Calvin K. Yip
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View article: Development of an inhibitory TTC7B selective nanobody that blocks EFR3 recruitment of PI4KA
Development of an inhibitory TTC7B selective nanobody that blocks EFR3 recruitment of PI4KA Open
Phosphatidylinositol 4 kinase IIIα (PI4KIIIα/PI4KA) is an essential lipid kinase that plays a critical role in regulating plasma membrane identity. PI4KA is primarily recruited to the plasma membrane through the targeted recruitment by the…
View article: Revisiting the evolution of the yeast Atg1 complex
Revisiting the evolution of the yeast Atg1 complex Open
The budding yeast Saccharomyces cerevisiae Atg1 complex coordinates the initiation of nonselective autophagy and consists of the Atg1 kinase, Atg13 regulatory subunit, and an S-shaped scaffold formed by Atg17, Atg29, and Atg31. In contrast…
View article: Development of an inhibitory TTC7B selective nanobody that blocks EFR3 recruitment of PI4KA
Development of an inhibitory TTC7B selective nanobody that blocks EFR3 recruitment of PI4KA Open
Phosphatidylinositol 4 kinase IIIα (PI4KIIIα/PI4KA) is an essential lipid kinase that plays a critical role in regulating plasma membrane identity. PI4KA is primarily recruited to the plasma membrane through the targeted recruitment by the…
View article: Structure of the human autophagy factor EPG5 and the molecular basis of its conserved mode of interaction with Atg8-family proteins
Structure of the human autophagy factor EPG5 and the molecular basis of its conserved mode of interaction with Atg8-family proteins Open
The multi-step macroautophagy/autophagy process ends with the cargo-laden autophagosome fusing with the lysosome to deliver the materials to be degraded. The metazoan-specific autophagy factor EPG5 plays a crucial role in this step by enfo…
View article: Molecular basis for plasma membrane recruitment of PI4KA by EFR3
Molecular basis for plasma membrane recruitment of PI4KA by EFR3 Open
The lipid kinase phosphatidylinositol 4 kinase III α (PI4KIIIα/PI4KA) is a master regulator of the lipid composition and asymmetry of the plasma membrane. PI4KA exists primarily in a heterotrimeric complex with its regulatory proteins TTC7…
View article: Molecular basis for plasma membrane recruitment of PI4KA by EFR3
Molecular basis for plasma membrane recruitment of PI4KA by EFR3 Open
The lipid kinase phosphatidylinositol 4 kinase III alpha (PI4KIIIα/PI4KA) is a master regulator of the lipid composition and asymmetry of the plasma membrane. PI4KA exists primarily in a heterotrimeric complex with its regulatory proteins …
View article: Structure of Calcineurin bound to PI4KA reveals dual interface in both PI4KA and FAM126A
Structure of Calcineurin bound to PI4KA reveals dual interface in both PI4KA and FAM126A Open
Phosphatidylinositol 4-kinase alpha (PI4KA) maintains the PI4P and phosphatidylserine pools of the plasma membrane. A key regulator of PI4KA is its association into a complex with TTC7 and FAM126 proteins. This complex can be regulated by …
View article: Molecular structures and function of the autophagosome-lysosome fusion machinery
Molecular structures and function of the autophagosome-lysosome fusion machinery Open
Macroautophagy (also known as autophagy) plays a pivotal role in maintaining cellular homeostasis. The terminal step of the multi-step autophagy degradation pathway involves fusion between the cargo-laden, double-membraned autophagosome an…
View article: Novel Genetic and Phenotypic Expansion in GOSR2-Related Progressive Myoclonus Epilepsy
Novel Genetic and Phenotypic Expansion in GOSR2-Related Progressive Myoclonus Epilepsy Open
Biallelic variants in the Golgi SNAP receptor complex member 2 gene (GOSR2) have been reported in progressive myoclonus epilepsy with neurodegeneration. Typical clinical features include ataxia and areflexia during early childhood, followe…
View article: Allosteric activation or inhibition of PI3Kγ mediated through conformational changes in the p110γ helical domain
Allosteric activation or inhibition of PI3Kγ mediated through conformational changes in the p110γ helical domain Open
PI3Kγ is a critical immune signaling enzyme activated downstream of diverse cell surface molecules, including Ras, PKCβ activated by the IgE receptor, and Gβγ subunits released from activated GPCRs. PI3Kγ can form two distinct complexes, w…
View article: Author Response: Allosteric activation or inhibition of PI3Kγ mediated through conformational changes in the p110γ helical domain
Author Response: Allosteric activation or inhibition of PI3Kγ mediated through conformational changes in the p110γ helical domain Open
PI3Kγ is a critical immune signaling enzyme activated downstream of diverse cell surface molecules, including Ras, PKCβ activated by the IgE receptor, and Gβγ subunits released from activated GPCRs. PI3Kγ can form two distinct complexes, w…
View article: Allosteric activation or inhibition of PI3Kγ mediated through conformational changes in the p110γ helical domain
Allosteric activation or inhibition of PI3Kγ mediated through conformational changes in the p110γ helical domain Open
PI3Kγ is a critical immune signaling enzyme activated downstream of diverse cell surface molecules, including Ras, PKCβ activated by the IgE receptor, and Gβγ subunits released from activated GPCRs. PI3Kγ can form two distinct complexes, w…
