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View article: The Neuroimmunome of Hepatitis Patients Associates With Disease Severity
The Neuroimmunome of Hepatitis Patients Associates With Disease Severity Open
Hepatitis is a systemic disease marked by neuroimmune dysregulation beyond hepatic inflammation. Using a systems biology approach, we conducted transcriptomic meta‐analyses across in vitro models, liver tissues, and PBMCs from hepatitis vi…
View article: Combinational BET and mTOR inhibition unveils EGR1 as acute myeloid leukemia prognostic biomarker
Combinational BET and mTOR inhibition unveils EGR1 as acute myeloid leukemia prognostic biomarker Open
This study investigated the anti-leukemic potential of BET inhibitors in combination with mTOR inhibitors, focusing on both BET-resistant and BET-sensitive AML cell lines. Our findings reveal a significant suppression of proliferation and …
View article: Downregulation of Enteroendocrine Genes Predicts Survival in Colon Cancer: A Bioinformatics-Based Analysis
Downregulation of Enteroendocrine Genes Predicts Survival in Colon Cancer: A Bioinformatics-Based Analysis Open
Colorectal cancer (CRC) is the fourth most common and the third mostly deadly cancer globally. Even with alternative therapies, some patients do not respond to treatment. Identifying modulations in the tumor microenvironment (TME) of CRC i…
View article: Metabolic reprogramming drives acquired venetoclax resistance in Acute Myeloid Leukemia and reveals targetable vulnerabilities
Metabolic reprogramming drives acquired venetoclax resistance in Acute Myeloid Leukemia and reveals targetable vulnerabilities Open
Despite the clinical success of the BCL2 inhibitor venetoclax in acute myeloid leukemia (AML), treatment resistance frequently emerges, leading to relapse. Mounting evidence suggests that metabolic reprogramming contributes to venetoclax r…
View article: Sulforaphane-Loaded Hydrogel Prolongs Fully MHC-Mismatched Skin Allograft Survival
Sulforaphane-Loaded Hydrogel Prolongs Fully MHC-Mismatched Skin Allograft Survival Open
Despite immunosuppression, acute rejection (AR) is still a common setback among transplantation patients and is a risk factor for graft survival. Sulforaphane (SFN), a phytochemical present in crucifers, has been shown to have anti-inflamm…
View article: Downregulation of Enteroendocrine Genes Predicts Survival in Colon Cancer: A Bioinformatics-Based Analysis
Downregulation of Enteroendocrine Genes Predicts Survival in Colon Cancer: A Bioinformatics-Based Analysis Open
Colorectal cancer (CRC) is the fourth and the third most common and deadlycancer, respectively, worldwide. Even with alternative therapies, some patients do notrespond to treatment. Identifying modulations in the tumor microenvironment (TM…
View article: Artificial intelligence and systems biology analysis in stem cell research and therapeutics development
Artificial intelligence and systems biology analysis in stem cell research and therapeutics development Open
Background: Stem cell research has rapidly advanced during the past decades, but the translation into approved clinical products is still lagging behind. Multiple barriers to effective clinical translation exist. We hypothesize that an ine…
View article: HTLV-1-Induced Neuroimmunome Correlates with Disease Progression and Severity
HTLV-1-Induced Neuroimmunome Correlates with Disease Progression and Severity Open
HTLV-1 infects 10–20 million people globally. While most remain asymptomatic, some develop severe neuroinflammatory or malignant diseases, such as adult T-cell leukemia/lymphoma (ATL) and HTLV-1-associated myelopathy/tropical spastic parap…
View article: Protection of Adipose Tissue by Pioglitazone in a Mouse Model of Doxorubicin Treatment
Protection of Adipose Tissue by Pioglitazone in a Mouse Model of Doxorubicin Treatment Open
Cancer is a global epidemic with increasing incidence, which needs continuous efforts to enhance treatment efficacy and reduce side effects. Our study focuses on the impact of doxorubicin, a widely used chemotherapeutic agent, on white adi…
View article: COVID-19 vaccination atlas using an integrative systems vaccinology approach
COVID-19 vaccination atlas using an integrative systems vaccinology approach Open
