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View article: Pathogenic mitochondrial DNA mutations inhibit melanoma metastasis
Pathogenic mitochondrial DNA mutations inhibit melanoma metastasis Open
Mitochondrial DNA (mtDNA) mutations are frequent in cancer, yet their precise role in cancer progression remains debated. To functionally evaluate the impact of mtDNA variants on tumor growth and metastasis, we developed an enhanced cytopl…
View article: Metabolic inflexibility promotes mitochondrial health during liver regeneration
Metabolic inflexibility promotes mitochondrial health during liver regeneration Open
Mitochondria are critical for proper organ function and mechanisms to promote mitochondrial health during regeneration would benefit tissue homeostasis. We report that during liver regeneration, proliferation is suppressed in electron tran…
View article: Contribution of thick ascending limb and distal convoluted tubule to glucose-induced hypercalciuria in healthy controls
Contribution of thick ascending limb and distal convoluted tubule to glucose-induced hypercalciuria in healthy controls Open
Sugar increases urine calcium and magnesium as well as kidney stone and bone disease risk. Our study provided new insights into the underlying mechanism as we gave healthy subjects an oral glucose load and used newer tools such as fraction…
View article: Pathogenic mitochondrial DNA mutations inhibit melanoma metastasis
Pathogenic mitochondrial DNA mutations inhibit melanoma metastasis Open
Mitochondrial DNA (mtDNA) mutations are frequently observed in cancer, but their contribution to tumor progression is controversial. To evaluate the impact of mtDNA variants on tumor growth and metastasis, we created human melanoma cytopla…
View article: The outer mitochondrial membrane protein TMEM11 demarcates spatially restricted BNIP3/BNIP3L-mediated mitophagy
The outer mitochondrial membrane protein TMEM11 demarcates spatially restricted BNIP3/BNIP3L-mediated mitophagy Open
Mitochondria play critical roles in cellular metabolism and to maintain their integrity, they are regulated by several quality control pathways, including mitophagy. During BNIP3/BNIP3L-dependent receptor-mediated mitophagy, mitochondria a…
View article: Differential requirements for mitochondrial electron transport chain components in the adult murine liver
Differential requirements for mitochondrial electron transport chain components in the adult murine liver Open
Mitochondrial electron transport chain (ETC) dysfunction due to mutations in the nuclear or mitochondrial genome is a common cause of metabolic disease in humans and displays striking tissue specificity depending on the affected gene. The …
View article: A mitofusin 2/HIF1α axis sets a maturation checkpoint in regenerating skeletal muscle
A mitofusin 2/HIF1α axis sets a maturation checkpoint in regenerating skeletal muscle Open
A fundamental issue in regenerative medicine is whether there exist endogenous regulatory mechanisms that limit the speed and efficiency of the repair process. We report the existence of a maturation checkpoint during muscle regeneration t…
View article: Author response: Differential requirements for mitochondrial electron transport chain components in the adult murine liver
Author response: Differential requirements for mitochondrial electron transport chain components in the adult murine liver Open
Article Figures and data Abstract Editor's evaluation eLife digest Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Mitochond…
View article: Differential requirements for mitochondrial electron transport chain components in the adult murine liver
Differential requirements for mitochondrial electron transport chain components in the adult murine liver Open
Summary Mitochondrial electron transport chain (ETC) dysfunction due to mutations in the nuclear or mitochondrial genome is a common cause of metabolic disease in humans, and displays striking tissue specificity depending on the affected g…