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View article: Biomolecular Interaction, Molecular Docking, Antimicrobial, Antioxidant, Antitumor, Cell Cycle Analysis, and Annexin V/PI Assay Efficiency of Some Co (II), Cu (II), Mn (II), Ni (II), Pd (II), and Pt (II) Complexes With a Halogenated Bidentate Schiff Base
Biomolecular Interaction, Molecular Docking, Antimicrobial, Antioxidant, Antitumor, Cell Cycle Analysis, and Annexin V/PI Assay Efficiency of Some Co (II), Cu (II), Mn (II), Ni (II), Pd (II), and Pt (II) Complexes With a Halogenated Bidentate Schiff Base Open
This study addresses the bioactivity evaluation of some complexes with a halogenated Schiff base ( HL ). The investigation of the biological potential was first performed in silico, through molecular docking studies. Thus, binding affiniti…
View article: Cellular Metabolic Responses to Copper Nanoparticles: Comparison Between Normal and Breast Cancer Cells
Cellular Metabolic Responses to Copper Nanoparticles: Comparison Between Normal and Breast Cancer Cells Open
The use of copper nanoparticles (CuNPs) seems to be an alternative therapeutic strategy for cancer therapy due to low-cost synthesis and anticancer activity. In this work, CuNPs’ effects were tested in various concentrations on two types o…
View article: Aristolochic Acid I Adsorption onto Activated Carbon: Kinetics, Equilibrium, and Thermodynamic Studies
Aristolochic Acid I Adsorption onto Activated Carbon: Kinetics, Equilibrium, and Thermodynamic Studies Open
The removal of phytotoxins from herbal preparations is important due to evidence linking exposure to aristolochic acid I (AAI), a toxin found in Aristolochiaceae species, with certain kidney diseases. This study evaluates the effectiveness…
View article: Fe3O4@β-cyclodextrin Nanosystem: A Promising Adjuvant Approach in Cancer Treatment
Fe3O4@β-cyclodextrin Nanosystem: A Promising Adjuvant Approach in Cancer Treatment Open
The high incidence of melanoma leading to a poor prognosis rate endorses the development of alternative and innovative approaches in the treatment of melanoma. Therefore, the present study aims to develop and characterize, in terms of phys…
View article: A new pathway towards immunotherapy-supported radiology for targeted Boron Neutron Capture Therapy (BNCT)
A new pathway towards immunotherapy-supported radiology for targeted Boron Neutron Capture Therapy (BNCT) Open
Background: We present our novel, patented paradigm of immunotherapy-supported radiology designed to augment conventional FDA-approved Boron Neutron Capture Therapy (BNCT). This innovative approach employs immunocompetent cells as vectors …
View article: In Vitro Antioxidant Effects of Coenzyme Q10 on Cellular Metabolism in Aged Mesenchymal Stem Cells
In Vitro Antioxidant Effects of Coenzyme Q10 on Cellular Metabolism in Aged Mesenchymal Stem Cells Open
(1) Background: this study investigates the short-term effects of coenzyme Q10 (CoQ10) on mitochondrial respiration, fatty acid metabolism, oxidative stress gene expression, and sirtuin activity in young (passage 5, P5) and aged (passage 1…
View article: Quercetin and Mesenchymal Stem Cell Metabolism: A Comparative Analysis of Young and Senescent States
Quercetin and Mesenchymal Stem Cell Metabolism: A Comparative Analysis of Young and Senescent States Open
Quercetin is a natural flavonoid renowned for its potent antioxidant, anti-inflammatory, anti-diabetic, and antibacterial properties, making it a highly promising candidate for the treatment of various medical conditions. Our current study…
View article: Aristolochia clematitis L. Ethanolic Extracts: In Vitro Evaluation of Antioxidant Activity and Cytotoxicity on Caco-2 Cell Line
Aristolochia clematitis L. Ethanolic Extracts: In Vitro Evaluation of Antioxidant Activity and Cytotoxicity on Caco-2 Cell Line Open
Aristolochia sp. plants are used in traditional medicine because of their immunostimulatory and anticarcinogenic properties, despite their content of aristolochic acids (AAs), carcinogenic and nephrotoxic agents. Therefore, ethanolic extra…
View article: Mitochondrial Dysfunction in Aristolochic Acid I-Induced Kidney Diseases: What We Know and What We Do Not Know
Mitochondrial Dysfunction in Aristolochic Acid I-Induced Kidney Diseases: What We Know and What We Do Not Know Open
Aristolochic acids, compounds derived from Aristolochiaceae plant species, are associated with significant renal nephrotoxicity and carcinogenicity. Aristolochic acid I (AAI), the most predominant and potent of these compounds, is a primar…
View article: Experimental Device for the “Green” Synthesis of Unbranched Aliphatic Esters C4–C8 Using an Audio Frequency Electric Field
Experimental Device for the “Green” Synthesis of Unbranched Aliphatic Esters C4–C8 Using an Audio Frequency Electric Field Open