The COVID-19 vaccinations have played a significant role in controlling the pandemic. To elucidate their impact on the immune system, a COVID-19 vaccination atlas was developed using an integrative systems vaccinology approach. The atlas i…
View article: Spatial immune profiling reveals distinct microenvironments in medullary thyroid carcinoma
Spatial immune profiling reveals distinct microenvironments in medullary thyroid carcinoma Open
Introduction Medullary thyroid carcinoma (MTC) is a rare and aggressive thyroid cancer with a challenging prognosis. While the immune microenvironment plays a crucial role in cancer progression, its role in MTC remains underexplored compar…
View article: SARM1: a key multifaceted component in immunoregulation, inflammation and neurodegeneration
SARM1: a key multifaceted component in immunoregulation, inflammation and neurodegeneration Open
The downstream signaling pathways of TLR activation involve a family of adaptor proteins, including MYD88, TIRAP, TRIF, TRAM, and SARM1. The first four proteins stimulate inflammatory and antiviral responses, playing crucial roles in innat…
View article: Sustainable wafer-scale integration of epitaxial ZnO on silicon for piezoelectric devices
Sustainable wafer-scale integration of epitaxial ZnO on silicon for piezoelectric devices Open
To sustainably support the ongoing energetic transition, we need functional metal oxides capable of converting energy, and produce storage, and sensing devices. However, these materials suffer from a high economic cost of manufacturing, an…
View article: Policy from Scientific Publications from São Paulo Researchers: Analysis from the Overton Database
Policy from Scientific Publications from São Paulo Researchers: Analysis from the Overton Database Open
Policy interventions often aim to address complex challenges (e.g, the UN Sustainable Development Goals) requiring input from various stakeholders. Funding organizations are placing a greater emphasis on the longer-term socioeconomic impac…
View article: Vascular injury in glomerulopathies: the role of the endothelium
Vascular injury in glomerulopathies: the role of the endothelium Open
In glomerulopathies, endothelial dysfunction and the presence of histological vascular lesions such as thrombotic microangiopathy, arteriolar hyalinosis, and arteriosclerosis are related to a severe clinical course and worse renal prognosi…
View article: CXCR3-expressing myeloid cells recruited to the hypothalamus protect against diet-induced body mass gain and metabolic dysfunction
CXCR3-expressing myeloid cells recruited to the hypothalamus protect against diet-induced body mass gain and metabolic dysfunction Open
Microgliosis plays a critical role in diet-induced hypothalamic inflammation. A few hours after a high-fat diet (HFD), hypothalamic microglia shift to an inflammatory phenotype, and prolonged fat consumption leads to the recruitment of bon…
View article: Multiomics reveals age-dependent metabolic reprogramming of macrophages by wound bed niche secreted signals
Multiomics reveals age-dependent metabolic reprogramming of macrophages by wound bed niche secreted signals Open
Summary The cellular metabolism of macrophages depends on tissue niches and can control macrophage inflammatory or resolving phenotypes. Yet, the identity of signals within tissue niches that control macrophage metabolism is not well under…
View article: Immunoglobulin A Antibodies: From Protection to Harmful Roles
Immunoglobulin A Antibodies: From Protection to Harmful Roles Open
Immunoglobulin A (IgA) is the most abundantly produced antibody in humans. IgA is a unique class of immunoglobulin due to its multiple molecular forms, and a defining difference between the two subclasses: IgA1 has a long hinge‐region that…
View article: A self-adjuvanted VLPs-based Covid-19 vaccine proven versatile, safe, and highly protective
A self-adjuvanted VLPs-based Covid-19 vaccine proven versatile, safe, and highly protective Open
Vaccination has played a critical role in mitigating COVID-19. Despite the availability of licensed vaccines, there remains a pressing need for improved vaccine platforms that provide high protection, safety, and versatility, while also re…