Calvin R. Wei
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View article: Multidrug-resistant tuberculosis (MDR-TB); an evolving threat to the nigerian health system; a review
Multidrug-resistant tuberculosis (MDR-TB); an evolving threat to the nigerian health system; a review Open
Multi-drug-resistant tuberculosis (MDR-TB) is an increasing public health issue that threatens the efforts in the treatment and control of tuberculosis (TB) worldwide, including in Nigeria. According to the World Health Organization (WHO),…
View article: Malaria in the Democratic Republic of Congo: how support programs consolidate elimination gains and protect at-risk populations from recrudescence
Malaria in the Democratic Republic of Congo: how support programs consolidate elimination gains and protect at-risk populations from recrudescence Open
Malaria remains a significant public health challenge in the Democratic Republic of Congo (DR Congo), particularly among pregnant women and children under 5, who bear the highest burden of disease and mortality. Despite efforts to scale up…
View article: Association Between Elevated Neutrophil-to-Lymphocyte Ratio and Mortality Risk in Community-Acquired Pneumonia: A Systematic Review and Meta-Analysis
Association Between Elevated Neutrophil-to-Lymphocyte Ratio and Mortality Risk in Community-Acquired Pneumonia: A Systematic Review and Meta-Analysis Open
The neutrophil-to-lymphocyte ratio (NLR), derived from routine complete blood count parameters, has emerged as a potential prognostic biomarker reflecting systemic inflammation and immune dysfunction. This systematic review and meta-analys…
View article: Effectiveness and reliability of AI in diagnosis and robot-assisted spinal and cranial surgery: efficient outcomes and ethical worries
Effectiveness and reliability of AI in diagnosis and robot-assisted spinal and cranial surgery: efficient outcomes and ethical worries Open
Background: Artificial intelligence (AI) and machine learning (ML) have significantly advanced medical diagnostics and surgical procedures, particularly in spinal and cranial surgery. Robotic-assisted surgery has emerged as a transformativ…
View article: Advancements in myelofibrosis management: a comprehensive analysis of Ojjaara (Momelotinib) therapy and clinical perspectives
Advancements in myelofibrosis management: a comprehensive analysis of Ojjaara (Momelotinib) therapy and clinical perspectives Open
Myelofibrosis (MF) is a rare and progressive blood disorder marked by fibrosis of the bone marrow, abnormal blood cell production, and often severe anemia. The disease is commonly associated with debilitating symptoms such as fatigue, weak…
View article: Bioactive Potential and Health Benefits of <i>Trigonella foenum‐graecum</i> L.: A Comprehensive Review
Bioactive Potential and Health Benefits of <i>Trigonella foenum‐graecum</i> L.: A Comprehensive Review Open
Fenugreek seeds ( Trigonella foenum‐graecum L.) are known for their impressive range of health benefits, thanks to their diverse array of phytochemicals. These include steroidal sapogenins like diosgenin, alkaloids such as trigonelline, as…
View article: National strategies and challenges in the fight against typhoid fever and other invasive salmonellosis in Kenya: the urgency to act
National strategies and challenges in the fight against typhoid fever and other invasive salmonellosis in Kenya: the urgency to act Open
Salmonellosis and typhoid fever are public health challenges in Kenya causing a significant mortality rate, especially among vulnerable children. Typhoid fever is endemic in Kenya, with an estimated 126 000 cases occurring annually. In mos…
View article: Kenya’s national burden of monkeypox: a public health emergency, a review
Kenya’s national burden of monkeypox: a public health emergency, a review Open
Infection with Orthopoxvirus Mpox is steadily becoming a public health menace in Kenya. This review seeks to provide insight into the disease’s epidemiology, clinical-attendance, preventive mechanisms, surveillance efforts, and the associa…
