD) is a naturally occurring progressive neurodegenerative disease that commonly affects geriatric dogs, with age being the primary risk factor. CCD presents a valuable model for studying …
View article: Celebrating neuropathology's contributions to Alzheimer's Disease Research Centers
Celebrating neuropathology's contributions to Alzheimer's Disease Research Centers Open
Our understanding of Alzheimer's disease (AD) and related dementias (ADRD) has grown exponentially, thanks to significant investments by the National Institute on Aging (NIA). This article celebrates the 40th anniversary of the NIA's Alzhe…
View article: Down syndrome and a presenilin 2 variant: dual genetic risk of Alzheimer’s disease
Down syndrome and a presenilin 2 variant: dual genetic risk of Alzheimer’s disease Open
Early onset familial Alzheimer's disease (EOFAD) is rare compared to sporadic AD, but dominant variants in genes involved in amyloid β (Aβ) processing are well-described. One such variant is in the presenilin 2 (PSEN2) gene, N141I, and was…
View article: The companion dog as a translational model for Alzheimer's disease: Development of a longitudinal research platform and <i>post mortem</i> protocols
The companion dog as a translational model for Alzheimer's disease: Development of a longitudinal research platform and <i>post mortem</i> protocols Open
INTRODUCTION Canine cognitive dysfunction is a valuable model for Alzheimer's disease (AD) and Alzheimer's disease related dementias (ADRD) due to condensed lifespan, naturally occurring clinical signs, genetic diversity, shared environmen…
View article: Tri-snRNP activity modulates tauopathy phenotypes
Tri-snRNP activity modulates tauopathy phenotypes Open
Alzheimer’s disease (AD) and other tauopathies are neurodegenerative disorders with devastating consequences for cognition and memory. Pathogenic accumulation of tau can be modeled in Caenorhabditis elegans, which recapitulate human neurod…
View article: Tau filaments with the Alzheimer fold in human MAPT mutants V337M and R406W
Tau filaments with the Alzheimer fold in human MAPT mutants V337M and R406W Open
Frontotemporal dementia (FTD) and Alzheimer’s disease (AD) are the most common forms of early-onset dementia. Unlike AD, FTD begins with behavioral changes before the development of cognitive impairment. Dominantly inherited mutations in M…
View article: Satellite microglia: marker of traumatic brain injury and regulator of neuronal excitability
Satellite microglia: marker of traumatic brain injury and regulator of neuronal excitability Open
View article: Multidimensional MRI reveals cortical astrogliosis linked to dementia in Alzheimer’s disease
Multidimensional MRI reveals cortical astrogliosis linked to dementia in Alzheimer’s disease Open
Despite the presence of significant Alzheimer's disease pathology, characterized by amyloid β (Aβ) plaques and phosphorylated tau (pTau) tangles, some cognitively unimpaired elderly individuals do not inevitably develop dementia. Cortical …
View article: Neuropathological correlates of vulnerability and resilience in the cerebellum in Alzheimer's disease
Neuropathological correlates of vulnerability and resilience in the cerebellum in Alzheimer's disease Open
INTRODUCTION We investigated whether the cerebellum develops neuropathology that correlates with well‐accepted Alzheimer's disease (AD) neuropathological markers and cognitive status. METHODS We studied cerebellar cytoarchitecture in a coh…
View article: Transcriptomic changes preceding neurodegeneration in a <i>C. elegans</i> model of tau and TDP‐43 co‐pathology
Transcriptomic changes preceding neurodegeneration in a <i>C. elegans</i> model of tau and TDP‐43 co‐pathology Open
Background Alzheimer’s disease (AD), the most common aging‐associated neurodegenerative dementia disorder, is defined by the presence of amyloid beta (Aβ) and tau aggregates in the brain. However, more than half of patients also exhibit ag…
View article: A digital brain sampling protocol atlas to simplify and accelerate biorepository tissue requests
A digital brain sampling protocol atlas to simplify and accelerate biorepository tissue requests Open
