Cameron D. Adams
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View article: Development of the aganglionic colon following surgical rescue in a cell therapy model of Hirschsprung disease in rat
Development of the aganglionic colon following surgical rescue in a cell therapy model of Hirschsprung disease in rat Open
Patients with Hirschsprung disease lack enteric ganglia in the distal colon and propulsion of colorectal content is substantially impaired. Proposed stem cell therapies to replace neurons require surgical bypass of the aganglionic bowel du…
View article: Engineered AAVs for non-invasive gene delivery to rodent and non-human primate nervous systems
Engineered AAVs for non-invasive gene delivery to rodent and non-human primate nervous systems Open
Gene therapy offers great promise in addressing neuropathologies associated with the central and peripheral nervous systems (CNS and PNS). However, genetic access remains difficult, reflecting the critical need for the development of effec…
View article: Engineered AAVs for Non-Invasive Functional Transgene Expression in Rodent and Non-Human Primate Central and Peripheral Nervous Systems
Engineered AAVs for Non-Invasive Functional Transgene Expression in Rodent and Non-Human Primate Central and Peripheral Nervous Systems Open
View article: Surgical method to prevent early death of neonatal rat pups with Hirschsprung disease, thus permitting development of long-term therapeutic approaches
Surgical method to prevent early death of neonatal rat pups with Hirschsprung disease, thus permitting development of long-term therapeutic approaches Open
Hirschsprung disease occurs when children are born with no intrinsic nerve cells in varying lengths of the large intestine. In the most severe cases, neurons are also missing from the distal part of the small intestine. Nerve-mediated rela…
View article: Activation of lateral hypothalamic group III metabotropic glutamate receptors suppresses cocaine-seeking following abstinence and normalizes drug-associated increases in excitatory drive to orexin/hypocretin cells
Activation of lateral hypothalamic group III metabotropic glutamate receptors suppresses cocaine-seeking following abstinence and normalizes drug-associated increases in excitatory drive to orexin/hypocretin cells Open
View article: Activation of lateral hypothalamic group III mGluRs suppresses drug-seeking following abstinence and cocaine-associated increases in excitatory drive to orexin/hypocretin cells
Activation of lateral hypothalamic group III mGluRs suppresses drug-seeking following abstinence and cocaine-associated increases in excitatory drive to orexin/hypocretin cells Open
The perifornical/lateral hypothalamic area (LHA) orexin (hypocretin) system is involved in drug-seeking behavior elicited by drug-associated stimuli. Cocaine exposure is associated with presynaptic plasticity at LHA orexin cells such that …
View article: Chemogenetic activation of the lateral hypothalamus reverses early life stress‐induced deficits in motivational drive
Chemogenetic activation of the lateral hypothalamus reverses early life stress‐induced deficits in motivational drive Open
Altered motivated behaviour is a cardinal feature of several neuropsychiatric conditions including mood disorders. One well‐characterized antecedent to the development of mood disorders is exposure to early life stress ( ELS ). A key brain…