Explanipedia

Association between autism spectrum disorder and intentional self-harm Open

Ashley Blanchard, Stanford Chihuri, Caleb Ing, Carolyn DiGuiseppi, Guohua Li · 2025

ASD is associated with a significantly increased risk of ED-treated intentional self-harm, particularly in patients with co-occurring ADHD or ID. Poisoning from psychotropic and other pharmaceutical drugs is the leading mechanism of intent…

Unintentional Drowning Incidents Involving Children with Autism Spectrum Disorder Treated in US Emergency Departments, 2016–2020 Open

Kristal Xie, Ashley Blanchard, Stanford Chihuri, Matthew B. Russell, Caleb Ing , et al. · 2025

Mode of delivery and behavioral and neuropsychological outcomes in children at 10 years of age Open

Andrew Massa, Zhixin Yang, R.D.F. Tamashiro, Oliver G. Isik, Ruth Landau , et al. · 2024

Objectives Previous studies have reported that mode of delivery, particularly cesarean delivery (CD), is associated with neurodevelopmental outcomes in children. This study evaluates behavioral and neuropsychological test scores in childre…

Association between Specialist Palliative Care Use and End-of-Life Care in Patients with Metastatic Cancer (RP321) Open

May Hua, Guo Ling, Caleb Ing, Deven Lackraj, Shuang Wang , et al. · 2024

Behavioural disorders after prenatal exposure to anaesthesia for maternal surgery Open

Caleb Ing, Jeffrey H. Silber, Deven Lackraj, Mark Olfson, Caleb H. Miles , et al. · 2024

Unanswered questions of anesthesia neurotoxicity in the developing brain Open

Caleb Ing, László Vutskits · 2023

Purpose of review This article reviews recent advances and controversies of developmental anesthesia neurotoxicity research with a special focus on the unanswered questions in the field both from clinical and preclinical perspectives. Rece…

Anesthetic Exposure During Childhood and Neurodevelopmental Outcomes Open

Charles Reighard, Shaqif Junaid, William M. Jackson, Ayesha Arif, Hannah Waddington , et al. · 2022

These findings support the hypothesis that associations between anesthetic exposure during childhood and subsequent neurodevelopmental deficits differ based on neurodevelopmental domain.

Long-Term Increases in Mental Disorder Diagnoses After Invasive Mechanical Ventilation for Severe Childhood Respiratory Disease: A Propensity Matched Observational Cohort Study* Open

Andrew S. Geneslaw, Yewei Lu, Caleb H. Miles, May Hua, Joshua Cappell , et al. · 2021

OBJECTIVES: To evaluate neurodevelopmental and mental disorders after PICU hospitalization in children requiring invasive mechanical ventilation for severe respiratory illness. DESIGN: Retrospective longitudinal observational cohort. SETTI…

Prenatal Exposure to General Anesthesia and Childhood Behavioral Deficit Open

Caleb Ing, Ruth Landau, David DeStephano, Caleb H. Miles, Britta S. von Ungern‐Sternberg , et al. · 2021

BACKGROUND: Exposure to surgery and anesthesia in early childhood has been found to be associated with an increased risk of behavioral deficits. While the US Food and Drug Administration (FDA) has warned against prenatal exposure to anesth…

Prospectively assessed neurodevelopmental outcomes in studies of anaesthetic neurotoxicity in children: a systematic review and meta-analysis Open

Caleb Ing, William M. Jackson, Michael J. Zaccariello, Terry E. Goldberg, Mary-Ellen McCann , et al. · 2020

Temporal trends in the incidence of post-dural puncture headache following labor neuraxial analgesia in the United States, 2006 to 2015 Open

Jean Guglielminotti, Ruth Landau, Caleb Ing, G. Li · 2020

Association of Delirium With Long-term Cognitive Decline Open

Terry E. Goldberg, Chen Chen, Yuanjia Wang, Eunice Jung, Antoinette Swanson , et al. · 2020

In this meta-analysis, delirium was significantly associated with long-term cognitive decline in both surgical and nonsurgical patients.

Long-term Healthcare Utilization by Medicaid Enrolled Children with Neonatal Abstinence Syndrome Open

Walter M. Taylor, Yewei Lu, Shuang Wang, Lena S. Sun, Guohua Li , et al. · 2020

Table of Contents Open

Janis M. Dionne, Stephen Bremner, Simin Baygani, Beau Batton, Ebru Ergenekon , et al. · 2020

GAS, PANDA, and MASK: Comment Open

Caleb Ing, Michael J. Zaccariello, Alexandra C. Kirsch, Guohua Li, David O. Warner · 2020

In their recent Editorial, Drs. Vutskits and Culley discuss the General Anesthesia or Awake-regional Anesthesia in Infancy (GAS), Pediatric Anesthesia Neurodevelopment Assessment (PANDA), and Mayo Anesthesia Safety in Kids (MASK) studies.1…

Exposure to Surgery and Anesthesia in Early Childhood and Subsequent Use of Attention Deficit Hyperactivity Disorder Medications Open

