Cameron Shaw
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Cognitive simulation for the procedural skills learning of medical students: A systematic review. Open
Background Cognitive simulation, where individuals deliberately rehearse procedural tasks using the mind without physical action, has been demonstrated to improve technical skills across various disciplines such as aviation and elite sport…
Cognitive simulation for the procedural skills learning of medical students: A systematic review. Open
Background Cognitive simulation where individuals deliberately rehearse procedural tasks using the mind without physical action has been demonstrated to improve technical skills across various disciplines such as aviation and elite sport. …
Heritable intraspecific variation among prey in size and movement interact to shape predation risk and potential natural selection Open
Predator and prey traits are important determinants of the outcomes of trophic interactions. In turn, the outcomes of trophic interactions shape predator and prey trait evolution. How species' traits respond to selection from trophic inter…
View article: Longitudinal epidemiology of multiple sclerosis over 60 years in Newcastle, Australia: 1961 to 2021
Longitudinal epidemiology of multiple sclerosis over 60 years in Newcastle, Australia: 1961 to 2021 Open
The Newcastle region continues to be a high frequency zone for MS. The incidence rate from onset is significantly increased from previous estimates, but incidence rate from diagnosis is stable. Prevalence and incidence sex ratios have stab…
The Impact of Simulated Ward Rounds on the Clinical Education of Final-Year Medical Students: A Systematic Review Open
(1) Background: Final-year medical students often feel under prepared for their transition into clinical practice. Clinical ward rounds and shadowing approach this issue by building transferable skills; however, they are highly variable, w…
Heritable intraspecific variation among prey in size and movement interact to shape predation risk and potential natural selection Open
Predator and prey traits are important determinants of the outcomes of trophic interactions. In turn, the outcomes of trophic interactions shape the evolution of predator and prey traits. How species’ traits are likely to respond to select…
View article: Vitamin D did not reduce multiple sclerosis disease activity after a clinically isolated syndrome
Vitamin D did not reduce multiple sclerosis disease activity after a clinically isolated syndrome Open
Low serum levels of 25-hydroxyvitamin D [25(OH)D] and low sunlight exposure are known risk factors for the development of multiple sclerosis. Add-on vitamin D supplementation trials in established multiple sclerosis have been inconclusive.…
2675 Longitudinal epidemiology of multiple sclerosis in Townsville, Queensland, Australia 2012–2022 Open
Background Multiple sclerosis (MS) is the most common cause of nontraumatic disability in young adults. Though Australia is a high frequency region for MS, North Queensland is regarded as a region of low prevalence. However the previous es…
Longitudinal epidemiology of multiple sclerosis in Townsville, Queensland, Australia, 2012-2022 Open
These results show that Townsville is a high-frequency region for MS, with prevalence and incidence on par with that seen at higher latitudes in Australia. These results have implications for clinical practice in the region and for organis…
View article: The risk of secondary progressive multiple sclerosis is geographically determined but modifiable
The risk of secondary progressive multiple sclerosis is geographically determined but modifiable Open
Geographical variations in the incidence and prevalence of multiple sclerosis have been reported globally. Latitude as a surrogate for exposure to ultraviolet radiation but also other lifestyle and environmental factors are regarded as dri…
View article: Comparative Effectiveness of Autologous Hematopoietic Stem Cell Transplant vs Fingolimod, Natalizumab, and Ocrelizumab in Highly Active Relapsing-Remitting Multiple Sclerosis
Comparative Effectiveness of Autologous Hematopoietic Stem Cell Transplant vs Fingolimod, Natalizumab, and Ocrelizumab in Highly Active Relapsing-Remitting Multiple Sclerosis Open
Importance Autologous hematopoietic stem cell transplant (AHSCT) is available for treatment of highly active multiple sclerosis (MS). Objective To compare the effectiveness of AHSCT vs fingolimod, natalizumab, and ocrelizumab in relapsing-…
A pro-inflammatory diet in people with multiple sclerosis is associated with an increased rate of relapse and increased FLAIR lesion volume on MRI in early multiple sclerosis: A prospective cohort study Open
Background: A pro-inflammatory diet has been posited to induce chronic inflammation within the central nervous system (CNS), and multiple sclerosis (MS) is an inflammatory disease of the CNS. Objective: We examined whether Dietary Inflamma…
View article: Early non-disabling relapses are important predictors of disability accumulation in people with relapsing-remitting multiple sclerosis
Early non-disabling relapses are important predictors of disability accumulation in people with relapsing-remitting multiple sclerosis Open
Background: The prognostic significance of non-disabling relapses in people with relapsing-remitting multiple sclerosis (RRMS) is unclear. Objective: To determine whether early non-disabling relapses predict disability accumulation in RRMS…
View article: Comparative effectiveness in multiple sclerosis: A methodological comparison
Comparative effectiveness in multiple sclerosis: A methodological comparison Open
