Cambyz Irajie
YOU?
Author Swipe
View article: Cinnamic acid conjugated with triazole acetamides as anti-Alzheimer and anti-melanogenesis candidates: an in vitro and in silico study
Cinnamic acid conjugated with triazole acetamides as anti-Alzheimer and anti-melanogenesis candidates: an in vitro and in silico study Open
View article: Amino-7,8-dihydro-4H-chromenone derivatives as potential inhibitors of acetylcholinesterase and butyrylcholinesterase for Alzheimer’s disease management; in vitro and in silico study
Amino-7,8-dihydro-4H-chromenone derivatives as potential inhibitors of acetylcholinesterase and butyrylcholinesterase for Alzheimer’s disease management; in vitro and in silico study Open
View article: Unveiling promising breast cancer biomarkers: an integrative approach combining bioinformatics analysis and experimental verification
Unveiling promising breast cancer biomarkers: an integrative approach combining bioinformatics analysis and experimental verification Open
View article: Design, synthesis, in vitro, and in silico evaluations of kojic acid derivatives linked to amino pyridine moiety as potent tyrosinase inhibitors
Design, synthesis, in vitro, and in silico evaluations of kojic acid derivatives linked to amino pyridine moiety as potent tyrosinase inhibitors Open
In the present study, novel series of kojic acid derivatives conjugated to amino pyridine moiety were designed and synthesized to explore their inhibitory activity against tyrosinase. To this end, the structure of all derivatives was chara…
View article: Escherichia coli <i>cytosine deaminase: Structural and biotechnological aspects</i>
Escherichia coli <i>cytosine deaminase: Structural and biotechnological aspects</i> Open
Suicide gene therapy involves introducing viral or bacterial genes into tumor cells, which enables the conversion of a nontoxic prodrug into a toxic‐lethal drug. The application of the bacterial cytosine deaminase (bCD)/5‐fluorocytosine (5…
View article: Correction to: Identification of potential RapJ hits as sporulation pathway inducer candidates in Bacillus coagulans via structure-based virtual screening and molecular dynamics simulation studies
Correction to: Identification of potential RapJ hits as sporulation pathway inducer candidates in Bacillus coagulans via structure-based virtual screening and molecular dynamics simulation studies Open
View article: Tissue Extract from Brittle Star Undergoing Arm Regeneration Promotes Wound Healing in Rat
Tissue Extract from Brittle Star Undergoing Arm Regeneration Promotes Wound Healing in Rat Open
This study set out to evaluate the wound healing properties of brittle star extracts in vitro and in vivo. Due to the great arm regeneration potential of the brittle star, Ophiocoma cynthiae, the present study aimed to evaluate the wound h…
View article: Synthesis and tyrosinase inhibitory activities of novel isopropylquinazolinones
Synthesis and tyrosinase inhibitory activities of novel isopropylquinazolinones Open
To find new anti-browning and whitening agents in this study, new series of isopropylquinazolinone derivatives were designed and synthesized. All derivatives were evaluated as possible tyrosinase inhibitors and compound 9q bearing 4-fluoro…
View article: [1,2,4]triazolo[3,4-b][1,3,4]thiadiazole derivatives as new therapeutic candidates against urease positive microorganisms: design, synthesis, pharmacological evaluations, and in silico studies
[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole derivatives as new therapeutic candidates against urease positive microorganisms: design, synthesis, pharmacological evaluations, and in silico studies Open
Regarding the important role of the urease enzyme as a virulence factor in urease-positive microorganisms in this study, new series of [1,2,4]triazolo[3,4-b][1,3,4]thiadiazole derivatives were designed and synthesized. All compounds evalua…
View article: Synthesis, in vitro α-glucosidase inhibitory activities, and molecular dynamic simulations of novel 4-hydroxyquinolinone-hydrazones as potential antidiabetic agents
Synthesis, in vitro α-glucosidase inhibitory activities, and molecular dynamic simulations of novel 4-hydroxyquinolinone-hydrazones as potential antidiabetic agents Open