View article: Reviewer #2 (Public Review): Allosteric activation or inhibition of PI3Kγ mediated through conformational changes in the p110γ helical domain
Reviewer #2 (Public Review): Allosteric activation or inhibition of PI3Kγ mediated through conformational changes in the p110γ helical domain Open
PI3Kγ is a critical immune signaling enzyme activated downstream of diverse cell surface molecules, including Ras, PKCβ activated by the IgE receptor, and Gβγ subunits released from activated GPCRs. PI3Kγ can form two distinct complexes, w…
View article: Reviewer #1 (Public Review): Allosteric activation or inhibition of PI3Kγ mediated through conformational changes in the p110γ helical domain
Reviewer #1 (Public Review): Allosteric activation or inhibition of PI3Kγ mediated through conformational changes in the p110γ helical domain Open
PI3Kγ is a critical immune signaling enzyme activated downstream of diverse cell surface molecules, including Ras, PKCβ activated by the IgE receptor, and Gβγ subunits released from activated GPCRs. PI3Kγ can form two distinct complexes, w…
View article: Allosteric activation or inhibition of PI3Kγ mediated through conformational changes in the p110γ helical domain
Allosteric activation or inhibition of PI3Kγ mediated through conformational changes in the p110γ helical domain Open
PI3Kγ is a critical immune signaling enzyme activated downstream of diverse cell surface molecules, including Ras, PKCβ activated by the IgE receptor, and Gβγ subunits released from activated GPCRs. PI3Kγ can form two distinct complexes, w…
View article: Allosteric activation or inhibition of PI3Kγ mediated through conformational changes in the p110γ helical domain
Allosteric activation or inhibition of PI3Kγ mediated through conformational changes in the p110γ helical domain Open
PI3Kγ is a critical immune signaling enzyme activated downstream of diverse cell surface molecules, including Ras, PKCβ activated by the IgE receptor, and Gβγ subunits released from activated GPCRs. PI3Kγ can form two distinct complexes, w…
View article: Allosteric activation or inhibition of PI3Kγ mediated through conformational changes in the p110γ helical domain
Allosteric activation or inhibition of PI3Kγ mediated through conformational changes in the p110γ helical domain Open
PI3Kγ is a critical immune signaling enzyme activated downstream of diverse cell surface molecules, including Ras, PKCβ activated by the IgE receptor, and Gβγ subunits released from activated GPCRs. PI3Kγ can form two distinct complexes, w…
View article: Biochemical Characterization of the TINTIN Module of the NuA4 Complex Reveals Allosteric Regulation of Nucleosome Interaction
Biochemical Characterization of the TINTIN Module of the NuA4 Complex Reveals Allosteric Regulation of Nucleosome Interaction Open
Trimer Independent of NuA4 involved in Transcription Interactions with Nucleosomes (TINTIN) is an integral module of the essential yeast lysine acetyltransferase complex NuA4 that plays key roles in transcription regulation and DNA repair.…
View article: A balancing act: interactions within NuA4/TIP60 regulate picNuA4 function in <i>Saccharomyces cerevisiae</i> and humans
A balancing act: interactions within NuA4/TIP60 regulate picNuA4 function in <i>Saccharomyces cerevisiae</i> and humans Open
The NuA4 lysine acetyltransferase complex acetylates histone and nonhistone proteins and functions in transcription regulation, cell cycle progression, and DNA repair. NuA4 harbors an interesting duality in that its catalytic module can fu…
View article: Rational Generation of Monoclonal Antibodies Selective for Pathogenic Forms of Alpha-Synuclein
Rational Generation of Monoclonal Antibodies Selective for Pathogenic Forms of Alpha-Synuclein Open
Misfolded toxic forms of alpha-synuclein (α-Syn) have been implicated in the pathogenesis of synucleinopathies, including Parkinson’s disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA). The α-Syn oligomers and…
View article: Molecular basis for differential activation of p101 and p84 complexes of PI3Kγ by Ras and GPCRs
Molecular basis for differential activation of p101 and p84 complexes of PI3Kγ by Ras and GPCRs Open
Class IB phosphoinositide 3-kinase (PI3Kγ) is activated in immune cells by diverse stimuli and can form two distinct complexes, with the p110γ catalytic subunit binding to either p101 or p84 regulatory subunits. These two complexes are dif…
View article: Biochemical and Structural Characterization of Human Core Elongator and Its Subassemblies
Biochemical and Structural Characterization of Human Core Elongator and Its Subassemblies Open
Conserved from yeast to humans and composed of six core subunits (Elp1-Elp6), Elongator is a multiprotein complex that catalyzes the modification of the anticodon loop of transfer RNAs (tRNAs) and in turn regulates messenger RNA decoding e…
View article: Structure of the phosphoinositide 3-kinase (PI3K) p110γ-p101 complex reveals molecular mechanism of GPCR activation
Structure of the phosphoinositide 3-kinase (PI3K) p110γ-p101 complex reveals molecular mechanism of GPCR activation Open
The structure of class IB PI3K (p110γ-p101) reveals mechanism of GPCR activation and differences from class IA PI3Ks.