Cameron D. Wright
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View article: Does Surgical Removal of the Thymus Have Deleterious Consequences?
Does Surgical Removal of the Thymus Have Deleterious Consequences? Open
The role of immunosenescence, particularly the natural process of thymic involution during aging, is increasingly acknowledged as a factor contributing to the development of autoimmune diseases and cancer. Recently, a concern has been rais…
View article: The ASCENT Trial: a phase 2 study of induction and consolidation afatinib and chemoradiation with or without surgery in stage III EGFR-mutant NSCLC
The ASCENT Trial: a phase 2 study of induction and consolidation afatinib and chemoradiation with or without surgery in stage III EGFR-mutant NSCLC Open
Background The role of tyrosine kinase inhibitors (TKIs) in early-stage and metastatic oncogene-driven non–small cell lung cancer (NSCLC) is established, but it remains unknown how best to integrate TKIs with concurrent chemoradiotherapy (…
View article: Microscopic Small Airway Abnormalities Identified in Early Idiopathic Pulmonary Fibrosis <i>In Vivo</i> Using Endobronchial Optical Coherence Tomography
Microscopic Small Airway Abnormalities Identified in Early Idiopathic Pulmonary Fibrosis <i>In Vivo</i> Using Endobronchial Optical Coherence Tomography Open
Rationale: Idiopathic pulmonary fibrosis (IPF) affects the subpleural lung but is considered to spare small airways. Micro-computed tomography (micro-CT) studies demonstrated small airway reduction in end-stage IPF explanted lungs, raising…
View article: Longitudinal Molecular Analysis of Tumor Exome and Transcriptome to Evaluate Clonal Evolution and Identify Novel Therapeutic Targets in Thymoma
Longitudinal Molecular Analysis of Tumor Exome and Transcriptome to Evaluate Clonal Evolution and Identify Novel Therapeutic Targets in Thymoma Open
The rarity of thymic epithelial tumors and limited preclinical modeling constrain our understanding of disease biology and the advancement of rational treatment strategies.Tumor mutational profiling has demonstrated sporadic activating mut…
View article: Supplementary Data from Exploiting MCL1 Dependency with Combination MEK + MCL1 Inhibitors Leads to Induction of Apoptosis and Tumor Regression in <i>KRAS</i>-Mutant Non–Small Cell Lung Cancer
Supplementary Data from Exploiting MCL1 Dependency with Combination MEK + MCL1 Inhibitors Leads to Induction of Apoptosis and Tumor Regression in <i>KRAS</i>-Mutant Non–Small Cell Lung Cancer Open
Supplementary Figure 1-5, Supplementary Tables 1-3
View article: Data from Exploiting MCL1 Dependency with Combination MEK + MCL1 Inhibitors Leads to Induction of Apoptosis and Tumor Regression in <i>KRAS</i>-Mutant Non–Small Cell Lung Cancer
Data from Exploiting MCL1 Dependency with Combination MEK + MCL1 Inhibitors Leads to Induction of Apoptosis and Tumor Regression in <i>KRAS</i>-Mutant Non–Small Cell Lung Cancer Open
BH3 mimetic drugs, which inhibit prosurvival BCL2 family proteins, have limited single-agent activity in solid tumor models. The potential of BH3 mimetics for these cancers may depend on their ability to potentiate the apoptotic response t…
View article: Data from Exploiting MCL1 Dependency with Combination MEK + MCL1 Inhibitors Leads to Induction of Apoptosis and Tumor Regression in <i>KRAS</i>-Mutant Non–Small Cell Lung Cancer
Data from Exploiting MCL1 Dependency with Combination MEK + MCL1 Inhibitors Leads to Induction of Apoptosis and Tumor Regression in <i>KRAS</i>-Mutant Non–Small Cell Lung Cancer Open
BH3 mimetic drugs, which inhibit prosurvival BCL2 family proteins, have limited single-agent activity in solid tumor models. The potential of BH3 mimetics for these cancers may depend on their ability to potentiate the apoptotic response t…
View article: Supplementary Data from Exploiting MCL1 Dependency with Combination MEK + MCL1 Inhibitors Leads to Induction of Apoptosis and Tumor Regression in <i>KRAS</i>-Mutant Non–Small Cell Lung Cancer
Supplementary Data from Exploiting MCL1 Dependency with Combination MEK + MCL1 Inhibitors Leads to Induction of Apoptosis and Tumor Regression in <i>KRAS</i>-Mutant Non–Small Cell Lung Cancer Open
Supplementary Figure 1-5, Supplementary Tables 1-3
View article: Intralesional microbleeding in resected thymic cysts indeterminate on imaging
Intralesional microbleeding in resected thymic cysts indeterminate on imaging Open
Resected thymic cysts in this cohort often showed features suggestive of intralesional microbleeding, inflammation, and fibrosis, which may explain their appearance and behavior over time on CT and MRI.