Background The structural, cellular, and biomolecular research necessary for a mechanistic understanding of Alzheimer’s Disease (AD) relies on brain tissue collected according to a brain sampling protocol (BSP) and preserved in bioreposito…
View article: A systems‐biology approach to identify candidate genes associated with composite brain pathology scores in the Adult Changes of Thought (ACT) and the Religious Orders Study and Memory and Aging Project (ROSMAP) autopsy cohorts
A systems‐biology approach to identify candidate genes associated with composite brain pathology scores in the Adult Changes of Thought (ACT) and the Religious Orders Study and Memory and Aging Project (ROSMAP) autopsy cohorts Open
Background Previously, we developed a co‐calibrated and harmonized brain pathology score (BPS) across prospective cohort studies with research brain donation that incorporates multiple forms of postmortem neuropathology, using confirmatory…
View article: Hereditary spastic paraplegia with thin corpus callosum and <scp><i>SPG11</i></scp> mutation: A neuropathological evaluation
Hereditary spastic paraplegia with thin corpus callosum and <span><i>SPG11</i></span> mutation: A neuropathological evaluation Open
Hereditary spastic paraplegia (HSP) with thin corpus callosum can be due to a variety of genetic causes, the most common of which are biallelic variants in SPG11 (HSP11). Only six cases of neuropathologic examination of HSP11 have been rep…
View article: Epithelial downgrowth masquerading as granulomatous anterior and intermediate uveitis with histopathologic evidence of 5-FU treatment
Epithelial downgrowth masquerading as granulomatous anterior and intermediate uveitis with histopathologic evidence of 5-FU treatment Open
Purpose: Highlight an unusual case of epithelial downgrowth (EDG) masquerading as granulomatous anterior and intermediate uveitis with histopathologic evidence of 5-fluorouracil (5-FU) treatment. Case description: A 33-year-old man present…
View article: Editorial: Meeting new challenges in translationally relevant neurodegenerative disease research
Editorial: Meeting new challenges in translationally relevant neurodegenerative disease research Open
Citation: Latimer CS, Quadri Z and Cook DG (2024) Editorial: Meeting new challenges in translationally relevant neurodegenerative disease research. Front. Neurosci. 18:1453770. doi: 10.3389/fnins.2024.1453770
View article: Aquaporin-4 mis-localization slows glymphatic clearance of α-synuclein and promotes α-synuclein pathology and aggregate propagation
Aquaporin-4 mis-localization slows glymphatic clearance of α-synuclein and promotes α-synuclein pathology and aggregate propagation Open
The appearance of misfolded and aggregated proteins is a pathological hallmark of numerous neurodegenerative diseases including Alzheimer's disease and Parkinson's disease. Sleep disruption is proposed to contribute to these pathological p…
View article: Clinicopathologic Characterization of 2 Individuals With <i>TBK1</i> Variants—1 Novel Splice Variant, 2 Proteinopathies
Clinicopathologic Characterization of 2 Individuals With <i>TBK1</i> Variants—1 Novel Splice Variant, 2 Proteinopathies Open
Although all pathogenic TBK1 variants are associated with TDP-43 pathology, the clinical and histologic features can be highly variable. Within one family, we describe distinct neurologic presentations which we propose are all cause…
View article: Author response: Machine learning of dissection photographs and surface scanning for quantitative 3D neuropathology
Author response: Machine learning of dissection photographs and surface scanning for quantitative 3D neuropathology Open
View article: Resiliency to Alzheimer’s disease neuropathology can be distinguished from dementia using cortical astrogliosis imaging
Resiliency to Alzheimer’s disease neuropathology can be distinguished from dementia using cortical astrogliosis imaging Open
Despite the presence of significant Alzheimer’s disease (AD) pathology, characterized by amyloid β (Aβ) plaques and phosphorylated tau (pTau) tangles, some cognitively normal elderly individuals do not inevitably develop dementia. These fi…
View article: Tau filaments with the Alzheimer fold in cases with<i>MAPT</i>mutations V337M and R406W
Tau filaments with the Alzheimer fold in cases with<i>MAPT</i>mutations V337M and R406W Open
