Cheng Tian
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View article: Development and Validation of Machine Learning Models in Predicting Prognosis of Breast Cancer Patients with Lymph Nodes Metastasis Following Neoadjuvant Chemotherapy
Development and Validation of Machine Learning Models in Predicting Prognosis of Breast Cancer Patients with Lymph Nodes Metastasis Following Neoadjuvant Chemotherapy Open
The deep learning radiomics offers a promising approach to predict LN status and survival outcome in breast cancer patients undergoing NAC. This could facilitate personalized treatment strategies and improve clinical decision-making.
View article: Defenestration of Liver Sinusoidal Endothelial Cells: The Trigger of Liver Fibrosis
Defenestration of Liver Sinusoidal Endothelial Cells: The Trigger of Liver Fibrosis Open
Liver fibrosis is a common pathological manifestation of various chronic liver diseases, distinguished by the excessive accumulation of the extracellular matrix. If unresolved, liver fibrosis can progress to cirrhosis or hepatocellular car…
View article: Selective Synthesis of Furan‐3(<i>2H</i>)‐one Fused Seven‐, Eight‐, or Nine‐Membered Ring from the Reaction of Diynone and Cyclic β‐Keto Ester
Selective Synthesis of Furan‐3(<i>2H</i>)‐one Fused Seven‐, Eight‐, or Nine‐Membered Ring from the Reaction of Diynone and Cyclic β‐Keto Ester Open
A domino reaction of diynone and cyclic β‐keto ester has been disclosed. This reaction provides a new strategy for the synthesis of a series of furan‐3( 2H )‐one fused seven‐, eight‐, or nine‐membered ring with good stereoselectivity and a…
View article: Type IIIa Esophageal Atresia, Duodenal Atresia, and Intestinal Atresia in One of the Monochorionic, Diamniotic Twins: A Multi-Surgery Approach for Treatment
Type IIIa Esophageal Atresia, Duodenal Atresia, and Intestinal Atresia in One of the Monochorionic, Diamniotic Twins: A Multi-Surgery Approach for Treatment Open
One of the monochorionic, diamniotic twins combined with type IIIa esophageal atresia, duodenal atresia, and intestinal atresia pose a rare management challenge. A female neonate from a monochorionic, diamniotic twin pregnancy who was diag…
View article: Supramolecular Brake for Slowing Fentanyl Into Brain to Ameliorate Its Therapeutic Outcome
Supramolecular Brake for Slowing Fentanyl Into Brain to Ameliorate Its Therapeutic Outcome Open
Fentanyl (Fen) analogs, clinically used anesthetic adjuvants, are often trouble with overdose‐induced adverse effects due to rapid entry into the brain plus short retention time. Advanced approaches that can relieve related life‐threatenin…
View article: Parameter Analysis for the Flexural Performance of Concrete Beams Using Near-Surface Mounted-Strengthening Application
Parameter Analysis for the Flexural Performance of Concrete Beams Using Near-Surface Mounted-Strengthening Application Open
In this paper, a systematical study on the influence of strengthening parameters on the flexural performance of RC beams using the NSM application was carried out. Experimental results consist of two reference beams and 25 beams divided in…
View article: Improved Prognosis in HER2-Low Breast Cancer Patients with Reduced Ki67 Index After Neoadjuvant Chemotherapy: A Multi-Center Retrospective Study
Improved Prognosis in HER2-Low Breast Cancer Patients with Reduced Ki67 Index After Neoadjuvant Chemotherapy: A Multi-Center Retrospective Study Open
Our study demonstrates that HER2-low breast cancer patients with δKi67 values below the cut-off point after NAC are associated with improved prognosis. Monitoring δKi67 index and HER2 status may help identify patients who are likely to ben…
View article: SIRT1: Harnessing multiple pathways to hinder NAFLD
SIRT1: Harnessing multiple pathways to hinder NAFLD Open
Non-alcoholic fatty liver disease (NAFLD) encompasses hepatic steatosis, non-alcoholic steatohepatitis (NASH), fibrosis, cirrhosis, and hepatocellular carcinoma. It is the primary cause of chronic liver disorders, with a high prevalence bu…
View article: Porous pillar[6]arene-based polymers for reversible iodine capture
Porous pillar[6]arene-based polymers for reversible iodine capture Open
Iodine in nuclear waste can cause serious environment pollution and health risks, and has thus driven more development of materials for iodine capture.
