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View article: Chemical reprogramming ameliorates cellular hallmarks of aging and extends lifespan
Chemical reprogramming ameliorates cellular hallmarks of aging and extends lifespan Open
The dedifferentiation of somatic cells into a pluripotent state by cellular reprogramming coincides with a reversal of age-associated molecular hallmarks. Although transcription factor induced cellular reprogramming has been shown to ameli…
View article: Loss of H3K9 trimethylation leads to premature aging
Loss of H3K9 trimethylation leads to premature aging Open
Aging is the major risk factor for most human diseases and represents a major socio-economical challenge for modern societies. Despite its importance, the process of aging remains poorly understood. Epigenetic dysregulation has been propos…
View article: Neuron-specific partial reprogramming in the dentate gyrus impacts mouse behavior and ameliorates age-related decline in memory and learning
Neuron-specific partial reprogramming in the dentate gyrus impacts mouse behavior and ameliorates age-related decline in memory and learning Open
Age-associated neurodegenerative disorders represent significant challenges due to progressive neuronal decline and limited treatments. In aged mice, partial reprogramming, characterized by pulsed expression of reprogramming factors, has s…
View article: Loss of H3K9 trimethylation leads to premature aging
Loss of H3K9 trimethylation leads to premature aging Open
SUMMARY Aging is the major risk factor for most human diseases and represents a major socio-economical challenge for modern societies. Despite its importance, the process of aging remains poorly understood. Epigenetic dysregulation has bee…
View article: Comparative analysis of mouse strains for<i>in vivo</i>reprogramming
Comparative analysis of mouse strains for<i>in vivo</i>reprogramming Open
Summary In vivo reprogramming through the forced expression of Oct4, Sox2, Klf4, and c-Myc (OSKM) has demonstrated great potential for reversing age-associated phenotypes, as the combination of these transcription factors actively promote …
View article: Initiation phase cellular reprogramming ameliorates DNA damage in the ERCC1 mouse model of premature aging
Initiation phase cellular reprogramming ameliorates DNA damage in the ERCC1 mouse model of premature aging Open
Unlike aged somatic cells, which exhibit a decline in molecular fidelity and eventually reach a state of replicative senescence, pluripotent stem cells can indefinitely replenish themselves while retaining full homeostatic capacity. The co…
View article: DNA repair‐deficient premature aging models display accelerated epigenetic age
DNA repair‐deficient premature aging models display accelerated epigenetic age Open
Several premature aging mouse models have been developed to study aging and identify interventions that can delay age‐related diseases. Yet, it is still unclear whether these models truly recapitulate natural aging. Here, we analyzed DNA m…
View article: Initiation phase cellular reprogramming ameliorates DNA damage in the ERCC1 mouse model of premature aging
Initiation phase cellular reprogramming ameliorates DNA damage in the ERCC1 mouse model of premature aging Open
Unlike aged somatic cells, which exhibit a decline in molecular fidelity and eventually reach a state of replicative senescence, pluripotent stem cells can indefinitely replenish themselves while retaining full homeostatic capacity. The co…
View article: ERCC1 mice, unlike other premature aging models, display accelerated epigenetic age
ERCC1 mice, unlike other premature aging models, display accelerated epigenetic age Open
Over the last decades, several premature aging mouse models have been developed to study aging and identify interventions that can delay age-related diseases. Yet, it is still unclear whether these models truly recapitulate natural aging. …
View article: Chemical reprogramming ameliorates cellular hallmarks of aging and extends lifespan
Chemical reprogramming ameliorates cellular hallmarks of aging and extends lifespan Open
The dedifferentiation of somatic cells into a pluripotent state by cellular reprogramming coincides with a reversal of age-associated molecular hallmarks. Although transcription factor induced cellular reprogramming has been shown to ameli…
View article: In vivo reprogramming leads to premature death due to hepatic and intestinal failure
In vivo reprogramming leads to premature death due to hepatic and intestinal failure Open
SUMMARY The induction of cellular reprogramming by forced expression of the transcription factors OCT4, SOX2, KLF4, and C-MYC (OSKM) has been shown to allow the dedifferentiation of somatic cells and ameliorate age-associated phenotypes in…