View article: Economics of Task‐Shifting in Surgery: A Systematic Review
Economics of Task‐Shifting in Surgery: A Systematic Review Open
Background and Aim Due to the global shortage in the surgical workforce, especially in low‐resource settings, one solution to increase surgical volume is to delegate certain roles of surgeons to other trained non‐surgeon health workers. Ho…
View article: Cumulative Hepatoprotective, Antihyperlipidemic and Antioxidant Effects of Methanolic Seeds Extract of <scp> <i>Citrullus lanatus</i> </scp> , <scp> <i>Cucumis melo</i> </scp> , <scp> <i>Cucumis sativus</i> </scp> , and <scp> <i>Cucurbita maxima</i> </scp> With <scp>GC</scp> – <scp>MS</scp> Profile
Cumulative Hepatoprotective, Antihyperlipidemic and Antioxidant Effects of Methanolic Seeds Extract of <span> <i>Citrullus lanatus</i> </span> , <span> <i>Cucumis melo</i> </span> , <span> <i>Cucumis sativus</i> </span> , and <span> <i>Cucurbita maxima</i> </span> With <span>GC</span> – <span>MS</span> Profile Open
The complex pathophysiological mechanism of nonalcoholic fatty liver (NAFLD) disease has made the prevention and treatment of the disease problematic. The aim of the current study is to evaluate the cumulative hepatoprotective, antihyperli…
View article: A Review on Cold Plasma Technology for Pesticide-Free Food Safety: Mechanisms, Efficiency, and Future Perspectives
A Review on Cold Plasma Technology for Pesticide-Free Food Safety: Mechanisms, Efficiency, and Future Perspectives Open
Pesticides are essential in modern agriculture but often leave harmful residues on food, raising considerable health and environmental concerns. Cold plasma technology, initially developed for applications in the polymer and electronics in…
View article: Exploring the national burden and challenges in the fight against yellow fever in the Democratic Republic of Congo: a review
Exploring the national burden and challenges in the fight against yellow fever in the Democratic Republic of Congo: a review Open
The Democratic Republic of Congo (DR Congo) is facing a public health emergency due to numerous infectious diseases, predominately yellow fever. Since 2015, numerous outbreaks of the illness have occurred in the country which resulted in d…
View article: Exploring murE protein inhibitors of Tropheryma whipplei through pharmacoinformatic approaches incorporating solubility-enhancing formulation insights
Exploring murE protein inhibitors of Tropheryma whipplei through pharmacoinformatic approaches incorporating solubility-enhancing formulation insights Open
Tropheryma whipplei the causative agent of Whipple disease, presents a diagnostic challenge due to its diverse symptomatology, including weight loss, abdominal pain, diarrhea, joint pain, fever, and occasionally neurological manifestations…
View article: Prevalence and risk of antibiotic self-medication and unexpected determinants among patients admitted to the emergency department in a resource-limited setting: a cross-sectional study
Prevalence and risk of antibiotic self-medication and unexpected determinants among patients admitted to the emergency department in a resource-limited setting: a cross-sectional study Open
Background The overuse of antibiotics without a medical prescription has a major consequence: the development of bacterial resistance, which can lead to incurable invasive infections and increase global mortality. This study aims to determ…
View article: Interventional three-tube method for the management of duodenal perforation after endoscopic retrograde cholangiopancreatography for choledocholithiasis: a case series
Interventional three-tube method for the management of duodenal perforation after endoscopic retrograde cholangiopancreatography for choledocholithiasis: a case series Open
The interventional three-tube method is an effective method for treating duodenal perforations following ERCP, offering a less invasive alternative for this type of complication.
