Cameron K. Tebbi
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Aspergillus flavus with Mycovirus as an Etiologic Factor for Acute Leukemias in Susceptible Individuals: Evidence and Discussion Open
Several etiologic factors for the development of acute leukemias have been suggested; however, none is applicable to all cases. We isolated a certain mycovirus-containing Aspergillus flavus (MCAF) from the home of a patient with acute lymp…
Mycovirus-Containing <em>Aspergillus flavus</em> as an Etiologic Factor for Acute Leukemias in Genetically Susceptible Individuals Open
Several etiologic factors for the development of acute leukemias have been suggested, however, none is applicable to all cases. We have isolated a certain mycovirus-containing Aspergillus flavus (MCAF) from the home of a patient with acute…
Mycovirus-Containing Aspergillus flavus Alters Transcription Factors in Normal and Acute Lymphoblastic Leukemia Cells Open
Transcription factors control genes to maintain normal hemopoiesis, and dysregulation of some factors can lead to acute lymphoblastic leukemia (ALL). Mycoviruses are known to alter the genetics of their fungal host. The present study evalu…
Exposure to Mycovirus-Containing Aspergillus flavus Alters Transcription Factors in Normal and Leukemia Cell Lines Open
Transcription factors bind specific DNA motifs to regulate the expression of target genes in order to maintain normal hematopoiesis [...]
Mycoviruses in Fungi: Carcinogenesis of Fungal Agents May Not Always Be Mycotoxin Related Open
Certain viruses have been found to induce diverse biological pathways to carcinogenesis, evidenced by the presence of viral gene products in some tumors. Despite the fact that many fungal agents contain mycoviruses, until recently, their p…
Sickle Cell Disease, a Review Open
Sickle cell disease and its variants constitute the most common inherited blood disorders affecting millions of individuals worldwide. Significant information regarding the nature of the genetic mutations and modifier genes that result in …
View article: Mycovirus Containing <i>Aspergillus flavus</i> and Acute Lymphoblastic Leukemia: Carcinogenesis beyond Mycotoxin Production
Mycovirus Containing <i>Aspergillus flavus</i> and Acute Lymphoblastic Leukemia: Carcinogenesis beyond Mycotoxin Production Open
Carcinogenic effects of Aspergillus spp. have been well established and generally attributed to a variety of mycotoxin productions, particularly aflatoxins. It is known that most carcinogenic mycotoxins, with the exception of fumonisins, a…
Etiology of Acute Leukemia: A Review Open
Acute leukemias constitute some of the most common malignant disorders. Despite significant progress made in the treatment of these disorders, their etiology remains unknown. A large and diverse group of genetic and environmental variables…
View article: Effect of Poloxamer 188 vs Placebo on Painful Vaso-Occlusive Episodes in Children and Adults With Sickle Cell Disease
Effect of Poloxamer 188 vs Placebo on Painful Vaso-Occlusive Episodes in Children and Adults With Sickle Cell Disease Open
ClinicalTrials.gov Identifier: NCT01737814.
Etiology of Acute Leukemia. A Review Open
Acute leukemias constitute some of the most common malignant disorders. Despite significant progress made in the treatment of these disorders, their etiology remains unknown. A large and diverse group of genetic and environmental variables…
Exposure to a mycovirus containing Aspergillus Flavus reproduces acute lymphoblastic leukemia cell surface and genetic markers in cells from patients in remission and not controls Open
The etiology of acute lymphoblastic leukemia (ALL) remains unknown. A recent "two-hit" model for the occurrence of precursor B cell acute lymphoblastic leukemia propose that this disease arises through a two-step process, including predisp…