Caleb A. Wood
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View article: Additional file 1 of Doxycycline for transgene control disrupts gut microbiome diversity without compromising acute neuroinflammatory response
Additional file 1 of Doxycycline for transgene control disrupts gut microbiome diversity without compromising acute neuroinflammatory response Open
Additional file 1. Supplementary Table 1.
View article: The TMEM106B T186S coding variant increases neurite arborization and synaptic density in primary hippocampal neurons
The TMEM106B T186S coding variant increases neurite arborization and synaptic density in primary hippocampal neurons Open
The lysosomal protein TMEM106B was identified as a risk modifier of multiple dementias including frontotemporal dementia and Alzheimer’s disease. The gene comes in two major haplotypes, one associated with disease risk, and by comparison, …
View article: Cell-type resolved transcriptomic approaches for dissecting selective vulnerability in neurodegeneration
Cell-type resolved transcriptomic approaches for dissecting selective vulnerability in neurodegeneration Open
Department of Neuroscience, Baylor College of Medicine, Houston, TX, USA (Wood CA) Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA (Tran NM) *Correspondence to: Nicholas M. Tran, PhD, [email protect…
View article: TMEM106B coding variant is protective and deletion detrimental in a mouse model of tauopathy
TMEM106B coding variant is protective and deletion detrimental in a mouse model of tauopathy Open
TMEM106B is a risk modifier for a growing list of age-associated dementias including Alzheimer’s and frontotemporal dementia, yet its function remains elusive. Two key questions that emerge from past work are whether the conservative T185S…
View article: Author response: Activity disruption causes degeneration of entorhinal neurons in a mouse model of Alzheimer’s circuit dysfunction
Author response: Activity disruption causes degeneration of entorhinal neurons in a mouse model of Alzheimer’s circuit dysfunction Open
Article Figures and data Abstract Editor's evaluation eLife digest Introduction Results Discussion Methods Data availability References Decision letter Author response Article and author information Metrics Abstract Neurodegenerative disea…
View article: Acute silencing uncovers multiple forms of activity-dependent neuronal survival in the mature entorhinal cortex
Acute silencing uncovers multiple forms of activity-dependent neuronal survival in the mature entorhinal cortex Open
Neurodegenerative diseases are characterized by selective vulnerability of distinct cell populations; however, the cause for this specificity remains elusive. Many circuits that degenerate in disease are shaped by neural activity during de…
View article: Gene therapy using Aβ variants for amyloid reduction
Gene therapy using Aβ variants for amyloid reduction Open