View article: Efficacy and Safety of Vitamin E in Adults With Metabolic Dysfunction-Associated Steatohepatitis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Efficacy and Safety of Vitamin E in Adults With Metabolic Dysfunction-Associated Steatohepatitis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials Open
This systematic review and meta-analysis evaluated the efficacy and safety of vitamin E supplementation in adults with metabolic dysfunction-associated steatohepatitis (MASH), formerly known as nonalcoholic steatohepatitis (NASH). A compre…
View article: A Comparative Analysis of Global Responses to Monkeypox Outbreaks: Lessons Learned and Future Directions – a Mini Narrative Review
A Comparative Analysis of Global Responses to Monkeypox Outbreaks: Lessons Learned and Future Directions – a Mini Narrative Review Open
Background and Aims: The widespread of Mpox, a zoonotic disease, beyond its endemic regions and declaration of Mpox as a public health emergency by WHO, has raised a global concern. This study aims to compare and analyze the response of va…
View article: A retrospective cohort study on retrograde intramedullary nailing in management of femur fractures in tertiary care hospital at Bujumbura, Burundi
A retrospective cohort study on retrograde intramedullary nailing in management of femur fractures in tertiary care hospital at Bujumbura, Burundi Open
Intramedullary nailing happens to be the standard treatment for fractures. The purpose of this project is to weigh the place of retrograde intramedullary nailing in the management of femoral fractures in a surgical setting of a low-income …
View article: Efficacy of Blinatumomab in Pediatric Acute Lymphoblastic Leukemia: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Efficacy of Blinatumomab in Pediatric Acute Lymphoblastic Leukemia: A Systematic Review and Meta-Analysis of Randomized Controlled Trials Open
Blinatumomab, a bispecific T-cell engager antibody, has emerged as a promising immunotherapeutic agent for pediatric acute lymphoblastic leukemia (ALL), yet comprehensive evidence regarding its efficacy remains limited. This systematic rev…
View article: Clinical manifestation and management in a resource-limited setting of Ballantyne syndrome (Mirror syndrome) associated with preeclampsia, a case report
Clinical manifestation and management in a resource-limited setting of Ballantyne syndrome (Mirror syndrome) associated with preeclampsia, a case report Open
Introduction and importance: Ballantyne syndrome, also known as triple edema or maternal mirror syndrome, is an extremely rare clinical condition characterized by maternal edema, placentomegaly, and fetal hydrops. Its rarity and overlappin…
View article: Prevalence of Vitamin D Deficiency in Children and Adolescents With Type 1 Diabetes Mellitus: A Systematic Review and Meta-Analysis
Prevalence of Vitamin D Deficiency in Children and Adolescents With Type 1 Diabetes Mellitus: A Systematic Review and Meta-Analysis Open
Our systematic review and meta-analysis examined the proportion of vitamin D deficiency in children and adolescents with type 1 diabetes mellitus (T1DM). We conducted a comprehensive literature search across multiple databases, including P…
View article: Comparative Cardiovascular Outcomes of Dapagliflozin Versus Empagliflozin in Patients With Type 2 Diabetes: A Meta-Analysis
Comparative Cardiovascular Outcomes of Dapagliflozin Versus Empagliflozin in Patients With Type 2 Diabetes: A Meta-Analysis Open
Sodium-glucose co-transporter-2 (SGLT2) inhibitors have demonstrated significant cardiovascular benefits in patients with type 2 diabetes. However, head-to-head comparisons between dapagliflozin and empagliflozin, two widely prescribed SGL…
View article: Comparative Efficacy of Continuous Positive Airway Pressure Versus High-Flow Nasal Cannula Therapy in Children With Acute Bronchiolitis: A Systematic Review and Meta-Analysis
Comparative Efficacy of Continuous Positive Airway Pressure Versus High-Flow Nasal Cannula Therapy in Children With Acute Bronchiolitis: A Systematic Review and Meta-Analysis Open
This systematic review and meta-analysis compared the efficacy of continuous positive airway pressure (CPAP) and high-flow nasal cannula (HFNC) therapy in children with acute bronchiolitis. A comprehensive literature search across multiple…
View article: Artificial intelligence in dental radiology: a narrative review
Artificial intelligence in dental radiology: a narrative review Open
This article examines how artificial intelligence (AI) is revolutionizing dental radiology, a vital aspect of dental diagnosis and treatment planning. AI improves diagnosis accuracy through sophisticated applications like automated anomaly…
View article: Hemodynamically stable despite ruptured cesarean scar ectopic pregnancy: a case report and literature review
Hemodynamically stable despite ruptured cesarean scar ectopic pregnancy: a case report and literature review Open
Introduction and importance: The increasing prevalence of cesarean sections has raised concerns regarding associated risks such as ectopic pregnancy, placenta previa, and placenta accreta. Cesarean scar ectopic pregnancy (CSEP), although u…
View article: A pelvis MR transformer-based deep learning model for predicting lung metastases risk in patients with rectal cancer
A pelvis MR transformer-based deep learning model for predicting lung metastases risk in patients with rectal cancer Open
Objective Accurate preoperative evaluation of rectal cancer lung metastases (RCLM) is critical for implementing precise medicine. While artificial intelligence (AI) methods have been successful in detecting liver and lymph node metastases …