View article: Hydroalcoholic extract of Glycyrrhiza glabra root combined with Linum usitatissimum oil as an alternative for hormone replacement therapy in ovariectomized rats
Hydroalcoholic extract of Glycyrrhiza glabra root combined with Linum usitatissimum oil as an alternative for hormone replacement therapy in ovariectomized rats Open
View article: Synthesis and structure–activity relationship studies of benzimidazole-thioquinoline derivatives as α-glucosidase inhibitors
Synthesis and structure–activity relationship studies of benzimidazole-thioquinoline derivatives as α-glucosidase inhibitors Open
In this article, different s-substituted benzimidazole-thioquinoline derivatives were designed, synthesized, and evaluated for their possible α-glucosidase inhibitory activities. The most active compound in this series, 6j (X = 4-bromobenz…
View article: Thioquinoline derivatives conjugated to thiosemicarbazide as potent tyrosinase inhibitors with anti-melanogenesis properties
Thioquinoline derivatives conjugated to thiosemicarbazide as potent tyrosinase inhibitors with anti-melanogenesis properties Open
View article: Primary Spontaneous Pneumothorax: Open Thoracotomy vs. Video-assisted Thoracoscopic Surgery: A Single-center Retrospective Cohort Study.
Primary Spontaneous Pneumothorax: Open Thoracotomy vs. Video-assisted Thoracoscopic Surgery: A Single-center Retrospective Cohort Study. Open
When compared to open thoracotomy, VATS could be the primary treatment option in the surgical treatment of PSP due to the shorter length of surgery and decreased complications such as air leakage.
View article: Design and synthesis of new N-thioacylated ciprofloxacin derivatives as urease inhibitors with potential antibacterial activity
Design and synthesis of new N-thioacylated ciprofloxacin derivatives as urease inhibitors with potential antibacterial activity Open
View article: The effect of hydroalcoholic extract of Psidium guajava L. on experimentally induced oral mucosal wound in rat
The effect of hydroalcoholic extract of Psidium guajava L. on experimentally induced oral mucosal wound in rat Open
View article: New solid phase methodology for the synthesis of biscoumarin derivatives: experimental and in silico approaches
New solid phase methodology for the synthesis of biscoumarin derivatives: experimental and in silico approaches Open
The simple and greener one-pot approach for the synthesis of biscoumarin derivatives using catalytic amounts of nano-MoO 3 catalyst under mortar-pestle grinding was described. The use of non-toxic and mild catalyst, cost-effectiveness, ord…
View article: The Promising Therapeutic and Preventive Properties of Anthocyanidins/Anthocyanins on Prostate Cancer
The Promising Therapeutic and Preventive Properties of Anthocyanidins/Anthocyanins on Prostate Cancer Open
As water-soluble flavonoid derivatives, anthocyanidins and anthocyanins are the plants pigments mostly rich in berries, pomegranate, grapes, and dark color fruits. Many bioactivity properties of these advantageous phytochemicals have been …
View article: Investigating the Effect of Hydroalcoholic Extract of Licorice Root to Prevent Ovariectomy‐Mediated Complications
Investigating the Effect of Hydroalcoholic Extract of Licorice Root to Prevent Ovariectomy‐Mediated Complications Open
Introduction . The importance of women’s health and the quality of life after menopause is a critical issue. To prevent disability and menopause complications as well as avoid the side effects of hormone replacement therapy (HRT), in this …
View article: Linarin, a Glycosylated Flavonoid, with Potential Therapeutic Attributes: A Comprehensive Review
Linarin, a Glycosylated Flavonoid, with Potential Therapeutic Attributes: A Comprehensive Review Open
Many flavonoids, as eminent phenolic compounds, have been commercialized and consumed as dietary supplements due to their incredible human health benefits. In the present study, a bioactive flavone glycoside linarin (LN) was designated to …
View article: A left lung with four lobes: a new discovery during the thoracotomy for recurrent primary spontaneous pneumothorax
