Caleb F. Anderson
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View article: Modulating Neutrophil Extracellular Trap Formation <i>In Vivo</i> with Locoregional Precision Using Differently Charged Self-Assembled Hydrogels
Modulating Neutrophil Extracellular Trap Formation <i>In Vivo</i> with Locoregional Precision Using Differently Charged Self-Assembled Hydrogels Open
Neutrophil extracellular traps (NETs) are DNA networks released by neutrophils, first described as a defense response against pathogens but have since been associated with numerous inflammatory diseases. Diverse physical material propertie…
View article: Modulating Neutrophil Extracellular Trap Formation<i>In Vivo</i>with Locoregional Precision using Differently Charged Self-Assembled Hydrogels
Modulating Neutrophil Extracellular Trap Formation<i>In Vivo</i>with Locoregional Precision using Differently Charged Self-Assembled Hydrogels Open
Neutrophil extracellular traps (NETs) are DNA networks released by neutrophils first described as a defense response against pathogens but have since been associated with numerous inflammatory diseases. The ability to induce NETs with loco…
View article: Kinetically Controlled Polyelectrolyte Complex Assembly of microRNA‐Peptide Nanoparticles toward Treating Mesothelioma
Kinetically Controlled Polyelectrolyte Complex Assembly of microRNA‐Peptide Nanoparticles toward Treating Mesothelioma Open
Broad size distributions and poor long‐term colloidal stability of microRNA‐carrying nanoparticles, especially those formed by polyelectrolyte complexation, represent major hurdles in realizing their clinical translation. Herein, peptide d…
View article: The Design of a Participatory Peptide Nucleic Acid Duplex Crosslinker to Enhance the Stiffness of Self‐Assembled Peptide Gels
The Design of a Participatory Peptide Nucleic Acid Duplex Crosslinker to Enhance the Stiffness of Self‐Assembled Peptide Gels Open
Herein, peptide nucleic acids (PNAs) are employed in the design of a participatory duplex PNA‐peptide crosslinking agent. Biophysical and mechanical studies show that crosslinkers present during peptide assembly leading to hydrogelation pa…
View article: Supramolecular filaments for concurrent ACE2 docking and enzymatic activity silencing enable coronavirus capture and infection prevention
Supramolecular filaments for concurrent ACE2 docking and enzymatic activity silencing enable coronavirus capture and infection prevention Open
View article: Antiviral supramolecular polymeric hydrogels by self-assembly of tenofovir-bearing peptide amphiphiles
Antiviral supramolecular polymeric hydrogels by self-assembly of tenofovir-bearing peptide amphiphiles Open
Tenofovir-conjugated peptide amphiphiles can assemble and form hydrogels under physiological conditions for sustained therapeutic release. Varying the number of valines in the designs impacts their self-assembly, gelation, and release beha…
View article: Leveraging the therapeutic, biological, and self-assembling potential of peptides for the treatment of viral infections
Leveraging the therapeutic, biological, and self-assembling potential of peptides for the treatment of viral infections Open
View article: Collagen-Binding Peptide-Enabled Supramolecular Hydrogel Design for Improved Organ Adhesion and Sprayable Therapeutic Delivery
Collagen-Binding Peptide-Enabled Supramolecular Hydrogel Design for Improved Organ Adhesion and Sprayable Therapeutic Delivery Open
Spraying serves as an attractive, minimally invasive means of administering hydrogels for localized delivery, particularly due to high-throughput deposition of therapeutic depots over an entire target site of uneven surfaces. However, it r…
View article: Adaptable antibody Nanoworms designed for non-Hodgkin lymphoma
Adaptable antibody Nanoworms designed for non-Hodgkin lymphoma Open
View article: Tumour sensitization via the extended intratumoural release of a STING agonist and camptothecin from a self-assembled hydrogel
Tumour sensitization via the extended intratumoural release of a STING agonist and camptothecin from a self-assembled hydrogel Open
View article: The role of critical micellization concentration in efficacy and toxicity of supramolecular polymers
The role of critical micellization concentration in efficacy and toxicity of supramolecular polymers Open
Significance Critical micellization concentration (CMC) is an important design consideration for developing all supramolecular biomaterials, and in particular for drug delivery systems. Once placed in an in vivo setting, supramolecular mat…
View article: Inhalable nanotherapeutics to improve treatment efficacy for common lung diseases
Inhalable nanotherapeutics to improve treatment efficacy for common lung diseases Open
Respiratory illnesses are prevalent around the world, and inhalation‐based therapies provide an attractive, noninvasive means of directly delivering therapeutic agents to their site of action to improve treatment efficacy and limit adverse…
View article: Kinetic Control in Assembly of Plasmid DNA/Polycation Complex Nanoparticles
Kinetic Control in Assembly of Plasmid DNA/Polycation Complex Nanoparticles Open
Polyelectrolyte complex (PEC) nanoparticles assembled from plasmid DNA (pDNA) and polycations such as linear polyethylenimine (lPEI) represent a major nonviral delivery vehicle for gene therapy tested thus far. Efforts to con…
View article: Protease-Sensitive Nanomaterials for Cancer Therapeutics and Imaging
Protease-Sensitive Nanomaterials for Cancer Therapeutics and Imaging Open
Many diseases can be characterized by the abnormal activity exhibited by various biomolecules, the targeting of which can provide therapeutic and diagnostic utility. Recent trends in medicine and nanotechnology have prompted the developmen…
View article: Peptide-templated noble metal catalysts: syntheses and applications
Peptide-templated noble metal catalysts: syntheses and applications Open
Noble metal catalysts have been widely used in many applications because of their high activity and selectivity. However, a controllable preparation of noble metal catalysts still remains as a significant challenge. To overcome this challe…