Callum G. Davidson
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View article: The Use of Enhanced Analytical Pipelines for the Characterization of Poly(A) and Poly(A)-LNP Formulation Critical Quality Attributes
The Use of Enhanced Analytical Pipelines for the Characterization of Poly(A) and Poly(A)-LNP Formulation Critical Quality Attributes Open
The number of nucleic acid therapeutics is set to grow within the pharmaceutical industry sector, deploying nanocarrier-based delivery systems as drug products. Poly(A) is a widely used model sequence used in lipid nanoparticle (LNP) formu…
View article: Assessment of biophysical properties of the first-in-class anti-cancer IgE antibody drug MOv18 IgE demonstrates monomeric purity and stability
Assessment of biophysical properties of the first-in-class anti-cancer IgE antibody drug MOv18 IgE demonstrates monomeric purity and stability Open
Therapeutic monoclonal antibodies, which are almost exclusively IgG isotypes, show significant promise but are prone to poor solution stability, including aggregation and elevated solution viscosity at dose-relevant concentrations. Recombi…
View article: Low-Cost Microfluidic Mixers: Are They up to the Task?
Low-Cost Microfluidic Mixers: Are They up to the Task? Open
Background/Objectives: Microfluidic mixing has become the gold standard procedure for manufacturing nucleic acid lipid-based delivery systems, offering precise control over critical process parameters. The choice and design of microfluidic…
View article: The use of orthogonal analytical approaches to profile lipid nanoparticle physicochemical attributes
The use of orthogonal analytical approaches to profile lipid nanoparticle physicochemical attributes Open
Lipid nanoparticles (LNPs) have become a major disruptor within the drug delivery field of complex RNA molecules. The wide applicability of prototype nanomedicines has the potential to fill clinical requirements for use against current unt…
View article: Higher or Lower? - The Resolution of Analytical Pipelines for the Evaluation of Lipid Nanoparticle Critical Quality Attributes
Higher or Lower? - The Resolution of Analytical Pipelines for the Evaluation of Lipid Nanoparticle Critical Quality Attributes Open
Dynamic light scattering (DLS) is a routinely used analytical technique to measure the size distribution of a colloidal sample. Nanoparticle tracking analysis (NTA) has more recently emerged as an orthogonal technique to determine particle…