Caiyun Ma
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View article: METTL3-m6A methylase regulates the osteo-/odontogenic potential of stem cells from apical papilla via NFIC in apical periodontitis
METTL3-m6A methylase regulates the osteo-/odontogenic potential of stem cells from apical papilla via NFIC in apical periodontitis Open
Stem cells from the apical papilla (SCAPs) show strong odontogenic ability and can form root dentin. However, the underlying mechanisms that control the odontogenic differentiation of SCAPs in an inflammatory environment need further explo…
View article: Combination therapy dramatically promotes remyelination
Combination therapy dramatically promotes remyelination Open
Multiple sclerosis (MS) is an immune-mediated disease in the central nervous system that is characterized by demyelination, axonal degeneration, and progressive neurological disability and is so far incurable. Current medications are predo…
View article: Reprogramming astrocytes into dopaminergic neurons to restore motor dysfunction in Parkinson<b>'</b>s disease model rats.
Reprogramming astrocytes into dopaminergic neurons to restore motor dysfunction in Parkinson<b>'</b>s disease model rats. Open
Lentiviral overexpression of NURR1 and ASCL1 efficiently reprograms AS into DA neurons. Transplantation of reprogrammed DA neurons significantly improves motor function in PD rats, highlighting their potential as donor cells for the treatm…
View article: [Parkin deletion affects PINK1/Parkin-mediated mitochondrial autophagy to exacerbate neuroinflammation and accelerate progression of Parkinson's disease in mice].
[Parkin deletion affects PINK1/Parkin-mediated mitochondrial autophagy to exacerbate neuroinflammation and accelerate progression of Parkinson's disease in mice]. Open
Parkin deletion causes mitochondrial autophagy disorder to accelerate PD progression and exacerbates neuroinflammation in mice by affecting the PINK1/Parkin signaling pathway, suggesting the important role of Parkin in early pathogenesis o…
View article: Characteristics and Multilineage Differentiation of a Novel Type of Pulmonary Mesenchymal Stem Cells Derived from Goose Embryos
Characteristics and Multilineage Differentiation of a Novel Type of Pulmonary Mesenchymal Stem Cells Derived from Goose Embryos Open
Pulmonary mesenchymal stem cells (PMSCs) are considered important in therapeutic and regenerative responses to lung injury. Despite extensive studies on the human, porcine, sheep, mouse and rat, it was found that PMSCs, which can been perf…
View article: [Directed differentiation of human induced pluripotent stem cells into midbrain].
[Directed differentiation of human induced pluripotent stem cells into midbrain]. Open
HiPSCs can be effectively induced to differentiate into DAPs capable of differentiating into functional neurons both in vivo and in vitro. In rat models of PD, the transplanted hiPSCs-DAPs can survive for more than 8 weeks in the MFB and d…
View article: In Vitro Culture and Multipotency Evaluation of Broiler Umbilical Cord Mesenchymal Stem Cells
In Vitro Culture and Multipotency Evaluation of Broiler Umbilical Cord Mesenchymal Stem Cells Open
Umbilical cord mesenchymal stem cells (UMSCs) from fetal tissues have become a valuable source of cell regeneration therapy due to their low immunogenicity, high plasticity and antimicrobial peptides. Most researches about UMSCs mainly foc…
View article: PN-QRS: An Uncertainty-aware QRS-complex Detection Method for Wearable ECGs
PN-QRS: An Uncertainty-aware QRS-complex Detection Method for Wearable ECGs Open
Long-term wearable ECG monitoring has increased the influence of ambiguous factors on QRS-complex detection. Reliable ECG information must be extracted from abundant noises and confusing artifacts. To address this issue, we suggest a posit…
View article: PN-QRS: An Uncertainty-aware QRS-complex Detection Method for Wearable ECGs
PN-QRS: An Uncertainty-aware QRS-complex Detection Method for Wearable ECGs Open
Long-term wearable ECG monitoring has increased the influence of ambiguous factors on QRS-complex detection. Reliable ECG information must be extracted from abundant noises and confusing artifacts. To address this issue, we suggest a posit…
View article: Neural progenitor cells derived from fibroblasts induced by small molecule compounds under hypoxia for treatment of Parkinson’s disease in rats
Neural progenitor cells derived from fibroblasts induced by small molecule compounds under hypoxia for treatment of Parkinson’s disease in rats Open
Neural progenitor cells (NPCs) capable of self-renewal and differentiation into neural cell lineages offer broad prospects for cell therapy for neurodegenerative diseases. However, cell therapy based on NPC transplantation is limited by th…
View article: Therapeutic function of a novel rat induced pluripotent stem cell line in a 6‑OHDA‑induced rat model of Parkinson's disease
Therapeutic function of a novel rat induced pluripotent stem cell line in a 6‑OHDA‑induced rat model of Parkinson's disease Open
Parkinson's disease (PD) is a progressive neurodegenerative movement disorder of the central nervous system that results from the loss of dopaminergic (DA) nigral neurons. Induced pluripotent stem cells (iPSCs) have shown potential for cel…
View article: Neural progenitor cells derived from fibroblasts induced by small molecule compounds under hypoxia for treatment of Parkinson's disease in rats
Neural progenitor cells derived from fibroblasts induced by small molecule compounds under hypoxia for treatment of Parkinson's disease in rats Open
Neural progenitor cells (NPCs) capable of self-renewal and differentiation into neural cell lineages offer broad prospe ts for cell therapy for neurodegenerative diseases. However, cell therapy based on NPC transplantation is limited by th…
View article: [VCR, a Small Molecule Compound, Induces Reprogramming of Rat Fibroblasts into Neural Progenitor Cells under Hypoxic Condition].