One of the most important reactions in organic synthesis is esterification, and the compounds generated using this process are esters with a wide range of applications in various industries. Numerous approaches have been employed to enhanc…
View article: Stem Cells Derived from Human Exfoliated Deciduous Teeth Functional Assessment: Exploring the Changes of Free Fatty Acids Composition during Cultivation
Stem Cells Derived from Human Exfoliated Deciduous Teeth Functional Assessment: Exploring the Changes of Free Fatty Acids Composition during Cultivation Open
The metabolic regulation of stemness is widely recognized as a crucial factor in determining the fate of stem cells. When transferred to a stimulating and nutrient-rich environment, mesenchymal stem cells (MSCs) undergo rapid proliferation…
View article: Urine Metabolomic Signature of People Diagnosed with Balkan Endemic Nephropathy and Other Types of Chronic Kidney Disease Compared with Healthy Subjects in Romania
Urine Metabolomic Signature of People Diagnosed with Balkan Endemic Nephropathy and Other Types of Chronic Kidney Disease Compared with Healthy Subjects in Romania Open
Metabolomic analysis methods were employed to determine biomarkers for various chronic kidney diseases (CKDs). Modern analytical methods were developed and applied successfully to find a specific metabolomic profile in urine samples from C…
View article: Selection at Multiple Checkpoints Focuses V H 12 B Cell Differentiation toward a Single B-1 Cell Specificity
Selection at Multiple Checkpoints Focuses V H 12 B Cell Differentiation toward a Single B-1 Cell Specificity Open
Phosphatidyl choline (PtC)-specific B cells segregate to the B-1 subset, where they comprise up to 10% of the B-1 repertoire. About half express VH12 and Vκ4/5H and are restricted in VHCDR3. We have previously reported that anti-PtC VHCDR3…
View article: PRELIMINARY STUDY OF SOIL COMPOSITION FROM BALKAN ENDEMIC NEPHROPATHY AREAS, USING A GC-MS METHOD
PRELIMINARY STUDY OF SOIL COMPOSITION FROM BALKAN ENDEMIC NEPHROPATHY AREAS, USING A GC-MS METHOD Open
Balkan endemic nephropathy (BEN) is a chronic kidney disease occurring predominantly in certain rural villages from Balkan Peninsula, including Romania.Peculiar environmental factors, such as drinking water, organic contaminants derived fr…
View article: Design, Synthesis and Biological Activity Evaluation of S-Substituted 1H-5-Mercapto-1,2,4-Triazole Derivatives as Antiproliferative Agents in Colorectal Cancer
Design, Synthesis and Biological Activity Evaluation of S-Substituted 1H-5-Mercapto-1,2,4-Triazole Derivatives as Antiproliferative Agents in Colorectal Cancer Open
Colon cancer is a widespread pathology with complex biochemical etiology based on a significant number of intracellular signaling pathways that play important roles in carcinogenesis, tumor proliferation and metastasis. These pathways func…
View article: Dataset for: Toxicity and Chemistry of Wastewater from Hydraulic Fracture and Conventional Shale Gas Wells
Dataset for: Toxicity and Chemistry of Wastewater from Hydraulic Fracture and Conventional Shale Gas Wells Open
New technology has enabled recovery of inaccessible natural gas shale deposits, however, the human health risks from the migration of brines into drinking water or surface spills are unknown. To provide information that can inform these ri…
View article: Effects of ursolic and oleanolic on SK-MEL-2 melanoma cells: In vitro and in vivo assays
Effects of ursolic and oleanolic on SK-MEL-2 melanoma cells: In vitro and in vivo assays Open
Among the triterpenoids, oleanolic acid (OA) and its isomer, ursolic acid (UA) are promising therapeutic candidates, with potential benefits in the management of melanoma. In this study, we aimed to examine the in vitro and in vivo anti‑in…
View article: Is Aristolochic Acid Really the Cause of the Balkan Endemic Nephropathy?
Is Aristolochic Acid Really the Cause of the Balkan Endemic Nephropathy? Open
In recent years, aristolochic acid has been promoted vigorously as the causal agent of the Balkan endemic nephropathy because of similarities to some other nephropathies, association with DNA adducts and a perception of human exposure via …
View article: Revealing a Pre-neoplastic Renal Tubular Lesion by p-S6 Protein Immunohistochemistry after Rat Exposure to Aristolochic Acid
Revealing a Pre-neoplastic Renal Tubular Lesion by p-S6 Protein Immunohistochemistry after Rat Exposure to Aristolochic Acid Open
Aristolochic acid (AA) has, in the last decade, become widely promoted as the cause of the Balkan endemic nephropathy and associated renal or urothelial tumours, although without substantial focal evidence of the quantitative dietary expos…