View article: Raman and fourier transform infrared spectroscopy techniques for detection of coronavirus (COVID-19): a mini review
Raman and fourier transform infrared spectroscopy techniques for detection of coronavirus (COVID-19): a mini review Open
Coronavirus pandemic has been a huge jeopardy to human health in various systems since it outbroke, early detection and prevention of further escalation has become a priority. The current popular approach is to collect samples using the na…
View article: CARD9 deficiency promotes pancreatic cancer growth by blocking dendritic cell maturation via SLC6A8-mediated creatine transport
CARD9 deficiency promotes pancreatic cancer growth by blocking dendritic cell maturation via SLC6A8-mediated creatine transport Open
Pancreatic cancer (PC) is featured with low survival rate and poor outcomes. Herein, we found that the expression of caspase-recruitment domain-containing protein 9 (CARD9), predominantly expressed in innate immune cells, was positively re…
View article: Regenerating islet‐derived protein 3 gamma (Reg3g) ameliorates tacrolimus‐induced pancreatic β‐cell dysfunction in mice by restoring mitochondrial function
Regenerating islet‐derived protein 3 gamma (Reg3g) ameliorates tacrolimus‐induced pancreatic β‐cell dysfunction in mice by restoring mitochondrial function Open
Background and Purpose Tacrolimus a first‐line medication used after transplantation can induce β‐cell dysfunction, causing new‐onset diabetes mellitus (NODM). Regenerating islet‐derived protein 3 gamma (Reg3g), a member of the pancreatic …
View article: Reg3g ameliorates Tacrolimus-induced pancreatic β cell dysfunction by restoring mitochondrial function
Reg3g ameliorates Tacrolimus-induced pancreatic β cell dysfunction by restoring mitochondrial function Open
Background and Purpose: Tacrolimus (Tac) induces pancreatic β cell dysfunction, causing new-onset diabetes mellitus (NODM) after transplantation. Reg3g is a member of the pancreatic regenerative gene family, as reported to improve type 1 d…
View article: Saliva specimen complements anal swab in assessing patients with COVID-19 for discharge from hospital
Saliva specimen complements anal swab in assessing patients with COVID-19 for discharge from hospital Open
Since December 2019, coronavirus disease 2019 (COVID-19) caused by SARS coronavirus 2 (SARS-CoV-2) has spread and threatens public health worldwide. The recurrence of SARS-CoV-2 RNA detection in patients after discharge from hospital signa…
View article: The Role of CARD9 in Metabolic Diseases
The Role of CARD9 in Metabolic Diseases Open
Summary Caspase recruitment domain containing protein 9 (CARD9) is an adaptor protein that plays a critical role in pattern recognition receptors (PRRs)-mediated activation of NF-?B and mitogen-activated protein kinase (MAPK). This elicits…
View article: Clinical Features of COVID-19-Related Liver Damage
Clinical Features of COVID-19-Related Liver Damage Open
BACKGROUND A recent outbreak of SARS-CoV-2 infection occurs mainly in China, with rapidly increasing the number of cases (namely COVID-19). Abnormal liver functions are frequently present in these patients, here we aimed to clarify the cli…
View article: Genetic Exploration of Hereditary Immune Diseases
Genetic Exploration of Hereditary Immune Diseases Open
An autoimmune disease is a condition arising from an abnormal immune response to a normal body part.There are at least 80 types of autoimmune diseases, rheumatoid arthritis and systemic sclerosis are two of them.My study focuses on these t…
View article: Using IFN-γ antibodies to identify the pathogens of fungal rhinosinusitis: A novel immunohistochemical approach
Using IFN-γ antibodies to identify the pathogens of fungal rhinosinusitis: A novel immunohistochemical approach Open
Fungal rhinosinusitis (FRS) is commonly caused by various Aspergillus species (spp) and Mucorales fungi, and the treatment and prognosis of cases differ depending on the causative fungus. The present study describes a novel immunohistochem…
View article: Mitochondrial Ca2+ uptake by the voltage-dependent anion channel 2 regulates cardiac rhythmicity
Mitochondrial Ca2+ uptake by the voltage-dependent anion channel 2 regulates cardiac rhythmicity Open
Tightly regulated Ca2+ homeostasis is a prerequisite for proper cardiac function. To dissect the regulatory network of cardiac Ca2+ handling, we performed a chemical suppressor screen on zebrafish tremblor embryos, which suffer from Ca2+ e…
View article: From angiomyolipoma to malignant epithelioid angiomyolipoma of the kidney, a case report with a history of eight years.
From angiomyolipoma to malignant epithelioid angiomyolipoma of the kidney, a case report with a history of eight years. Open
Epithelioid angiomyolipoma (EAML) is a rare subtype of angiomyolipoma (AML) with potential has malign tendency. UP to now, the biological association between EMAL and typical AML is not well known. In the present study, we reported a case …