Conan J O O’Brien
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View article: Class A Scavenger Receptor MARCO negatively regulates Ace expression and aldosterone production
Class A Scavenger Receptor MARCO negatively regulates Ace expression and aldosterone production Open
Aldosterone is a potent cholesterol-derived steroid hormone that plays a major role in controlling blood pressure via regulation of blood volume. The release of aldosterone is typically controlled by the renin-angiotensin aldosterone syste…
View article: Macrophage Regulation of Hypothalamic-Pituitary-Adrenal and Gonadal Axis Homeostasis and Hormonal Output
Macrophage Regulation of Hypothalamic-Pituitary-Adrenal and Gonadal Axis Homeostasis and Hormonal Output Open
Macrophages are critical immune cells present in virtually every tissue, where they contribute to tissue homeostasis beyond their traditional immune roles. Past and recent evidence highlights their involvement in endocrine regulation, part…
View article: Navigating Total Ankle Replacement: A Patient's Guide Through the Web
Navigating Total Ankle Replacement: A Patient's Guide Through the Web Open
Category: Ankle; Arthroscopy Introduction/Purpose: Ankle osteoarthritis, primarily posttraumatic, affects younger patients with extended life expectancies, significantly impacting their physical and mental quality of life. Surgical interve…
View article: Drug repurposing screen identifies novel anti-inflammatory activity of sunitinib in macrophages
Drug repurposing screen identifies novel anti-inflammatory activity of sunitinib in macrophages Open
Inflammation is a driver of human disease and an unmet clinical need exists for new anti-inflammatory medicines. As a key cell type in both acute and chronic inflammatory pathologies, macrophages are an appealing therapeutic target for ant…
View article: Reviewer #1 (Public Review): MARCO in alveolar macrophages negatively regulates Ace expression and aldosterone production
Reviewer #1 (Public Review): MARCO in alveolar macrophages negatively regulates Ace expression and aldosterone production Open
Aldosterone is a potent cholesterol-derived steroid hormone that plays a major role in controlling blood pressure via regulation of blood volume. The release of aldosterone is typically controlled by the renin-angiotensin aldosterone syste…
View article: Reviewer #2 (Public Review): MARCO in alveolar macrophages negatively regulates Ace expression and aldosterone production
Reviewer #2 (Public Review): MARCO in alveolar macrophages negatively regulates Ace expression and aldosterone production Open
Aldosterone is a potent cholesterol-derived steroid hormone that plays a major role in controlling blood pressure via regulation of blood volume. The release of aldosterone is typically controlled by the renin-angiotensin aldosterone syste…
View article: MARCO in alveolar macrophages negatively regulates Ace expression and aldosterone production
MARCO in alveolar macrophages negatively regulates Ace expression and aldosterone production Open
Aldosterone is a potent cholesterol-derived steroid hormone that plays a major role in controlling blood pressure via regulation of blood volume. The release of aldosterone is typically controlled by the renin-angiotensin aldosterone syste…
View article: Author Response: MARCO in alveolar macrophages negatively regulates Ace expression and aldosterone production
Author Response: MARCO in alveolar macrophages negatively regulates Ace expression and aldosterone production Open
Aldosterone is a potent cholesterol-derived steroid hormone that plays a major role in controlling blood pressure via regulation of blood volume. The release of aldosterone is typically controlled by the renin-angiotensin aldosterone syste…
View article: Class A scavenger receptor MARCO negatively regulates Ace expression and aldosterone production
Class A scavenger receptor MARCO negatively regulates Ace expression and aldosterone production Open
Aldosterone is a potent cholesterol-derived steroid hormone that plays a major role in controlling blood pressure via regulation of blood volume. The release of aldosterone is typically controlled by the renin–angiotensin–aldosterone syste…
View article: Class A Scavenger Receptor MARCO negatively regulates Ace expression and aldosterone production
Class A Scavenger Receptor MARCO negatively regulates Ace expression and aldosterone production Open
Aldosterone is a potent cholesterol-derived steroid hormone that plays a major role in controlling blood pressure via regulation of blood volume. The release of aldosterone is typically controlled by the renin-angiotensin aldosterone syste…
View article: Distinct adrenal gland macrophages regulate corticosteroid production
Distinct adrenal gland macrophages regulate corticosteroid production Open
Summary The adrenal glands are hormone secreting glands that sit on top of the kidneys. Adrenal glands produce glucocorticoids, mineralocorticoids, and catecholamines, and are therefore critical regulators of the stress response, the immun…
View article: Immunomodulatory Leptin Receptor<sup>+</sup>Sympathetic Perineurial Cells Protect Against Obesity by Facilitating Neuroendocrine-Mediated Brown Adipose Tissue Thermogenesis
Immunomodulatory Leptin Receptor<sup>+</sup>Sympathetic Perineurial Cells Protect Against Obesity by Facilitating Neuroendocrine-Mediated Brown Adipose Tissue Thermogenesis Open
Summary Adipose tissues (ATs) are innervated by sympathetic nerves, which drive reduction of fat mass via lipolysis and thermogenesis. Here, we report a population of immunomodulatory leptin receptor (LepR)-expressing barrier cells which e…
View article: A Tale of Three Systems: Toward a Neuroimmunoendocrine Model of Obesity
A Tale of Three Systems: Toward a Neuroimmunoendocrine Model of Obesity Open
The prevalence of obesity is on the rise. What was once considered a simple disease of energy imbalance is now recognized as a complex condition perpetuated by neuro- and immunopathologies. In this review, we summarize the current knowledg…
View article: An anti-obesity immunotherapy?
An anti-obesity immunotherapy? Open
Adipose tissue–resident macrophages promote lipid storage in mice but can be stopped with antibody treatment
View article: Identification of Sex Differences in Tumor-Specific T Cell Infiltration in Bladder Tumor-Bearing Mice Treated with BCG Immunotherapy
Identification of Sex Differences in Tumor-Specific T Cell Infiltration in Bladder Tumor-Bearing Mice Treated with BCG Immunotherapy Open
BACKGROUND: Bladder cancer is the fourth most common cancer for men. However, women are often diagnosed with later stage disease and have poorer outcomes. Whether immune-based sex differences contribute to this discrepancy is unclear. In a…
View article: Identification of sex differences in tumor-specific T cell infiltration in bladder tumor-bearing mice treated with BCG immunotherapy
Identification of sex differences in tumor-specific T cell infiltration in bladder tumor-bearing mice treated with BCG immunotherapy Open
Bladder cancer is the fourth most common cancer for men. However, women are often diagnosed with later stage disease and have poorer outcomes. Whether immune-based sex differences contribute to this discrepancy is unclear. In addition, mod…
View article: Randomised controlled trial to improve health and reduce substance use in established psychosis (IMPaCT): cost-effectiveness of integrated psychosocial health promotion
Randomised controlled trial to improve health and reduce substance use in established psychosis (IMPaCT): cost-effectiveness of integrated psychosocial health promotion Open
ISRCTN58667926 . Date retrospectively registered: 23/04/2010. Recruitment start date: 01/03/2010.