A left lung with four lobes: a new discovery during the thoracotomy for recurrent primary spontaneous pneumothorax Open
View article: Comparative Evaluation of the Analgesic Effects of Pistacia atlantica Leaves, Gum, and Fruit Extracts in Rats
Comparative Evaluation of the Analgesic Effects of Pistacia atlantica Leaves, Gum, and Fruit Extracts in Rats Open
Background: Pistacia atlantica (PA) trees grow in all areas of Iran. Pistacia atlantica fruit is edible and mostly consumed by residents. Also, PA leaves, gum, and fruit are considered to have medicinal value in traditional medicine. Objec…
View article: The Antioxidant and Anti-Inflammatory Effects of Quercus brantii Extract on TNBS-Induced Ulcerative Colitis in Rats
The Antioxidant and Anti-Inflammatory Effects of Quercus brantii Extract on TNBS-Induced Ulcerative Colitis in Rats Open
Objectives. Ulcerative colitis is a common subtype of persistent inflammatory bowel disease with high morbidity consequences. Despite unknown definite pathogenesis, multiple anti-inflammatory medications are used for its treatment. Traditi…
View article: In Silico Design and Evaluation of PRAME+FliCΔD2D3 as a New Breast Cancer Vaccine Candidate.
In Silico Design and Evaluation of PRAME+FliCΔD2D3 as a New Breast Cancer Vaccine Candidate. Open
PRAME+FliCΔD2D3 is a stable and soluble chimeric protein that can stimulate humoral and cellular immunity. The obtained results can be utilized for the development of an experimental vaccine against breast cancer.
View article: WITHDRAWN: Evaluating the Five Escherichia coli Derivative Strains as Platform for Arginine Deiminase Overproduction
WITHDRAWN: Evaluating the Five Escherichia coli Derivative Strains as Platform for Arginine Deiminase Overproduction Open
Escherichia coli is one of the most preferred host microorganisms for the production of recombinant proteins due to its well-characterized genome, availability of various expression vectors and host strains. Choosing a proper host strain f…
View article: Effect of flaxseed oil on biochemical parameters, hormonal indexes and stereological changes in ovariectomized rats
Effect of flaxseed oil on biochemical parameters, hormonal indexes and stereological changes in ovariectomized rats Open
The ovariectomized rat is a widely used preclinical model for studying postmenopausal and its complications. In this study, the therapeutic effect of flaxseed oil on the ovariectomized adult rats was investigated. Our results showed that b…
View article: The protective effects of grape seed oil on induced osteoarthritis of the knee in male rat models
The protective effects of grape seed oil on induced osteoarthritis of the knee in male rat models Open
View article: Effect of hydroalcoholic extract of Berberis integerrima and resveratrol on ovarian morphology and biochemical parameters in Letrozole-induced polycystic ovary syndrome rat model: An experimental study
Effect of hydroalcoholic extract of Berberis integerrima and resveratrol on ovarian morphology and biochemical parameters in Letrozole-induced polycystic ovary syndrome rat model: An experimental study Open
Background: Resveratrol and Berberis integerrima (B. integerrima) are known to be natural antioxidants and regulators of human metabolism. However, the effects of resveratrol and B. integerrima on the ovarian morphology in polycystic ovary…
View article: In Silico Design and Evaluation of scFv-CdtB as a Novel Immunotoxin for Breast Cancer Treatment
In Silico Design and Evaluation of scFv-CdtB as a Novel Immunotoxin for Breast Cancer Treatment Open
Background: Breast cancer is the most prevalent type of cancer among the female population, and about 15% to 20% of patients with breast cancer is human epidermal growth factor receptor 2 (HER2)-positive. The current cancer treatment metho…
View article: In silico analysis of signal peptides for secretory production of a-amylase in Bacillus subtilis
In silico analysis of signal peptides for secretory production of a-amylase in Bacillus subtilis Open
α-Amylases are important commercial enzymes and have a broad application in industrial processes and medicine. Gram-positive bacteria such as Bacillus subtilis are possible host organisms for α-amylases secretory production. Secretion of α…