Background: In the absence of evidence from randomised controlled trials, observational data can be used to emulate clinical trials and guide clinical decisions. Observational studies are, however, susceptible to confounding and bias. Amon…
View article: Variability of the response to immunotherapy among subgroups of patients with multiple sclerosis
Variability of the response to immunotherapy among subgroups of patients with multiple sclerosis Open
Background and purpose This study assessed the effect of patient characteristics on the response to disease‐modifying therapy (DMT) in multiple sclerosis (MS). Methods We extracted data from 61,810 patients from 135 centers across 35 count…
2327 Latitude, UVR and multiple sclerosis severity Open
Objectives This study aimed to investigate the association between latitude of residence, ultraviolet B radiation exposure (UVB) and MS severity. Methods This observational study used MSBase registry data. Included patients met the 2005 or…
View article: Treatment satisfaction in patients with relapsing-remitting multiple sclerosis initiated on teriflunomide in routine clinical practice: Australian observational data
Treatment satisfaction in patients with relapsing-remitting multiple sclerosis initiated on teriflunomide in routine clinical practice: Australian observational data Open
Background Adherence and persistence are critical to optimising therapeutic benefit from disease-modifying therapies (DMTs) in relapsing-remitting multiple sclerosis (RRMS). This prospective, open-label, multicentre, observational study (A…
View article: Confirmed disability progression as a marker of permanent disability in multiple sclerosis
Confirmed disability progression as a marker of permanent disability in multiple sclerosis Open
Background and purpose The prevention of disability over the long term is the main treatment goal in multiple sclerosis (MS); however, randomized clinical trials evaluate only short‐term treatment effects on disability. This study aimed to…
Long-term trajectories of employment status, workhours and disability support pension status, after a first episode of CNS demyelination Open
Background: People with multiple sclerosis face significant employment-related challenges, with little known of the drivers of these outcomes. Objective: We examined prospective trajectories of employment-related outcomes up to 11 years fo…
Neurological Health: Not Merely the Absence of Disease: Current Wellbeing Instruments Across the Spectrum of Neurology Open
Objective. Well-being and quality of life can vary independently of disease. Instruments measuring well-being and quality of life are commonly used in neurology, but there has been little investigation into the extent in which they accurat…
View article: Association of Latitude and Exposure to Ultraviolet B Radiation With Severity of Multiple Sclerosis
Association of Latitude and Exposure to Ultraviolet B Radiation With Severity of Multiple Sclerosis Open
In temperate zones, MS severity is associated with latitude. This association is mainly, but not exclusively, driven by UVB exposure contributing to both MS susceptibility and severity.
Physician Burnout and the Electronic Health Record Leading Up to and During the First Year of COVID-19: Systematic Review Open
Background Physician burnout was first documented in 1974, and the electronic health record (EHR) has been known to contribute to the symptoms of physician burnout. Authors pondered the extent of this effect, recognizing the increased use …
Physician Burnout and the Electronic Health Record Leading Up to and During the First Year of COVID-19: Systematic Review (Preprint) Open
BACKGROUND Physician burnout was first documented in 1974, and the electronic health record (EHR) has been known to contribute to the symptoms of physician burnout. Authors pondered the extent of this effect, recognizing the increased use …
250 New Zealand super rugby injury surveillance: match injuries from 2015–2018 Open
Background Rugby union is a collision-based sport, as such the occurrence of injuries resulting in time-loss from participation is inevitable. In 2015 New Zealand Rugby (NZR) began an injury surveillance program with all NZ-based Super Rug…
Developing a clinical–environmental–genotypic prognostic index for relapsing-onset multiple sclerosis and clinically isolated syndrome Open
Our inability to reliably predict disease outcomes in multiple sclerosis remains an issue for clinicians and clinical trialists. This study aims to create, from available clinical, genetic and environmental factors; a clinical–environmenta…
View article: MRI Patterns Distinguish AQP4 Antibody Positive Neuromyelitis Optica Spectrum Disorder From Multiple Sclerosis
MRI Patterns Distinguish AQP4 Antibody Positive Neuromyelitis Optica Spectrum Disorder From Multiple Sclerosis Open
Neuromyelitis optica spectrum disorder (NMOSD) and multiple sclerosis (MS) are inflammatory diseases of the CNS. Overlap in the clinical and MRI features of NMOSD and MS means that distinguishing these conditions can be difficult. With the…
006 Comparison of multiple disease modifying therapies in multiple sclerosis with marginal structural models Open
Background Because of methodological challenges comparisons of multiple treatments in multiple sclerosis cohorts have been limited to pairwise and triple comparisons. Objectives Extend marginal structural models (MSM) to allow simultaneous…
Effect of Disease-Modifying Therapy on Disability in Relapsing-Remitting Multiple Sclerosis Over 15 Years Open
This study provides Class IV evidence that, for patients with relapsing-remitting MS, long-term exposure to immunotherapy prevents neurologic disability.