Caleb Ing, Xiaoyue Ma, Ming Sun, Yewei Lu, Melanie M. Wall , et al. · 2020

BACKGROUND: Some recent clinical studies have found that early childhood exposure to anesthesia is associated with increased risks of behavioral deficits and clinical diagnoses of attention deficit hyperactivity disorder (ADHD). While diag…

Outcomes Research in Vulnerable Pediatric Populations Open

Ka-Eun M. Lee, Thomas G. Diacovo, Johanna Calderon, Mary Byrne, Caleb Ing · 2018

The Pediatric Anesthesia and Neurodevelopment Assessment (PANDA) study team held its biennial symposium in April 2018 to discuss issues on anesthetic neurotoxicity in the developing brain. One of the sessions invited speakers with differen…

Prolonged Anesthetic Exposure in Children and Factors Associated With Exposure Duration Open

Caleb Ing, Xiaoyue Ma, Anna J. Klausner, Richard P. Dutton, Guohua Li · 2018

Introduction: Anesthetic exposure duration has come under scrutiny because of a Food and Drug Administration warning against prolonged use of anesthesia in children, defined as exposures longer than 3 hours. Methods: Data for 2,613,344 ped…

Identification of perioperative pulmonary aspiration in children using quality assurance and hospital administrative billing data Open

Lisa Eisler, Grace C. Huang, K. Lee, Jennifer Busse, Ming Sun , et al. · 2018

Summary Background Perioperative aspiration is a rare but potentially devastating complication, occurring in 1‐10 per 10 000 anesthetics based on studies of quality assurance databases. Quality assurance reporting is known to underestimate…

Epidemiologic patterns of in-hospital anaphylaxis in pediatric surgical patients Open

Sara A. Sun, Xiaoyue Ma, Guohua Li, Caleb Ing · 2017

Age at Exposure to Surgery and Anesthesia in Children and Association With Mental Disorder Diagnosis Open

Caleb Ing, Ming Sun, Mark Olfson, Charles DiMaggio, Lena S. Sun , et al. · 2017

BACKGROUND: Animals exposed to anesthetics during specific age periods of brain development experience neurotoxicity, with neurodevelopmental changes subsequently observed during adulthood. The corresponding vulnerable age in children, how…

Differences in intraoperative hemodynamics between spinal and general anesthesia in infants undergoing pyloromyotomy Open

Caleb Ing, Lena S. Sun, Alexander F. Friend, Minjae Kim, Mitchell F. Berman , et al. · 2017

Background Hypotension and bradycardia are known side effects of spinal anesthesia in pregnant women undergoing cesarean section and adults undergoing other surgical procedures. Whether children experience similar hemodynamic changes is un…

Duration of general anaesthetic exposure in early childhood and long-term language and cognitive ability Open

Caleb Ing, Mary Hegarty, Jonathon Perkins, Andrew Whitehouse, Charles DiMaggio , et al. · 2016

Summary of the Update Session on Clinical Neurotoxicity Studies Open

Teeda Pinyavat, David O. Warner, Randall P. Flick, Mary Ellen McCann, Dean B. Andropoulos , et al. · 2016

During the Fifth Pediatric Anesthesia Neurodevelopmental Assessment Symposium, experts and stakeholders met to present and discuss recent advances made in the study of neurodevelopmental outcomes after exposure to anesthetic drugs in infan…

What Next After GAS and PANDA? Open

Caleb Ing, Virginia Rauh, David O. Warner, Lena S. Sun · 2016

On April 16 and 17, 2016, the Fifth biennial Pediatric Anesthesia & Neurodevelopment Assessment (PANDA) symposium was convened at the Morgan Stanley Children’s Hospital of New York at Columbia University Medical Center. During the symposiu…

Latent Class Analysis of Neurodevelopmental Deficit After Exposure to Anesthesia in Early Childhood Open

Caleb Ing, Melanie M. Wall, Charles DiMaggio, Andrew Whitehouse, Mary Hegarty , et al. · 2016

Introduction: Although some studies have reported an association between early exposure to anesthesia and surgery and long-term neurodevelopmental deficit, the clinical phenotype of children exposed to anesthesia is still unknown. Methods:…

Adverse Events and Resource Utilization After Spinal and General Anesthesia in Infants Undergoing Pyloromyotomy Open

Caleb Ing, Lena S. Sun, Alexander F. Friend, Arthur Roh, Susan Lei , et al. · 2016

Infants undergoing pyloromyotomy with SA had shorter OR times and postoperative LOS, no significant differences in AE rates, and decreased exposure to IV and inhaled anesthetics, although SA infants often still required supplemental anesth…

Early Anesthesia Exposure and the Effect on Visual Acuity, Refractive Error, and Retinal Nerve Fiber Layer Thickness of Young Adults Open

Seyhan Yazar, Alex W. Hewitt, Hannah Forward, Angela Jacques, Caleb Ing , et al. · 2015

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