[VCR, a Small Molecule Compound, Induces Reprogramming of Rat Fibroblasts into Neural Progenitor Cells under Hypoxic Condition]. Open
Our study demonstrates that VCR, a small molecule compound, can directly induce, under a hypoxic condition, the reprogramming of REFs to form ciRNPCs with the potential to be induced for differentiation into glial cells and neurons in vivo…
View article: Identification and Characterization of a Novel Type of Cartilage Stem/ Progenitor Cells from Tibetan Mastiff
Identification and Characterization of a Novel Type of Cartilage Stem/ Progenitor Cells from Tibetan Mastiff Open
This study reports the presence of 119 species from 45 families belonging to 19 orders in the Kocaçay Delta, Turkey, within the borders of the Karacabey District of Bursa Province, in a study conducted over the course of one year (2017).Th…
View article: [Directed differentiation of porcine induced pluripotent stem cells into forebrain GABAergic neuron progenitors].
[Directed differentiation of porcine induced pluripotent stem cells into forebrain GABAergic neuron progenitors]. Open
The miniature-swine iPSCsderived GABA progenitors may serve as promising donor cells for neural grafting for treatment of neurodegenerative diseases.
View article: Multiple functions of reversine on the biological characteristics of sheep fibroblasts
Multiple functions of reversine on the biological characteristics of sheep fibroblasts Open
Previous reports have demonstrated that Reversine can reverse differentiation of lineage-committed cells to mesenchymal stem cells and suppress tumors growth. However, the molecular mechanisms of antitumor activity and promoting cellular d…
View article: RepSox effectively promotes the induced differentiation of sheep fibroblasts into adipocytes via the inhibition of the TGF‑β1/Smad pathway
RepSox effectively promotes the induced differentiation of sheep fibroblasts into adipocytes via the inhibition of the TGF‑β1/Smad pathway Open
Previous reports have demonstrated that RepSox can function as a replacement for cMyc and Sox2 in the reprogramming of cells into induced pluripotent stem cells (iPSCs), as well as increasing the levels of bone morphogenetic protein (BMP)‑…
View article: Long-term neurodevelopment outcomes of hand, foot and mouth disease inpatients infected with EV-A71 or CV-A16, a retrospective cohort study
Long-term neurodevelopment outcomes of hand, foot and mouth disease inpatients infected with EV-A71 or CV-A16, a retrospective cohort study Open
Hand, foot and mouth disease (HFMD) is a common infectious disease in western Asia area and the full range of the long-term sequelae of HFMD remains poorly described. We conducted a retrospective hospital-based cohort study of HFMD patient…
View article: Dendrite-Free Li Metal Plating/Stripping Onto Three-Dimensional Vertical-Graphene@Carbon-Cloth Host
Dendrite-Free Li Metal Plating/Stripping Onto Three-Dimensional Vertical-Graphene@Carbon-Cloth Host Open
Lithium metal is deemed as an ideal anode material for next-generation lithium ion batteries (LIBs) due to its high specific capacity and low redox potential. However, uncontrolled lithium dendrite formation during electrochemical depositi…
View article: Whole exome sequencing and methylation‑specific multiplex ligation‑dependent probe amplification applied to identify Angelman syndrome due to paternal uniparental disomy in two unrelated patients
Whole exome sequencing and methylation‑specific multiplex ligation‑dependent probe amplification applied to identify Angelman syndrome due to paternal uniparental disomy in two unrelated patients Open
Angelman syndrome (AS) is a congenital neuro-developmental disorder typically occurring due to functional defects of the UBE3A gene caused by uniparental disomy (UPD), translocation or single gene mutation. UBE3A gene exhibits imprinting e…
View article: Urchin-Like Ni2/3Co1/3(CO3)1/2(OH)·0.11H2O for High-Performance Supercapacitors
Urchin-Like Ni2/3Co1/3(CO3)1/2(OH)·0.11H2O for High-Performance Supercapacitors Open
Here, we report our finding in the fabrication of novel porous urchin-like Ni2/3Co1/3(CO3)1/2(OH)·0. 11H2O (denoted as NC) nanomaterial composed of numerous nanoneedles through an one-step hydrothermal method, which deliveres a high specif…
View article: Multilineage potential research of Beijing duck amniotic mesenchymal stem cells
Multilineage potential research of Beijing duck amniotic mesenchymal stem cells Open
Amnion, which is usually discarded as medical waste, is considered as abundant sources for mesenchymal stem cells. In human and veterinary medicine, the multipotency of mesenchymal stem cells derived from amnion (AMSCs) together with their…
View article: Isolation and biological characteristic evaluation of a novel type of cartilage stem/progenitor cell derived from Small‑tailed Han sheep embryos
Isolation and biological characteristic evaluation of a novel type of cartilage stem/progenitor cell derived from Small‑tailed Han sheep embryos Open
Cartilage stem/progenitor cells (CSPCs) are a novel stem cell population and function as promising therapeutic candidates for cell‑based cartilage repair. Until now, numerous existing research materials have been obtained from humans, hors…
View article: Isolation, culture and biological characteristics of multipotent porcine tendon-derived stem cells
Isolation, culture and biological characteristics of multipotent porcine tendon-derived stem cells Open
Tendon-derived stem cells (TDSCs), a postulated multi-potential stem cell population, play significant role in the postnatal replenishment of tendon injuries. However, the majority of experimental materials were obtained from horse, rat, h…
View article: A Variant of the Autophagy-Related 5 Gene Is Associated with Child Cerebral Palsy
A Variant of the Autophagy-Related 5 Gene Is Associated with Child Cerebral Palsy Open
Cerebral palsy (CP) is a major cause of childhood disability in developed and developing countries, but the pathogenic mechanisms of CP development remain largely unknown. Autophagy is a highly conserved cellular self-digestion of damaged …