Frontotemporal dementia (FTD) and Alzheimer’s disease are the most common forms of early-onset dementia. Dominantly inherited mutations in MAPT , the microtubule-associated protein tau gene, cause FTD and parkinsonism linked to chromosome …
View article: Author Response: Machine learning of dissection photographs and surface scanning for quantitative 3D neuropathology
Author Response: Machine learning of dissection photographs and surface scanning for quantitative 3D neuropathology Open
We present open-source tools for 3D analysis of photographs of dissected slices of human brains, which are routinely acquired in brain banks but seldom used for quantitative analysis. Our tools can: (i) 3D reconstruct a volume from the pho…
View article: Machine learning of dissection photographs and surface scanning for quantitative 3D neuropathology
Machine learning of dissection photographs and surface scanning for quantitative 3D neuropathology Open
We present open-source tools for 3D analysis of photographs of dissected slices of human brains, which are routinely acquired in brain banks but seldom used for quantitative analysis. Our tools can: (i) 3D reconstruct a volume from the pho…
View article: Transcriptomic evaluation of tau and TDP-43 synergism shows tauopathy predominance and reveals potential modulating targets
Transcriptomic evaluation of tau and TDP-43 synergism shows tauopathy predominance and reveals potential modulating targets Open
View article: Author Response: Machine learning of dissection photographs and surface scanning for quantitative 3D neuropathology
Author Response: Machine learning of dissection photographs and surface scanning for quantitative 3D neuropathology Open
We present open-source tools for 3D analysis of photographs of dissected slices of human brains, which are routinely acquired in brain banks but seldom used for quantitative analysis. Our tools can: (i) 3D reconstruct a volume from the pho…
View article: Machine learning of dissection photographs and surface scanning for quantitative 3D neuropathology
Machine learning of dissection photographs and surface scanning for quantitative 3D neuropathology Open
We present open-source tools for 3D analysis of photographs of dissected slices of human brains, which are routinely acquired in brain banks but seldom used for quantitative analysis. Our tools can: (i) 3D reconstruct a volume from the pho…
View article: Neuropathologic Burden and Dementia in Nonagenarians and Centenarians
Neuropathologic Burden and Dementia in Nonagenarians and Centenarians Open
Our results suggest that specific neuropathologic features may differ in their effect on dementia among nonagenarians and centenarians from cohorts with different selection criteria and study design. Furthermore, microvascular lesions seem…
View article: Machine learning of dissection photographs and surface scanning for quantitative 3D neuropathology
Machine learning of dissection photographs and surface scanning for quantitative 3D neuropathology Open
We present open-source tools for 3D analysis of photographs of dissected slices of human brains, which are routinely acquired in brain banks but seldom used for quantitative analysis. Our tools can: (i) 3D reconstruct a volume from the pho…
View article: Reviewer #1 (Public Review): Machine learning of dissection photographs and surface scanning for quantitative 3D neuropathology
Reviewer #1 (Public Review): Machine learning of dissection photographs and surface scanning for quantitative 3D neuropathology Open
We present open-source tools for 3D analysis of photographs of dissected slices of human brains, which are routinely acquired in brain banks but seldom used for quantitative analysis. Our tools can: (i) 3D reconstruct a volume from the pho…
View article: Author Response: Machine learning of dissection photographs and surface scanning for quantitative 3D neuropathology
Author Response: Machine learning of dissection photographs and surface scanning for quantitative 3D neuropathology Open
We present open-source tools for 3D analysis of photographs of dissected slices of human brains, which are routinely acquired in brain banks but seldom used for quantitative analysis. Our tools can: (i) 3D reconstruct a volume from the pho…