View article: B cell‐dependent subtypes and treatment‐based immune correlates to survival in stage 3 and 4 lung adenocarcinomas
B cell‐dependent subtypes and treatment‐based immune correlates to survival in stage 3 and 4 lung adenocarcinomas Open
Lung cancer is the leading cause of cancer‐related deaths worldwide. Surgery and chemoradiation are the standard of care in early stages of non‐small cell lung cancer (NSCLC), while immunotherapy is the standard of care in late‐stage NSCLC…
View article: COVID-19-related Post-intubation Tracheal Stenosis
COVID-19-related Post-intubation Tracheal Stenosis Open
Tapias, Luis F. MD; Lanuti, Michael MD; Wright, Cameron D. MD; Hron, Tiffiny A. MD; Ly, Amy MD; Mathisen, Douglas J. MD; Ott, Harald C. MD Author Information
View article: Pregnancy-associated idiopathic laryngotracheal stenosis: presentation, management and results of surgical treatment
Pregnancy-associated idiopathic laryngotracheal stenosis: presentation, management and results of surgical treatment Open
OBJECTIVES Idiopathic laryngotracheal stenosis (ILTS) is an uncommon problem arising mostly in women. In some, it arises during or is exacerbated by pregnancy. Experience with management of patients with this rare association is limited. T…
View article: Monotone Catenary Degree in Numerical Monoids
Monotone Catenary Degree in Numerical Monoids Open
Recent investigations on the catenary degrees of numerical monoids have demonstrated that this invariant is a powerful tool in understanding the factorization theory of this class of monoids. Although useful, the catenary degree is largely…
View article: Hyperbaric oxygen therapy in the prevention and management of tracheal and oesophageal anastomotic complications
Hyperbaric oxygen therapy in the prevention and management of tracheal and oesophageal anastomotic complications Open
OBJECTIVES Failure of anastomotic healing is a morbid complication after airway or oesophageal surgery. Hyperbaric oxygen therapy (HBOT) has been used extensively in the management of complex wound-healing problems. We demonstrate the use …
View article: Esophageal and Esophagogastric Junction Cancers, Version 2.2019, NCCN Clinical Practice Guidelines in Oncology
Esophageal and Esophagogastric Junction Cancers, Version 2.2019, NCCN Clinical Practice Guidelines in Oncology Open
Esophageal cancer is the sixth leading cause of cancer-related deaths worldwide. Squamous cell carcinoma is the most common histology in Eastern Europe and Asia, and adenocarcinoma is most common in North America and Western Europe. Surger…
View article: Management of Pulmonary Hemorrhage Complicating Pulmonary Thromboendarterectomy
Management of Pulmonary Hemorrhage Complicating Pulmonary Thromboendarterectomy Open
Airway management during pulmonary thromboendarterectomy (PTE) can prove challenging, especially in the face of unexpected intraoperative pulmonary hemorrhage. Utilization of proper airway equipment on induction is crucial for the successf…
View article: Feasibility of Perioperative Micro–Computed Tomography of Human Lung Cancer Specimens: A Pilot Study
Feasibility of Perioperative Micro–Computed Tomography of Human Lung Cancer Specimens: A Pilot Study Open
Context.— Lesion localization during intraoperative frozen section of lung resection specimens can be challenging. Imaging could aid lesion localization while enabling 3-dimensional specimen analysis. Objective.— To assess the feasibility …