Cally J. Ho
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View article: Loss of ATG4B and ATG4A results in two-stage cell cycle defects in pancreatic ductal adenocarcinoma cells
Loss of ATG4B and ATG4A results in two-stage cell cycle defects in pancreatic ductal adenocarcinoma cells Open
Pancreatic ductal adenocarcinoma (PDAC) exhibits elevated levels of autophagy, which promote tumor progression and treatment resistance. ATG4B is an autophagy-related cysteine protease under consideration as a potential therapeutic target,…
View article: Chloroquine treatment induces secretion of autophagy-related proteins and inclusion of Atg8-family proteins in distinct extracellular vesicle populations
Chloroquine treatment induces secretion of autophagy-related proteins and inclusion of Atg8-family proteins in distinct extracellular vesicle populations Open
Chloroquine (CQ), a lysosomotropic agent, is commonly used to inhibit lysosomal degradation and macroautophagy/autophagy. Here we investigated the cell-extrinsic effects of CQ on secretion. We showed that lysosomal and autophagy inhibition…
View article: Chloroquine treatment induces secretion of autophagy-related proteins and inclusion of Atg8-family proteins in distinct extracellular vesicle populations
Chloroquine treatment induces secretion of autophagy-related proteins and inclusion of Atg8-family proteins in distinct extracellular vesicle populations Open
Chloroquine (CQ), a lysosomotropic agent, is commonly used to inhibit lysosomal degradation and macroautophagy/autophagy. Here we investigated the cell-extrinsic effects of CQ on secretion. We showed that lysosomal and autophagy inhibition…
View article: Puncta intended: connecting the dots between autophagy and cell stress networks
Puncta intended: connecting the dots between autophagy and cell stress networks Open
Proteome profiling and global protein-interaction approaches have significantly improved our knowledge of the protein interactomes of autophagy and other cellular stress-response pathways. New discoveries regarding protein complexes, inter…
View article: Molecular Mechanisms Underlying Autophagy-Mediated Treatment Resistance in Cancer
Molecular Mechanisms Underlying Autophagy-Mediated Treatment Resistance in Cancer Open
Despite advances in diagnostic tools and therapeutic options, treatment resistance remains a challenge for many cancer patients. Recent studies have found evidence that autophagy, a cellular pathway that delivers cytoplasmic components to …
View article: Autophagy Regulation of Metabolism Is Required for CD8+ T Cell Anti-tumor Immunity
Autophagy Regulation of Metabolism Is Required for CD8+ T Cell Anti-tumor Immunity Open
Autophagy is a cell survival process essential for the regulation of immune responses to infections. However, the role of T cell autophagy in anti-tumor immunity is less clear. Here, we demonstrate a cell-autonomous role for autophagy in t…
View article: Diverse mechanisms of autophagy dysregulation and their therapeutic implications: does the shoe fit?
Diverse mechanisms of autophagy dysregulation and their therapeutic implications: does the shoe fit? Open
In its third edition, the Vancouver Autophagy Symposium presented a platform for vibrant discussion on the differential roles of macroautophagy/autophagy in disease. This one-day symposium was held at the BC Cancer Research Centre in Vanco…
View article: A membrane-spanning macrocyclic bolaamphiphile lipid mimic of archaeal lipids
A membrane-spanning macrocyclic bolaamphiphile lipid mimic of archaeal lipids Open
The synthesis of a 72-membered macrocyclic tetraester bolaamphiphile is accomplished in six chemical steps from commercially available starting materials using copper-accelerated azide–alkyne coupling to close the macrocycle in high yield.…